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Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

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dc.contributor.author Takenaka, Maisa C.
dc.contributor.author Gabriely, Galina
dc.contributor.author Rothhammer, Veit
dc.contributor.author Mascanfroni, Ivan D.
dc.contributor.author Wheeler, Michael A.
dc.contributor.author Chao, Chun-Cheih
dc.contributor.author Gutiérrez-Vázquez, Cristina
dc.contributor.author Kenison, Jessica
dc.contributor.author Tjon, Emily C.
dc.contributor.author Barroso, Andreia
dc.contributor.author Vandeventer, Tyler
dc.contributor.author Alves de Lima, Kalil
dc.contributor.author Rothweiler, Sonja
dc.contributor.author Mayo, Lior
dc.contributor.author Ghannam, Soufiene
dc.contributor.author Zandee, Stephanie
dc.contributor.author Healy, Luke
dc.contributor.author Sherr, David
dc.contributor.author Farez, Mauricio Franco
dc.contributor.author Prat, Alexandre
dc.contributor.author Antel, Jack
dc.contributor.author Reardon, David A.
dc.contributor.author Zhang, Hailei
dc.contributor.author Robson, Simon C.
dc.contributor.author Getz, Gad
dc.contributor.author Weiner, Howard L.
dc.contributor.author Quintana, Francisco J.
dc.date.accessioned 2020-11-02T14:24:36Z
dc.date.available 2020-11-02T14:24:36Z
dc.date.issued 2019-04-08
dc.identifier.citation Takenaka, M.C., Gabriely, G., Rothhammer, V., Mascanfroni, I.D., Wheeler, M.A., Chao, C.-C., Gutiérrez-Vázquez, C., Kenison, J., Tjon, E.C., Barroso, A., Vandeventer, T., de Lima, K.A., Rothweiler, S., Mayo, L., Ghannam, S., Zandee, S., Healy, L., Sherr, D., Farez, M.F., Pratt, A., Antel, J., Reardon, D.A., Zhang, H., Robson, S.C., Getz, G., Weiner, H.L., Quintana, F.J. Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat. Neurosci. 2019 May;22(5):729-740. doi: 10.1038/s41593-019-0370-y. Epub 2019 Apr 8. Erratum in: Nat Neurosci. 2019 Sep;22(9):1533. en_US
dc.identifier.uri https://doi.org/10.1038/s41593-019-0370-y
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/216
dc.description.abstract Tumor-associated macrophages (TAMs) play an important role in the immune response to cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell immunity are not completely understood. Here we report that kynurenine produced by glioblastoma cells activates aryl hydrocarbon receptor (AHR) in TAMs to modulate their function and T cell immunity. AHR promotes CCR2 expression, driving TAM recruitment in response to CCL2. AHR also drives the expression of KLF4 and suppresses NF-κB activation in TAMs. Finally, AHR drives the expression of the ectonucleotidase CD39 in TAMs, which promotes CD8+ T cell dysfunction by producing adenosine in cooperation with CD73. In humans, the expression of AHR and CD39 was highest in grade 4 glioma, and high AHR expression was associated with poor prognosis. In summary, AHR and CD39 expressed in TAMs participate in the regulation of the immune response in glioblastoma and constitute potential targets for immunotherapy. en_US
dc.language.iso eng en_US
dc.publisher Nature Publishing Group en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Macrophages en_US
dc.subject Macrófagos en_US
dc.subject T-Lymphocytes en_US
dc.subject Linfocitos T en_US
dc.subject Glioblastoma en_US
dc.title Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39 en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Takenaka, Maisa C. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Gabriely, Galina. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Rothhammer, Veit. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Mascanfroni, Ivan D. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Wheeler, Michael A. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Chao, Chun-Cheih. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Gutiérrez-Vázquez, Cristina. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Kenison, Jessica. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Tjon, Emily C. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Barroso, Andreia. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Vandeventer, Tyler. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Alves de Lima, Kalil. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Rothweiler, Sonja. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Mayo, Lior. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Ghannam, Soufiene. Université de Montréal; Canadá.
dc.description.fil Fil: Zandee, Stephanie. Université de Montréal; Canadá.
dc.description.fil Fil: Healy, Luke. McGill University; Canadá.
dc.description.fil Fil: Sherr, David. Boston University School of Public Health; Estados Unidos.
dc.description.fil Fil: Farez, Mauricio Franco. Fil: Farez, Mauricio Franco. Fleni. Centro para la Investigación de Enfermedades Neuroinmunológicas; Argentina. Fleni. Centro de Epidemiología, Bioestadística y Salud Pública; Argentina.
dc.description.fil Fil: Prat, Alexandre. Université de Montréal; Canadá.
dc.description.fil Fil: Antel, Jack. McGill University; Canadá.
dc.description.fil Fil: Reardon, David A. Brigham and Women's Hospital; Estados Unidos.
dc.description.fil Fil: Zhang, Hailei. The Broad Institute of MIT and Harvard; Estados Unidos.
dc.description.fil Fil: Robson, Simon C. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Getz, Gad. The Broad Institute of MIT and Harvard; Estados Unidos.
dc.description.fil Fil: Weiner, Howard L. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Quintana, Francisco J. Harvard Medical School; Estados Unidos. The Broad Institute of MIT and Harvard; Estados Unidos.
dc.relation.ispartofVOLUME 22
dc.relation.ispartofNUMBER 5
dc.relation.ispartofPAGINATION 729-740
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Nueva York
dc.relation.ispartofTITLE Nature neuroscience
dc.relation.ispartofISSN 1546-1726
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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