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dc.contributor.author | Bottiroli, Sara | |
dc.contributor.author | Allena, Marta | |
dc.contributor.author | Sances, Grazia | |
dc.contributor.author | De Icco, Roberto | |
dc.contributor.author | Avenali, Micol | |
dc.contributor.author | Fadic, Ricardo | |
dc.contributor.author | Katsarava, Zaza | |
dc.contributor.author | Lainez, Miguel J. A. | |
dc.contributor.author | Goicochea, María Teresa | |
dc.contributor.author | Bendtsen, Lars | |
dc.contributor.author | Højland Jensen, Rigmor | |
dc.contributor.author | Nappi, Giuseppe | |
dc.contributor.author | Tassorelli, Cristina | |
dc.contributor.author | COMOESTAS Consortium | |
dc.date.accessioned | 2020-11-11T11:58:53Z | |
dc.date.available | 2020-11-11T11:58:53Z | |
dc.date.issued | 2018-06-27 | |
dc.identifier.citation | Bottiroli, S., Allena, M., Sances, G., De Icco, R., Avenali, M., Fadic, R., Katsarava, Z., Lainez, M.J., Goicochea, M.T., Bendtsen, L. Psychological, clinical, and therapeutic predictors of the outcome of detoxification in a large clinical population of medication-overuse headache: A six-month follow-up of the COMOESTAS Project. Cephalalgia. 2019;39(1):135–147. doi:10.1177/0333102418783317 | en_US |
dc.identifier.uri | https://doi.org/10.1177/0333102418783317 | |
dc.identifier.uri | https://repositorio.fleni.org.ar/handle/123456789/227 | |
dc.description.abstract | Aim: To identify factors that may be predictors of the outcome of a detoxification treatment in medication-overuse headache. Methods: Consecutive patients entering a detoxification program in six centres in Europe and Latin America were evaluated and followed up for 6 months. We evaluated anxious and depressive symptomatology (though patients with severe psychiatric comorbidity were excluded), quality of life, headache-related disability, headache characteristics, and prophylaxis upon discharge. Results: Of the 492 patients who completed the six-month follow up, 407 ceased overuse following the detoxification (non overusers), another 23 ceased overuse following detoxification but relapsed during the follow-up. In the 407 non-overusers, headache acquired an episodic pattern in 287 subjects (responders). At the multivariate analyses, lower depression scores (odds ratio = 0.891; p = 0.001) predicted ceasing overuse. The primary headache diagnosis - migraine with respect to tension-type headache (odds ratio = 0.224; p = 0.001) or migraine plus tension-type headache (odds ratio = 0.467; p = 0.002) - and the preventive treatment with flunarizine (compared to no such treatment) (odds ratio = 0.891; p = 0.001) predicted being a responder. A longer duration of chronic headache (odds ratio = 1.053; p = 0.032) predicted relapse into overuse. Quality of life and disability were not associated with any of the outcomes. Conclusions: Though exploratory in nature, these findings point to specific factors that are associated with a positive outcome of medication-overuse headache management, while identifying others that may be associated with a negative outcome. Evaluation of the presence/absence of these factors may help to optimize the management of this challenging groups of chronic headache sufferers. Keywords: Withdrawal; anxiety; depression; disability; quality of life; relapse. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Sage | en_US |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/2.5/ar/ | |
dc.subject | Anxiety | en_US |
dc.subject | Ansiedad | en_US |
dc.subject | Depression | en_US |
dc.subject | Depresión | en_US |
dc.subject | Headache Disorders, Secondary | en_US |
dc.subject | Cefaleas Secundarias | en_US |
dc.subject | Substance-Related Disorders | en_US |
dc.subject | Trastornos Relacionados con Sustancias | en_US |
dc.title | Psychological, clinical, and therapeutic predictors of the outcome of detoxification in a large clinical population of medication-overuse headache: A six-month follow-up of the COMOESTAS Project | en_US |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.type | info:eu-repo/semantics/article | en_US |
dc.description.fil | Fil: Bottiroli, Sara. Mondino Foundation; Italia. | |
dc.description.fil | Fil: Allena, Marta. Mondino Foundation; Italia. | |
dc.description.fil | Fil: Sances, Grazia. Mondino Foundation; Italia. | |
dc.description.fil | Fil: De Icco, Roberto. Mondino Foundation; Italia. University of Pavia; Italia. | |
dc.description.fil | Fil: Avenali, Micol. Mondino Foundation; Italia. University of Pavia; Italia. | |
dc.description.fil | Fil: Fadic, Ricardo. Pontificia Catolica University of Chile; Chile. | |
dc.description.fil | Fil: Katsarava, Zaza. University of Essen; Alemania. | |
dc.description.fil | Fil: Lainez, Miguel J. A. Foundation of the Valencian Community; España. | |
dc.description.fil | Fil: Goicochea, María Teresa. Fleni. Departamento de Neurología. Clínica del Dolor. Clínica de Cefaleas; Argentina. | |
dc.description.fil | Fil: Bendtsen, Lars. Danish Headache Centre; Dinamarca. | |
dc.description.fil | Fil: Højland Jensen, Rigmor. Danish Headache Centre; Dinamarca. | |
dc.description.fil | Fil: Nappi, Giuseppe. Mondino Foundation; Italia. | |
dc.description.fil | Fil: Tassorelli, Cristina. Mondino Foundation; Italia. University of Pavia; Italia. | |
dc.relation.ispartofVOLUME | 39 | |
dc.relation.ispartofNUMBER | 1 | |
dc.relation.ispartofPAGINATION | 135-147 | |
dc.relation.ispartofCOUNTRY | Reino Unido | |
dc.relation.ispartofCITY | Londres | |
dc.relation.ispartofTITLE | Cephalalgia | |
dc.relation.ispartofISSN | 1468-2982 | |
dc.type.snrd | info:ar-repo/semantics/artículo | es_ES |