ListarNeurociencias por tema "Sistemas CRISPR-Cas"

Mostrando ítems 1-5 de 5

Generation of myostatin edited horse embryos using CRISPR/Cas9 technology and somatic cell nuclear transfer

Moro, Lucía Natalia; Viale, Diego Luis; Bastón, Juan Ignacio; Arnold, Victoria; Suva, Mariana; Wiedenmann, Elisabet; Olguín, Martín; Miriuka, Santiago Gabriel; Vichera, Gabriel (Nature Publishing Group, 2020-08-24)

The application of new technologies for gene editing in horses may allow the generation of improved sportive individuals. Here, we aimed to knock out the myostatin gene (MSTN), a negative regulator of muscle mass development, ...
Generation of myostatin knockout horse embryos using clustered regularly interspaced short palindromic repeats/CRISPR-associated gene 9 and somatic cell nuclear transfer

Vichera, Gabriel; Viale, Diego Luis; Olivera, Ramiro; Arnold, Victoria; Grundnig, A.; Bastón, Juan Ignacio; Miriuka, Santiago Gabriel; Moro, Lucía Natalia (Csiro Publishing, 2018-12-03)

Historically, livestock improvement by selective breeding was the principal selection force in animal production and welfare, but the desired phenotype may involve more than 1 generation. Nowadays, new technologies such ...
Generation of two edited iPSCs lines by CRISPR/Cas9 with point mutations in PKP2 gene for arrhythmogenic cardiomyopathy in vitro modeling

Amín, Guadalupe; Castañeda, Sheila; Zabalegui, Federico; Belli, Carolina; Atorrasagasti Fernández, María Catalina; Miriuka, Santiago Gabriel; Moro, Lucía Natalia (Elsevier, 2023-06-25)

The arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disease characterized by the progressive replacement of contractile myocardium by fibro-fatty adipose tissue, that generates ventricular arrhythmias and ...
Kat6b Modulates Oct4 and Nanog Binding to Chromatin in Embryonic Stem Cells and Is Required for Efficient Neural Differentiation

Cosentino, María Soledad; Oses, Camila; Vázquez Echegaray, Camila; Solari, Claudia; Waisman, Ariel; Álvarez, Yanina; Petrone, María Victoria; Francia, Marcos; Schultz, Marcelo; Sevlever, Gustavo Emilio; Miriuka, Santiago Gabriel; Levi, Valeria; Guberman, Alejandra S. (Academic Press, 2019-03-15)

Chromatin remodeling is fundamental for the dynamical changes in transcriptional programs that occur during development and stem cell differentiation. The histone acetyltransferase Kat6b is relevant for neurogenesis in ...
Myostatin gene editing by CRISPR/Cas9 technology of Brangus fetal fibroblasts to produce edited embryos by cloning

Bastón, Juan Ignacio; Viale, Diego Luis; Olguín, Martín; Wiedenmann, Elisabet; Arnold, Victoria; Suva, Mariana; Luzzani, Carlos Daniel; Miriuka, Santiago Gabriel; Moro, Lucía Natalia; Vichera, Gabriel (Csiro Publishing, 2021-01-08)

Some European cattle breeds, such as Charolais and Maine Anjou, have natural mutations in the myostatin gene (MSTN) that inhibit its expression and result in an increase in muscle mass and protein content. An innovative ...

ListarNeurociencias por tema "Sistemas CRISPR-Cas"

ListarNeurociencias por tema "Sistemas CRISPR-Cas"

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