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Childhood adversity modulation of central autonomic network components during cognitive regulation of emotion in major depressive disorder and borderline personality disorder

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dc.contributor.author Wainsztein, Agustina Edith
dc.contributor.author Castro, Mariana Nair
dc.contributor.author Goldberg, Ximena
dc.contributor.author Camacho Téllez, Vicente
dc.contributor.author Vulcano, Mercedes
dc.contributor.author Abulafia, Carolina
dc.contributor.author Ladrón de Guevara, Soledad
dc.contributor.author Cardoner, Narcís
dc.contributor.author Nemeroff, Charles B.
dc.contributor.author Menchón, José Manuel
dc.contributor.author Soriano-Mas, Carles
dc.contributor.author Villarreal, Mirta Fabiana
dc.contributor.author Guinjoan, Salvador Martín
dc.date.accessioned 2021-11-03T14:46:42Z
dc.date.available 2021-11-03T14:46:42Z
dc.date.issued 2021-10-10
dc.identifier.citation Wainsztein AE, Castro MN, Goldberg X, Camacho-Téllez V, Vulcano M, Abulafia C, Ladrón de Guevara S, Cardoner N, Nemeroff CB, Menchón JM, Soriano-Mas C, Villarreal MF, Guinjoan SM. Childhood adversity modulation of central autonomic network components during cognitive regulation of emotion in major depressive disorder and borderline personality disorder. Psychiatry Res Neuroimaging. 2021 Oct 10;318:111394. doi: 10.1016/j.pscychresns.2021.111394. es_ES
dc.identifier.uri https://doi.org/10.1016/j.pscychresns.2021.111394
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/614
dc.description.abstract Adverse childhood experiences (ACEs) have lifelong effects on emotional behavior and are frequent in Borderline Personality Disorder (BPD) and Major Depressive Disorder (MDD). The Central Autonomic Network (CAN), which modulates heart rate variability (HRV), comprises brain regions that mediate emotion regulation processes. However, it remains unclear the effect of ACEs on CAN dynamics and its relationship with HRV in these disorders. We studied the effects of ACEs on the brain and HRV simultaneously, during regulation of psychological stress in 19 BPD, 20 MDD and 20 healthy controls (HC). Participants underwent a cognitive reappraisal task during fMRI with simultaneous ECG acquisition. ACEs exposure was associated with increased activity of CAN and salience network components in patients with MDD compared to BPD during cognitive reappraisal. A brain-autonomic coupling was found in BPD relative to HC during emotion regulation, whereby greater activity of left anterior cingulate and medial superior frontal gyrus areas was coupled with increased HRV. Results suggest that ACEs exposure is associated with a distinct activation of the CAN and salience network regions governing responses to psychological stress in MDD compared to BPD. These alterations may constitute a distinctive neurobiological mechanism for abnormal emotion processing and regulation related to ACEs in MDD. es_ES
dc.language.iso eng es_ES
dc.publisher Elsevier es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Autonomic Nervous System es_ES
dc.subject Sistema Nervioso Autónomo es_ES
dc.subject Borderline Personality Disorder es_ES
dc.subject Trastorno de Personalidad Limítrofe es_ES
dc.subject Depression es_ES
dc.subject Depresión es_ES
dc.title Childhood adversity modulation of central autonomic network components during cognitive regulation of emotion in major depressive disorder and borderline personality disorder es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Wainsztein, Agustina Edith. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Universidad Católica Argentina; Argentina.
dc.description.fil Fil: Castro, Mariana Nair. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Universidad de Buenos Aires; Argentina.
dc.description.fil Fil: Goldberg, Ximena. Universitat Autònoma de Barcelona; España.
dc.description.fil Fil: Camacho Téllez, Vicente. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Fleni. Servicio de Psiquiatría; Argentina.
dc.description.fil Fil: Vulcano, Mercedes. Fleni. Departamento de Neurología. Servicio de Psiquiatría; Argentina. Universidad de Buenos Aires; Argentina.
dc.description.fil Fil: Abulafia, Carolina. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Universidad Católica Argentina; Argentina.
dc.description.fil Fil: Ladrón de Guevara, Soledad. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina.
dc.description.fil Fil: Cardoner, Narcís. Universitat Autònoma de Barcelona; España.
dc.description.fil Fil: Nemeroff, Charles B. The University of Texas at Austin; Estados Unidos.
dc.description.fil Fil: Menchón, José Manuel. Bellvitge University Hospital; España.
dc.description.fil Fil: Soriano-Mas, Carles. Bellvitge University Hospital; España.
dc.description.fil Fil: Villarreal, Mirta Fabiana. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Universidad de Buenos Aires; Argentina.
dc.description.fil Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental; Argentina.
dc.relation.ispartofVOLUME 318
dc.relation.ispartofPAGINATION 111394
dc.relation.ispartofCOUNTRY Países Bajos
dc.relation.ispartofCITY Amsterdam
dc.relation.ispartofTITLE Psychiatry research. Neuroimaging
dc.relation.ispartofISSN 1872-7506
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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