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Impaired brain glucose metabolism and presynaptic dopaminergic functioning in a mouse model of schizophrenia

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dc.contributor.author Tomasella, Eugenia
dc.contributor.author Falasco, Germán
dc.contributor.author Urrutia, Leandro
dc.contributor.author Bechelli, Lucila
dc.contributor.author Padilla, Lucia
dc.contributor.author Gelman, Diego M.
dc.date.accessioned 2021-01-28T15:30:34Z
dc.date.available 2021-01-28T15:30:34Z
dc.date.issued 2020-03-17
dc.identifier.citation Tomasella, E., Falasco, G., Urrutia, L., Bechelli, L., Padilla, L., Gelman, D.M., 2020. Impaired brain glucose metabolism and presynaptic dopaminergic functioning in a mouse model of schizophrenia. EJNMMI Res 10, 39. https://doi.org/10.1186/s13550-020-00629-x en_US
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/350
dc.identifier.uri https://doi.org/10.1186/s13550-020-00629-x
dc.description.abstract Background: Schizophrenia is a disease diagnosed by visible signs and symptoms from late adolescence to early adulthood. The etiology of this disease remains unknown. An objective diagnostic approach is required. Here, we used a mouse model that shows schizophrenia-like phenotypes to study brain glucose metabolism and presynaptic dopaminergic functioning by positron emission tomography (PET) and immunohistochemistry. PET scannings were performed on mice after the administration of [18F]-FDG or [18F]-F-DOPA. Glucose metabolism was evaluated in basal conditions and after the induction of a hyperdopaminergic state. Results: Mutant animals show reduced glucose metabolism in prefrontal cortex, amygdala, and nucleus reuniens under the hyperdopaminergic state. They also show reduced [18F]-F-DOPA uptake in prefrontal cortex, substantia nigra reticulata, raphe nucleus, and ventral striatum but increased [18F]-F-DOPA uptake in dorsal striatum. Mutant animals also show reduced tyrosine hydroxylase expression on midbrain neurons. Conclusions: Dopamine D2 mutant animals show reduced glucose metabolism and impaired presynaptic dopaminergic functioning, in line with reports from human studies. This mouse line may be a valuable model of schizophrenia, useful to test novel tracers for PET scanning diagnostic. en_US
dc.language.iso eng en_US
dc.publisher Springer en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Dopamine en_US
dc.subject Dopamina en_US
dc.subject Schizophrenia en_US
dc.subject Esquizofrenia en_US
dc.title Impaired brain glucose metabolism and presynaptic dopaminergic functioning in a mouse model of schizophrenia en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.relation.ispartofVOLUME 10
dc.relation.ispartofNUMBER 1
dc.relation.ispartofPAGINATION 39
dc.relation.ispartofCOUNTRY Alemania
dc.relation.ispartofCITY Berlín
dc.relation.ispartofTITLE EJNMMI research
dc.relation.ispartofISSN 2191-219X
dc.type.snrd info:ar-repo/semantics/artículo es_ES

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