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SWAN-Venule: An Optimized MRI Technique to Detect the Central Vein Sign in MS Plaques

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dc.contributor.author Gaitán, María Inés
dc.contributor.author Yáñez, Paulina
dc.contributor.author Paday Formenti, María Emilia
dc.contributor.author Calandri, Ismael Luis
dc.contributor.author Figueiredo, E.
dc.contributor.author Sati, P.
dc.contributor.author Correale, Jorge
dc.date.accessioned 2020-12-03T15:37:47Z
dc.date.available 2020-12-03T15:37:47Z
dc.date.issued 2020-03
dc.identifier.citation Gaitán, M.I., Yañez, P., Paday Formenti, M.E., Calandri, I., Figueiredo, E., Sati, P., Correale, J., 2020. SWAN-Venule: An Optimized MRI Technique to Detect the Central Vein Sign in MS Plaques. AJNR Am J Neuroradiol 41, 456-460. https://doi.org/10.3174/ajnr.A6437 en_US
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/253
dc.identifier.uri https://doi.org/10.3174/ajnr.A6437
dc.description.abstract Background and purpose: Multiple sclerosis lesions develop around small veins that are radiologically described as the so-called central vein sign. With 7T MR imaging and magnetic susceptibility-based sequences, the central vein sign has been observed in 80%-100% of MS lesions in patients' brains. However, a lower proportion ∼50% has been reported at 3T using susceptibility-weighted angiography (SWAN). Our aim was to assess a modified version of SWAN optimized at 3T for sensitive detection of the central vein sign. Materials and methods: Thirty subjects with MS were scanned on a 3T clinical MR imaging system. 3D T2-weighted FLAIR and optimized 3D SWAN called SWAN-venule, were acquired after injection of a gadolinium-based contrast agent. Patients showing >3 focal white matter lesions were included. The central vein sign was recorded by 2 trained raters on SWAN-venule images in the supratentorial brain. Results: Twenty patients showing >3 white matter lesions were included. A total of 380 white matter lesions (135 periventricular, 144 deep white matter, and 101 juxtacortical) seen on both FLAIR and SWAN-venule images were analyzed. Overall, the central vein sign was detected in 86% of the white matter lesions (periventricular, 89%; deep white matter, 95%; and juxtacortical, 78%). Conclusions: The SWAN-venule technique is an optimized MR imaging sequence for highly sensitive detection of the central vein sign in MS brain lesions. This work will facilitate the validation and integration of the central vein sign to increase the diagnostic certainty of MS and further prevent misdiagnosis in clinical practice. en_US
dc.language.iso eng en_US
dc.publisher Williams & Wilkins en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Magnetic Resonance Imaging en_US
dc.subject Imagen por Resonancia Magnética en_US
dc.title SWAN-Venule: An Optimized MRI Technique to Detect the Central Vein Sign in MS Plaques en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Calandri, Ismael Luis. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Gaitán, María Inés. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Yáñez, Paulina. Fleni. Departamento de Diagnóstico por Imágenes; Argentina.
dc.description.fil Fil: Paday Formenti, María Emilia. Fleni. Departamento de Diagnóstico por Imágenes; Argentina.
dc.description.fil Fil: Figueiredo E. GE healthcare; Brasil.
dc.description.fil Fil: Sati P. National Institutes of Health. National Institute of Neurological Disorders and Stroke. Translational Neuroradiology Section (P.S.); Estados Unidos.
dc.relation.ispartofVOLUME 41
dc.relation.ispartofPAGINATION 456-460.
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Baltimore
dc.relation.ispartofTITLE AJNR. American journal of neuroradiolog
dc.relation.ispartofISSN 3
dc.relation.ispartofISSN 1936-959X
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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