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Browsing Neurociencias.artículos by Title

Browsing Neurociencias.artículos by Title

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  • Galectins as Emerging Glyco-Checkpoints and Therapeutic Targets in Glioblastoma 
    Videla Richardson, Guillermo Agustín; Morris-Hanon, Olivia; Torres, Nicolás I.; Esquivel, Myrian Inés; Vera, Mariana Belén; Ripari, Luisina Belén; Croci, Diego O.; Sevlever, Gustavo Emilio; Rabinovich, Gabriel A. (Molecular Diversity Preservation International, 2021-12-28)
    Despite recent advances in diagnosis and treatment, glioblastoma (GBM) represents the most common and aggressive brain tumor in the adult population, urging identification of new rational therapeutic targets. Galectins, a ...
  • GEMA—An Automatic Segmentation Method for Real-Time Analysis of Mammalian Cell Growth in Microfluidic Devices 
    Isa-Jara, Ramiro; Pérez-Sosa, Camilo; Macote-Yparraguirre, Erick; Revollo, Natalia; Lerner, Betiana; Miriuka, Santiago Gabriel; Delrieux, Claudio; Pérez, Maximiliano S.; Mertelsmann, Roland (MDPI, 2022-10-14)
    Nowadays, image analysis has a relevant role in most scientific and research areas. This process is used to extract and understand information from images to obtain a model, knowledge, and rules in the decision process. ...
  • Gender-specific associations between metabolic dysfunction-associated fatty liver disease with atherosclerosis, inflammation, and eating habits 
    Rodriguez-Granillo, Gaston A.; Poggio, Rosana; Rubilar, Alejandra B.; Garron-Arias, Sarah Y.; Solari, Claudia; La Greca, Alejandro; Luzzani, Carlos; Fontana, Lucia; Arnone, Carolina V.; Ingino, Carlos; Miriuka, Santiago Gabriel (Elsevier, 2025-11-11)
    Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) has multifactorial pathogenesis. Given its close relationship with dietary habits, and the need for improved geographical representation and sex ...
  • Generation of a human induced pluripotent stem cell line (INEUi001-A) from an amyotrophic lateral sclerosis/frontotemporal dementia patient with a C9ORF72 G4C2 genotype of <2 (GGGGCCG) and 10 repeats 
    Nievas, Micaela; Romorini, Leonardo; Isaja, Luciana; Clas, Giulia Solange; Rodríguez Varela, María Soledad; Mucci, Sofía; Itzcovich, Tatiana; de Ambrosi, Bruno; Scassa, María Élida; Sevlever, Gustavo Emilio; Surace, Ezequiel Ignacio; Marazita, Mariela Claudia (Elsevier, 2023-03-22)
    Human induced pluripotent stem cell (hiPSC) line INEUi001-A was reprogrammed from peripheral blood mononuclear cells (PBMC) using the lentiviral-hSTEMCCA-loxP vector. PBMCs were obtained from a 75- year-old female ALS/FTD ...
  • Generation of a human induced pluripotent stem cell line from a familial Alzheimer's disease PSEN1 T119I patient 
    Isaja, Luciana; Rodríguez Varela, María Soledad; Marazita, Mariela Claudia; Mucci, Sofía; Itzcovich, Tatiana; Chrem Méndez, Patricio Alexis; Niikado, Matías; Ferriol Laffouillere, Sofía Luján; Allegri, Ricardo Francisco; Martinetto, Horacio; Sevlever, Gustavo Emilio; Scassa, María Élida; Surace, Ezequiel Ignacio; Romorini, Leonardo (Elsevier, 2021-04-05)
    Human induced pluripotent stem cells (hiPSC) line FLENIi001-A was reprogrammed from dermal fibroblasts using the lentiviral-hSTEMCCA-loxP vector. Fibroblasts were obtained from a skin biopsy of a 72-year-old Caucasian male ...
  • Generation of an iPSC line from congenital hypopituitarism patient with a nonsense heterozygous variant in FOXA2 
    Camilletti, María Andrea; Chirino Felker, Gonzalo Tomás; Castañeda, Sheila; Zabalegui, Federico; Amín, Guadalupe; Belgorosky, Alicia; Ciaccio, Marta; Di Palma, Maria Isabel; Vaiani, Elisa; Waisman, Ariel; Miriuka, Santiago Gabriel; Pérez Millán, María Inés; Moro, Lucia Natalia (Elsevier, 2025-07-15)
    Forkhead box A2 (FOXA2) is a pioneer transcription factor, necessary for human development. Mutations in FOXA2 were recently associated with congenital hypopituitarism (CH); however, the pathogenic mechanism remains unknown. ...
