• Droplets for Gene Editing Using CRISPR-Cas9 and Clonal Selection Improvement Using Hydrogels. 

  Pérez Sosa, Camilo; Pérez, Maximiliano S.; Vallejo Janeta, Alexander Paolo; Bhansali, Shekhar; Miriuka, Santiago Gabriel; Lerner, Betiana (MDPI, 2024-02-19)

  Gene editing tools have triggered a revolutionary transformation in the realms of cellular and molecular physiology, serving as a fundamental cornerstone for the evolution of disease models and assays in cell culture ...
• Peritumoral adipose tissue promotes lipolysis and white adipocytes browning by paracrine action 

  Pagnotta, Priscila; Gantov, Mariana; Fletcher, Sabrina; Lombardi, Antonella; Crosbie, María Lujan; Santiso, Natalia; Ursino, Anabela; Frascarolli, Celeste; Amato, Alicia; Dreszman, Rubén; Calvo, Juan Carlos; Toneatto, Judith (Frontiers Research Foundation, 2023-04-26)

  Background: Stromal adipocytes and tumor breast epithelial cells undergo a mutual metabolic adaptation within tumor microenvironment. Therefore, browning and lipolysis occur in cancer associated adipocytes (CAA). However, ...
• A miR-137-Related Biological Pathway of Risk for Schizophrenia Is Associated With Human Brain Emotion Processing 

  Pergola, Giulio; Rampino, Antonio; Sportelli, Leonardo; Borcuk, Christopher James; Passiatore, Roberta; Di Carlo, Pasquale; Marakhovskaia, Aleksandra; Fazio, Leonardo; Amoroso, Nicola; Castro, Mariana Nair; Domenici, Enrico; Gennarelli, Massimo; Khlghatyan, Jivan; Christos Kikidis, Gianluca; Lella, Annalisa; Magri, Chiara; Monaco, Alfonso; Papalino, Marco; Parihar, Madhur; Popolizio, Teresa (Elsevier, 2023-11-22)

  Background: miR-137 is a microRNA involved in brain development, regulating neurogenesis and neuronal maturation. Genome-wide association studies have implicated miR-137 in schizophrenia risk but do not explain its involvement ...
• PluriBAC: A Versatile Baculovirus-Based Modular System to Express Heterologous Genes in Different Biotechnological Platforms 

  Amorós Morales, Leslie C.; Marchesini, Abril; Gómez Bergna, Santiago M.; García Fallit, Matías; Tongiani, Silvana E.; Vásquez, Larisa; Ferrelli, María Leticia; Videla Richardson, Guillermo Agustín; Candolfi, Marianela; Romanowski, Víctor; Pidre, Matías L. (MDPI, 2023-09-23)

  Baculoviruses are insect-specific pathogens widely used in biotechnology. In particular, the Autographa californica nucleopolyhedrovirus (AcMNPV) has been exploited as a platform for bio-inputs production. This is why the ...
• Role of hydroxymethylglutharyl-coenzyme A reductase in the induction of stem-like states in breast cancer 

  Marks, María Paula; Giménez, Carla Alejandra; Isaja, Luciana; Vera, Mariana Belén; Borzone, Francisco Raúl; Pereyra-Bonnet, Federico; Romorini, Leonardo; Videla Richardson, Guillermo Agustín; Chasseing, Norma Alejandra; Calvo, Juan Carlos; Vellón, Luciano (Springer-Verlag, 2024-02-28)

  Purpose: De novo synthesis of cholesterol and its rate-limiting enzyme, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMGCR), is deregulated in tumors and critical for tumor cell survival and proliferation. However, ...
• Broad-Spectrum Antiviral Effect of Cannabidiol Against Enveloped and Nonenveloped Viruses 

  Marquez, Agostina B.; Vicente, Josefina; Castro, Eliana; Vota, Daiana; Rodríguez Varela, María Soledad; Lanza Castronuovo, Priscila A.; Fuentes, Giselle M.; Parise, Alejandro R.; Romorini, Leonardo; Alvarez, Diego E.; Bueno, Carlos A.; Ramirez, Cristina L.; Alaimo, Agustina; García, Cybele C. (Mary Ann Liebert, 2023-09-08)

  Introduction: Cannabidiol (CBD), the main non-psychoactive cannabinoid of the Cannabis sativa plant, is a powerful antioxidant compound that in recent years has increased interest due to causes effects in a wide range of ...
• Mitochondrial Peptide Humanin Facilitates Chemoresistance in Glioblastoma Cells 

