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An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder

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dc.contributor.author De la Peña-Arteaga, Víctor
dc.contributor.author Berruga-Sánchez, Mercedes
dc.contributor.author Steward, Trevor
dc.contributor.author Martínez-Zalacaín, Ignacio
dc.contributor.author Goldberg, Ximena
dc.contributor.author Wainsztein, Agustina Edith
dc.contributor.author Abulafia, Carolina
dc.contributor.author Cardoner, Narcís
dc.contributor.author Castro, Mariana Nair
dc.contributor.author Villarreal, Mirta Fabiana
dc.contributor.author Menchón, José Manuel
dc.contributor.author Guinjoan, Salvador Martín
dc.contributor.author Soriano-Mas, Carles
dc.date.accessioned 2021-09-20T17:57:14Z
dc.date.available 2021-09-20T17:57:14Z
dc.date.issued 2021-09-01
dc.identifier.citation De la Peña-Arteaga V, Berruga-Sánchez M, Steward T, Martínez-Zalacaín I, Goldberg X, Wainsztein A, Abulafia C, Cardoner N, Castro MN, Villarreal M, Menchón JM, Guinjoan SM, Soriano-Mas C. An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder. Eur Psychiatry. 2021 Sep 1:1-20. doi: 10.1192/j.eurpsy.2021.2231 es_ES
dc.identifier.uri https://doi.org/10.1192/j.eurpsy.2021.2231
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/587
dc.description.abstract Background: One common denominator to the clinical phenotypes of borderline personality disorder (BPD) and major depressive disorder (MDD) is emotion regulation impairment. Although these two conditions have been extensively studied separately, it remains unclear whether their emotion regulation impairments are underpinned by shared or distinct neurobiological alterations. Methods: We contrasted the neural correlates of negative emotion regulation across an adult sample of BPD patients (n = 19), MDD patients (n = 20), and healthy controls (HCs; n = 19). Emotion regulation was assessed using an established functional magnetic resonance imaging cognitive reappraisal paradigm. We assessed both task-related activations and modulations of interregional connectivity. Results: When compared to HCs, patients with BPD and MDD displayed homologous decreased activation in the right ventrolateral prefrontal cortex (vlPFC) during cognitive reappraisal. In addition, the MDD group presented decreased activations in other prefrontal areas (i.e., left dorsolateral and bilateral orbitofrontal cortices), while the BPD group was characterized by a more extended pattern of alteration in the connectivity between the vlPFC and cortices of the visual ventral stream during reappraisal. Conclusions: This study identified, for the first time, a shared neurobiological contributor to emotion regulation deficits in MDD and BPD characterized by decreased vlPFC activity, although we also observed disorder-specific alterations. In MDD, results suggest a primary deficit in the strength of prefrontal activations, while BPD is better defined by connectivity disruptions between the vlPFC and temporal emotion processing regions. These findings substantiate, in neurobiological terms, the different profiles of emotion regulation alterations observed in these disorders. es_ES
dc.language.iso eng es_ES
dc.publisher Cambridge University Press es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Borderline Personality Disorder es_ES
dc.subject Trastorno de Personalidad Limítrofe es_ES
dc.subject Emotional Regulation es_ES
dc.subject Regulación Emocional es_ES
dc.subject Magnetic Resonance Imaging es_ES
dc.subject Imagen por Resonancia Magnética es_ES
dc.subject Depressive Disorder, Major es_ES
dc.subject Trastorno Depresivo Mayor es_ES
dc.title An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: De la Peña-Arteaga, Víctor. L'Hospitalet de Llobregat; España.
dc.description.fil Fil: Berruga-Sánchez, Mercedes. L'Hospitalet de Llobregat; España.
dc.description.fil Fil: Steward, Trevor. University of Melbourne; Australia.
dc.description.fil Fil: Martínez-Zalacaín, Ignacio. L'Hospitalet de Llobregat; España.
dc.description.fil Fil: Goldberg, Ximena. Institut d'Investigació i Innovació Sanitària Parc Taulí; España.
dc.description.fil Fil: Wainsztein, Agustina Edith. Consejo Nacional de Investigación Científica y Tecnológica; Argentina. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina.Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Universidad Católica Argentina; Argentina.
dc.description.fil Fil: Abulafia, Carolina. Consejo Nacional de Investigación Científica y Tecnológica; Argentina. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina.
dc.description.fil Fil: Cardoner, Narcís. Institut d'Investigació i Innovació Sanitària Parc Taulí; España.
dc.description.fil Fil: Castro, Mariana Nair. Consejo Nacional de Investigación Científica y Tecnológica; Argentina. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina.
dc.description.fil Fil: Guinjoan, Salvador Martín. Laureate Institute for Brain Research; Estados Unidos.
dc.description.fil Fil: Soriano-Mas, Carles. L'Hospitalet de Llobregat; España.
dc.relation.ispartofVOLUME 64
dc.relation.ispartofNUMBER 1
dc.relation.ispartofPAGINATION e56
dc.relation.ispartofCOUNTRY Reino Unido
dc.relation.ispartofCITY Cambridge
dc.relation.ispartofTITLE European psychiatry
dc.relation.ispartofISSN 1778-3585
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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