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Increased risk of preneoplastic colonic lesions and colorectal carcinoma in acromegaly: multicenter case-control study

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dc.contributor.author Battistone, María Florencia
dc.contributor.author Miragaya, Karina
dc.contributor.author Rogozinski, Amelia
dc.contributor.author Agüero, Mónica
dc.contributor.author Alfieri, Analía
dc.contributor.author Ballarino, María Carolina
dc.contributor.author Boero, Laura
dc.contributor.author Danilowicz, Karina
dc.contributor.author Diez, Sabrina
dc.contributor.author Donoso, Marina
dc.contributor.author Fainstein Day, Patricia
dc.contributor.author Furioso, Alejandra
dc.contributor.author Garcia Basavilbaso, Natalia Ximena
dc.contributor.author Glerean, Mariela
dc.contributor.author Katz, Débora Adela
dc.contributor.author Loto, Mónica
dc.contributor.author Mallea-Gil, María Susana
dc.contributor.author Sabate, María Isabel
dc.contributor.author Servidio, Marisa
dc.contributor.author Slavinsky, Patricia
dc.date.accessioned 2021-08-24T12:10:46Z
dc.date.available 2021-08-24T12:10:46Z
dc.date.issued 2021-02
dc.identifier.citation Battistone MF, Miragaya K, Rogozinski A, Agüero M, Alfieri A, Ballarino MC, Boero L, Danilowicz K, Diez S, Donoso M, Fainstein Day P, Furioso A, García Basavilbaso N, Glerean M, Katz D, Loto M, Mallea-Gil S, Martinez M, Sabate MI, Servidio M, Slavinsky P, Stalldecker G, Sosa S, Szuman G, Tkatch J, Caldo I, Lubieniecki D, Guitelman M. Increased risk of preneoplastic colonic lesions and colorectal carcinoma in acromegaly: multicenter case-control study. Pituitary. 2021 Feb;24(1):96-103. doi: 10.1007/s11102-020-01090-8. Epub 2020 Oct 15. PMID: 33057946. https://doi.org/10.1007/s11102-020-01090-8 es_ES
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/558
dc.identifier.uri https://doi.org/10.1007/s11102-020-01090-8
dc.description.abstract Purpose: Current international guidelines recommend colonoscopy in patients with acromegaly at the time of diagnosis, even though the risk of developing colorectal neoplasm is still controversial. The main objective of this Argentine multicenter study was to analyze through screening colonoscopy the presence of advanced neoplastic lesions considered as precancerous, in patients with acromegaly compared to a control group. Methods: This is a case-control retrospective study. Full length colonoscopy of 70 acromegalic patients and 128 control subjects were studied. Polyps were classified into non pre-cancerous lesions and advance neoplastic lesions which included advanced adenomas (preneoplastic) and colorectal carcinomas. Results: Thirty three out of 70 acromegalic patients and 32 out of 128 subjects controls presented polyps in the colonoscopy [47.1% vs 25%, p = 0.002, OR 2.68]. Non precancerous polyps were found in 11 (15.7%) and 23 (17.9%) (p = 0.690), while advanced neoplastic lesions were found in 22 (31.4%) and 9 (7.0%) (p = 0,0001 - OR: 6.06) patients and controls respectively. Advanced adenomas and colorectal carcinomas were found in 18 (27.3%) and 9 (7.0%) (p = 0,0006-OR: 4,57), and 4 (5.7%) and 0 (0.0%) p = 0.0063) of patients and controls respectively. The presence of insulin resistance was the only statistically significant associated factor among acromegalic patients with and without colonic polyps. Conclusions: Our findings show an increased risk of preneoplastic colonic lesions and colorectal carcinoma in patients with chronic and sustained GH excess compared to a control group. This supports the recommendation to perform screening colonoscopy at diagnosis of acromegaly. es_ES
dc.language.iso eng es_ES
dc.publisher Springer es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Acromegaly es_ES
dc.subject Acromegalia es_ES
dc.subject Neoplasms es_ES
dc.subject Colorectal Neoplasms es_ES
dc.subject Neoplasias Colorrectales es_ES
dc.title Increased risk of preneoplastic colonic lesions and colorectal carcinoma in acromegaly: multicenter case-control study es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Katz, Débora Adela. Fleni. Departamento de Neurología. Servicio de Neuroendocrinología; Argentina.
dc.description.fil Fil: Slavinsky, Patricia. Fleni. Departamento de Neurología. Servicio de Neuroendocrinología; Argentina.
dc.description.fil Fil: Battistone, María. Hospital Carlos G. Durand. División Endocrinología; Argentina.
dc.description.fil Fil: Miragaya, Karina. Sanatorio Güemes. Servicio de Endocrinología; Argentina.
dc.description.fil Fil: Rogozinski, Amelia. Hospital Ramos Mejía. División Endocrinología; Argentina.
dc.description.fil Fil: Agüero, Mónica. Hospital Tornú. Grupo de trabajo Endocrinología; Argentina.
dc.description.fil Fil: Alfieri, Analía. Hospital Nacional Profesor A. Posadas. Servicio de Endocrinología; Argentina.
dc.description.fil Fil: Ballarino, Maria Carolina. Hospital Militar Central. Servicio de Endocrinología; Argentina.
dc.description.fil Fil: Boero, Laura. Hospital de Clínicas José de San Martin. División de Endocrinología; Argentina.
dc.description.fil Fil: Danilowicz, Karina. Hospital de Clínicas José de San Martin. División de Endocrinología; Argentina.
dc.description.fil Fil: Diez, Sabrina. Hospital General de Agudos Dr. Ignacio Pirovano. Servicio de Endocrinología; Argentina.
dc.description.fil Fil: Donoso, Marina. Hospital Nacional Profesor A. Posadas. Servicio de Endocrinología; Argentina.
dc.description.fil Fil: Fainstein Day, Patricia. Hospital Italiano. Servicio de Endocrinología; Argentina.
dc.description.fil Fil: Furioso, Alejandra. Hospital Ramos Mejía. División Endocrinología; Argentina.
dc.description.fil Fil: Garcia Basavilbaso, Natalia Ximena. Sanatorio Las Lomas. Servicio de Endocrinología; Argentina.
dc.description.fil Fil: Glerean, Mariela. Hospital Italiano. Servicio de Endocrinología; Argentina.
dc.description.fil Fil: Loto, Mónica. Hospital Británico. Servicio de Endocrinología; Argentina.
dc.description.fil Fil: Mallea-Gil, María Susana. Hospital Militar Central. Servicio de Endocrinología; Argentina.
dc.description.fil Fil: Sabate, María Isabel. Hospital Universitario Austral. Servicio de Endocrinología; Argentina.
dc.description.fil Fil: Servidio, Marisa. Hospital Teodoro Álvarez. Unidad de Endocrinología; Argentina.
dc.relation.ispartofVOLUME 24
dc.relation.ispartofVOLUME 1
dc.relation.ispartofPAGINATION 96-103
dc.relation.ispartofCOUNTRY Inglaterra
dc.relation.ispartofISSN 573-7403
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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