  Peña Agudelo, Jorge A.; Pidre, Matías L.; Garcia Fallit, Matias; Pérez Küper, Melanie; Zuccato, Camila; Nicola Candia, Alejandro J.; Marchesini, Abril; Vera, Mariana Belén; De Simone, Emilio; Giampaoli, Carla; Amorós Morales, Leslie C.; Gonzalez, Nazareno; Romanowski, Víctor; Videla Richardson, Guillermo Agustín; Seilicovich, Adriana; Candolfi, Marianela (MDPI, 2023-08-11)

  Humanin (HN) is a mitochondrial-derived peptide with robust cytoprotective effects in many cell types. Although the administration of HN analogs has been proposed to treat degenerative diseases, its role in the pathogenesis ...
• Spirituality and Cognitive Neurosciences 

  Allegri, Ricardo Francisco; Román, Fabián; Barceló Martínez, Ernesto (Universidad de la Costa, 2023-10-23)
• Editorial: Advances in platforms for disease modelling 

  Romorini, Leonardo; Baweja, Sukriti; Martin Mateos, Rosa Maria; Mehta, Gautam; Jalan-Sakrikar, Nidhi (Frontiers Media, 2023-04-19)

  Resumen no disponible
• Low-dimensional organization of global brain states of reduced consciousness 

  Perl, Yonatan Sanz; Pallavicini, Carla; Piccinini, Juan; Demertzi, Athena; Bonhomme, Vincent; Martial, Charlotte; Panda, Rajanikant; Alnagger, Naji; Annen, Jitka; Gosseries, Olivia; Ibañez, Agustín; Laufs, Helmut; Sitt, Jacobo D.; Jirsa, Viktor K.; Kringelbach, Morten; Laureys, Steven; Deco, Gustavo; Tagliazucchi, Enzo (Elsevier, 2023-05-11)

  Brain states are frequently represented using a unidimensional scale measuring the richness of subjective experience (level of consciousness). This description assumes a mapping between the high-dimensional space of ...
• Body mass index, waist circumference, insulin, and leptin plasma levels differentiate between clozapine-responsive and clozapine-resistant schizophrenia 

  Hönig, Guillermo; Daray, Federico M.; Rodante, Demián; Drucaroff, Lucas Javier; Gutiérrez, María Laura; Lenze, Mariela; García Bournissen, Facundo; Wikinski, Silvia (Sage, 2023-06-28)

  Background: Between 25% and 50% of patients suffering from treatment-resistant schizophrenia fail to achieve a clinical response with clozapine. The rapid identification and treatment of this subgroup of patients represents ...
• Chromatographic Scalable Method to Isolate Engineered Extracellular Vesicles Derived from Mesenchymal Stem Cells for the Treatment of Liver Fibrosis in Mice 

  Domínguez, Luciana M.; Bueloni, Bárbara; Cantero, María José; Albornoz, Milagros; Pacienza, Natalia; Biani, María Celeste; Luzzani, Carlos Daniel; Miriuka, Santiago Gabriel; García, Mariana; Atorrasagasti, Catalina; Yannarelli, Gustavo; Bayo, Juan; Fiore, Esteban; Mazzolini, Guillermo (MDPI, 2023-05-31)

  New therapeutic options for liver cirrhosis are needed. Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have emerged as a promising tool for delivering therapeutic factors in regenerative medicine. Our aim ...
• The role of microfluidics and 3D-bioprinting in the future of exosome therapy 

  Amondarain, Mikele; Gallego, Idoia; Puras, Gustavo; Saenz-Del-Burgo, Laura; Luzzani, Carlos Daniel; Pedraz, José Luis (Elsevier, 2023-06-09)

  Exosome-based strategies constitute a promising tool for therapeutics, avoiding potential immunogenic and tumorigenic side-effects of cell therapies. However, the collection of a suitable exosome pool, and the need for ...
• Generation of two edited iPSCs lines by CRISPR/Cas9 with point mutations in PKP2 gene for arrhythmogenic cardiomyopathy in vitro modeling 

  Amín, Guadalupe; Castañeda, Sheila; Zabalegui, Federico; Belli, Carolina; Atorrasagasti, Catalina; Miriuka, Santiago Gabriel; Moro, Lucía Natalia (Elsevier, 2023-06-25)

  The arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disease characterized by the progressive replacement of contractile myocardium by fibro-fatty adipose tissue, that generates ventricular arrhythmias and ...
• Generation of a human induced pluripotent stem cell line (INEUi001-A) from an amyotrophic lateral sclerosis/frontotemporal dementia patient with a C9ORF72 G4C2 genotype of <2 (GGGGCCG) and 10 repeats 

