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Heart rate variability and falls in Huntington's disease

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dc.contributor.author Terroba Chambi, Cinthia
dc.contributor.author Bruno, Verónica
dc.contributor.author Vigo, Daniel Eduardo
dc.contributor.author Merello, Marcelo
dc.date.accessioned 2021-01-28T14:12:38Z
dc.date.available 2021-01-28T14:12:38Z
dc.date.issued 2020-02-06
dc.identifier.citation Terroba Chambi, C., Bruno, V., Vigo, D.E., Merello, M., 2020. Heart rate variability and falls in Huntington’s disease. Clin Auton Res. https://doi.org/10.1007/s10286-020-00669-2 en_US
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/349
dc.identifier.uri https://doi.org/10.1007/s10286-020-00669-2
dc.description.abstract Purpose: Persons with Huntington's disease (HD) have a high incidence of falls. Autonomic nervous system dysfunction has been reported even in early stages of this disease. To date, there has been no analysis of the relationship between heart rate variability (HRV) and falls in this patient population. The aim of the study reported here was to evaluate the relationship between HRV and falls in persons with HD. Methods: Huntington's disease patients enrolled in a prospective study on fear of falling and falls were assessed using short-term HRV analyses and blood pressure measures in both the resting and standing states. Time-frequency domains and nonlinear parameters were calculated. Data on falls, the risk of falling (RoF) and disease-specific scales were collected at baseline and at the end of the 6-month follow-up. Results: Of the 24 HD patients who were invited to participate in the study, 20 completed the baseline analysis and 18 completed the 6-month follow-up. At baseline, seven (35%) HD patients reported at least one fall (single fallers) and 13 (65%) reported ≥ 2 falls (recurrent fallers) in the previous 12 months. At baseline, recurrent fallers had lower RMSSD (root mean square of successive RR interval differences) in the resting state (RMSSD-resting), higher LF/HF (low/high frequency) ratio in both states and higher DFA-α1 parameter (detrended fluctuation analyses over the short term) in both states. This association was similar at the 6-month follow-up for recurrent fallers, who showed lower RMSSD-resting and higher LF/HF ratio in the standing state (LF/HF-standing) than single fallers. Significant correlations were found between the number of falls, RMSSD-resting and LF/HF-standing. No differences were found between recurrent and single fallers for any blood pressure measures. Conclusions: The observed HRV pattern is consistent with a higher sympathetic prevalence associated with a higher RoF. Reduced parasympathetic HRV values in this patient population predict being a recurrent faller at 6 months of follow-up, independently of orthostatic phenomena. en_US
dc.language.iso eng en_US
dc.publisher Rapid Communications of Oxford en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Autonomic Nervous System en_US
dc.subject Sistema Nervioso Autónomo en_US
dc.subject Huntington Disease en_US
dc.subject Enfermedad de Huntington en_US
dc.title Heart rate variability and falls in Huntington's disease en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Merello, Marcelo. Fleni. Departamento de Neurología. Servicio de Movimientos Anormales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.description.fil Fil: Terroba Chambi, Cinthia. Fleni. Departamento de Neurología. Servicio de Movimientos Anormales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.description.fil Fil: Bruno, Verónica. University of Calgary. Department of Neurosciences; Canada.
dc.description.fil Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontifical Catholic University of Argentina. Institute for Biomedical Research; Argentina.Katholieke Universiteit Leuven. Faculty of Psychology and Educational Sciences; Bélgica.
dc.relation.ispartofTITLE Clinical autonomic research : official journal of the Clinical Autonomic Research Society
dc.relation.ispartofISSN 1619-1560
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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