  • Generation of human induced pluripotent stem cell lines from two down syndrome patients, including a down syndrome/Alzheimer's disease case (FLENIi002-A) and a beta-amyloid-resistant case (FLENIi003-A) 
    Clas, Giulia Solange; Marazita, Mariela Claudia; Pertierra, Lucía; Vázquez, Silvia; Isaja, Luciana; Rodríguez Varela, María Soledad; Mucci, Sofía; Helou, María Belén; Tapajóz Pereira de Sampaio, Fernanda; Magrath Guimet, Nahuel; Bérgamo, Yanina; Allegri, Ricardo Francisco; Sevlever, Gustavo Emilio; Scassa, María Élida; Surace, Ezequiel Ignacio; Romorini, Leonardo (Elsevier, 2025-05-01)
    Two human induced pluripotent stem cell (hiPSC) lines, FLENIi002-A and FLENIi003-A, were generated from peripheral blood mononuclear cells (PBMCs) using the lentiviral-hSTEMCCA-loxP vector. FLENIi002-A was derived from a ...
  • Generation of myostatin edited horse embryos using CRISPR/Cas9 technology and somatic cell nuclear transfer 
    Moro, Lucía Natalia; Viale, Diego Luis; Bastón, Juan Ignacio; Arnold, Victoria; Suva, Mariana; Wiedenmann, Elisabet; Olguín, Martín; Miriuka, Santiago Gabriel; Vichera, Gabriel (Nature Publishing Group, 2020-08-24)
    The application of new technologies for gene editing in horses may allow the generation of improved sportive individuals. Here, we aimed to knock out the myostatin gene (MSTN), a negative regulator of muscle mass development, ...
  • Generation of two edited iPSCs lines by CRISPR/Cas9 with point mutations in PKP2 gene for arrhythmogenic cardiomyopathy in vitro modeling 
    Amín, Guadalupe; Castañeda, Sheila; Zabalegui, Federico; Belli, Carolina; Atorrasagasti Fernández, María Catalina; Miriuka, Santiago Gabriel; Moro, Lucía Natalia (Elsevier, 2023-06-25)
    The arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disease characterized by the progressive replacement of contractile myocardium by fibro-fatty adipose tissue, that generates ventricular arrhythmias and ...
  • Glial Cell Metabolic Profile Upon Iron Deficiency: Oligodendroglial and Astroglial Casualties of Bioenergetic Adjustments 
    Rosato-Siri, María Victoria; Martino Adami, Pamela V.; Guitart, María Eugenia; Verstraeten, Sandra V.; Morelli, Laura; Correale, Jorge; Pasquini, Juana María (Humana Press, 2023-01-03)
    Iron deficiency (ID) represents one of the most prevalent nutritional deficits, affecting almost two billion people worldwide. Gestational iron deprivation induces hypomyelination due to oligodendroglial maturation ...
  • Hand bone conduction sound study by using the DSP Logger MX 300 
    Adler, Melanie Victoria; Fialá Sánchez, Mariana; Martini, Constanza; Vartabedian, Luciana Mariam; Zazzali, Matías Nicolás; Quintero Rincón, Antonio (Sociedad Argentina de Bioingeniería, 2020)
    Bone conduction is the transmission of acoustic energy to the inner ear by different paths involving the bones of the skull. In this work, we use the path the hand provides in order to transmit the sound coming from the ...
  • HIV infection drives proinflammatory adipocyte differentiation in an in vitro model and reveals a new inflammatory pathway 
    Freiberger, Rosa Nicole; López, Cynthia Alicia Marcela; Sviercz, Franco Agustin; Jarmoluk, Patricio; Palma, María Belén; García, Marcela Nilda; Quarleri, Jorge; Delpino, M. Victoria (Frontiers Media, 2025-07-17)
    Introduction: Adipose tissue regulates metabolic homeostasis and serves as a reservoir for mesenchymal stem cells (MSCs), which differentiate into osteoblasts and adipocytes, balancing bone and lipid metabolism. Bone loss ...
  • HIV Modulates Osteoblast Differentiation via Upregulation of RANKL and Vitronectin 
    Freiberger, Rosa Nicole; López, Cynthia Alicia Marcela; Palma, María Belén; Cevallos, Cintia; Sviercz, Franco Agustin; Jarmolu, Patricio; García, Marcela Nilda; Quarleri, Jorge; Delpino, M. Victoria (MDPI AG, 2024-09-15)
    Bone loss is a prevalent characteristic among people with HIV (PWH). We focused on mesenchymal stem cells (MSCs) and osteoblasts, examining their susceptibility to different HIV strains (R5- and X4-tropic) and the subsequent ...
