DSpace Repository

Retrieval of Retrained and Reconsolidated Memories Are Associated With a Distinct Neural Network

Show simple item record

dc.contributor.author Bavassi, Luz
dc.contributor.author Forcato, Cecilia
dc.contributor.author Fernández, Rodrigo Sebastián
dc.contributor.author De Pino, Gabriela
dc.contributor.author Pedreira, María Eugenia
dc.contributor.author Villarreal, Mirta Fabiana
dc.date.accessioned 2020-02-05T14:00:52Z
dc.date.available 2020-02-05T14:00:52Z
dc.date.issued 2019-01-28
dc.identifier.citation Bavassi, L., Forcato, C., Fernández, R.S., De Pino, G., Pedreira, M.E., Villarreal, M.F. Retrieval of retrained and reconsolidated memories are associated with a distinct neural network. Scientific Reports 2019 Jan 28;9(1):784. doi: 10.1038/s41598-018-37089-2. Erratum in: Sci Rep. 2019 Apr 10;9(1):6098. en_US
dc.identifier.uri https://doi.org/10.1038/s41598-018-37089-2
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/175
dc.description.abstract Consolidated memories can persist from a single day to years, and persistence is improved by retraining or retrieval-mediated plasticity. One retrieval-based way to strengthen memory is the reconsolidation process. Strengthening occurs simply by the presentation of specific cues associated with the original learning. This enhancement function has a fundamental role in the maintenance of memory relevance in animals everyday life. In the present study, we made a step forward in the identification of brain correlates imprinted by the reconsolidation process studying the long-term neural consequences when the strengthened memory is stable again. To reach such a goal, we compared the retention of paired-associate memories that went through retraining process or were labilizated-reconsolidated. Using functional magnetic resonance imaging (fMRI), we studied the specific areas activated during retrieval and analyzed the functional connectivity of the whole brain associated with the event-related design. We used Graph Theory tools to analyze the global features of the network. We show that reconsolidated memories imprint a more locally efficient network that is better at exchanging information, compared with memories that were retrained or untreated. For the first time, we report a method to elucidate the neural footprints associated with a relevant function of memory reconsolidation. en_US
dc.language.iso eng en_US
dc.publisher Nature Publishing Group en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Memory en_US
dc.subject Memoria en_US
dc.subject Neuroimaging en_US
dc.subject Neuroimagen en_US
dc.title Retrieval of Retrained and Reconsolidated Memories Are Associated With a Distinct Neural Network en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Bavassi, Luz. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina.
dc.description.fil Fil: Forcato, Cecilia. Universidad Nacional "Arturo Jauretche". Hospital de Alta Complejidad en Red El Cruce "Néstor Kirchner". Unidad Ejecutora de Estudios de Neurociencias y Sistemas Complejos; Argentina.
dc.description.fil Fil: Fernández, Rodrigo Sebastián. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina.
dc.description.fil Fil: De Pino, Gabriela. Fleni. Departamento de Diagnóstico por Imágenes. Laboratorio de Neuroimágenes; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología. Centro Universitario de Imágenes Médicas; Argentina. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina.
dc.description.fil Fil: Pedreira, María Eugenia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina.
dc.description.fil Fil: Villarreal, Mirta Fabiana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina.
dc.relation.ispartofVOLUME 9
dc.relation.ispartofNUMBER 1
dc.relation.ispartofCOUNTRY Reino Unido
dc.relation.ispartofCITY Londres
dc.relation.ispartofTITLE Scientific reports
dc.relation.ispartofISSN 2045-2322
dc.type.snrd info:ar-repo/semantics/artículo es_ES


Files in this item

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/openAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/openAccess

Search DSpace


Browse

My Account

Statistics