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Acromegaly and thyroid cancer: analysis of evolution in a series of patients

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dc.contributor.author Danilowicz, Karina
dc.contributor.author Sosa, Soledad
dc.contributor.author González Pernas, Mariana Soledad
dc.contributor.author Bamberger, Elizabeth
dc.contributor.author Diez, Sabrina
dc.contributor.author Fainstein Day, Patricia
dc.contributor.author Furioso, Alejandra
dc.contributor.author Glerean, Mariela
dc.contributor.author Guitelman, Mirtha
dc.contributor.author Katz, Débora Adela
dc.contributor.author Lemaitre, Nicole
dc.contributor.author Lowenstein, Alicia
dc.contributor.author Del Valle Luna, Mariela
dc.contributor.author Martínez, María Paz
dc.contributor.author Miragaya, Karina
dc.contributor.author Moncet, Daniel
dc.contributor.author Ortuño, María Victoria
dc.contributor.author Pignatta, Analía
dc.contributor.author Ramacciotti, Constanza Fernanda
dc.contributor.author Reyes, Adriana
dc.contributor.author Rogozinski, Amelia
dc.contributor.author Slavinsky, Patricia
dc.contributor.author Tkatch, Julieta
dc.contributor.author Pitoia, Fabián
dc.date.accessioned 2021-08-02T15:43:48Z
dc.date.available 2021-08-02T15:43:48Z
dc.date.issued 2020-11-17
dc.identifier.citation Danilowicz K, Sosa S, Gonzalez Pernas MS, Bamberger E, Diez SM, Fainstein Day P, Furioso A, Glerean M, Guitelman M, Katz D, Lemaitre N, Lowenstein A, Del Valle Luna M, Martínez MP, Miragaya K, Moncet D, Ortuño MV, Pignatta A, Ramacciotti CF, Reyes A, Rogozinski AS, Slavinsky P, Tkatch J, Pitoia F. Acromegaly and thyroid cancer: analysis of evolution in a series of patients. Clin Diabetes Endocrinol. 2020 Nov 17;6(1):24. doi: 10.1186/s40842-020-00113-4. es_ES
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/550
dc.identifier.uri https://clindiabetesendo.biomedcentral.com/articles/10.1186/s40842-020-00113-4
dc.description.abstract Background: Acromegaly is associated with higher morbidity and mortality mainly due to cardiovascular disease. Data on the incidence and evolution of thyroid cancer in acromegaly are controversial. Our objective was to describe the characteristics of a group of acromegalic patients with differentiated thyroid carcinoma (DTC) and analyze their evolution. Methods: This is a retrospective multicenter study of 24 acromegalic patients with DTC. The AJCC Staging System 8th Edition was used for TNM staging, and the initial risk of recurrence (RR), initial response and response at the end of follow-up (RFU) were defined according to the 2015 ATA Guidelines. As a control group, 92 patients with DTC without acromegaly were randomly included. Statistical analyses were done using SPSS Statistics 20.0. Results: Median age of patients at diagnosis of acromegaly was 49.5 years (range 12-69). The median delay in diagnosis of acromegaly was 3 years (range 0.5-23). Mean baseline IGF-1 level was 2.9 ± 1.1 ULN. Median age at DTC diagnosis was 51.5 years (18-69). At the moment of diagnosis of DTC, 58.3% of the patients had active acromegaly. Median time from DTC diagnosis to acromegaly control was 1.25 years (0.5-7). Mean DTC tumor diameter of the biggest lesion was 14.6 ± 9.2 mm, being multifocal in 37.5%. All tumors were papillary carcinomas, two cases being of an aggressive variety. Lymph node dissection was performed in 8 out of 24 patients and 62.5% had metastases. Only one patient had distant metastases. Radioiodine ablation was given to 87.5% of patients. Nineteen patients (79%) were stage I, four (17%) stage II and one (4%) stage IVb. Initial RR was low in 87% (21/24), intermediate in 9% (2/24) and high in 4% (1/24) patient. RFU was: 83% (19/23) patients with no evidence of disease, 9% (2/23) with indeterminate response, 4% (1/23) with biochemical incomplete response and 4% (1/23) with structural incomplete response, at a median time of FU of 36.5 months. When comparing RFU between acromegalics and controls no statistically significant differences were found. Conclusions: Patients with acromegaly and DTC mostly had a low initial RR. When compared with the control group, we found that DTC patients with acromegaly did not have a worse evolution. es_ES
dc.language.iso eng es_ES
dc.publisher BioMed Central es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Acromegaly es_ES
dc.subject Acromegalia es_ES
dc.subject Neoplasms es_ES
dc.subject Thyroid Neoplasms es_ES
dc.subject Neoplasias de la Tiroides es_ES
dc.title Acromegaly and thyroid cancer: analysis of evolution in a series of patients es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Danilowicz, Karina. Hospital de Clínicas José de San Martín; Argentina. Sociedad Argentina de Endocrinología y Metabolismo; Argentina.
