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Gamma knife radiosurgery in pituitary adenomas. A single-center experience

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dc.contributor.author Slavinsky, Patricia
dc.contributor.author González Pernas, Mariana Soledad
dc.contributor.author Miragaya, Karina
dc.contributor.author Antico, Julio
dc.contributor.author Margni, Alejandro
dc.contributor.author Condomí Alcorta, Mariana
dc.contributor.author Katz, Débora Adela
dc.date.accessioned 2022-10-20T14:34:37Z
dc.date.available 2022-10-20T14:34:37Z
dc.date.issued 2022
dc.identifier.citation Slavinsky P, Gonzalez Pernas MS, Miragaya K, Antico J, Margni A, Condomí Alcorta M, Katz DA. Gamma knife radiosurgery in pituitary adenomas. A single-center experience. Medicina (B Aires). 2022;82(1):111-116. es_ES
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/700
dc.identifier.uri https://www.medicinabuenosaires.com/PMID/35037869.pdf
dc.description.abstract Stereotactic radiosurgery with gamma knife (GKS) is a treatment option for persistent or recurrent pituitary adenoma. The aim of our study was to report Argentine experience in GKS, assessing the efficacy and safety in our patients with pituitary adenomas. We performed a retrospective analysis of patients with pituitary adenomas treated with GKS between 2002 and 2017 in a single institution. Patient characteristics, biochemical remission rate (for functioning tumors), tumor control rate and adverse effects with GKS were investigated. The study cohort comprised 99 patients with a mean follow-up of 63 months: 51 somatotropinomas, 28 non-functioning adenomas, 15 corticotropinomas, 2 prolactinomas and 3 mixed pituitary tumors. The mean radiation dose was 30.6Gy for corticotropinomas, 29.3Gy for somatotropinomas and 19.6Gy for non-secreting adenomas. Global tumor control rate was 94.2%. Biochemical remission rate was 55.9%, being higher in acromegaly than in Cushing's disease (OR4.7, 95%Ci 2.1-10.4, p <0.0001). The mean time to remission was 29.5 months (range: 6-156). Hypopituitarism occurred in 26% of patients and those with Cushing's disease were more prone to develop new hormone deficiency after GKS (OR 2.93, 95%Ci 1.2-7.2, p = 0.019). This study shows argentine experience with the use of GKS in patients with pituitary adenomas, with similar results to those reported by centers with large radiosurgical experience. We achieved biochemical remission in more than 50% of patients and global tumor control in most of them. Hypopituitarism was the most frequent adverse effect, while others were infrequent. es_ES
dc.language.iso eng es_ES
dc.publisher Fundación Revista Medicina (Buenos Aires) es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Pituitary Metastases es_ES
dc.subject Metástasis hipofisarias es_ES
dc.subject Radiocirugía es_ES
dc.subject Radiosurgery es_ES
dc.title Gamma knife radiosurgery in pituitary adenomas. A single-center experience es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Slavinsky, Patricia. Fleni. Departamento de Neurología. Servicio de Neuroendocrinología; Argentina.
dc.description.fil Fil: González Pernas, Mariana Soledad. Fleni. Departamento de Neurología. Servicio de Neuroendocrinología; Argentina.
dc.description.fil Fil: Miragaya, Karina. Fleni. Departamento de Neurología. Servicio de Neuroendocrinología; Argentina.
dc.description.fil Fil: Antico, Julio. Fleni. Departamento de Neurocirugía. Sección Gamma Knife; Argentina.
dc.description.fil Fil: Margni, Alejandro. Fleni. Departamento de Neurocirugía. Sección Gamma Knife; Argentina.
dc.description.fil Fil: Condomí Alcorta, Mariana. Fleni. Departamento de Neurocirugía. Sección Gamma Knife; Argentina.
dc.description.fil Fil: Katz, Débora Adela. Fleni. Departamento de Neurología. Servicio de Neuroendocrinología; Argentina.
dc.relation.ispartofVOLUME 82
dc.relation.ispartofNUMBER 1
dc.relation.ispartofPAGINATION 111-116.
dc.relation.ispartofCOUNTRY Argentina
dc.relation.ispartofCITY Buenos Aires
dc.relation.ispartofTITLE Medicina
dc.relation.ispartofISSN 1669-9106
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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