Introducción: Las ataxias espinocerebelosas (SCA) son un grupo de trastornos neurodegenerativos y heterogéneos desde el punto de vista clínico y genético que se caracterizan por la presencia de ataxia progresiva como ...

Background and purpose: Clinical correlates of fear of falling (FoF) are scarcely studied in patients with progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). This study was undertaken to evaluate the ...

Objective: To determine whether technetium-99m-labeled tropane derivative single-photon emission computed tomography (99mTcTRODAT-1 SPECT) provides results comparable to those of the less widely available, less accessible ...

Background: As gene-targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of ...

Spinocerebellar ataxia type 17 or ATX-TBP is a CAG/CAA repeat expansion disorder characterized by marked clinical heterogeneity. Reports of affected carriers with subthreshold repeat expansions and of patients with Parkinson's ...

Involuntary moaning has been reported in sporadic cases of neurodegenerative diseases. A five-generation Hispanic family with eight members exhibiting involuntary moaning, most of whom with isolated moaning in the absence ...

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Background: A myriad of disorders combine myoclonus and ataxia. Most causes are genetic and an increasing number of genes are being associated with myoclonus-ataxia syndromes (MAS), due to recent advances in genetic ...