dc.description.fil Fil: Sosa, Soledad. Hospital de Clínicas José de San Martín; Argentina. Sociedad Argentina de Endocrinología y Metabolismo; Argentina.
dc.description.fil Fil: González Pernas, Mariana Soledad. Sociedad Argentina de Endocrinología y Metabolismo; Argentina. Fleni. Departamento de Neurología. Servicio de Neuroendocrinología; Argentina.
dc.description.fil Fil: Bamberger, Elizabeth. Sociedad Argentina de Endocrinología y Metabolismo; Argentina. Centro Privado de Endocrinología; Argentina.
dc.description.fil Fil: Diez, Sabrina Mara. Sociedad Argentina de Endocrinología y Metabolismo; Argentina. Hospital Pirovano. División Endocrinología; Argentina.
dc.description.fil Fil: Fainstein Day, Patricia. Sociedad Argentina de Endocrinología y Metabolismo; Argentina. Hospital Italiano de Buenos Aires. Departamento de Endocrinología y Medicina Nuclear; Argentina.
dc.description.fil Fil: Furioso, Alejandra. Sociedad Argentina de Endocrinología y Metabolismo; Argentina. Hospital Ramos Mejía. División Endocrinología; Argentina.
dc.description.fil Fil: Glerean, Mariela. Sociedad Argentina de Endocrinología y Metabolismo; Argentina. Hospital Italiano de Buenos Aires. Departamento de Endocrinología y Medicina Nuclear; Argentina.
dc.description.fil Fil: Guitelman, Mirtha. Sociedad Argentina de Endocrinología y Metabolismo; Argentina. Hospital Carlos G. Durand. División Endocrinología; Argentina.
dc.description.fil Fil: Katz, Débora Adela. Sociedad Argentina de Endocrinología y Metabolismo; Argentina. Fleni. Departamento de Neurología. Servicio de Neuroendocrinología; Argentina.
dc.description.fil Fil: Lemaitre, Nicole. Hospital Ángel C. Padilla. División Endocrinología; Argentina.
dc.description.fil Fil: Lowenstein, Alicia. Hospital Ramos Mejía. División Endocrinología; Argentina.
dc.description.fil Fil: Del Valle Luna, Mariela. Hospital Ramos Mejía. División Endocrinología; Argentina.
dc.description.fil Fil: Martínez, María Paz. Hospital Alemán. División Endocrinología; Argentina.
dc.description.fil Fil: Miragaya, Karina. Hospital Alemán. División Endocrinología; Argentina.
dc.description.fil Fil: Moncet, Daniel. Hospital Privado de Comunidad. División Endocrinología; Argentina.
dc.description.fil Fil: Ortuño, María Victoria. Hospital Alemán. División Endocrinología; Argentina.
dc.description.fil Fil: Pignatta, Analía. Hospital Interzonal San Juan Bautista. División Endocrinología; Argentina.
dc.description.fil Fil: Ramacciotti, Constanza Fernanda. hospital Privado Universitario de Córdoba. División Endocrinología; Argentina.
dc.description.fil Fil: Reyes, Adriana. Hospital Ramos Mejía. División Endocrinología; Argentina.
dc.description.fil Fil: Rogozinski, Amelia. Sociedad Argentina de Endocrinología y Metabolismo; Argentina. Hospital Ramos Mejía. División Endocrinología; Argentina.
dc.description.fil Fil: Slavinsky, Patricia. Fleni. Departamento de Neurología. Servicio de Neuroendocrinología; Argentina. Sociedad Argentina de Endocrinologia y Metabolismo; Argentina.
dc.description.fil Fil: Tkatch, Julieta. Sociedad Argentina de Endocrinologia y Metabolismo; Argentina. Hospital Carlos G. Durand. División Endocrinología; Argentina.
dc.description.fil Fil: Pitoia, Fabián. Hospital de Clínicas José de San Martín; Argentina.
dc.relation.ispartofVOLUME 6
dc.relation.ispartofNUMBER 1
dc.relation.ispartofPAGINATION 24
dc.relation.ispartofCOUNTRY Inglaterra
dc.relation.ispartofCITY Londres
dc.relation.ispartofTITLE Clinical diabetes and endocrinology
dc.relation.ispartofISSN 2055-8260
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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