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Predicting Outcome in Guillain-Barré Syndrome: International Validation of the Modified Erasmus GBS Outcome Score

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dc.contributor.author Doets, Alex Y.
dc.contributor.author Lingsma, Hester F.
dc.contributor.author Walgaard, Christa
dc.contributor.author Islam, Badrul
dc.contributor.author Papri, Nowshin
dc.contributor.author Davidson, Amy
dc.contributor.author Yamagishi, Yuko
dc.contributor.author Kusunoki, Susumu
dc.contributor.author Dimachkie, Mazen M.
dc.contributor.author Waheed, Waqar
dc.contributor.author Kolb, Noah
dc.contributor.author Islam, Zhahirul
dc.contributor.author Deen Mohammad, Quazi
dc.contributor.author Harbo, Thomas
dc.contributor.author Sindrup, Soren H.
dc.contributor.author Chavada, Govindsinh
dc.contributor.author Willison, Hugh J.
dc.contributor.author Casasnovas, Carlos
dc.contributor.author Barroso, Fabio Adrián
dc.contributor.author IGOS consortium
dc.date.accessioned 2022-07-13T17:20:34Z
dc.date.available 2022-07-13T17:20:34Z
dc.date.issued 2021-12-22
dc.identifier.citation Doets AY, Lingsma HF, Walgaard C, Islam B, Papri N, Davidson A, Yamagishi Y, Kusunoki S, Dimachkie MM, Waheed W, Kolb N, Islam Z, Mohammad QD, Harbo T, Sindrup SH, Chavada G, Willison HJ, Casasnovas C, Bateman K, Miller JAL, van den Berg B, Verboon C, Roodbol J, Leonhard SE, Benedetti L, Kuwabara S, Van den Bergh P, Monges S, Marfia GA, Shahrizaila N, Galassi G, Péréon Y, Bürmann J, Kuitwaard K, Kleyweg RP, Marchesoni C, Sedano Tous MJ, Querol L, Illa I, Wang Y, Nobile-Orazio E, Rinaldi S, Schenone A, Pardo J, Vermeij FH, Lehmann HC, Granit V, Cavaletti G, Gutiérrez-Gutiérrez G, Barroso FA, Visser LH, Katzberg HD, Dardiotis E, Attarian S, van der Kooi AJ, Eftimov F, Wirtz PW, Samijn JPA, Gilhuis HJ, Hadden RDM, Holt JKL, Sheikh KA, Karafiath S, Vytopil M, Antonini G, Feasby TE, Faber CG, Gijsbers CJ, Busby M, Roberts RC, Silvestri NJ, Fazio R, van Dijk GW, Garssen MPJ, Straathof CSM, Gorson KC, Jacobs BC; IGOS Consortium. Predicting Outcome in Guillain-Barré Syndrome: International Validation of the Modified Erasmus GBS Outcome Score. Neurology. 2022 Feb 1;98(5):e518-e532. doi: 10.1212/WNL.0000000000013139. Epub 2021 Dec 22 es_ES
dc.identifier.uri https://doi.org/10.1212/WNL.0000000000013139
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/627
dc.description.abstract Background and objectives: The clinical course and outcome of the Guillain-Barré syndrome (GBS) are diverse and vary among regions. The modified Erasmus GBS Outcome Score (mEGOS), developed with data from Dutch patients, is a clinical model that predicts the risk of walking inability in patients with GBS. The study objective was to validate the mEGOS in the International GBS Outcome Study (IGOS) cohort and to improve its performance and region specificity. Methods: We used prospective data from the first 1,500 patients included in IGOS, aged ≥6 years and unable to walk independently. We evaluated whether the mEGOS at entry and week 1 could predict the inability to walk unaided at 4 and 26 weeks in the full cohort and in regional subgroups, using 2 measures for model performance: (1) discrimination: area under the receiver operating characteristic curve (AUC) and (2) calibration: observed vs predicted probability of being unable to walk independently. To improve the model predictions, we recalibrated the model containing the overall mEGOS score, without changing the individual predictive factors. Finally, we assessed the predictive ability of the individual