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  • Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease 
    Johnson, Erik C. B.; Bian, Shijia; Haque, Rafi U.; Carter, E. Kathleen; Watson, Caroline M.; Gordon, Brian A.; Ping, Lingyan; Duong, Duc M.; Epstein, Michael P.; McDade, Eric; Barthélemy, Nicolas R.; Karch, Celeste M.; Xiong, Chengjie; Cruchaga, Carlos; Perrin, Richard J.; Wingo, Aliza P.; Dominantly Inherited Alzheimer Network (Nature Publishing Company, 2023-08-07)
    Alzheimer's disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes-aggregation of the amyloid-β (Aβ) peptide into plaques and the microtubule protein tau into ...
  • Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer's Disease 
    Horie, Kanta; Li, Yan; Barthélemy, Nicolas R.; Gordon, Brian A.; Hassenstab, Jason; Benzinger, Tammie L.S.; Fagan, Anne M.; Morris, John C.; Karch, Celeste M.; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Ikeuchi, Takeshi; Kasuga, Kensaku; Noble, James M.; Farlow, Martin R.; Chhatwal, Jasmeer P.; Day, Gregory S.; Schofield, Peter R.; Dominantly Inherited Alzheimer Network (Wiley, 2023-03-16)
    Objective: Identifying cerebrospinal fluid measures of the microtubule binding region of tau (MTBR-tau) species that reflect tau aggregation could provide fluid biomarkers that track Alzheimer's disease related neurofibrillary ...
  • Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis 
    Crivelli, Lucía; Palmer, Katie; Calandri, Ismael Luis; Guekht, Alla; Beghi, Ettore; Carroll, William; Frontera, Jennifer; García-Azorín, David; Westenberg, Erica; Winkler, Andrea Sylvia; Mangialasche, Francesca; Allegri, Ricardo Francisco; Kivipelto, Miia (2022-05)
    Introduction: We conducted a systematic review and meta-analysis of the cognitive effects of coronavirus disease 2019 (COVID-19) in adults with no prior history of cognitive impairment. Methods: Searches in Medline/Web ...
  • Changes in the Care of Neurological Diseases During the First Wave of the COVID-19 Pandemic: A Single Private Center Study in Argentina 
    Calandri, Ismael Luis; Hawkes, Maximiliano Alberto; Marrodán, Mariano; Ameriso, Sebastián Francisco; Correale, Jorge; Allegri, Ricardo Francisco (Frontiers Research Foundation, 2021-09-03)
    Introduction: Healthcare systems are struggling to cope with the rapid evolution of the COVID-19 pandemic. In Argentina, the pandemic is advancing despite prolonged lockdown measures. We aim to analyze the impact of the ...
  • Chemical hypoxia induces apoptosis of human pluripotent stem cells by a NOXA-mediated HIF-1α and HIF-2α independent mechanism 
    Isaja, Luciana; Mucci, Sofía; Vera, Jonathan; Rodríguez Varela, María Soledad; Marazita, Mariela Claudia; Morris-Hanon, Olivia; Videla Richardson, Guillermo Agustín; Sevlever, Gustavo Emilio; Scassa, María Élida; Romorini, Leonardo (Nature Publishing Group, 2020-10-26)
    Human embryonic and induced pluripotent stem cells (hESCs and hiPSCs) are self-renewing human pluripotent stem cells (hPSCs) that can differentiate to a wide range of specialized cells. Notably, hPSCs enhance their ...
  • Childhood adversity modulates structural brain changes in borderline personality but not in major depression disorder. 
    Camacho Téllez, Vicente; Castro, Mariana Nair; Wainsztein, Agustina Edith; Goldberg, Ximena; De Pino, Gabriela; Costanzo, Elsa; Cardoner, Narcís; Menchón, José Manuel; Soriano-Mas, Carles; Guinjoan, Salvador Martín; Villarreal, Mirta Fabiana (Elsevier, 2024-03-01)
    Adverse childhood experiences (ACEs) negatively affect the function and structure of emotion brain circuits, increasing the risk of various psychiatric disorders. It is unclear if ACEs show disorder specificity with respect ...
  • Childhood adversity modulation of central autonomic network components during cognitive regulation of emotion in major depressive disorder and borderline personality disorder 
    Wainsztein, Agustina Edith; Castro, Mariana Nair; Goldberg, Ximena; Camacho Téllez, Vicente; Vulcano, Mercedes; Abulafia, Carolina; Ladrón de Guevara, Soledad; Cardoner, Narcís; Nemeroff, Charles B.; Menchón, José Manuel; Soriano-Mas, Carles; Villarreal, Mirta Fabiana; Guinjoan, Salvador Martín (Elsevier, 2021-10-10)
    Adverse childhood experiences (ACEs) have lifelong effects on emotional behavior and are frequent in Borderline Personality Disorder (BPD) and Major Depressive Disorder (MDD). The Central Autonomic Network (CAN), which ...
