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Hemispherectomy Outcome Prediction Scale: Development and validation of a seizure freedom prediction tool

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dc.contributor.author Weil, Alexander G.
dc.contributor.author Lewis, Evan C.
dc.contributor.author Ibrahim, George M.
dc.contributor.author Kola, Olivia
dc.contributor.author Tseng, Chi-Hong
dc.contributor.author Zhou, Xinkai
dc.contributor.author Lin, Kao-Min
dc.contributor.author Cai, Li-Xin
dc.contributor.author Liu, Qing-Zhu
dc.contributor.author Lin, Jiu-Luan
dc.contributor.author Zhou, Wen-Jing
dc.contributor.author Mathern, Gary W.
dc.contributor.author Smyth, Matthew D.
dc.contributor.author O'Neill, Brent R.
dc.contributor.author Dudley, Roy
dc.contributor.author Ragheb, John
dc.contributor.author Bhatia, Sanjiv
dc.contributor.author Pociecha, Juan
dc.contributor.author Chamorro, Noelia
dc.contributor.author Muro, Valeria L.
dc.date.accessioned 2021-03-18T13:06:17Z
dc.date.available 2021-03-18T13:06:17Z
dc.date.issued 2021-03-13
dc.identifier.citation Weil AG, Lewis EC, Ibrahim GM, Kola O, Tseng CH, Zhou X, Lin KM, Cai LX, Liu QZ, Lin JL, Zhou WJ, Mathern GW, Smyth MD, O'Neill BR, Dudley R, Ragheb J, Bhatia S, Delev D, Ramantani G, Zentner J, Ojemann J, Wang AC, Dorfer C, Feucht M, Czech T, Bollo RJ, Issabekov G, Zhu H, Connelly M, Steinbok P, Zhang JG, Zhang K, Hidalgo ET, Weiner HL, Wong-Kisiel L, Lapalme-Remis S, Tripathi M, Sarat Chandra P, Hader W, Wang FP, Yao Y, Olivier Champagne P, Guo Q, Li SC, Budke M, Pérez-Jiménez MA, Raftapoulos C, Finet P, Michel P, Schaller K, Stienen MN, Baro V, Cantillano Malone C, Pociecha J, Chamorro N, Muro VL, von Lehe M, Vieker S, Oluigbo C, Gaillard WD, Al Khateeb M, Al Otaibi F, Krayenbühl N, Bolton J, Pearl PL, Fallah A. Hemispherectomy Outcome Prediction Scale: Development and validation of a seizure freedom prediction tool. Epilepsia. 2021 Mar 13. doi: 10.1111/epi.16861 es_ES
dc.identifier.uri https://doi.org/10.1111/epi.16861
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/383
dc.description.abstract Objective To develop and validate a model to predict seizure freedom in children undergoing cerebral hemispheric surgery for the treatment of drug‐resistant epilepsy. Methods We analyzed 1267 hemispheric surgeries performed in pediatric participants across 32 centers and 12 countries to identify predictors of seizure freedom at 3 months after surgery. A multivariate logistic regression model was developed based on 70% of the dataset (training set) and validated on 30% of the dataset (validation set). Missing data were handled using multiple imputation techniques. Results Overall, 817 of 1237 (66%) hemispheric surgeries led to seizure freedom (median follow‐up = 24 months), and 1050 of 1237 (85%) were seizure‐free at 12 months after surgery. A simple regression model containing age at seizure onset, presence of generalized seizure semiology, presence of contralateral 18‐fluoro‐2‐deoxyglucose–positron emission tomography hypometabolism, etiologic substrate, and previous nonhemispheric resective surgery is predictive of seizure freedom (area under the curve = .72). A Hemispheric Surgery Outcome Prediction Scale (HOPS) score was devised that can be used to predict seizure freedom. Significance Children most likely to benefit from hemispheric surgery can be selected and counseled through the implementation of a scale derived from a multiple regression model. Importantly, children who are unlikely to experience seizure control can be spared from the complications and deficits associated with this surgery. The HOPS score is likely to help physicians in clinical decision‐making. es_ES
dc.language.iso eng es_ES
dc.publisher Wiley es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Epilepsy es_ES
dc.subject Epilepsia es_ES
dc.subject Hemispherectomy es_ES
dc.subject Hemisferectomía es_ES
dc.title Hemispherectomy Outcome Prediction Scale: Development and validation of a seizure freedom prediction tool es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Weil, Alexander G. Saint Justine University Hospital Centre; Canada.
dc.description.fil Fil: Lewis, Evan C. Neurology Centre of Toronto; Canada.
dc.description.fil Fil: Ibrahim, George M. University of Toronto; Canada.
dc.description.fil Fil: Kola, Olivia. David Geffen School of Medicine at University of California; Estados Unidos.
dc.description.fil Fil: Tseng, Chi-Hong. David Geffen School of Medicine at University of California; Estados Unidos.
dc.description.fil Fil: Zhou, Xinkai. University of California; Estados Unidos.
dc.description.fil Fil: Lin, Kao-Min. Xiamen Humanity Hospital; China.
dc.description.fil Fil: Cai, Li-Xin. Peking University First Hospital; China.
dc.description.fil Fil: Liu, Qing-Zhu. Tsinghua University; China.
dc.description.fil Fil: Lin, Jiu-Luan. Tsinghua University; China.
dc.description.fil Fil: Zhou, Wen-Jing. Tsinghua University; China.
dc.description.fil Fil: Mathern, Gary W. David Geffen School of Medicine at University of California; Estados Unidos.
dc.description.fil Fil: Smyth, Matthew D. St. Louis Children's Hospital; Estados Unidos.
dc.description.fil Fil: O'Neill, Brent R. Children's Hospital Colorado; Estados Unidos.
dc.description.fil Fil: Dudley, Roy. Montreal Children's Hospital; Canadá.
dc.description.fil Fil: Ragheb, John. Nicklaus Children's Hospital; Estados Unidos.
dc.description.fil Fil: Bhatia, Sanjiv. Nicklaus Children's Hospital; Estados Unidos.
dc.description.fil Fil: Pociecha, Juan. Fleni. Centro Integral de Epilepsia y Unidad de Monitoreo de Videoelectroencefalografía; Argentina.
dc.description.fil Fil: Chamorro, Noelia. Fleni. Centro Integral de Epilepsia y Unidad de Monitoreo de Videoelectroencefalografía; Argentina.
dc.description.fil Fil: Muro, Valeria L. Fleni. Centro Integral de Epilepsia y Unidad de Monitoreo de Videoelectroencefalografía; Argentina.
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Malden
dc.relation.ispartofTITLE Epilepsia
dc.relation.ispartofISSN 1528-1167
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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