• Disability outcomes in NMOSD and MOGAD patients: data from a nationwide registry in Argentina 

  Rojas, Juan I.; Pappolla, Agustín; Patrucco, Liliana; Cristiano, Edgardo; Miguez, Jimena; Liwacki, Susana; Tkachuk, Verónica; Balbuena, María E.; Vrech, Carlos; Deri, Norma; Correale, Jorge; Marrodán, Mariano; Ysrraelit, María Célica; Fiol, Marcela Paula; Leguizamon, Felisa; Luetic, Geraldine; Menichini, María L.; Lopez, Pablo A.; Pettinicchi, Juan Pablo; Criniti, Juan (Springer-Verlag Italia, 2023-01)

  The objective was to evaluate time to reach an EDSS of 4, 6, and 7 in NMOSD and MOGAD patients included in the Argentinean MS and NMOSD registry (RelevarEM, NCT 03,375,177). Methods: NMOSD patients diagnosed according ...
• Glial Cell Metabolic Profile Upon Iron Deficiency: Oligodendroglial and Astroglial Casualties of Bioenergetic Adjustments 

  Rosato-Siri, María Victoria; Martino Adami, Pamela V.; Guitart, María Eugenia; Verstraeten, Sandra; Morelli, Laura; Correale, Jorge; Pasquini, Juana María (Humana Press, 2023-01-03)

  Iron deficiency (ID) represents one of the most prevalent nutritional deficits, affecting almost two billion people worldwide. Gestational iron deprivation induces hypomyelination due to oligodendroglial maturation ...
• Evaluation of Baculoviruses as Gene Therapy Vectors for Brain Cancer 

  Garcia Fallit, Matías; Pidre, Matías L.; Asad, Antonela S.; Peña Agudelo, Jorge A.; Vera, Mariana B.; Nicola Candia, Alejandro J.; Sagripanti, Sofia B.; Pérez Kuper, Melanie; Amorós Morales, Leslie C.; Marchesini, Abril; Gonzalez, Nazareno; Caruso, Carla M.; Romanowski, Víctor; Seilicovich, Adriana; Videla-Richardson, Guillermo Agustín; Zanetti, Flavia A.; Candolfi, Marianela (MDPI, 2023-02-22)

  We aimed to assess the potential of baculoviral vectors (BV) for brain cancer gene therapy. We compared them with adenoviral vectors (AdV), which are used in neuro-oncology, but for which there is pre-existing immunity. ...
• Abnormal brain network community structure related to psychological stress in schizophrenia 

  Castro, Mariana Nair; Bocaccio, Hernán; De Pino, Gabriela; Sánchez, Stella M.; Agustina Edith, Wainsztein; Drucaroff, Lucas; Costanzo, Elsa; Crossley, Nicolas; Mirta Fabiana, Villarreal; Guinjoan, Salvador Martín (Elsevier, 2023-02-15)

  Recent functional imaging studies in schizophrenia consistently report a disruption of brain connectivity. However, most of these studies analyze the brain connectivity during resting state. Since psychological stress is ...
• A critical pathway in human development: C19MC micrornas regulates FGF2 response in a model of human pluripotent stem cells cardiac differentiation 

  Möbbs, Alan Miqueas; Garate, Ximena; Scarafia, Maria Agustina; Colli, Carolina; Moro, Natalia Lucía; Luzzani, Carlos; Waisman, Ariel; La Greca, Alejandro; Miriuka, Santiago Gabriel (Fundación Revista Medicina, 2021-11)

  Human pluripotent stem cells (hPSC) have the capacity to self-renew and differentiate in vitro into all cell types of the organism, and it is an established model for early human embryo development. Recently, we found ...
• Simple Microcontact Printing Technique to Obtain Cell Patterns by Lithography Using Grayscale, Photopolymer Flexographic Mold, and PDMS 

  Gimenez, Rocio; Pérez-Sosa, Camilo; Bourguignon, Natalia; Miriuka, Santiago Gabriel; Bhansali, Shekhar; Arroyo, Carlos R.; Debut, Alexis; Lerner, Betiana; Pérez, Maximiliano S. (MDPI AG, 2022-10-08)

  Microcontact printing using PDMS embossing tools and its variations have aroused the interest of a wide spectrum of research fields, hence the feasibility of defining micro and nanoscale patterns. In this work, we have ...
• A neurodegenerative disease landscape of rare mutations in Colombia due to founder effects 

