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Transverse Myelitis in Systemic Lupus Erythematosus: Clinical Features and Prognostic Factors in a Large Cohort of Latin American Patients.

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dc.contributor.author Chiganer, Edson Hernán
dc.contributor.author Lessa, Carmen Flora
dc.contributor.author Di Pace, José Luis
dc.contributor.author Perassolo, Mónica Beatriz
dc.contributor.author Carnero Contentti, Edgar
dc.contributor.author Alessandro, Lucas
dc.contributor.author Correale, Jorge
dc.contributor.author Farfan, María Fernanda
dc.contributor.author Galiana, Graciana Lourdes
dc.contributor.author Benavides, Marvin Sánchez
dc.contributor.author Pacello, Franco
dc.contributor.author Stagno, Mauro
dc.contributor.author Cardozo, Analía
dc.contributor.author Cantero, María Belén Nacimiento
dc.contributor.author Elizaur López, Juan Gabriel
dc.contributor.author Delgadillo, Pedro Daniel
dc.contributor.author Melgarejo, Patricia
dc.contributor.author Acosta Colman, Isabel
dc.contributor.author Vázquez Báez, Marcos Aurelio
dc.contributor.author Correa Díaz, Edgar Patricio
dc.contributor.author Jácome Sánchez, Elisa Carolina
dc.contributor.author Linares, Magaly Alva
dc.contributor.author Zamora Tehozol, Erick Adrian
dc.contributor.author Fragoso-Loyo, Hilda Esther
dc.contributor.author Quintanilla-González, Lauro
dc.contributor.author Batún-Garrido, José Antonio de Jesús
dc.contributor.author Sato, Emilia Inoue
dc.contributor.author do Reis-Neto, Edgard Torres
dc.contributor.author Carreño Nigro, María Angela
dc.contributor.author Hryb, Javier Pablo
dc.date.accessioned 2020-11-13T15:19:31Z
dc.date.available 2020-11-13T15:19:31Z
dc.date.issued 2020-02-05
dc.identifier.citation Chiganer EH, Lessa CF, Di Pace JL, Perassolo MB, Carnero Contentti E, Alessandro L, Correale J, Farfan MF, Galiana GL, Sánchez Benavides M, Pacello F, Stagno M, Cardozo A, Nacimiento Cantero MB, Elizaur López JG, Delgadillo PD, Melgarejo P, Acosta Colman I, Vázquez Báez MA, Correa Díaz EP, Jácome Sánchez EC, Linares MA, Zamora Tehozol EA, Fragoso-Loyo HE, Quintanilla-González L, Batún-Garrido JAJ, Sato EI, do Reis-Neto ET, Carreño Nigro MA, Hryb JP. Transverse Myelitis in Systemic Lupus Erythematosus: Clinical Features and Prognostic Factors in a Large Cohort of Latin American Patients. J Clin Rheumatol. 2020 Feb 5. doi: 10.1097/RHU.0000000000001322. Epub ahead of print. en_US
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/233
dc.identifier.uri https://journals.lww.com/jclinrheum/Abstract/9000/Transverse_Myelitis_in_Systemic_Lupus.98767.aspx
dc.description.abstract Background: Acute transverse myelitis (ATM) is an infrequent but severe complication of systemic lupus erythematosus (SLE). The purpose of study was to describe clinical features and prognostic factors of patients with SLE-related ATM. Methods: In this medical records review study, data were collected from 60 patients from 16 centers seen between 1996 and 2017 who met diagnostic criteria for SLE and myelitis as defined by the American College of Rheumatology/Systemic International Collaborating Clinics and the Working Group of the Transverse Myelitis Consortium, respectively. Objective neurological impairment was measured with American Spinal Injury Association Impairment Scale (AIS) and European Database for Multiple Sclerosis Grade Scale (EGS). Results: Among patients included, 95% (n = 57) were female, and the average age was 31.6 ± 9.6 years. Myelitis developed after diagnosis of SLE in 60% (n = 36). Symmetrical paraparesis with hypoesthesia, flaccidity, sphincter dysfunction, AIS = A/B, and EGS ≥ 8 was the most common presentation. Intravenous methylprednisolone was used in 95% (n = 57), and 78.3% (n = 47) received intravenous cyclophosphamide. Sensory/motor recovery at 6 months was observed in 75% (42 of 56), but only in 16.1% (9 of 56) was complete. Hypoglycorrhachia and EGS ≥ 7 in the nadir were associated with an unfavorable neurological outcome at 6 months (p < 0.05). A relapse rate during follow-up was observed in 30.4% (17 of 56). Hypoglycorrhachia and hypocomplementemia seem to be protective factors for relapse. Intravenous cyclophosphamide was associated with time delay to relapse. Conclusions: Systemic lupus erythematosus-related ATM may occur at any time of SLE course, leading to significant disability despite treatment. Relapses are infrequent and intravenous cyclophosphamide seems to delay it. Hypoglycorrhachia, hypocomplementemia, and EGS at nadir are the most important prognostic factors. en_US
dc.language.iso eng en_US
dc.publisher Lippincott Williams & Wilkins en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Myelitis en_US
dc.subject Mielitis en_US
dc.title Transverse Myelitis in Systemic Lupus Erythematosus: Clinical Features and Prognostic Factors in a Large Cohort of Latin American Patients. en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Carnero Contentti, Edgar. Hospital Alemán de Buenos Aires. Department of Neuroscience. Neuroimmunology Unit; Argentina.
