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Mechanical thrombectomy for reperfusion of acute ischemic stroke in a Stroke Unit in Argentina

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dc.contributor.author Alet, Matías Javier
dc.contributor.author Rodríguez Lucci, Federico
dc.contributor.author Ameriso, Sebastián Francisco
dc.date.accessioned 2020-10-15T14:56:15Z
dc.date.available 2020-10-15T14:56:15Z
dc.date.issued 2020-01
dc.identifier.citation Alet, M., Lucci, F.R., Ameriso, S., 2020b. Mechanical thrombectomy for reperfusion of acute ischemic stroke in a Stroke Unit in Argentina. Arq Neuropsiquiatr 78, 39–43. https://doi.org/10.1590/0004-282X20190150 en_US
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/206
dc.identifier.uri https://doi.org/10.1590/0004-282X20190150
dc.description.abstract Objective: Stroke is an important cause of morbidity and mortality worldwide. Reperfusion therapy with intravenous tissue plasminogen activator (IV-tPA) was first implemented in 1996. More recently, endovascular reperfusion with mechanical thrombectomy (MT) demonstrated a robust beneficial effect, extending the 4.5 h time window. In our country, there are difficulties to achieve the implementation of both procedures. Our purpose is to report the early experience of a Comprehensive Stroke Center in the use of MT for acute stroke. Methods: Analysis of consecutive patients from January 2015 to September 2018, who received reperfusion treatment with MT. Demographic data, treatment times, previous use of IV-tPA, site of obstruction, recanalization, outcomes and disability after stroke were assessed. Results: We admitted 891 patients with acute ischemic stroke during this period. Ninety-seven received IV-tPA (11%) and 27 were treated with MT (3%). In the MT group, mean age was 66.0±14.5 years. Median NIHSS before MT was 20 (range:14‒24). The most prevalent etiology was cardioembolic stroke (52%). Prior to MT, 16 of 27 patients (59%) received IV-tPA. Previous tPA treatment did not affect onset to recanalization time or door-to-puncture time. For MT, door-to-puncture time was 104±50 minutes and onset to recanalization was 289±153 minutes. Successful recanalization (mTICI grade 2b/3) was achieved in 21 patients (78%). At three-month follow-up, the median NIHSS was 5 (range:4‒15) and mRS was 0‒2 in 37%, and ≥3 in 63%. Conclusions: With adequate logistics and strict selection criteria, MT can be implemented in our population with results like those reported in large clinical trials. en_US
dc.language.iso eng en_US
dc.publisher Associacao Arquivos De Neuro-Psiquitria Dr Oswaldo Lange en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Argentina en_US
dc.subject Brain Ischemia en_US
dc.subject Isquemia Encefálica en_US
dc.subject Stroke en_US
dc.subject Mechanical Thrombolysis en_US
dc.subject Trombolisis Mecánica en_US
dc.title Mechanical thrombectomy for reperfusion of acute ischemic stroke in a Stroke Unit in Argentina en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Alet, Matías Javier. Fleni. Centro Integral de Neurología Vascular; Argentina.
dc.description.fil Fil: Rodríguez Lucci, Federico. Fleni. Departamento de Neurología. Servicio de Neurología Vascular; Argentina.
dc.description.fil Fil: Ameriso, Sebastián Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Vascular; Argentina.
dc.relation.ispartofVOLUME 78
dc.relation.ispartofNUMBER 1
dc.relation.ispartofPAGINATION 39-43
dc.relation.ispartofCOUNTRY Brasil
dc.relation.ispartofCITY Sao Paulo
dc.relation.ispartofTITLE Arquivos de neuro-psiquiatria
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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