• Peritumoral adipose tissue promotes lipolysis and white adipocytes browning by paracrine action 

  Pagnotta, Priscila; Gantov, Mariana; Fletcher, Sabrina; Lombardi, Antonella; Crosbie, María Lujan; Santiso, Natalia; Ursino, Anabela; Frascarolli, Celeste; Amato, Alicia; Dreszman, Rubén; Calvo, Juan Carlos; Toneatto, Judith (Frontiers Research Foundation, 2023-04-26)

  Background: Stromal adipocytes and tumor breast epithelial cells undergo a mutual metabolic adaptation within tumor microenvironment. Therefore, browning and lipolysis occur in cancer associated adipocytes (CAA). However, ...
• Childhood adversity modulates structural brain changes in borderline personality but not in major depression disorder. 

  Camacho Téllez, Vicente; Castro, Mariana Nair; Wainsztein, Agustina Edith; Goldberg, Ximena; De Pino, Gabriela; Costanzo, Elsa; Cardoner, Narcís; Menchón, José Manuel; Soriano-Mas, Carles; Guinjoan, Salvador Martín; Villarreal, Mirta Fabiana (Elsevier, 2024-03-01)

  Adverse childhood experiences (ACEs) negatively affect the function and structure of emotion brain circuits, increasing the risk of various psychiatric disorders. It is unclear if ACEs show disorder specificity with respect ...
• A miR-137-Related Biological Pathway of Risk for Schizophrenia Is Associated With Human Brain Emotion Processing 

  Pergola, Giulio; Rampino, Antonio; Sportelli, Leonardo; Borcuk, Christopher James; Passiatore, Roberta; Di Carlo, Pasquale; Marakhovskaia, Aleksandra; Fazio, Leonardo; Amoroso, Nicola; Castro, Mariana Nair; Domenici, Enrico; Gennarelli, Massimo; Khlghatyan, Jivan; Christos Kikidis, Gianluca; Lella, Annalisa; Magri, Chiara; Monaco, Alfonso; Papalino, Marco; Parihar, Madhur; Popolizio, Teresa (Elsevier, 2023-11-22)

  Background: miR-137 is a microRNA involved in brain development, regulating neurogenesis and neuronal maturation. Genome-wide association studies have implicated miR-137 in schizophrenia risk but do not explain its involvement ...
• Longitudinal clinical, cognitive and biomarker profiles in dominantly inherited versus sporadic early-onset Alzheimer's disease 

  Llibre Guerra, Jorge J.; Iaccarino, Leonardo; Coble, Dean; Edwards, Lauren; Li, Yan; McDade, Eric; Strom, Amelia; Gordon, Brian; Mundada, Nidhi; Schindler, Suzanne E.; Tsoy, Elena; Ma, Yinjiao; Lu, Ruijin; Fagan, Anne M.; Benzinger, Tammie L. S.; Soleimani-Meigooni, David; Aschenbrenner, Andrew J.; Allegri, Ricardo Francisco; Patricio Alexis, Chrem Méndez; Surace, Ezequiel Ignacio (Oxford University Press, 2023-10-18)

  Approximately 5% of Alzheimer's disease cases have an early age at onset (<65 years), with 5-10% of these cases attributed to dominantly inherited mutations and the remainder considered as sporadic. The extent to which ...
• PluriBAC: A Versatile Baculovirus-Based Modular System to Express Heterologous Genes in Different Biotechnological Platforms 

  Amorós Morales, Leslie C.; Marchesini, Abril; Gómez Bergna, Santiago M.; García Fallit, Matías; Tongiani, Silvana E.; Vásquez, Larisa; Ferrelli, María Leticia; Videla Richardson, Guillermo Agustín; Candolfi, Marianela; Romanowski, Víctor; Pidre, Matías L. (MDPI, 2023-09-23)

  Baculoviruses are insect-specific pathogens widely used in biotechnology. In particular, the Autographa californica nucleopolyhedrovirus (AcMNPV) has been exploited as a platform for bio-inputs production. This is why the ...
• Role of hydroxymethylglutharyl-coenzyme A reductase in the induction of stem-like states in breast cancer 

  Marks, María Paula; Giménez, Carla Alejandra; Isaja, Luciana; Vera, Mariana Belén; Borzone, Francisco Raúl; Pereyra-Bonnet, Federico; Romorini, Leonardo; Videla Richardson, Guillermo Agustín; Chasseing, Norma Alejandra; Calvo, Juan Carlos; Vellón, Luciano (Springer-Verlag, 2024-02-28)

