• Immune Single-Cell Annotation by Molecular Signature-Based Deconvolution with MIXTURE 

  Nava, Agustin; Nibeyro, Guadalupe; Orschanski, Daniela; Baronetto, Veronica; Llera, Andrea S.; Fernández, Elmer A. (Springer Nature, 2025-05-23)

  Accurate cell type identification in single-cell RNA sequencing (scRNA-seq) datasets is essential for dissecting the tumor immune microenvironment (TIME) and optimizing immunotherapy strategies. Here, we present an annotation ...
• Predicting Treatment Outcomes in Glioblastoma: A Risk Score Model for TMZ Resistance and Immune Checkpoint Inhibition 

  Gonzalez, Nazareno; Perez Küper, Melanie; Garcia Fallit, Matias; Nicola Candia, Alejandro J.; Peña Agudelo, Jorge A.; Suarez Velandia, Maicol; Romero, Ana Clara; Videla-Richardson, Guillermo Agustin; Candolfi, Marianela (MDPI, 2025-05-20)

  Glioblastoma (GBM) presents significant therapeutic challenges due to its invasive nature and resistance to standard chemotherapy, i.e., temozolomide (TMZ). This study aimed to identify gene signatures that predict poor ...
• Liquid biopsy based on whole blood transcriptome and artificial intelligence for the prediction of coronary artery calcification: a pilot study 

  Poggio, Rosana; Rodriguez-Granillo, Gaston A.; De Lillo, Florencia; Rubilar, Alejandra Bibiana; Garron-Arias, Sarah Y.; Pérez, Nelba; Hijazi, Razan; Solari, Claudia; Olivera-Mores, María; Rodríguez Varela, María Soledad; Möbbs, Alan; Mancini, Estefanía; Berdiñas, Ignacio; La Greca, Alejandro; Luzzani, Carlos; Miriuka, Santiago Gabriel (Oxford, 2025-05-02)

  Aims Whole blood RNA expression is modulated in response to signals from tissues, including the vessel wall. The primary objective of this study was to explore the ability of whole blood transcriptomes, analysed using ...
• Generation of human induced pluripotent stem cell lines from two down syndrome patients, including a down syndrome/Alzheimer's disease case (FLENIi002-A) and a beta-amyloid-resistant case (FLENIi003-A) 

  Clas, Giulia Solange; Marazita, Mariela Claudia; Pertierra, Lucía; Vázquez, Silvia; Isaja, Luciana; Rodríguez Varela, María Soledad; Mucci, Sofía; Helou, María Belén; Tapajóz Pereira de Sampaio, Fernanda; Magrath Guimet, Nahuel; Bérgamo, Yanina; Allegri, Ricardo Francisco; Sevlever, Gustavo Emilio; Scassa, María Élida; Surace, Ezequiel Ignacio; Romorini, Leonardo (Elsevier, 2025-05-01)

  Two human induced pluripotent stem cell (hiPSC) lines, FLENIi002-A and FLENIi003-A, were generated from peripheral blood mononuclear cells (PBMCs) using the lentiviral-hSTEMCCA-loxP vector. FLENIi002-A was derived from a ...
• Artificial Intelligence-Based Virtual Assistant for the Diagnostic Approach of Chronic Ataxias 

  Alessandro, Lucas; Bianciotti, Nicolas; Salama, Luciana; Volmaro, Santiago; Navarrine, Veronica; Ameghino, Lucía; Arena, Julieta E.; Bestoso, Santiago; Bruno, Veronica; Castillo Torres, Sergio; Chamorro, Mauricio; Couto, Blas; De La Riestra, Tomas; Echeverria, Florencia; Genco, Juan; Gonzalez Del Boca, Federico; Laffue, Alfredo Hernan; Tela, Marcela; Farez, Mauricio Franco; Rossi, Malco Damián (Wiley, 2025-03-22)

  Background: Chronic ataxias, a complex group of over 300 diseases, pose significant diagnostic challenges because of their clinical and genetic heterogeneity. Here, we propose that artificial intelligence (AI) can aid in ...
• Evaluation of the correlation coefficient to determine the severity of bone marrow infiltration between bone marrow burden, fat fraction and Lyso GL1 in adult patients with Gaucher disease. A Study from the Argentine group for the diagnosis and treatment of GD 

  Soberon, Barbara C.; Drelichman, Guillermo I.; Aguilar, Gabriel H.; Fernandez Escobar, Nicolas; Basack, Nora; Larroude, Maria S.; Martin-Noguerol, Teodoro; Watman, Nora; Elena, Graciela O.; Dragosky, Marta; Cuello, Maria F.; Arizó, Adriana D.V.; Quijano, Sandra L.; Mandrile, Laura; Diez, Blanca; Lanza, Victoria C.; Rocaspana, Adriana E.; Avalos, Vanesa; Degano, Adriana N.; Borchichi, Sandra R. (Elsevier, 2025-01-30)

