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Listar Neurociencias por título

Listar Neurociencias por título

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  • Downregulation of E-cadherin in pluripotent stem cells triggers partial EMT 
    Aban, Cyntia; Lombardi, Antonella; Neiman, Gabriel; Biani, María Celeste; La Greca, Alejandro; Waisman, Ariel; Moro, Lucía Natalia; Sevlever, Gustavo Emilio; Miriuka, Santiago Gabriel; Luzzani, Carlos Daniel (Nature Publishing Group, 2021-01-21)
    Epithelial to mesenchymal transition (EMT) is a critical cellular process that has been well characterized during embryonic development and cancer metastasis and it also is implicated in several physiological and pathological ...
  • Droplets for Gene Editing Using CRISPR-Cas9 and Clonal Selection Improvement Using Hydrogels. 
    Pérez Sosa, Camilo; Pérez, Maximiliano S.; Vallejo Janeta, Alexander Paolo; Bhansali, Shekhar; Miriuka, Santiago Gabriel; Lerner, Betiana (MDPI, 2024-02-19)
    Gene editing tools have triggered a revolutionary transformation in the realms of cellular and molecular physiology, serving as a fundamental cornerstone for the evolution of disease models and assays in cell culture ...
  • Editorial: Advances in platforms for disease modelling 
    Romorini, Leonardo; Baweja, Sukriti; Martin Mateos, Rosa Maria; Mehta, Gautam; Jalan-Sakrikar, Nidhi (Frontiers Media, 2023-04-19)
    Resumen no disponible
  • Effect of Embryo Aggregation on In Vitro Development of Adipose-Derived Mesenchymal Stem Cell-Derived Bovine Clones 
    Savy, Virginia; Alberio, Virgilia; Vans Landschoot, Geraldina; Moro, Lucía Natalia; Olea, Fernanda Daniela; Rodríguez-Álvarez, Lleretny; Salamone, Daniel Felipe (Mary Ann Liebert, 2021-10-12)
    Somatic cell nuclear transfer (SCNT) is a method with unique ability to reprogram the epigenome of a fully differentiated cell. However, its efficiency remains extremely low. In this work, we assessed and combined two ...
  • EFFECTS OF BACTERIAL LIPOPOLYSACCHARIDE AND SHIGA TOXIN ON INDUCED PLURIPOTENT STEM CELL-DERIVED MESENCHYMAL STEM CELLS 
    Martire-Greco, Daiana; La Greca, Alejandro; Castillo Montañez, Luis; Biani, María Celeste; Lombardi, Antonella; Birnberg-Weiss, Federico; Norris, Alessandra; Sacerdoti, Flavia; Amaral, María Marta; Rodrigues-Rodriguez, Nahuel; Pittaluga, Jose Ramón; Furmento, Verónica Alejandra; Landoni, Verónica Inés; Miriuka, Santiago Gabriel; Luzzani, Carlos Daniel; Fernández, Gabriela Cristina (Lippincott Williams & Wilkins, 2023-04-11)
    Background : Mesenchymal stem cells (MSCs) can be activated by different bacterial toxins. Lipopolysaccharides and Shiga Toxin (Stx) are the main toxins necessary for hemolytic uremic syndrome development. The main etiological ...
  • Embryo aggregation and adipose-derived mesenchymal donor cells in bovine somatic cell nuclear transfer 
    Alberio, Virgilia; Savy, Virginia; Vans Landschoot, Geraldina; Moro, Lucía Natalia; Olea, Fernanda Daniela; Rodríguez Álvarez, L.; Salamone, Daniel Felipe (Csiro Publishing, 2021-01-08)
    Somatic cell nuclear transfer (SCNT) is a powerful tool, but its efficiency remains low. The use of less differentiated donor cells or the embryo aggregation (EA) strategy improves the SCNT rates in several species. It ...
  • Embryoid Bodies-Based Multilineage Differentiation of Human Embryonic Stem Cells Grown on Feeder-Free Conditions 
    Isaja, Luciana; Ferriol Laffouillere, Sofía Luján; Mucci, Sofía; Rodríguez Varela, María Soledad; Romorini, Leonardo (Springer, 2021-10-06)
    Human embryonic stem cells (hESCs) can differentiate into any cell lineage (pluripotency potential) derived from the three germ layers: ectoderm, mesoderm, and endoderm. Pluripotency is usually demonstrated in vitro by ...
