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Emergence of KPC-31, a KPC-3 Variant Associated with Ceftazidime-Avibactam Resistance, in an Extensively Drug-Resistant ST235 Pseudomonas aeruginosa Clinical Isolate

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dc.contributor.author Faccone, Diego
dc.contributor.author De Mendieta, Juan M.
dc.contributor.author Albornoz, Ezequiel
dc.contributor.author Chavez, Magali
dc.contributor.author Genero, Fabiana
dc.contributor.author Echegorry, Mariano
dc.contributor.author Ceriana, Paola
dc.contributor.author Mora, Andrea
dc.contributor.author Seah, Christine
dc.contributor.author Corso, Alejandra
dc.contributor.author Melano, Roberto G.
dc.contributor.author Pasteran, Fernando
dc.date.accessioned 2023-01-11T11:28:18Z
dc.date.available 2023-01-11T11:28:18Z
dc.date.issued 2022-11-15
dc.identifier.citation Faccone D, de Mendieta JM, Albornoz E, Chavez M, Genero F, Echegorry M, Ceriana P, Mora A, Seah C, Corso A, Melano RG, Pasteran F. Emergence of KPC-31, a KPC-3 Variant Associated with Ceftazidime-Avibactam Resistance, in an Extensively Drug-Resistant ST235 Pseudomonas aeruginosa Clinical Isolate. Antimicrob Agents Chemother. 2022 Nov 15;66(11):e0064822. doi: 10.1128/aac.00648-22. Epub 2022 Oct 26. es_ES
dc.identifier.uri https://doi.org/10.1128/aac.00648-22
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/768
dc.description.abstract A ceftazidime-avibactam-resistant KPC-producing Pseudomonas aeruginosa strain was isolated in Argentina from a tracheal aspirate. The patient was treated with ceftazidime-avibactam in combination with other agents for 130 days. Whole-genome sequencing of P. aeruginosa identified a D179Y substitution in the Ω loop of KPC-3, corresponding to KPC-31, integrated at the chromosome. The strain belonged to the sequence type 235/O11 (ST235/O11) high-risk clone. Evaluation of carbapenemase detection assays most used by clinical laboratories failed to identify the isolate as a KPC producer. es_ES
dc.language.iso eng es_ES
dc.publisher American Society for Microbiology es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Pseudomonas aeruginosa es_ES
dc.subject Anti-Bacterial Agents es_ES
dc.subject Antibacterianos es_ES
dc.title Emergence of KPC-31, a KPC-3 Variant Associated with Ceftazidime-Avibactam Resistance, in an Extensively Drug-Resistant ST235 Pseudomonas aeruginosa Clinical Isolate es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Faccone, Diego. Instituto Nacional de Enfermedades Infecciosas - ANLIS "Dr. Carlos G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.description.fil Fil: De Mendieta, Juan M. Instituto Nacional de Enfermedades Infecciosas - ANLIS "Dr. Carlos G. Malbrán"; Argentina.
dc.description.fil Fil: Albornoz, Ezequiel. Instituto Nacional de Enfermedades Infecciosas - ANLIS "Dr. Carlos G. Malbrán"; Argentina.
dc.description.fil Fil: Chavez, Magali. Instituto Nacional de Enfermedades Infecciosas - ANLIS "Dr. Carlos G. Malbrán"; Argentina.
dc.description.fil Fil: Genero, Fabiana. Fleni. Servicio de Microbiología; Argentina.
dc.description.fil Fil: Echegorry, Mariano. Instituto Nacional de Enfermedades Infecciosas - ANLIS "Dr. Carlos G. Malbrán"; Argentina.
dc.description.fil Fil: Ceriana, Paola. Instituto Nacional de Enfermedades Infecciosas - ANLIS "Dr. Carlos G. Malbrán"; Argentina.
dc.description.fil Fil: Mora, Andrea. Fleni. Servicio de Infectología; Argentina.
dc.description.fil Fil: Seah, Christine. Public Health Ontariogrid.415400.4 Laboratory; Canadá.
dc.description.fil Fil: Corso, Alejandra. Instituto Nacional de Enfermedades Infecciosas - ANLIS "Dr. Carlos G. Malbrán"; Argentina.
dc.description.fil Fil: Melano, Roberto G. Public Health Ontariogrid.415400.4 Laboratory; Canadá. University of Toronto; Canadá.
dc.description.fil Fil: Pasteran, Fernando. nstituto Nacional de Enfermedades Infecciosas - ANLIS "Dr. Carlos G. Malbrán"; Argentina.
dc.relation.ispartofVOLUME 66
dc.relation.ispartofNUMBER 11
dc.relation.ispartofPAGINATION e0064822.
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Washington
dc.relation.ispartofTITLE Antimicrobial agents and chemotherapy
dc.relation.ispartofISSN 1098-6596
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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