dc.description.fil Fil: Chiganer, Edson Hernán. Hospital Carlos G. Durand. Departments of Immunology and Histocompatibility; Argentina.
dc.description.fil Fil: Lessa, Carmen Flora. Hospital Carlos G. Durand. Departments of Immunology and Histocompatibility; Argentina.
dc.description.fil Fil: Di Pace, José Luis. Hospital Carlos G. Durand. Departamento de Neurología; Argentina.
dc.description.fil Fil: Perassolo, Mónica Beatriz. Hospital Carlos G. Durand. Departamento de Neurología; Argentina.
dc.description.fil Fil: Alessandro, Lucas. Fleni. Fleni. Departamento de Neurología. Servicio de Neurología; Argentina.
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Farfan, María Fernanda. Hospital Luis C. Lagomaggiore. Department of Neurology; Argentina.
dc.description.fil Fil: Galiana, Graciana Lourdes. Hospital Luis C. Lagomaggiore. Department of Neurology; Argentina.
dc.description.fil Fil: Benavides, Marvin Sánchez. Hospital Rafael Ángel Calderón Guardia. Department of Rheumatology; Costa Rica.
dc.description.fil Fil: Pacello, Franco. Hospital Galán y Rocha. Department of Internal Medicine; Uruguay.
dc.description.fil Fil: Stagno, Mauro. Hospital Galán y Rocha. Department of Internal Medicine; Uruguay.
dc.description.fil Fil: Elizaur López, Juan Gabriel. Hospital Central del Instituto de Previsión Social. Rheumatology; Paraguay.
dc.description.fil Fil: Delgadillo, Pedro Daniel. Hospital Central del Instituto de Previsión Social. Rheumatology; Paraguay.
dc.description.fil Fil: Melgarejo, Patricia. Hospital Central del Instituto de Previsión Social. Rheumatology; Paraguay.
dc.description.fil Fil: Vázquez Báez, Marcos Aurelio. Hospital de Clínicas Universidad Nacional de Asunción. Department of Rheumatology; Paraguay.
dc.description.fil Fil: Jácome Sánchez, Elisa Carolina. Hospital Carlos Andrade Marin. Department of Neurology; Ecuador.
dc.description.fil Fil: Correa Díaz, Edgar Patricio. Hospital Carlos Andrade Marin. Department of Neurology; Ecuador.
dc.description.fil Fil: Linares, Magaly Alva. Hospital Nacional Edgardo Rebagliati Martins. Rheumatology Division; Perú.
dc.description.fil Fil: Zamora Tehozol, Erick Adrian. Hospital de Especialidades. Centro Médico Nacional Siglo XXI. Department of Rheumatology; México
dc.description.fil Fil: Quintanilla-González, Lauro. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran. Department of Immunology and Rheumatology; Mexico.
dc.description.fil Fil: Batún-Garrido, José Antonio de Jesús. Hospital de Alta Especialidad Dr Gustavo A. Rovirosa Perez. Department of Internal Medicine; Mexico.
dc.description.fil Fil: Sato, Emilia Inoue. Universidade Federal de Sao Paulo, São Paulo. Department of Medicine. Rheumatology Division; Brasil.
dc.description.fil Fil: do Reis-Neto, Edgard Torres. Universidade Federal de Sao Paulo, São Paulo. Department of Medicine. Rheumatology Division; Brasil.
dc.description.fil Fil: Carreño Nigro, María Angela. Clinica Las Condes. Department of Rheumatology; Chile.
dc.description.fil Fil: Hryb, Javier Pablo. Hospital Carlos G. Durand. Departamento de Neurología; Argentina.
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Baltimore
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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