factors. Results: For validation of mEGOS at entry, 809 patients were eligible (Europe/North America [n = 677], Asia [n = 76], other [n = 56]), and 671 for validation of mEGOS at week 1 (Europe/North America [n = 563], Asia [n = 65], other [n = 43]). AUC values were >0.7 in all regional subgroups. In the Europe/North America subgroup, observed outcomes were worse than predicted; in Asia, observed outcomes were better than predicted. Recalibration improved model accuracy and enabled the development of a region-specific version for Europe/North America (mEGOS-Eu/NA). Similar to the original mEGOS, severe limb weakness and higher age were the predominant predictors of poor outcome in the IGOS cohort. Discussion: mEGOS is a validated tool to predict the inability to walk unaided at 4 and 26 weeks in patients with GBS, also in countries outside the Netherlands. We developed a region-specific version of mEGOS for patients from Europe/North America. Classification of evidence: This study provides Class II evidence that the mEGOS accurately predicts the inability to walk unaided at 4 and 26 weeks in patients with GBS. Trial registration information: NCT01582763. es_ES
dc.language.iso eng es_ES
dc.publisher Lippincott Williams & Wilkins es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Síndrome de Guillain-Barré es_ES
dc.subject Guillain-Barre Syndrome es_ES
dc.subject Evaluación de Resultado en la Atención de Salud es_ES
dc.subject utcome Assessment, Health Care es_ES
dc.title Predicting Outcome in Guillain-Barré Syndrome: International Validation of the Modified Erasmus GBS Outcome Score es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Doets, Alex Y. University Medical Centre Rotterdam; Países Bajos.
dc.description.fil Fil: Lingsma, Hester F. University Medical Centre Rotterdam; Países Bajos.
dc.description.fil Fil: Walgaard, Christa. University Medical Centre Rotterdam; Países Bajos.
dc.description.fil Fil: Islam, Badrul. Icddr; Bangladesh
dc.description.fil Fil: Papri, Nowshin. Icddr; Bangladesh
dc.description.fil Fil: Davidson, Amy. University of Glasgow; Reino Unido.
dc.description.fil Fil: Yamagishi, Yuko. Kindai University Faculty of Medicine; Japón.
dc.description.fil Fil: Kusunoki, Susumu. Kindai University Faculty of Medicine; Japón.
dc.description.fil Fil: Dimachkie, Mazen M. University of Kansas Medical Center; Estados Unidos.
dc.description.fil Fil: Waheed, Waqar. University of Vermont Medical Centre; Estados Unidos.
dc.description.fil Fil: Kolb, Noah. University of Vermont Medical Centre; Estados Unidos.
dc.description.fil Fil: Islam, Zhahirul. Icddrb; Bangladesh
dc.description.fil Fil: Deen Mohammad, Quazi. National Institute of Neurosciences and Hospital; Bangladesh.
dc.description.fil Fil: Harbo, Thomas. Aarhus University Hospital; Dinamarca.
dc.description.fil Fil: Sindrup, Soren H.. Odense University Hospital; Dinamarca.
dc.description.fil Fil: Chavada, Govindsinh. University of Glasgow; Reino Unido.
dc.description.fil Fil: Willison, Hugh J. University of Glasgow; Reino Unido.
dc.description.fil Fil: Casasnovas, Carlos. Bellvitge University Hospital; España.
dc.description.fil Fil: Barroso, Fabio Adrián. Fleni. Departamento de Neurología. Sección de Enfermedades Neuromusculares; Argentina.
dc.relation.ispartofVOLUME 98
dc.relation.ispartofNUMBER 5
dc.relation.ispartofPAGINATION e518-e532
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Hagerstown
dc.relation.ispartofTITLE Neurology
dc.relation.ispartofISSN 1526-632X
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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