dc.contributor.author |
Bottiroli, Sara |
|
dc.contributor.author |
Allena, Marta |
|
dc.contributor.author |
Sances, Grazia |
|
dc.contributor.author |
De Icco, Roberto |
|
dc.contributor.author |
Avenali, Micol |
|
dc.contributor.author |
Fadic, Ricardo |
|
dc.contributor.author |
Katsarava, Zaza |
|
dc.contributor.author |
Lainez, Miguel J. A. |
|
dc.contributor.author |
Goicochea, María Teresa |
|
dc.contributor.author |
Bendtsen, Lars |
|
dc.contributor.author |
Højland Jensen, Rigmor |
|
dc.contributor.author |
Nappi, Giuseppe |
|
dc.contributor.author |
Tassorelli, Cristina |
|
dc.contributor.author |
COMOESTAS Consortium |
|
dc.date.accessioned |
2020-11-11T11:58:53Z |
|
dc.date.available |
2020-11-11T11:58:53Z |
|
dc.date.issued |
2018-06-27 |
|
dc.identifier.citation |
Bottiroli, S., Allena, M., Sances, G., De Icco, R., Avenali, M., Fadic, R., Katsarava, Z., Lainez, M.J., Goicochea, M.T., Bendtsen, L. Psychological, clinical, and therapeutic predictors of the outcome of detoxification in a large clinical population of medication-overuse headache: A six-month follow-up of the COMOESTAS Project. Cephalalgia. 2019;39(1):135–147. doi:10.1177/0333102418783317 |
en_US |
dc.identifier.uri |
https://doi.org/10.1177/0333102418783317 |
|
dc.identifier.uri |
https://repositorio.fleni.org.ar/handle/123456789/227 |
|
dc.description.abstract |
Aim: To identify factors that may be predictors of the outcome of a detoxification treatment in medication-overuse headache.
Methods: Consecutive patients entering a detoxification program in six centres in Europe and Latin America were evaluated and followed up for 6 months. We evaluated anxious and depressive symptomatology (though patients with severe psychiatric comorbidity were excluded), quality of life, headache-related disability, headache characteristics, and prophylaxis upon discharge.
Results: Of the 492 patients who completed the six-month follow up, 407 ceased overuse following the detoxification (non overusers), another 23 ceased overuse following detoxification but relapsed during the follow-up. In the 407 non-overusers, headache acquired an episodic pattern in 287 subjects (responders). At the multivariate analyses, lower depression scores (odds ratio = 0.891; p = 0.001) predicted ceasing overuse. The primary headache diagnosis - migraine with respect to tension-type headache (odds ratio = 0.224; p = 0.001) or migraine plus tension-type headache (odds ratio = 0.467; p = 0.002) - and the preventive treatment with flunarizine (compared to no such treatment) (odds ratio = 0.891; p = 0.001) predicted being a responder. A longer duration of chronic headache (odds ratio = 1.053; p = 0.032) predicted relapse into overuse. Quality of life and disability were not associated with any of the outcomes.
Conclusions: Though exploratory in nature, these findings point to specific factors that are associated with a positive outcome of medication-overuse headache management, while identifying others that may be associated with a negative outcome. Evaluation of the presence/absence of these factors may help to optimize the management of this challenging groups of chronic headache sufferers.
Keywords: Withdrawal; anxiety; depression; disability; quality of life; relapse. |
en_US |
dc.language.iso |
eng |
en_US |
dc.publisher |
Sage |
en_US |
dc.rights |
info:eu-repo/semantics/openAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/2.5/ar/ |
|
dc.subject |
Anxiety |
en_US |
dc.subject |
Ansiedad |
en_US |
dc.subject |
Depression |
en_US |
dc.subject |
Depresión |
en_US |
dc.subject |
Headache Disorders, Secondary |
en_US |
dc.subject |
Cefaleas Secundarias |
en_US |
dc.subject |
Substance-Related Disorders |
en_US |
dc.subject |
Trastornos Relacionados con Sustancias |
en_US |
dc.title |
Psychological, clinical, and therapeutic predictors of the outcome of detoxification in a large clinical population of medication-overuse headache: A six-month follow-up of the COMOESTAS Project |
en_US |
dc.type |
info:eu-repo/semantics/publishedVersion |
|
dc.type |
info:eu-repo/semantics/article |
en_US |
dc.description.fil |
Fil: Bottiroli, Sara. Mondino Foundation; Italia. |
|
dc.description.fil |
Fil: Allena, Marta. Mondino Foundation; Italia. |
|
dc.description.fil |
Fil: Sances, Grazia. Mondino Foundation; Italia. |
|
dc.description.fil |
Fil: De Icco, Roberto. Mondino Foundation; Italia. University of Pavia; Italia. |
|
dc.description.fil |
Fil: Avenali, Micol. Mondino Foundation; Italia. University of Pavia; Italia. |
|
dc.description.fil |
Fil: Fadic, Ricardo. Pontificia Catolica University of Chile; Chile. |
|
dc.description.fil |
Fil: Katsarava, Zaza. University of Essen; Alemania. |
|
dc.description.fil |
Fil: Lainez, Miguel J. A. Foundation of the Valencian Community; España. |
|
dc.description.fil |
Fil: Goicochea, María Teresa. Fleni. Departamento de Neurología. Clínica del Dolor. Clínica de Cefaleas; Argentina. |
|
dc.description.fil |
Fil: Bendtsen, Lars. Danish Headache Centre; Dinamarca. |
|
dc.description.fil |
Fil: Højland Jensen, Rigmor. Danish Headache Centre; Dinamarca. |
|
dc.description.fil |
Fil: Nappi, Giuseppe. Mondino Foundation; Italia. |
|
dc.description.fil |
Fil: Tassorelli, Cristina. Mondino Foundation; Italia. University of Pavia; Italia. |
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dc.relation.ispartofVOLUME |
39 |
|
dc.relation.ispartofNUMBER |
1 |
|
dc.relation.ispartofPAGINATION |
135-147 |
|
dc.relation.ispartofCOUNTRY |
Reino Unido |
|
dc.relation.ispartofCITY |
Londres |
|
dc.relation.ispartofTITLE |
Cephalalgia |
|
dc.relation.ispartofISSN |
1468-2982 |
|
dc.type.snrd |
info:ar-repo/semantics/artículo |
es_ES |