  • Evaluation of Baculoviruses as Gene Therapy Vectors for Brain Cancer 
    García Fallit, Matías; Pidre, Matías L.; Asad, Antonela S.; Peña Agudelo, Jorge A.; Vera, Mariana Belén; Nicola Candia, Alejandro J.; Sagripanti, Sofia B.; Pérez Küper, Melanie; Amorós Morales, Leslie C.; Marchesini, Abril; Gonzalez, Nazareno; Caruso, Carla M.; Romanowski, Víctor; Seilicovich, Adriana; Videla Richardson, Guillermo Agustín; Zanetti, Flavia A.; Candolfi, Marianela (MDPI, 2023-02-22)
    We aimed to assess the potential of baculoviral vectors (BV) for brain cancer gene therapy. We compared them with adenoviral vectors (AdV), which are used in neuro-oncology, but for which there is pre-existing immunity. ...
  • Extraction-free protocol combining proteinase K and heat inactivation for detection of SARS-CoV-2 by RT-qPCR 
    Genoud, Valeria; Stortz, Martin; Waisman, Ariel; Berardino, Bruno G.; Verneri, Paula; Dansey, Virginia; Salvatori, Melina; Remes Lenicov, Federico; Levi, Valeria (PLoS One, 2021-02-26)
    Real-time reverse transcription PCR (RT-qPCR) is the gold-standard technique for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection in nasopharyngeal swabs specimens. The analysis by RT-qPCR usually ...
  • Galectins as Emerging Glyco-Checkpoints and Therapeutic Targets in Glioblastoma 
    Videla Richardson, Guillermo Agustín; Morris Hanon, Olivia; Torres, Nicolás I.; Esquivel, Myrian Inés; Vera, Mariana Belén; Ripari, Luisina Belén; Croci, Diego O.; Sevlever, Gustavo Emilio; Rabinovich, Gabriel A. (Molecular Diversity Preservation International, 2021-12-28)
    Despite recent advances in diagnosis and treatment, glioblastoma (GBM) represents the most common and aggressive brain tumor in the adult population, urging identification of new rational therapeutic targets. Galectins, a ...
  • GEMA—An Automatic Segmentation Method for Real-Time Analysis of Mammalian Cell Growth in Microfluidic Devices 
    Isa-Jara, Ramiro; Pérez-Sosa, Camilo; Macote-Yparraguirre, Erick; Revollo, Natalia; Lerner, Betiana; Miriuka, Santiago Gabriel; Delrieux, Claudio; Pérez, Maximiliano S.; Mertelsmann, Roland (MDPI, 2022-10-14)
    Nowadays, image analysis has a relevant role in most scientific and research areas. This process is used to extract and understand information from images to obtain a model, knowledge, and rules in the decision process. ...
  • Generation of a human induced pluripotent stem cell line (INEUi001-A) from an amyotrophic lateral sclerosis/frontotemporal dementia patient with a C9ORF72 G4C2 genotype of <2 (GGGGCCG) and 10 repeats 
    Nievas, Micaela; Romorini, Leonardo; Isaja, Luciana; Clas, Giulia S.; Rodríguez Varela, María Soledad; Mucci, Sofía; Itzcovich, Tatiana; de Ambrosi, Bruno; Scassa, María Élida; Sevlever, Gustavo Emilio; Surace, Ezequiel Ignacio; Marazita, Mariela Claudia (Elsevier, 2023-03-22)
    Human induced pluripotent stem cell (hiPSC) line INEUi001-A was reprogrammed from peripheral blood mononuclear cells (PBMC) using the lentiviral-hSTEMCCA-loxP vector. PBMCs were obtained from a 75- year-old female ALS/FTD ...
  • Generation of a human induced pluripotent stem cell line from a familial Alzheimer's disease PSEN1 T119I patient 
    Isaja, Luciana; Rodríguez Varela, María Soledad; Marazita, Mariela Claudia; Mucci, Sofía; Itzcovich, Tatiana; Chrem Méndez, Patricio Alexis; Niikado, Matías; Ferriol Laffouillere, Sofía Luján; Allegri, Ricardo Francisco; Martinetto, Horacio; Sevlever, Gustavo Emilio; Scassa, María Élida; Surace, Ezequiel Ignacio; Romorini, Leonardo (Elsevier, 2021-04-05)
    Human induced pluripotent stem cells (hiPSC) line FLENIi001-A was reprogrammed from dermal fibroblasts using the lentiviral-hSTEMCCA-loxP vector. Fibroblasts were obtained from a skin biopsy of a 72-year-old Caucasian male ...
