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Can we stop the stuttering in stroke? Interventions in 40 patients with acute lacunes

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dc.contributor.author Hawkes, Maximiliano Alberto
dc.contributor.author Braksick, Sherri A.
dc.contributor.author Zhang, Wei
dc.contributor.author Wijdicks, Eelco F.M.
dc.contributor.author Rabinstein, Alejandro A.
dc.date.accessioned 2020-01-27T13:55:46Z
dc.date.available 2020-01-27T13:55:46Z
dc.date.issued 2019-06-15
dc.identifier.citation Hawkes MA, Braksick SA, Zhang W, Wijdicks EFM, Rabinstein AA. Can we stop the stuttering in stroke? Interventions in 40 patients with acute lacunes. J Neurol Sci. 2019;401:1-4. doi:10.1016/j.jns.2019.04.009 en_US
dc.identifier.uri https://doi.org/10.1016/j.jns.2019.04.009
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/167
dc.description.abstract Background Whether any treatment can stop fluctuations of stuttering lacunar syndromes (SLS) is unclear. Case reports have variably suggested effectiveness of intravenous thrombolysis, dual antiplatelet treatment, blood pressure augmentation and anticoagulation. We aim to describe our experience with different treatments used in in patients presenting with SLS and their effect on clinical fluctuations and functional outcome. Methods We collected demographic and clinical data of consecutive adult patients with SLS. Descriptive summaries were reported as median and inter-quartile range (IQR) for continuous variables and as frequencies and percentages for categorical variables. Results Forty patients (72 ± 10 years, 36% female) were included. Pure motor syndrome (57%) was the most frequent clinical presentation. Clinical fluctuations stopped and the improvement was temporally related to aspirin-clopidogrel in 11/17 cases, intravenous thrombolysis in 4/6 cases, blood pressure augmentation in 1/3 cases and aspirin in 1/7 cases. Two patients continued fluctuating after IVT and later responded to blood pressure augmentation (n = 1) or aspirin-clopidogrel (n = 1). Conclusions Aspirin plus clopidogrel may be followed by clinical improvement when intravenous thrombolysis is not an option. Blood pressure augmentation may beneficial as ad-on treatment in patients with labile blood pressure. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Cerebrovascular Disorders en_US
dc.subject Trastornos Cerebrovasculares en_US
dc.subject Stroke en_US
dc.subject Accidente Cerebrovascular en_US
dc.subject Stuttering en_US
dc.subject Tartamudeo en_US
dc.title Can we stop the stuttering in stroke? Interventions in 40 patients with acute lacunes en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Hawkes, Maximiliano Alberto. Fleni. Departamento de Medicina Interna; Argentina. Fleni. Departamento de Neurología; Argentina.
dc.description.fil Fil: Braksick, Sherri A. University of Kansas Medical Center. Department of Neurology; Estados Unidos.
dc.description.fil Fil: Zhang, Wei. Mayo Clinic. Department of Neurology. Division of Critical Care Neurology; Estados Unidos.
dc.description.fil Fil: Wijdicks, Eelco F.M. Mayo Clinic. Department of Neurology. Division of Critical Care Neurology; Estados Unidos.
dc.description.fil Fil: Rabinstein, Alejandro A. Mayo Clinic. Department of Neurology. Division of Critical Care Neurology; Estados Unidos.
dc.relation.ispartofVOLUME 401
dc.relation.ispartofPAGINATION 1-4
dc.relation.ispartofCOUNTRY Países Bajos
dc.relation.ispartofCITY Amsterdam
dc.relation.ispartofISSN 1878-5883
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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