  • Chromatographic Scalable Method to Isolate Engineered Extracellular Vesicles Derived from Mesenchymal Stem Cells for the Treatment of Liver Fibrosis in Mice 
    Domínguez, Luciana M.; Bueloni, Bárbara; Cantero, María José; Albornoz, Milagros; Pacienza, Natalia; Biani, María Celeste; Luzzani, Carlos Daniel; Miriuka, Santiago Gabriel; García, Mariana; Atorrasagasti Fernández, María Catalina; Yannarelli, Gustavo; Bayo, Juan; Fiore, Esteban; Mazzolini, Guillermo (MDPI, 2023-05-31)
    New therapeutic options for liver cirrhosis are needed. Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have emerged as a promising tool for delivering therapeutic factors in regenerative medicine. Our aim ...
  • Clinical correlates of fear of falling in progressive supranuclear palsy and multiple system atrophy 
    Martínez Villota, Viviana Alexandra; Terroba Chambi, Cinthia; Castillo Torres, Sergio Andrés; Rossi, Malco Damián; Merello, Marcelo (Wiley, 2023-05-14)
    Background and purpose: Clinical correlates of fear of falling (FoF) are scarcely studied in patients with progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). This study was undertaken to evaluate the ...
  • Cognitive consequences of COVID-19: results of a cohort study from South America 
    Crivelli, Lucía; Calandri, Ismael Luis; Corvalán, Nicolás; Carello, María Agostina; Keller, Greta; Martínez Canyazo, Carlos; Arruabarrena, Micaela María; Allegri, Ricardo Francisco (Associacao Arquivos De Neuro-Psiquitria Dr Oswaldo Lange, 2021-10-11)
    Background: Neurological and psychiatric manifestations associated with SARS-CoV-2 infection have been reported throughout the scientific literature. However, studies on post-COVID cognitive impairment in people with no ...
  • Comment on: The Geographic Diversity of Spinocerebellar Ataxias (SCAs) in the Americas 
    Guarnaschelli, Marlen; Rossi, Malco Damián; Zajd, Ana; Igarreta, Pilar (Wiley, 2020-01-25)
    Resumen no disponible
  • Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease 
    Allegri, Ricardo Francisco; Dincer, Aylin; Gordon, Brian A.; Hari-Raj, Amrita; Keefe, Sarah J.; Flores, Shaney; McKay, Nicole S.; Paulick, Angela M.; Shady Lewis, Kristine E.; Feldman, Rebecca L.; Hornbeck, Russ C.; Ances, Beau M.; Berman, Sarah B.; Brickman, Adam M.; Brooks, William S.; Cash, David M.; Chhatwal, Jasmeer P.; Farlow, Martin R.; La Fougère, Christian; Fox, Nick C.; Fulham, Michael J.; Jack Jr, Clifford R.; Joseph-Mathurin, Nelly; Karch, Celeste M.; Lee, Athene; Levin, Johannes; Masters, Colin L.; McDade, Eric; Oh, Hwamee; Perrin, Richard J.; Raji, Cyrus; Salloway, Stephen; Schofield, Peter R.; Su, Yi; Villemagne, Victor L.; Wang, Qing; Weiner, Michael W.; Xiong, Chengjie; Yakushev, Igor; Morris, John C.; Bateman, Randall J.; Benzinger, Tammie L.S.; Dominantly Inherited Alzheimer Network (Elsevier, 2020-11-05)
    Defining a signature of cortical regions of interest preferentially affected by Alzheimer disease (AD) pathology may offer improved sensitivity to early AD compared to hippocampal volume or mesial temporal lobe alone. Since ...
  • Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study 
    Boerwinkle, Anna H.; Gordon, Brian A.; Wisch, Julie K.; Flores, Shaney; Henson, Rachel L.; Butt, Omar H.; McKay, Nicole S.; Chen, Charles D.; Benzinger, Tammie L.S.; Fagan, Anne M.; Handen, Benjamin L.; Christian, Bradley T.; Head, Elizabeth; Mapstone, Mark; Rafii, Michael S.; Alzheimer's Biomarker Consortium-Down Syndrome; Dominantly Inherited Alzheimer Network; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Egido, Noelia (Elsevier, 2022-12-12)
    Background: Important insights into the early pathogenesis of Alzheimer's disease can be provided by studies of autosomal dominant Alzheimer's disease and Down syndrome. However, it is unclear whether the timing and spatial ...
