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Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy: international individual patient data pooled analysis

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dc.contributor.author Hostettler, Isabel Charlotte
dc.contributor.author Wilson, Duncan
dc.contributor.author Fiebelkorn, Catherine Arnold
dc.contributor.author Aum, Diane
dc.contributor.author Ameriso, Sebastián Francisco
dc.contributor.author Eberbach, Federico
dc.contributor.author Beitzke, Markus
dc.contributor.author Kleinig, Timothy
dc.contributor.author Phan, Thanh
dc.contributor.author Marchina, Sarah
dc.contributor.author Schneckenburger, Romain
dc.contributor.author Carmona-Iragui, María
dc.contributor.author Charidimou, Andreas
dc.contributor.author Mourand, Isabelle
dc.contributor.author Parreira, Sara
dc.contributor.author Ambler, Gareth
dc.contributor.author Rolf Jäger, Hans
dc.contributor.author Singhal, Shaloo
dc.contributor.author Ly, John
dc.contributor.author Bruno, Verónica
dc.date.accessioned 2021-07-20T13:09:12Z
dc.date.available 2021-07-20T13:09:12Z
dc.date.issued 2021-07-17
dc.identifier.citation Hostettler IC, Wilson D, Fiebelkorn CA, Aum D, Ameriso SF, Eberbach F, Beitzke M, Kleinig T, Phan T, Marchina S, Schneckenburger R, Carmona-Iragui M, Charidimou A, Mourand I, Parreira S, Ambler G, Jäger HR, Singhal S, Ly J, Ma H, Touzé E, Geraldes R, Fonseca AC, Melo T, Labauge P, Lefèvre PH, Viswanathan A, Greenberg SM, Fortea J, Apoil M, Boulanger M, Viader F, Kumar S, Srikanth V, Khurram A, Fazekas F, Bruno V, Zipfel GJ, Refai D, Rabinstein A, Graff-Radford J, Werring DJ. Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy: international individual patient data pooled analysis. J Neurol. 2021 Jul 17. doi: 10.1007/s00415-021-10706-3 es_ES
dc.identifier.uri https://doi.org/10.1007/s00415-021-10706-3
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/535
dc.description.abstract Objective To investigate the frequency, time-course and predictors of intracerebral haemorrhage (ICH), recurrent convexity subarachnoid haemorrhage (cSAH), and ischemic stroke after cSAH associated with cerebral amyloid angiopathy (CAA). Methods We performed a systematic review and international individual patient-data pooled analysis in patients with cSAH associated with probable or possible CAA diagnosed on baseline MRI using the modified Boston criteria. We used Cox proportional hazards models with a frailty term to account for between-cohort differences. Results We included 190 patients (mean age 74.5 years; 45.3% female) from 13 centers with 385 patient-years of follow-up (median 1.4 years). The risks of each outcome (per patient-year) were: ICH 13.2% (95% CI 9.9–17.4); recurrent cSAH 11.1% (95% CI 7.9–15.2); combined ICH, cSAH, or both 21.4% (95% CI 16.7–26.9), ischemic stroke 5.1% (95% CI 3.1–8) and death 8.3% (95% CI 5.6–11.8). In multivariable models, there is evidence that patients with probable CAA (compared to possible CAA) had a higher risk of ICH (HR 8.45, 95% CI 1.13–75.5, p = 0.02) and cSAH (HR 3.66, 95% CI 0.84–15.9, p = 0.08) but not ischemic stroke (HR 0.56, 95% CI 0.17–1.82, p = 0.33) or mortality (HR 0.54, 95% CI 0.16–1.78, p = 0.31). Conclusions Patients with cSAH associated with probable or possible CAA have high risk of future ICH and recurrent cSAH. Convexity SAH associated with probable (vs possible) CAA is associated with increased risk of ICH, and cSAH but not ischemic stroke. Our data provide precise risk estimates for key vascular events after cSAH associated with CAA which can inform management decisions. es_ES
dc.language.iso eng es_ES
dc.publisher Springer es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Cerebral Amyloid Angiopathy es_ES
dc.subject Angiopatía Amiloide Cerebral es_ES
dc.subject Cerebral Hemorrhage es_ES
dc.subject Hemorragia Cerebral es_ES
dc.subject Ischemic Stroke es_ES
dc.subject Accidente Cerebrovascular Isquémico es_ES
dc.subject Stroke es_ES
dc.subject Accidente Cerebrovascular es_ES
dc.title Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy: international individual patient data pooled analysis es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Hostettler, Isabel Charlotte. National Hospital of Neurology and Neurosurgery; Reino Unido.
dc.description.fil Fil: Wilson, Duncan. National Hospital of Neurology and Neurosurgery; Reino Unido.
dc.description.fil Fil: Fiebelkorn, Catherine Arnold. Mayo Clinic; Estados Unidos.
dc.description.fil Fil: Aum, Diane. Mayo Clinic; Estados -unidos.
dc.description.fil Fil: Ameriso, Sebastián Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Vascular; Argentina.
dc.description.fil Fil: Eberbach, Federico. Fleni. Departamento de Neurología. Servicio de Neurología Vascular; Argentina.
dc.description.fil Fil: Beitzke, Markus. Medical University of Graz; Austria.
dc.description.fil Fil: Kleinig, Timothy. Royal Adelaide Hospital; Australia.
dc.description.fil Fil: Phan, Thanh. Monash Health and Stroke and Ageing Research Group; Australia.
dc.description.fil Fil: Marchina, Sarah. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Schneckenburger, Romain. CHU Caen Normandie; Francia.
dc.description.fil Fil: Carmona-Iragui, María. Universitat Autònoma de Barcelona; España.
dc.description.fil Fil: Charidimou, Andreas. Massachusetts General Hospital and Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Mourand, Isabelle. Hôpital Gui-de-Chauliac; Francia.
dc.description.fil Fil: Parreira, Sara. University of Lisbon; Portugal.
dc.description.fil Fil: Ambler, Gareth. Department of Statistical Science; Reino Unido.
dc.description.fil Fil: Rolf Jäger, Hans. University College London; Reino Unido.
dc.description.fil Fil: Singhal, Shaloo. Monash Health and Stroke and Ageing Research Group; Australia.
dc.description.fil Fil: Ly, John. Monash Health and Stroke and Ageing Research Group; Australia.
dc.description.fil Fil: Bruno, Verónica. Fleni. Departamento de Neurología. Servicio de Neurología Vascular; Argentina.
dc.relation.ispartofCOUNTRY Alemania
dc.relation.ispartofCITY Berlín
dc.relation.ispartofTITLE Journal of neurology
dc.relation.ispartofISSN 1432-1459
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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