  Acosta-Uribe, Juliana; Aguillón, David; Cochran, J. Nicholas; Giraldo, Margarita; Madrigal, Lucía; Killingsworth, Bradley W.; Singhal, Rijul; Labib, Sarah; Alzate, Diana; Velilla, Lina; Moreno, Sonia; García, Gloria P.; Saldarriaga, Amanda; Piedrahita, Francisco; Hincapié, Liliana; López, Hugo E.; Perumal, Nithesh; Surace, Ezequiel Ignacio; Itzcovich, Tatiana; Allegri, Ricardo Francisco (BioMed Central, 2022-03-08)

  Background: The Colombian population, as well as those in other Latin American regions, arose from a recent tri-continental admixture among Native Americans, Spanish invaders, and enslaved Africans, all of whom passed ...
• Neurosciences and Neuro post-COVID-19 

  Allegri, Ricardo Francisco; Román, Fabián; Barceló, Ernesto (Universidad de la Costa, 2021-03-23)

  Editorial
• Consecuencias Neurológicas y Psiquiátricas a largo plazo (6 meses) en pacientes con COVID leve de la comunidad 

  Allegri, Ricardo Francisco; Calandri, Ismael Luis; Caride, A.; Román, F.; Llera, J.; Palma, A.; Bartoloni, L.; Carozzela, A.; González-Sanz, P.; Mouchet, E.; Fernández-Díaz, Paula C.; Morasso, C.; Tarulla, Adriana (Universidad de la Costa, 2022-06-08)

  Las complicaciones neurológicas a largo plazo de la infección por coronavirus han sido descriptas en los pacientes hospitalizados en el episodio agudo. De ellos el 63% presentaron fatiga y debilidad muscular, el 26% ...
• Acute severe hypoxia induces apoptosis of human pluripotent stem cells by a HIF-1α and P53 independent mechanism 

  Mucci, Sofía; Isaja, Luciana; Rodríguez-Varela, María Soledad; Ferriol-Laffouillere, Sofía Luján; Marazita, Mariela Claudia; Videla-Richardson, Guillermo Agustín; Sevlever, Gustavo Emilio; Scassa, María Elida; Romorini, Leonardo (Nature Publishing Group, 2022-10-05)

  Human embryonic and induced pluripotent stem cells are self-renewing pluripotent stem cells (hPSCs) that can differentiate into a wide range of specialized cells. Although moderate hypoxia (5% O2) improves hPSC self-renewal, ...
• SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy 

  Muñiz, Javier Andrés; Facal, Carolina Lucía; Urrutia, Leandro; Clerici-Delville, Ramiro; Damianich, Ana; Ferrario, Juan E.; Falasco, Germán; Avale, María Elena (Frontiers Media S.A., 2022-09-05)

  Tau is a microtubule-associated protein predominantly expressed in neurons, which participates in microtubule polymerization and axonal transport. Abnormal tau metabolism leads to neurodegenerative diseases named tauopathies, ...
• Single cell transfection of human-induced pluripotent stem cells using a droplet-based microfluidic system 

  Pérez-Sosa, Camilo; Sanluis-Verdes, Anahí; Waisman, Ariel; Lombardi, Antonella; Rosero, Gustavo; La Greca, Alejandro; Bhansali, Shekhar; Bourguignon, Natalia; Luzzani, Carlos; Pérez, Maximiliano S.; Miriuka, Santiago Gabriel; Lerner, Betiana (Royal Society Publishing, 2022-01-12)

  Microfluidic tools have recently made possible many advances in biological and biomedical research. Research in fields such as physics, engineering, chemistry and biology have combined to produce innovation in microfluidics ...
• Natural language signatures of psilocybin microdosing 

  Sanz, Camila; Cavanna, Federico; Muller, Stephanie; de la Fuente, Laura A; Zamberlan, Federico; Palmucci, Matías; Janeckova, Lucie; Kuchar, Martin; Carrillo, Facundo; García, Adolfo M.; Pallavicini, Carla; Tagliazucchi, Enzo (Springer-Verlag, 2022-09)

