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Long‐term mortality, disability and stroke recurrence in patients with basilar artery occlusion

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dc.contributor.author Hawkes, Maximiliano Alberto
dc.contributor.author Blaginykh, Elena
dc.contributor.author Ruff, Michael W.
dc.contributor.author Burrus, Tamika
dc.contributor.author Wijdicks, Eelco F.M.
dc.contributor.author Rabinstein, Alejandro A.
dc.date.accessioned 2020-12-10T13:57:04Z
dc.date.available 2020-12-10T13:57:04Z
dc.date.issued 2020-03-00
dc.identifier.citation Hawkes, M. A., Blaginykh, E., Ruff, M.W., Burrus, T., Wijdicks, E.F.M., Rabinstein, A.A., 2020. Long-term mortality, disability and stroke recurrence in patients with basilar artery occlusion. Eur J Neurol 27, 579–585. https://doi.org/10.1111/ene.14126 en_US
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/260
dc.description.abstract Background and purpose: The long-term outcomes and stroke recurrence after basilar artery occlusion (BAO) are largely unknown. We aimed to assess these variables in a comparatively large series of consecutive patients. Methods: Adults with acute BAO were retrospectively identified from 1976 to 2011. Post-discharge records were reviewed to assess for stroke recurrences, mortality and disability. Exploratory analysis of survival was carried out using Kaplan-Meier and log-rank tests. Factors associated with survival time were determined using Cox models. Results: A total of 86 patients (34% female, median age 72 [interquartile range (IQR), 60-79] years) with a median National Institutes of Health Stroke Scale score of 11 (IQR, 6-27) were included. Twenty-nine patients (34%) died during the initial hospitalization. Median modified Rankin Scale (mRS) score at discharge among survivors was 4 (IQR, 2.5-5.5). At 1 and 5 years, 70% of survivors ad a mRS ≤3. Seventeen patients had recurrent strokes during the hospitalization and 12 patients had 19 recurrent strokes after discharge. The median survival time was 52 days (IQR, 6-1846). Older age per decade on admission [adjusted hazard ratios (aHR), 1.32; 95% confidence interval (CI), 1.05-1.66, P = 0.02] and a higher mRS at discharge (aHR, 4.48; 95% CI, 2.72-7.39, P < 0.0001) were associated with mortality. Patients who were not treated with any reperfusion therapy had a trend towards reduced mortality (aHR, 0.39; 95% CI, 0.14-1.08, P = 0.07). Conclusions: Survivors from BAO had severe short-term functional disability. Most deaths and stroke recurrences occurred within the first year following the initial event. The risk of death was higher in older and more disabled survivors. However, favorable long-term recovery was possible. en_US
dc.description.uri https://doi.org/10.1111/ene.14126
dc.language.iso eng en_US
dc.publisher Wiley en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Stroke en_US
dc.subject Accidente Cerebrovascular en_US
dc.title Long‐term mortality, disability and stroke recurrence in patients with basilar artery occlusion en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Hawkes, Maximiliano Alberto. Fleni. Departamento de Neurología; Argentina. Fleni. Departamento de Medicina Interna; Argentina. Mayo Clinic. Department of Neurology; Estados Unidos.
dc.description.fil Fil: Blaginykh, Elena. Kent State University. Department of Public Healt; Estados Unidos.
dc.description.fil Fil: Ruff, Michael W. Mayo Clinic. Department of Neurology; Estados Unidos.
dc.description.fil Fil: Burrus, Tamika. Avanti Hospitals. Department of Neurology; Estados Unidos.
dc.description.fil Fil: Wijdicks, E.F.M. Mayo Clinic. Department of Neurology; Estados Unidos.
dc.description.fil Fil: Rabinstein, A.A. Mayo Clinic. Department of Neurology; Estados Unidos.
dc.relation.ispartofVOLUME 27
dc.relation.ispartofNUMBER 3
dc.relation.ispartofPAGINATION 579-585.
dc.relation.ispartofCOUNTRY Inglaterra
dc.relation.ispartofCITY Oxford
dc.relation.ispartofISSN 1468-1331
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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