  Resumen no disponible
• SARS-CoV-2 Impairs Osteoblast Differentiation Through Spike Glycoprotein and Cytokine Dysregulation 

  Freiberger, Rosa Nicole; López, Cynthia Alicia Marcela; Jarmoluk, Patricio; Palma, María Belén; Cevallos, Cintia; Sviercz, Franco Agustin; Grosso, Tomás Martín; García, Marcela Nilda; Quarleri, Jorge; Delpino, María Victoria (MDPI, 2025-01-22)

  Pulmonary and extrapulmonary manifestations have been reported following infection with SARS-CoV-2, the causative agent of COVID-19. The virus persists in multiple organs due to its tropism for various tissues, including ...
• The pleomorphic phenotype of neurosarcoidosis 

  Garat, Oscar E.; Perez Arana, Carolina I.; Perandones, Carlos E.; Correale, Jorge; Marrodán, Mariano (Springer-Verlag Italia, 2024-12-20)
• Advancing biobanking in Latin America: success stories and challenges ahead 

  Sevlever, Gustavo Emilio; Crivelli, Lucía; Kimie Suemoto, Claudia; Surace, Ezequiel Ignacio; Taratuto, Ana Lía (Elsevier, 2025-03-03)

  Resumen no disponible
• Characterization of a novel heterozygous variant in the histidyl-tRNA synthetase gene associated with Charcot-Marie-Tooth disease type 2W 

  Wilhelm, Sarah D. P.; Moresco, Angelica A.; Rivero, Alberto Daniel; Mok Siu, Victoria; Heinemann, Ilka U. (Taylor & Francis, 2024-10-01)

  Heterozygous pathogenic variants in the histidyl-tRNA synthetase (HARS) gene are associated with Charcot-Marie-Tooth (CMT) type 2W disease, classified as an axonal peripheral neuropathy. To date, at least 60 variants causing ...
• HIV Modulates Osteoblast Differentiation via Upregulation of RANKL and Vitronectin 

  Freiberger, Rosa Nicole; López, Cynthia Alicia Marcela; Palma, María Belén; Cevallos, Cintia; Sviercz, Franco Agustin; Jarmolu, Patricio; García, Marcela Nilda; Quarleri, Jorge; Delpino, M. Victoria (MDPI AG, 2024-09-15)

  Bone loss is a prevalent characteristic among people with HIV (PWH). We focused on mesenchymal stem cells (MSCs) and osteoblasts, examining their susceptibility to different HIV strains (R5- and X4-tropic) and the subsequent ...
• CDK5 Deficiency Does not Impair Neuronal Differentiation of Human Induced Pluripotent Stem Cells but Affects Neurite Outgrowth 

  Mucci, Sofía; Clas, Giulia Solange; Allio, Camila Paola; Rodríguez Varela, María Soledad; Isaja, Luciana; Marazita, Mariela Claudia; Sevlever, Gustavo Emilio; Scassa, María Élida; Romorini, Leonardo (Humana Press, 2024-06-28)

  Cyclin-dependent kinase 5 (CDK5) is a protein kinase involved in neuronal homeostasis and development critical for neuronal survival. Besides, its deregulation is linked to neurodegenerative pathologies such as Alzheimer's ...
• Country-level gender inequality is associated with structural differences in the brains of women and men 

  Zugman, Andre; Alliende, Luz María; Medel, Vicente; A I Bethlehem, Richard; Seidlitz, Jakob; Ringlein, Grace; Arango, Celso; Arnatkevičiūtė, Aurina; Asmal, Laila; Bellgrove, Mark; Benegal, Vivek; Bernardo, Miquel; Billeke, Pablo; Bosch-Bayard, Jorge; Bressan, Rodrigo; Busatto, Geraldo F.; Castro, Mariana Nair; Chaim-Avancini, Tiffany; Compte, Albert; Villarreal, Mirta Fabiana (National Academy of Sciences, 2023-05-16)

  Gender inequality across the world has been associated with a higher risk to mental health problems and lower academic achievement in women compared to men. We also know that the brain is shaped by nurturing and adverse ...
• EFFECTS OF BACTERIAL LIPOPOLYSACCHARIDE AND SHIGA TOXIN ON INDUCED PLURIPOTENT STEM CELL-DERIVED MESENCHYMAL STEM CELLS 