  Nievas, Micaela; Romorini, Leonardo; Isaja, Luciana; Clas, Giulia S.; Rodríguez Varela, María Soledad; Mucci, Sofía; Itzcovich, Tatiana; de Ambrosi, Bruno; Scassa, María Élida; Sevlever, Gustavo Emilio; Surace, Ezequiel Ignacio; Marazita, Mariela Claudia (Elsevier, 2023-03-22)

  Human induced pluripotent stem cell (hiPSC) line INEUi001-A was reprogrammed from peripheral blood mononuclear cells (PBMC) using the lentiviral-hSTEMCCA-loxP vector. PBMCs were obtained from a 75- year-old female ALS/FTD ...
• Disability outcomes in NMOSD and MOGAD patients: data from a nationwide registry in Argentina 

  Rojas, Juan Ignacio; Pappolla, Agustín; Patrucco, Liliana; Cristiano, Edgardo; Miguez, Jimena; Liwacki, Susana; Tkachuk, Verónica A.; Balbuena Aguirre, María Eugenia; Vrech, Carlos; Deri, Norma; Correale, Jorge; Marrodán, Mariano; Ysrraelit, María Célica; Fiol, Marcela Paula; Leguizamón, Felisa; Luetic, Geraldine G.; Menichini, María L.; López, Pablo Adrián; Pettinicchi, Juan Pablo; Criniti, Juan (Springer-Verlag Italia, 2022-09-27)

  The objective was to evaluate time to reach an EDSS of 4, 6, and 7 in NMOSD and MOGAD patients included in the Argentinean MS and NMOSD registry (RelevarEM, NCT 03,375,177). Methods: NMOSD patients diagnosed according ...
• Glial Cell Metabolic Profile Upon Iron Deficiency: Oligodendroglial and Astroglial Casualties of Bioenergetic Adjustments 

  Rosato-Siri, María Victoria; Martino Adami, Pamela V.; Guitart, María Eugenia; Verstraeten, Sandra V.; Morelli, Laura; Correale, Jorge; Pasquini, Juana María (Humana Press, 2023-01-03)

  Iron deficiency (ID) represents one of the most prevalent nutritional deficits, affecting almost two billion people worldwide. Gestational iron deprivation induces hypomyelination due to oligodendroglial maturation ...
• Evaluation of Baculoviruses as Gene Therapy Vectors for Brain Cancer 

  Garcia Fallit, Matías; Pidre, Matías L.; Asad, Antonela S.; Peña Agudelo, Jorge A.; Vera, Mariana Belén; Nicola Candia, Alejandro J.; Sagripanti, Sofia B.; Pérez Kuper, Melanie; Amorós Morales, Leslie C.; Marchesini, Abril; Gonzalez, Nazareno; Caruso, Carla M.; Romanowski, Víctor; Seilicovich, Adriana; Videla Richardson, Guillermo Agustín; Zanetti, Flavia A.; Candolfi, Marianela (MDPI, 2023-02-22)

  We aimed to assess the potential of baculoviral vectors (BV) for brain cancer gene therapy. We compared them with adenoviral vectors (AdV), which are used in neuro-oncology, but for which there is pre-existing immunity. ...
• Abnormal brain network community structure related to psychological stress in schizophrenia 

  Castro, Mariana Nair; Bocaccio, Hernán; De Pino, Gabriela; Sánchez, Stella Maris; Wainsztein, Agustina Edith; Drucaroff, Lucas J.; Costanzo, Elsa; Crossley, Nicolas; Mirta Fabiana, Villarreal; Guinjoan, Salvador Martín (Elsevier, 2023-02-15)

  Recent functional imaging studies in schizophrenia consistently report a disruption of brain connectivity. However, most of these studies analyze the brain connectivity during resting state. Since psychological stress is ...
• A critical pathway in human development: C19MC micrornas regulates FGF2 response in a model of human pluripotent stem cells cardiac differentiation 

  Möbbs, Alan Miqueas; Garate, Ximena; Scarafia, María Agustina; Colli, Carolina; Moro, Lucía Natalia; Luzzani, Carlos Daniel; Waisman, Ariel; La Greca, Alejandro; Miriuka, Santiago Gabriel (Fundación Revista Medicina, 2021-11)

  Human pluripotent stem cells (hPSC) have the capacity to self-renew and differentiate in vitro into all cell types of the organism, and it is an established model for early human embryo development. Recently, we found ...

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