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Browsing Neurociencias by Author "Isaja, Luciana"

Browsing Neurociencias by Author "Isaja, Luciana"

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  • Acute severe hypoxia induces apoptosis of human pluripotent stem cells by a HIF-1α and P53 independent mechanism 
    Mucci, Sofía; Isaja, Luciana; Rodríguez Varela, María Soledad; Ferriol Laffouillere, Sofía Luján; Marazita, Mariela Claudia; Videla Richardson, Guillermo Agustín; Sevlever, Gustavo Emilio; Scassa, María Élida; Romorini, Leonardo (Nature Publishing Group, 2022-10-05)
    Human embryonic and induced pluripotent stem cells are self-renewing pluripotent stem cells (hPSCs) that can differentiate into a wide range of specialized cells. Although moderate hypoxia (5% O2) improves hPSC self-renewal, ...
  • Chemical hypoxia induces apoptosis of human pluripotent stem cells by a NOXA-mediated HIF-1α and HIF-2α independent mechanism 
    Isaja, Luciana; Mucci, Sofía; Vera, Jonathan; Rodríguez Varela, María Soledad; Marazita, Mariela Claudia; Morris-Hanon, Olivia; Videla Richardson, Guillermo Agustín; Sevlever, Gustavo Emilio; Scassa, María Élida; Romorini, Leonardo (Nature Publishing Group, 2020-10-26)
    Human embryonic and induced pluripotent stem cells (hESCs and hiPSCs) are self-renewing human pluripotent stem cells (hPSCs) that can differentiate to a wide range of specialized cells. Notably, hPSCs enhance their ...
  • Embryoid Bodies-Based Multilineage Differentiation of Human Embryonic Stem Cells Grown on Feeder-Free Conditions 
    Isaja, Luciana; Ferriol Laffouillere, Sofía Luján; Mucci, Sofía; Rodríguez Varela, María Soledad; Romorini, Leonardo (Springer, 2021-10-06)
    Human embryonic stem cells (hESCs) can differentiate into any cell lineage (pluripotency potential) derived from the three germ layers: ectoderm, mesoderm, and endoderm. Pluripotency is usually demonstrated in vitro by ...
  • Generation of a human induced pluripotent stem cell line (INEUi001-A) from an amyotrophic lateral sclerosis/frontotemporal dementia patient with a C9ORF72 G4C2 genotype of <2 (GGGGCCG) and 10 repeats 
    Nievas, Micaela; Romorini, Leonardo; Isaja, Luciana; Clas, Giulia S.; Rodríguez Varela, María Soledad; Mucci, Sofía; Itzcovich, Tatiana; de Ambrosi, Bruno; Scassa, María Élida; Sevlever, Gustavo Emilio; Surace, Ezequiel Ignacio; Marazita, Mariela Claudia (Elsevier, 2023-03-22)
    Human induced pluripotent stem cell (hiPSC) line INEUi001-A was reprogrammed from peripheral blood mononuclear cells (PBMC) using the lentiviral-hSTEMCCA-loxP vector. PBMCs were obtained from a 75- year-old female ALS/FTD ...
  • Generation of a human induced pluripotent stem cell line from a familial Alzheimer's disease PSEN1 T119I patient 
    Isaja, Luciana; Rodríguez Varela, María Soledad; Marazita, Mariela Claudia; Mucci, Sofía; Itzcovich, Tatiana; Chrem Méndez, Patricio Alexis; Niikado, Matías; Ferriol Laffouillere, Sofía Luján; Allegri, Ricardo Francisco; Martinetto, Horacio; Sevlever, Gustavo Emilio; Scassa, María Élida; Surace, Ezequiel Ignacio; Romorini, Leonardo (Elsevier, 2021-04-05)
    Human induced pluripotent stem cells (hiPSC) line FLENIi001-A was reprogrammed from dermal fibroblasts using the lentiviral-hSTEMCCA-loxP vector. Fibroblasts were obtained from a skin biopsy of a 72-year-old Caucasian male ...
  • miR-302 family, miR-145 and miR-296 temporal expression profile along the cell cycle of human pluripotent stem cells 
    Rodríguez Varela, María Soledad; Mucci, Sofía; Videla Richardson, Guillermo Agustín; Isaja, Luciana; Sevlever, Gustavo Emilio; Scassa, María Élida; Romorini, Leonardo (Elsevier, 2021-01-21)
    Human pluripotent stem cells (hPSCs), like embryonic (hESCs) and induced pluripotent stem cells (hiPSCs), exhibit an unusual cell cycle structure characterized by a short G1 phase and cells being most of time in S phase. ...
  • Palbociclib Effectively Halts Proliferation but Fails to Induce Senescence in Patient-Derived Glioma Stem Cells 
    Morris-Hanon, Olivia; Marazita, Mariela Claudia; Romorini, Leonardo; Isaja, Luciana; Fernandez-Espinosa, Damián Darío; Sevlever, Gustavo Emilio; Scassa, María Élida; Videla Richardson, Guillermo Agustín (Springer, 2019-05-23)
    Glioblastoma multiforme is the most aggressive primary brain tumor. Current knowledge suggests that the growth and recurrence of these tumors are due in part to the therapy-resistant glioma stem cell subpopulation, which ...
  • Protocol for morphometric analysis of neurons derived from human pluripotent stem cells 
    Mucci, Sofía; Rodríguez Varela, María Soledad; Isaja, Luciana; Ferriol Laffouillere, Sofía Luján; Sevlever, Gustavo Emilio; Scassa, María Élida; Romorini, Leonardo (Cell Press, 2022-06-18)
    The analysis of morphological features of neurons derived from human pluripotent stem cells (hPSCs) is important to describe neuronal phenotypes and changes observed throughout development. Using free and easily accessible ...
  • Role of hydroxymethylglutharyl-coenzyme A reductase in the induction of stem-like states in breast cancer 
    Marks, María Paula; Giménez, Carla Alejandra; Isaja, Luciana; Vera, Mariana Belén; Borzone, Francisco Raúl; Pereyra-Bonnet, Federico; Romorini, Leonardo; Videla Richardson, Guillermo Agustín; Chasseing, Norma Alejandra; Calvo, Juan Carlos; Vellón, Luciano (Springer-Verlag, 2024-02-28)
    Purpose: De novo synthesis of cholesterol and its rate-limiting enzyme, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMGCR), is deregulated in tumors and critical for tumor cell survival and proliferation. However, ...

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