  Martire-Greco, Daiana; La Greca, Alejandro; Castillo Montañez, Luis; Biani, María Celeste; Lombardi, Antonella; Birnberg-Weiss, Federico; Norris, Alessandra; Sacerdoti, Flavia; Amaral, María Marta; Rodrigues-Rodriguez, Nahuel; Pittaluga, Jose Ramón; Furmento, Verónica Alejandra; Landoni, Verónica Inés; Miriuka, Santiago Gabriel; Luzzani, Carlos Daniel; Fernández, Gabriela Cristina (Lippincott Williams & Wilkins, 2023-04-11)

  Background : Mesenchymal stem cells (MSCs) can be activated by different bacterial toxins. Lipopolysaccharides and Shiga Toxin (Stx) are the main toxins necessary for hemolytic uremic syndrome development. The main etiological ...
• Iron deficiency in astrocytes alters cellular status and impacts on oligodendrocyte differentiation. 

  Marcora, María Silvina; Mattera, Vanesa S.; Goñi, Pilar; Aybar, Florencia; Correale, Jorge; Pasquini, Juana María (Wiley Interscience, 2024-04)

  Iron deficiency (ID) has been shown to affect central nervous system (CNS) development and induce hypomyelination. Previous work from our laboratory in a gestational ID model showed that both oligodendrocyte (OLG) and ...
• Droplets for Gene Editing Using CRISPR-Cas9 and Clonal Selection Improvement Using Hydrogels. 

  Pérez Sosa, Camilo; Pérez, Maximiliano S.; Vallejo Janeta, Alexander Paolo; Bhansali, Shekhar; Miriuka, Santiago Gabriel; Lerner, Betiana (MDPI, 2024-02-19)

  Gene editing tools have triggered a revolutionary transformation in the realms of cellular and molecular physiology, serving as a fundamental cornerstone for the evolution of disease models and assays in cell culture ...
• Peritumoral adipose tissue promotes lipolysis and white adipocytes browning by paracrine action 

  Pagnotta, Priscila; Gantov, Mariana; Fletcher, Sabrina; Lombardi, Antonella; Crosbie, María Lujan; Santiso, Natalia; Ursino, Anabela; Frascarolli, Celeste; Amato, Alicia; Dreszman, Rubén; Calvo, Juan Carlos; Toneatto, Judith (Frontiers Research Foundation, 2023-04-26)

  Background: Stromal adipocytes and tumor breast epithelial cells undergo a mutual metabolic adaptation within tumor microenvironment. Therefore, browning and lipolysis occur in cancer associated adipocytes (CAA). However, ...
• A miR-137-Related Biological Pathway of Risk for Schizophrenia Is Associated With Human Brain Emotion Processing 

  Pergola, Giulio; Rampino, Antonio; Sportelli, Leonardo; Borcuk, Christopher James; Passiatore, Roberta; Di Carlo, Pasquale; Marakhovskaia, Aleksandra; Fazio, Leonardo; Amoroso, Nicola; Castro, Mariana Nair; Domenici, Enrico; Gennarelli, Massimo; Khlghatyan, Jivan; Christos Kikidis, Gianluca; Lella, Annalisa; Magri, Chiara; Monaco, Alfonso; Papalino, Marco; Parihar, Madhur; Popolizio, Teresa (Elsevier, 2023-11-22)

  Background: miR-137 is a microRNA involved in brain development, regulating neurogenesis and neuronal maturation. Genome-wide association studies have implicated miR-137 in schizophrenia risk but do not explain its involvement ...
• PluriBAC: A Versatile Baculovirus-Based Modular System to Express Heterologous Genes in Different Biotechnological Platforms 

  Amorós Morales, Leslie C.; Marchesini, Abril; Gómez Bergna, Santiago M.; García Fallit, Matías; Tongiani, Silvana E.; Vásquez, Larisa; Ferrelli, María Leticia; Videla Richardson, Guillermo Agustín; Candolfi, Marianela; Romanowski, Víctor; Pidre, Matías L. (MDPI, 2023-09-23)

  Baculoviruses are insect-specific pathogens widely used in biotechnology. In particular, the Autographa californica nucleopolyhedrovirus (AcMNPV) has been exploited as a platform for bio-inputs production. This is why the ...
• Role of hydroxymethylglutharyl-coenzyme A reductase in the induction of stem-like states in breast cancer 

  Marks, María Paula; Giménez, Carla Alejandra; Isaja, Luciana; Vera, Mariana Belén; Borzone, Francisco Raúl; Pereyra-Bonnet, Federico; Romorini, Leonardo; Videla Richardson, Guillermo Agustín; Chasseing, Norma Alejandra; Calvo, Juan Carlos; Vellón, Luciano (Springer-Verlag, 2024-02-28)

  Purpose: De novo synthesis of cholesterol and its rate-limiting enzyme, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMGCR), is deregulated in tumors and critical for tumor cell survival and proliferation. However, ...

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