  Purpose: De novo synthesis of cholesterol and its rate-limiting enzyme, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMGCR), is deregulated in tumors and critical for tumor cell survival and proliferation. However, ...
• Therapeutic Potential in Wound Healing of Allogeneic Use of Equine Umbilical Cord Mesenchymal Stem Cells 

  Iribarne, Ailén; Palma, María Belén; Andrini, Laura; Riccillo, Fernando; Rodríguez, Delfina; Casella, Martín; Garay, Felipe; Spoto Zabala, Julieta; Mazza, Leandro; Muro, Adriana; Buero, Guillermo; Miriuka, Santiago Gabriel; Carosella, Edgardo; García, Marcela N. (MDPI, 2024-02-16)

  Wound healing after skin injury is a complex process, particularly in equines where leg wounds are prevalent and their repair is complicated due to the anatomical characteristics. Conventional treatments are not effective ...
• Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome 

  Gorijala, Priyanka; Aslam, M. Muaaz; Dang, Lam-Ha T.; Xicota, L.; Fernández, María V.; Sung, Yun Ju; Fan, Kang-Hsien; Feingold, Eleanor; Surace, Ezequiel Ignacio; Chhatwal, Jasmeer P.; Hom, Christy L.; Dominantly Inherited Alzheimer Network (DIAN), the Alzheimer's Disease Neuroimaging Initiative (ADNI); NIA-LOAD family study, for the Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS) Investigators; Hartley, Sigan L.; Hassenstab, Jason; Perrin, Richard J.; Mapstone, Mark; Zaman, Shahid H.; Ances, Beau M.; Kamboh, M. Ilyas; Lee, Joseph H.; Cruchaga, Carlos (John Wiley & Sons, 2023-10-19)

  Introduction: This study aimed to investigate the influence of the overall Alzheimer's disease (AD) genetic architecture on Down syndrome (DS) status, cognitive measures, and cerebrospinal fluid (CSF) biomarkers. Methods: ...
• Broad-Spectrum Antiviral Effect of Cannabidiol Against Enveloped and Nonenveloped Viruses 

  Marquez, Agostina B.; Vicente, Josefina; Castro, Eliana; Vota, Daiana; Rodríguez Varela, María Soledad; Lanza Castronuovo, Priscila A.; Fuentes, Giselle M.; Parise, Alejandro R.; Romorini, Leonardo; Alvarez, Diego E.; Bueno, Carlos A.; Ramirez, Cristina L.; Alaimo, Agustina; García, Cybele C. (Mary Ann Liebert, 2023-09-08)

  Introduction: Cannabidiol (CBD), the main non-psychoactive cannabinoid of the Cannabis sativa plant, is a powerful antioxidant compound that in recent years has increased interest due to causes effects in a wide range of ...
• Teaching NeuroImage: Shrimp Sign in Ataxic Cerebellar Progressive Multifocal Leukoencephalopathy 

  Varela, Francisco José; Chaves, Hernán; Rossi, Malco Damián (Lippincott Williams & Wilkins, 2023-08-31)

  Resumen no disponible
• Mitochondrial Peptide Humanin Facilitates Chemoresistance in Glioblastoma Cells 

  Peña Agudelo, Jorge A.; Pidre, Matías L.; Garcia Fallit, Matias; Pérez Küper, Melanie; Zuccato, Camila; Nicola Candia, Alejandro J.; Marchesini, Abril; Vera, Mariana Belén; De Simone, Emilio; Giampaoli, Carla; Amorós Morales, Leslie C.; Gonzalez, Nazareno; Romanowski, Víctor; Videla Richardson, Guillermo Agustín; Seilicovich, Adriana; Candolfi, Marianela (MDPI, 2023-08-11)

  Humanin (HN) is a mitochondrial-derived peptide with robust cytoprotective effects in many cell types. Although the administration of HN analogs has been proposed to treat degenerative diseases, its role in the pathogenesis ...
• Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease 

  Johnson, Erik C. B.; Bian, Shijia; Haque, Rafi U.; Carter, E. Kathleen; Watson, Caroline M.; Gordon, Brian A.; Ping, Lingyan; Duong, Duc M.; Epstein, Michael P.; McDade, Eric; Barthélemy, Nicolas R.; Karch, Celeste M.; Xiong, Chengjie; Cruchaga, Carlos; Perrin, Richard J.; Wingo, Aliza P.; Dominantly Inherited Alzheimer Network (Nature Publishing Company, 2023-08-07)

  Alzheimer's disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes-aggregation of the amyloid-β (Aβ) peptide into plaques and the microtubule protein tau into ...
• Effectiveness of cognitive rehabilitation on mild cognitive impairment using teleneuropsychology 