  Rationale: Serotonergic psychedelics are being studied as novel treatments for mental health disorders and as facilitators of improved well-being, mental function, and creativity. Recent studies have found mixed results ...
• GEMA—An Automatic Segmentation Method for Real-Time Analysis of Mammalian Cell Growth in Microfluidic Devices 

  Isa-Jara, Ramiro; Pérez-Sosa, Camilo; Macote-Yparraguirre, Erick; Revollo, Natalia; Lerner, Betiana; Miriuka, Santiago Gabriel; Delrieux, Claudio; Pérez, Maximiliano; Mertelsmann, Roland (MDPI, 2022-10-14)

  Nowadays, image analysis has a relevant role in most scientific and research areas. This process is used to extract and understand information from images to obtain a model, knowledge, and rules in the decision process. ...
• Galectins as Emerging Glyco-Checkpoints and Therapeutic Targets in Glioblastoma 

  Videla-Richardson, Guillermo Agustín; Morris-Hanon, Olivia; Torres, Nicolás I.; Esquivel, Myrian I.; Vera, Mariana B.; Ripari, Luisina B.; Croci, Diego O.; Sevlever, Gustavo Emilio; Rabinovich, Gabriel A. (Molecular Diversity Preservation International, 2021-12-28)

  Despite recent advances in diagnosis and treatment, glioblastoma (GBM) represents the most common and aggressive brain tumor in the adult population, urging identification of new rational therapeutic targets. Galectins, a ...
• Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study 

  Cavanna, Federico; Muller, Stephanie; de la Fuente, Laura A; Zamberlan, Federico; Palmucci, Matías; Janeckova, Lucie; Kuchar, Martin; Pallavicini, Carla (Nature Pub. Group, 2022-08-02)

  The use of low sub-perceptual doses of psychedelics ("microdosing") has gained popularity in recent years. Although anecdotal reports claim multiple benefits associated with this practice, the lack of placebo-controlled ...
• Protocol for morphometric analysis of neurons derived from human pluripotent stem cells 

  Mucci, Sofía; Rodriguez-Varela, María Soledad; Isaja, Luciana; Ferriol-Laffouillere, Sofía Luján; Sevlever, Gustavo Emilio; Scassa, María Elida; Romorini, Leonardo (Cell Press, 2022-06-18)

  The analysis of morphological features of neurons derived from human pluripotent stem cells (hPSCs) is important to describe neuronal phenotypes and changes observed throughout development. Using free and easily accessible ...
• Unifying turbulent dynamics framework distinguishes different brain states 

  Escrichs, Anira; Sanz Perl, Yonatan; Uribe, Carme; Camara, Estela; Türker, Basak; Pyatigorskaya, Nadya; López-González, Ane; Pallavicini, Carla; Panda, Rajanikant; Annen, Jitka; Gosseries, Olivia; Laureys, Steven; Naccache, Lionel; Sitt, Jacobo D.; Laufs, Helmut; Tagliazucchi, Enzo; Kringelbach, Morten L.; Deco, Gustavo (Nature Publishing Group UK, 2022-05-29)

  Significant advances have been made by identifying the levels of synchrony of the underlying dynamics of a given brain state. This research has demonstrated that non-conscious dynamics tend to be more synchronous than in ...
• Embryoid Bodies-Based Multilineage Differentiation of Human Embryonic Stem Cells Grown on Feeder-Free Conditions 

  Isaja, Luciana; Ferriol-Laffouillere, Sofía Luján; Mucci, Sofía; Rodríguez-Varela, María Soledad; Romorini, Leonardo (Springer, 2021-10-06)

  Human embryonic stem cells (hESCs) can differentiate into any cell lineage (pluripotency potential) derived from the three germ layers: ectoderm, mesoderm, and endoderm. Pluripotency is usually demonstrated in vitro by ...
• Effect of Embryo Aggregation on In Vitro Development of Adipose-Derived Mesenchymal Stem Cell-Derived Bovine Clones 

  Savy, Virginia; Alberio, Virgilia; Vans Landschoot, Geraldina; Moro, Lucía Natalia; Olea, Fernanda Daniela; Rodríguez-Álvarez, Lleretny; Salamone, Daniel Felipe (Mary Ann Liebert, 2021-10-12)

  Somatic cell nuclear transfer (SCNT) is a method with unique ability to reprogram the epigenome of a fully differentiated cell. However, its efficiency remains extremely low. In this work, we assessed and combined two ...

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