  • Generation of myostatin edited horse embryos using CRISPR/Cas9 technology and somatic cell nuclear transfer 
    Moro, Lucía Natalia; Viale, Diego Luis; Bastón, Juan Ignacio; Arnold, Victoria; Suva, Mariana; Wiedenmann, Elisabet; Olguín, Martín; Miriuka, Santiago Gabriel; Vichera, Gabriel (Nature Publishing Group, 2020-08-24)
    The application of new technologies for gene editing in horses may allow the generation of improved sportive individuals. Here, we aimed to knock out the myostatin gene (MSTN), a negative regulator of muscle mass development, ...
  • Generation of myostatin knockout horse embryos using clustered regularly interspaced short palindromic repeats/CRISPR-associated gene 9 and somatic cell nuclear transfer 
    Vichera, Gabriel; Viale, Diego Luis; Olivera, Ramiro; Arnold, Victoria; Grundnig, A.; Bastón, Juan Ignacio; Miriuka, Santiago Gabriel; Moro, Lucía Natalia (Csiro Publishing, 2018-12-03)
    Historically, livestock improvement by selective breeding was the principal selection force in animal production and welfare, but the desired phenotype may involve more than 1 generation. Nowadays, new technologies such ...
  • Generation of two edited iPSCs lines by CRISPR/Cas9 with point mutations in PKP2 gene for arrhythmogenic cardiomyopathy in vitro modeling 
    Amín, Guadalupe; Castañeda, Sheila; Zabalegui, Federico; Belli, Carolina; Atorrasagasti Fernández, María Catalina; Miriuka, Santiago Gabriel; Moro, Lucía Natalia (Elsevier, 2023-06-25)
    The arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disease characterized by the progressive replacement of contractile myocardium by fibro-fatty adipose tissue, that generates ventricular arrhythmias and ...
  • Glial Cell Metabolic Profile Upon Iron Deficiency: Oligodendroglial and Astroglial Casualties of Bioenergetic Adjustments 
    Rosato-Siri, María Victoria; Martino Adami, Pamela V.; Guitart, María Eugenia; Verstraeten, Sandra V.; Morelli, Laura; Correale, Jorge; Pasquini, Juana María (Humana Press, 2023-01-03)
    Iron deficiency (ID) represents one of the most prevalent nutritional deficits, affecting almost two billion people worldwide. Gestational iron deprivation induces hypomyelination due to oligodendroglial maturation ...
  • Hand bone conduction sound study by using the DSP Logger MX 300 
    Adler, Melanie Victoria; Fialá Sánchez, Mariana; Martini, Constanza; Vartabedian, Luciana Mariam; Zazzali, Matías Nicolás; Quintero Rincón, Antonio (Sociedad Argentina de Bioingeniería, 2020)
    Bone conduction is the transmission of acoustic energy to the inner ear by different paths involving the bones of the skull. In this work, we use the path the hand provides in order to transmit the sound coming from the ...
  • HLA-G gene editing: a novel therapeutic alternative in cancer immunotherapy 
    Palma, María Belén; Tronik-Le Roux, Diana; Amín, Guadalupe; Castañeda, Sheila; Möbbs, Alan Miqueas; Scarafía, María Agustina; La Greca, Alejandro; Daouya, Marina; Poras, Isabelle; Inda, Ana María; Moro, Lucía Natalia; Carosella, Edgardo D.; García, Marcela N.; Miriuka, Santiago Gabriel (bioRxiv, 2021-01-22)
    Cancer immunotherapies based mainly on the blockade of immune-checkpoint (IC) molecules by anti-IC antibodies offer new alternatives for treatment in oncological diseases. However, a considerable proportion of patients ...
  • Human embryonic stem cells display a pronounced sensitivity to the cyclin dependent kinase inhibitor Roscovitine 
    Videla Richardson, Guillermo Agustín; Furmento, Verónica Alejandra; García, Carolina Paola; Morris-Hanon, Olivia; Sevlever, Gustavo Emilio; Romorini, Leonardo; Scassa, María Élida (Biomed Central, 2019-08-28)
    BACKGROUND: The essentially unlimited expansion potential and the pluripotency of human embryonic stem cells (hESCs) make them attractive for cell-based therapeutic purposes. Although hESCs can indefinitely proliferate ...

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