Emergence of KPC-31, a KPC-3 Variant Associated with Ceftazidime-Avibactam Resistance, in an Extensively Drug-Resistant ST235 Pseudomonas aeruginosa Clinical Isolate

Faccone, Diego; De Mendieta, Juan M.; Albornoz, Ezequiel; Chavez, Magali; Genero, Fabiana; Echegorry, Mariano; Ceriana, Paola; Mora, Andrea; Seah, Christine; Corso, Alejandra; Melano, Roberto G.; Pasteran, Fernando

Emergence of KPC-31, a KPC-3 Variant Associated with Ceftazidime-Avibactam Resistance, in an Extensively Drug-Resistant ST235 Pseudomonas aeruginosa Clinical Isolate

Faccone, Diego; De Mendieta, Juan M.; Albornoz, Ezequiel; Chavez, Magali; Genero, Fabiana; Echegorry, Mariano; Ceriana, Paola; Mora, Andrea; Seah, Christine; Corso, Alejandra; Melano, Roberto G.; Pasteran, Fernando

URI: https://doi.org/10.1128/aac.00648-22
https://repositorio.fleni.org.ar/xmlui/handle/123456789/768

Datum: 2022-11-15

Zusammenfassung:

A ceftazidime-avibactam-resistant KPC-producing Pseudomonas aeruginosa strain was isolated in Argentina from a tracheal aspirate. The patient was treated with ceftazidime-avibactam in combination with other agents for 130 days. Whole-genome sequencing of P. aeruginosa identified a D179Y substitution in the Ω loop of KPC-3, corresponding to KPC-31, integrated at the chromosome. The strain belonged to the sequence type 235/O11 (ST235/O11) high-risk clone. Evaluation of carbapenemase detection assays most used by clinical laboratories failed to identify the isolate as a KPC producer.

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