  • HLA-G gene editing: a novel therapeutic alternative in cancer immunotherapy 
    Palma, María Belén; Tronik-Le Roux, Diana; Amín, Guadalupe; Castañeda, Sheila; Möbbs, Alan Miqueas; Scarafía, María Agustina; La Greca, Alejandro; Daouya, Marina; Poras, Isabelle; Inda, Ana María; Moro, Lucía Natalia; Carosella, Edgardo D.; García, Marcela Nilda; Miriuka, Santiago Gabriel (bioRxiv, 2021-01-22)
    Cancer immunotherapies based mainly on the blockade of immune-checkpoint (IC) molecules by anti-IC antibodies offer new alternatives for treatment in oncological diseases. However, a considerable proportion of patients ...
  • Human embryonic stem cells display a pronounced sensitivity to the cyclin dependent kinase inhibitor Roscovitine 
    Videla Richardson, Guillermo Agustín; Furmento, Verónica Alejandra; García, Carolina Paola; Morris-Hanon, Olivia; Sevlever, Gustavo Emilio; Romorini, Leonardo; Scassa, María Élida (Biomed Central, 2019-08-28)
    BACKGROUND: The essentially unlimited expansion potential and the pluripotency of human embryonic stem cells (hESCs) make them attractive for cell-based therapeutic purposes. Although hESCs can indefinitely proliferate ...
  • Immune Single-Cell Annotation by Molecular Signature-Based Deconvolution with MIXTURE 
    Nava, Agustin; Nibeyro, Guadalupe; Orschanski, Daniela; Baronetto, Veronica; Llera, Andrea S.; Fernández, Elmer A. (Springer Nature, 2025-05-23)
    Accurate cell type identification in single-cell RNA sequencing (scRNA-seq) datasets is essential for dissecting the tumor immune microenvironment (TIME) and optimizing immunotherapy strategies. Here, we present an annotation ...
  • Integrin alpha-5 subunit is critical for the early stages of human pluripotent stem cell cardiac differentiation 
    Neiman, Gabriel; Scarafía, María Agustina; La Greca, Alejandro; Santín Velazque, Natalia Lucía; Garate, Ximena; Waisman, Ariel; Möbbs, Alan Miqueas; Kasai-Brunswick, Tais Hanae; Mesquita, Fernanda C.P.; Martire-Greco, Daiana; Moro, Lucía Natalia; Luzzani, Carlos Daniel; Bastos Carvalho, Adriana; Sevlever, Gustavo Emilio; Campos de Carvalho, Antonio C.; Guberman, Alejandra S.; Miriuka, Santiago Gabriel (Nature Publishing Group, 2019-12-02)
    The stem cell niche has a strong influence in the differentiation potential of human pluripotent stem cells with integrins playing a major role in communicating cells with the extracellular environment. However, it is not ...
  • Iron deficiency in astrocytes alters cellular status and impacts on oligodendrocyte differentiation. 
    Marcora, María Silvina; Mattera, Vanesa S.; Goñi, Pilar; Aybar, Florencia; Correale, Jorge; Pasquini, Juana María (Wiley Interscience, 2024-04)
    Iron deficiency (ID) has been shown to affect central nervous system (CNS) development and induce hypomyelination. Previous work from our laboratory in a gestational ID model showed that both oligodendrocyte (OLG) and ...
  • Kat6b Modulates Oct4 and Nanog Binding to Chromatin in Embryonic Stem Cells and Is Required for Efficient Neural Differentiation 
    Cosentino, María Soledad; Oses, Camila; Vázquez Echegaray, Camila; Solari, Claudia; Waisman, Ariel; Álvarez, Yanina; Petrone, María Victoria; Francia, Marcos; Schultz, Marcelo; Sevlever, Gustavo Emilio; Miriuka, Santiago Gabriel; Levi, Valeria; Guberman, Alejandra S. (Academic Press, 2019-03-15)
    Chromatin remodeling is fundamental for the dynamical changes in transcriptional programs that occur during development and stem cell differentiation. The histone acetyltransferase Kat6b is relevant for neurogenesis in ...
  • The lateral neocortex is critical for contextual fear memory reconsolidation 
    de la Fuente, Verónica; Medina, Candela; Falasco, Germán; Urrutia, Leandro; Kravitz, Alexxai V.; Urbano, Francisco J.; Vázquez, Silvia; Pedreira, María Eugenia; Romano, Arturo (Nature Publishing Group, 2019-08-21)
    Memories are a product of the concerted activity of many brain areas. Deregulation of consolidation and reprocessing of mnemonic traces that encode fearful experiences might result in fear-related psychopathologies. Here, ...

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