  • Computational basis of decision-making impairment in multiple sclerosis 
    Fernández, Rodrigo Sebastián; Crivelli, Lucía; Pedreira, María Eugenia; Allegri, Ricardo Francisco; Correale, Jorge (Sage, 2021-12-21)
    Background: Multiple sclerosis (MS) is commonly associated with decision-making, neurocognitive impairments, and mood and motivational symptoms. However, their relationship may be obscured by traditional scoring ...
  • Connectivity and Patterns of Regional Cerebral Blood Flow, Cerebral Glucose Uptake, and Aβ-Amyloid Deposition in Alzheimer's Disease (Early and Late-Onset) Compared to Normal Ageing 
    Falasco, Germán; Damián, Andrés; Urrutia, Leandro; Niell, Nicolás; Lago, Graciela; Bérgamo, Yanina; Chrem Méndez, Patricio Alexis; Quagliata, Adriana; Bentancourt, Cecilia; Calandri, Ismael Luis; Cordero, Ismael; Ponce de León, Magdalena; Contreras, Valeria; Feuerstein, Viviana; Dansilio, Sergio; Allegri, Ricardo Francisco; Engler, Henry; Vazquez, Silvia (Bentham Science Publishers, 2021-11-15)
    Purpose: The aim of this study was to investigate the differences in early (EOAD) and late (LOAD) onset of Alzheimer´s disease, as well as glucose uptake, regional cerebral blood flow (R1), amyloid depositions, and functional ...
  • Consecuencias Neurológicas y Psiquiátricas a largo plazo (6 meses) en pacientes con COVID leve de la comunidad 
    Allegri, Ricardo Francisco; Calandri, Ismael Luis; Caride, Alejandro; Román, Fabián; Llera, J.; Palma, A.; Bartoloni, L.; Carozzela, A.; González Sanz, P.; Mouchet, E.; Fernández Díaz, Paula C.; Morasso, C.; Tarulla, Adriana (Universidad de la Costa, 2022-06-08)
    Las complicaciones neurológicas a largo plazo de la infección por coronavirus han sido descriptas en los pacientes hospitalizados en el episodio agudo. De ellos el 63% presentaron fatiga y debilidad muscular, el 26% ...
  • Country-level gender inequality is associated with structural differences in the brains of women and men 
    Zugman, Andre; Alliende, Luz María; Medel, Vicente; A I Bethlehem, Richard; Seidlitz, Jakob; Ringlein, Grace; Arango, Celso; Arnatkevičiūtė, Aurina; Asmal, Laila; Bellgrove, Mark; Benegal, Vivek; Bernardo, Miquel; Billeke, Pablo; Bosch-Bayard, Jorge; Bressan, Rodrigo; Busatto, Geraldo F.; Castro, Mariana Nair; Chaim-Avancini, Tiffany; Compte, Albert; Villarreal, Mirta Fabiana (National Academy of Sciences, 2023-05-16)
    Gender inequality across the world has been associated with a higher risk to mental health problems and lower academic achievement in women compared to men. We also know that the brain is shaped by nurturing and adverse ...
  • COVID-19 pneumonia accurately detected on chest radiographs with artificial intelligence 
    Dorr, Francisco; Chaves, Hernán; Serra, María Mercedes; Ramirez, Andrés; Costa, Martín Elías; Seia, Joaquín; Cejas, Claudia Patricia; Castro, Marcelo; Eyheremendy, Eduardo; Fernández Slezak, Diego; Farez, Mauricio Franco; Study Collaborators (Elsevier, 2020-12)
    Purpose: To investigate the diagnostic performance of an Artificial Intelligence (AI) system for detection of COVID-19 in chest radiographs (CXR), and compare results to those of physicians working alone, or with AI ...
  • Creative minds and neurosciences… 
    Allegri, Ricardo Francisco (Universidad de la Costa, 2021-08-27)
    Creativity is the ability to generate original ideas in the arts or sciences, leaving traditional stereotypes behind, ultimately introducing innovation to the social context in which they arise. It has been associated with ...
  • Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease 
    Xiong, Chengjie; McCue, Lena M.; Buckles, Virginia; Grant, Elizabeth; Agboola, Folasade; Coble, Dean; Bateman, Randall J.; Fagan, Anne M.; Benzinger, Tammie L.S.; Hassenstab, Jason; Schindler, Suzanne E.; McDade, Eric; Moulder, Krista L.; Gordon, Brian A.; Cruchaga, Carlos; Day, Gregory S.; Ikeuchi, Takeshi; Suzuki, Kazushi; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (Wiley, 2023-01-14)
    Background: Comparisons of late-onset Alzheimer's disease (LOAD) and autosomal dominant AD (ADAD) are confounded by age. Methods: We compared biomarkers from cerebrospinal fluid (CSF), magnetic resonance imaging, and ...

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