Emergence of KPC-31, a KPC-3 Variant Associated with Ceftazidime-Avibactam Resistance, in an Extensively Drug-Resistant ST235 Pseudomonas aeruginosa Clinical Isolate

Faccone, Diego; De Mendieta, Juan M.; Albornoz, Ezequiel; Chavez, Magali; Genero, Fabiana; Echegorry, Mariano; Ceriana, Paola; Mora, Andrea; Seah, Christine; Corso, Alejandra; Melano, Roberto G.; Pasteran, Fernando

dc.contributor.author	Faccone, Diego
dc.contributor.author	De Mendieta, Juan M.
dc.contributor.author	Albornoz, Ezequiel
dc.contributor.author	Chavez, Magali
dc.contributor.author	Genero, Fabiana
dc.contributor.author	Echegorry, Mariano
dc.contributor.author	Ceriana, Paola
dc.contributor.author	Mora, Andrea
dc.contributor.author	Seah, Christine
dc.contributor.author	Corso, Alejandra
dc.contributor.author	Melano, Roberto G.
dc.contributor.author	Pasteran, Fernando
dc.date.accessioned	2023-01-11T11:28:18Z
dc.date.available	2023-01-11T11:28:18Z
dc.date.issued	2022-11-15
dc.identifier.citation	Faccone D, de Mendieta JM, Albornoz E, Chavez M, Genero F, Echegorry M, Ceriana P, Mora A, Seah C, Corso A, Melano RG, Pasteran F. Emergence of KPC-31, a KPC-3 Variant Associated with Ceftazidime-Avibactam Resistance, in an Extensively Drug-Resistant ST235 Pseudomonas aeruginosa Clinical Isolate. Antimicrob Agents Chemother. 2022 Nov 15;66(11):e0064822. doi: 10.1128/aac.00648-22. Epub 2022 Oct 26.	es_ES
dc.identifier.uri	https://doi.org/10.1128/aac.00648-22
dc.identifier.uri	https://repositorio.fleni.org.ar/xmlui/handle/123456789/768
dc.description.abstract	A ceftazidime-avibactam-resistant KPC-producing Pseudomonas aeruginosa strain was isolated in Argentina from a tracheal aspirate. The patient was treated with ceftazidime-avibactam in combination with other agents for 130 days. Whole-genome sequencing of P. aeruginosa identified a D179Y substitution in the Ω loop of KPC-3, corresponding to KPC-31, integrated at the chromosome. The strain belonged to the sequence type 235/O11 (ST235/O11) high-risk clone. Evaluation of carbapenemase detection assays most used by clinical laboratories failed to identify the isolate as a KPC producer.	es_ES
dc.language.iso	eng	es_ES
dc.publisher	American Society for Microbiology	es_ES
dc.rights	info:eu-repo/semantics/openAccess
dc.rights.uri	https://creativecommons.org/licenses/by/2.5/ar/
dc.subject	Pseudomonas aeruginosa	es_ES
dc.subject	Anti-Bacterial Agents	es_ES
dc.subject	Antibacterianos	es_ES
dc.title	Emergence of KPC-31, a KPC-3 Variant Associated with Ceftazidime-Avibactam Resistance, in an Extensively Drug-Resistant ST235 Pseudomonas aeruginosa Clinical Isolate	es_ES
dc.type	info:eu-repo/semantics/article	es_ES
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.fil	Fil: Faccone, Diego. Instituto Nacional de Enfermedades Infecciosas - ANLIS "Dr. Carlos G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.description.fil	Fil: De Mendieta, Juan M. Instituto Nacional de Enfermedades Infecciosas - ANLIS "Dr. Carlos G. Malbrán"; Argentina.
dc.description.fil	Fil: Albornoz, Ezequiel. Instituto Nacional de Enfermedades Infecciosas - ANLIS "Dr. Carlos G. Malbrán"; Argentina.
dc.description.fil	Fil: Chavez, Magali. Instituto Nacional de Enfermedades Infecciosas - ANLIS "Dr. Carlos G. Malbrán"; Argentina.
dc.description.fil	Fil: Genero, Fabiana. Fleni. Servicio de Microbiología; Argentina.
dc.description.fil	Fil: Echegorry, Mariano. Instituto Nacional de Enfermedades Infecciosas - ANLIS "Dr. Carlos G. Malbrán"; Argentina.
dc.description.fil	Fil: Ceriana, Paola. Instituto Nacional de Enfermedades Infecciosas - ANLIS "Dr. Carlos G. Malbrán"; Argentina.
dc.description.fil	Fil: Mora, Andrea. Fleni. Servicio de Infectología; Argentina.
dc.description.fil	Fil: Seah, Christine. Public Health Ontariogrid.415400.4 Laboratory; Canadá.
dc.description.fil	Fil: Corso, Alejandra. Instituto Nacional de Enfermedades Infecciosas - ANLIS "Dr. Carlos G. Malbrán"; Argentina.
dc.description.fil	Fil: Melano, Roberto G. Public Health Ontariogrid.415400.4 Laboratory; Canadá. University of Toronto; Canadá.
dc.description.fil	Fil: Pasteran, Fernando. nstituto Nacional de Enfermedades Infecciosas - ANLIS "Dr. Carlos G. Malbrán"; Argentina.
dc.relation.ispartofVOLUME	66
dc.relation.ispartofNUMBER	11
dc.relation.ispartofPAGINATION	e0064822.
dc.relation.ispartofCOUNTRY	Estados Unidos
dc.relation.ispartofCITY	Washington
dc.relation.ispartofTITLE	Antimicrobial agents and chemotherapy
dc.relation.ispartofISSN	1098-6596
dc.type.snrd	info:ar-repo/semantics/artículo	es_ES