  Martínez Canyazo, Carlos; Keller, Greta; Helou, María Belén; Arruabarrena, Micaela María; Corvalán, Nicolás; Carello, María Agostina; Harris, Paula; Feldman, Mónica; Fernández, Rodrigo; Calandri, Ismael Luis; Martin, María Eugenia; Allegri, Ricardo Francisco; Crivelli, Lucía (Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento, 2023-07-24)

  The COVID-19 pandemic has affected the continuity of cognitive rehabilitation worldwide. However, the use of teleneuropsychology to provide cognitive rehabilitation has contributed significantly to the continuity of the ...
• Clinical correlates of fear of falling in progressive supranuclear palsy and multiple system atrophy 

  Martínez Villota, Viviana Alexandra; Terroba Chambi, Cinthia; Castillo Torres, Sergio Andrés; Rossi, Malco Damián; Merello, Marcelo (Wiley, 2023-05-14)

  Background and purpose: Clinical correlates of fear of falling (FoF) are scarcely studied in patients with progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). This study was undertaken to evaluate the ...
• Editorial: Advances in platforms for disease modelling 

  Romorini, Leonardo; Baweja, Sukriti; Martin Mateos, Rosa Maria; Mehta, Gautam; Jalan-Sakrikar, Nidhi (Frontiers Media, 2023-04-19)

  Resumen no disponible
• Derivation of two human induced pluripotent stem cell lines carrying a missense mutation in FHL1 (c.377G > A, p.C126Y) linked to familial muscular dystrophy 

  Zabalegui, Federico; Castañeda, Sheila; Amin, Guadalupe; Belli, Carolina; Miriuka, Santiago Gabriel; Moro, Lucía Natalia (Elsevier, 2024-01-10)

  FHL1 gene locates in the Xq26 region and encodes for four and half LIM domain protein 1. It plays a crucial role in muscle cells and mutations in FHL1 are related to muscular dystrophy (MD). Peripheral blood mononuclear ...
• Body mass index, waist circumference, insulin, and leptin plasma levels differentiate between clozapine-responsive and clozapine-resistant schizophrenia 

  Hönig, Guillermo; Daray, Federico M.; Rodante, Demián; Drucaroff, Lucas Javier; Gutiérrez, María Laura; Lenze, Mariela; García Bournissen, Facundo; Wikinski, Silvia (Sage, 2023-06-28)

  Background: Between 25% and 50% of patients suffering from treatment-resistant schizophrenia fail to achieve a clinical response with clozapine. The rapid identification and treatment of this subgroup of patients represents ...
• Chromatographic Scalable Method to Isolate Engineered Extracellular Vesicles Derived from Mesenchymal Stem Cells for the Treatment of Liver Fibrosis in Mice 

  Domínguez, Luciana M.; Bueloni, Bárbara; Cantero, María José; Albornoz, Milagros; Pacienza, Natalia; Biani, María Celeste; Luzzani, Carlos Daniel; Miriuka, Santiago Gabriel; García, Mariana; Atorrasagasti, Catalina; Yannarelli, Gustavo; Bayo, Juan; Fiore, Esteban; Mazzolini, Guillermo (MDPI, 2023-05-31)

  New therapeutic options for liver cirrhosis are needed. Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have emerged as a promising tool for delivering therapeutic factors in regenerative medicine. Our aim ...
• Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS): Study design and harmonization 

  Crivelli, Lucía; Calandri, Ismael Luis; Kimie Suemoto, Claudia; Salinas, Rosa María; Velilla, Lina M.; Sanches Yassuda, Mónica; Caramelli, Paulo; Lopera, Francisco; Nitrini, Ricardo; Sevlever, Gustavo Emilio; Sosa, Ana Luisa; Acosta, Daisy; Bérgamo, Yanina; Clarens, María Florencia; Demey, Ignacio; Helou, María Belén; Martin, María Eugenia; Querzé, Diego; Surace, Ezequiel Ignacio; Allegri, Ricardo Francisco (Wiley, 2023-05-19)

  Introduction: Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS) is the first non-pharmacological multicenter randomized clinical trial (RCT) to prevent cognitive impairment ...
• The role of microfluidics and 3D-bioprinting in the future of exosome therapy 

  Amondarain, Mikele; Gallego, Idoia; Puras, Gustavo; Saenz-Del-Burgo, Laura; Luzzani, Carlos Daniel; Pedraz, José Luis (Elsevier, 2023-06-09)

  Exosome-based strategies constitute a promising tool for therapeutics, avoiding potential immunogenic and tumorigenic side-effects of cell therapies. However, the collection of a suitable exosome pool, and the need for ...

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