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Clinical Subtypes of Medication Overuse Headache – Findings From a Large Cohort

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dc.contributor.author Viana, Michele
dc.contributor.author De Icco, Roberto
dc.contributor.author Allena, Marta
dc.contributor.author Sances, Grazia
dc.contributor.author Højland Jensen, Rigmor
dc.contributor.author Katsarava, Zaza
dc.contributor.author Lainez, Miguel J. A.
dc.contributor.author Fadic, Ricardo
dc.contributor.author Goicochea, María Teresa
dc.contributor.author Nappi, Giuseppe
dc.contributor.author Tassorelli, Cristina
dc.contributor.other COMOESTAS Consortium
dc.date.accessioned 2019-10-25T15:33:38Z
dc.date.available 2019-10-25T15:33:38Z
dc.date.issued 2019-10-03
dc.identifier.citation Viana M, De Icco R, Allena M, et al. Clinical Subtypes of Medication Overuse Headache - Findings From a Large Cohort. Headache. 2019;59(9): 1481-1491. doi:10.1111/head.13641 en_US
dc.identifier.uri https://doi.org/10.1111/head.13641
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/73
dc.description.abstract BACKGROUND: The International Classification of Headache Disorders lists different subtypes of medication overuse headache (MOH), according to the medication overused. The aim of this study is to evaluate whether the different subtypes correspond to clinically distinguishable phenotypes in a large population. METHOD: This descriptive cross-sectional observational study included 660 patients with MOH referred to headache centers in Europe and Latin America as a part of the COMOESTAS project. Information about clinical features was collected with structured patient interviews and with self-administered questionnaires for measuring disability, anxiety, and depression. RESULTS: Female/male ratio, body mass index, marital status, and level of education were similar among in subjects enrolled in the 5 centers. The mean age was higher among subjects overusing triptans (T-MOH) with respect to subjects overusing simple analgesic (A-MOH). Duration of headache before chronification was longer in T-MOH (19.2 ± 11.9 years) and in subjects overusing ergotamines (E-MOH, 17.8 ± 11.7 years) with respect to the A-MOH group (13.1 ± 10.9; P < .001 and P = .017, respectively) and in T-MOH with respect multiple drug classes (M-MOH, 14.9 ± 11.7; P = .030). Migraine Disability Assessment (MIDAS) score was significantly lower in E-MOH group (33.6 ± 41.6), while T-MOH group (56.8 ± 40.6) had a significant lower MIDAS score with respect to M-MOH (67.2 ± 62.5; P = .016 and P = .037, respectively). Prevalence of depression and anxiety was lower in patients overusing T with respect to other groups of patients (χ2 = 10.953, P = .027 and χ2 = 25.725, P < .001, respectively). CONCLUSION: In this study on a large and very well characterized population of MOH, we describe the distinctive clinical characteristics of MOH subtypes. These findings contribute to more clearly define the clinical picture of a poorly delineated headache disorder. They also provide some insights in the possible trajectories leading to this highly disabling chronic headache, that is classified as a secondary form, but whose occurrence is entirely dependent on an underlying primary headache. en_US
dc.language.iso eng en_US
dc.publisher Wiley en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Migraine Disorders en_US
dc.subject Trastornos Migrañosos en_US
dc.subject Analgesics en_US
dc.subject Analgésicos en_US
dc.subject Depression en_US
dc.subject Depresión en_US
dc.subject Prescription Drug Overuse en_US
dc.subject Uso Excesivo de Medicamentos Recetados en_US
dc.subject Tryptamines en_US
dc.subject Triptaminas en_US
dc.title Clinical Subtypes of Medication Overuse Headache – Findings From a Large Cohort en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Viana, Michele. IRCCS Mondino Foundation. Headache Science Center; Italia. Regional Hospital Lugano. Neurocenter of Southern Switzerland. Headache Center; Suiza. King's College London. Department of Basic and Clinical Neurosciences. Headache Group; Reino Unido.
dc.description.fil Fil: De Icco, Roberto. IRCCS Mondino Foundation. Headache Science Center; Italia. University of Pavia. Department of Brain and Behavioral Sciences; Italia.
dc.description.fil Fil: Allena, Marta. IRCCS Mondino Foundation. Headache Science Center; Italia.
dc.description.fil Fil: Sances, Grazia. IRCCS Mondino Foundation. Headache Science Center; Italia.
dc.description.fil Fil: Højland Jensen, Rigmor. Glostrup Hospital. Department of Neurology. Danish Headache Centre; Dinamarca.
dc.description.fil Fil: Katsarava, Zaza. University of Duisburg-Essen. Department of Neurology; Alemania. Evangelical Hospital Unna. Department of Neurology; Alemania. EVEX Medical Corporation; Estados Unidos. Sechenov University Moscow; Rusia.
dc.description.fil Fil: Lainez, Miguel J. A. University Clinical Hospital. Foundation of the Valencian Community; España.
dc.description.fil Fil: Fadic, Ricardo. Pontificia Universidad Católica de Chile. Department of Neurology; Chile.
dc.description.fil Fil: Goicochea, Maria Teresa. Fleni. Departamento de Neurología. Clínica del Color. Clínica de Cefaleas; Argentina.
dc.description.fil Fil: Nappi, Giuseppe. IRCCS Mondino Foundation. Headache Science Center; Italia.
dc.description.fil Fil: Tassorelli, Cristina. IRCCS Mondino Foundation. Headache Science Center; Italia. University of Pavia. Department of Brain and Behavioral Sciences; Italia.
dc.relation.ispartofVOLUME 59
dc.relation.ispartofNUMBER 9
dc.relation.ispartofPAGINATION 1481-1491
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Hoboken
dc.relation.ispartofTITLE Headache
dc.relation.ispartofISSN 1526-4610
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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