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Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease

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dc.contributor.author Duarte-Abritta, Bárbara
dc.contributor.author Sánchez, Stella Maris
dc.contributor.author Abulafia, Carolina
dc.contributor.author Gustafson, Deborah R.
dc.contributor.author Vázquez, Silvia
dc.contributor.author Sevlever, Gustavo Emilio
dc.contributor.author Castro, Mariana Nair
dc.contributor.author Fiorentini, Leticia
dc.contributor.author Villarreal, Mirta Fabiana
dc.contributor.author Guinjoan, Salvador Martín
dc.date.accessioned 2021-10-06T16:26:41Z
dc.date.available 2021-10-06T16:26:41Z
dc.date.issued 2021-10-30
dc.identifier.citation Duarte-Abritta B, Sánchez SM, Abulafia C, Gustafson DR, Vázquez S, Sevlever G, Castro MN, Fiorentini L, Villarreal MF, Guinjoan SM. Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease. Psychiatry Res Neuroimaging. 2021 Aug 2;316:111342. doi: 10.1016/j.pscychresns.2021.111342 es_ES
dc.identifier.uri https://doi.org/10.1016/j.pscychresns.2021.111342
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/599
dc.description.abstract A traditional hallmark of cognitive impairment associated with late-onset Alzheimer´s disease (LOAD) is episodic memory impairment. However, early alterations have been identified in brain regions associated with executive function in asymptomatic, middle-age offspring of patients with LOAD (O-LOAD) compared to those with no family history. We hypothesized that executive function among O-LOAD would correlate with structural and amyloid brain imaging differently from those without a family history of LOAD (control subjects, CS). Executive function, cortical thickness, and in-vivo Aβ deposits were quantified in 30 O-LOAD and 25 CS. Associations were observed among O-LOAD only. Cortical thickness in the left lateral orbitofrontal cortex was positively associated with Design Fluency. The Stroop Color and Word Test, correlated positively with right rostral mid-frontal cortex thickness. Trails Making Test-B was inversely related to left medial orbitofrontal thickness. Tower of London total time was positively associated with β-amyloid deposition in the right precuneus. These results support previous evidence that early executive dysfunction might reflect subtle, early changes in persons at risk of LOAD and suggests that executive function alterations deserve further exploration in the LOAD literature. es_ES
dc.language.iso eng es_ES
dc.publisher Elsevier es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Alzheimer Disease es_ES
dc.subject Enfermedad de Alzheimer es_ES
dc.subject Executive Function es_ES
dc.subject Función Ejecutiva es_ES
dc.subject Brain Cortical Thickness es_ES
dc.subject Grosor de la Corteza Cerebral es_ES
dc.title Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Duarte Abritta, Bárbara. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina.
dc.description.fil Fil: Sánchez, Stella Maris. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina.
dc.description.fil Fil: Abulafia, Carolina. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Universidad Católica Argentina; Argentina.
dc.description.fil Fil: Gustafson, Deborah R. State University of New York; Estados Unidos.
dc.description.fil Fil: Vázquez, Silvia. Fleni. Departamento de Diagnóstico por Imágenes. Centro de Imágenes Moleculares; Argentina.
dc.description.fil Fil: Sevlever, Gustavo Emilio. Fleni. Departamento de Neuropatología y Biología Molecular; Argentina.
dc.description.fil Fil: Castro, Mariana Nair. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental,; Argentina. Fleni. Servicio de Psiquiatría; Argentina.
dc.description.fil Fil: Fiorentini, Leticia. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Fleni. Servicio de Psiquiatría; Argentina.
dc.description.fil Fil: Villarreal, Mirta Fabiana. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina.
dc.description.fil Fil: Guinjoan, Salvador Martín. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina; Universidad de Buenos Aires. Facultad de Psicología. Neurofisiología; Argentina; Laureate Institute for Brain Research; Estados Unidos.
dc.relation.ispartofVOLUME 316
dc.relation.ispartofPAGINATION 111342
dc.relation.ispartofCOUNTRY Países Bajos
dc.relation.ispartofCITY Amsterdam
dc.relation.ispartofTITLE Psychiatry research. Neuroimaging
dc.relation.ispartofISSN 1872-7506
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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