• Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease 

  Xiong, Chengjie; McCue, Lena M.; Buckles, Virginia; Grant, Elizabeth; Agboola, Folasade; Coble, Dean; Bateman, Randall J.; Fagan, Anne M.; Benzinger, Tammie L. S.; Hassenstab, Jason; Schindler, Suzanne E.; McDade, Eric; Moulder, Krista; Gordon, Brian A.; Cruchaga, Carlos; Day, Gregory S.; Ikeuchi, Takeshi; Suzuki, Kazushi; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (DIAN) (Wiley, 2023-01-14)

  Background: Comparisons of late-onset Alzheimer's disease (LOAD) and autosomal dominant AD (ADAD) are confounded by age. Methods: We compared biomarkers from cerebrospinal fluid (CSF), magnetic resonance imaging, and ...
• Embracing Monogenic Parkinson's Disease: The MJFF Global Genetic PD Cohort 

  Vollstedt, Eva-Juliane; Schaake, Susen; Lohmann, Katja; Padmanabhan, Shalini; Brice, Alexis; Lesage, Suzanne; Tesson, Christelle; Vidailhet, Marie; Wurster, Isabel; Hentati, Faycel; Mirelman, Anat; Giladi, Nir; Marder, Karen; Waters, Cheryl; Fahn, Stanley; Kasten, Meike; Brüggemann, Norbert; Rossi, Malco; Merello, Marcelo; MJFF Global Genetic Parkinson's Disease Study Group (Wiley, 2023-01-24)

  Background: As gene-targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of ...
• LatAm Fingers Initiative: Bringing Diversity Upfront 

  Crivelli, Lucía (The Alzheimer's Association, 2022-12)
• Life events and the onset of motor symptoms in Parkinson's disease 

  Paez-Maggio, Mauricio; Rossi, Malco; Martinez, V.; Wainberg, Florencia N.; Merello, Marcelo (Elsevier, 2023-01-11)

  Background: Whether there may be any relationship between stressful or traumatic life events (LE) and the subsequent motor symptoms onset in Parkinson's disease (PD) is still controversial. Objectives: To explore whether ...
• Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study 

  Millar, Peter R.; Gordon, Brian A.; Luckett, Patrick H.; Benzinger, Tammie L. S.; Cruchaga, Carlos; Fagan, Anne M.; Hassenstab, Jason J.; Perrin, Richard J.; Schindler, Suzanne E.; Allegri, Ricardo Francisco; Day, Gregory S.; Farlow, Martin R.; Mori, Hiroshi; Nübling, Georg; Dominantly Inherited Alzheimer Network; Bateman, Randall J.; Morris, John C.; Ances, Beau M. (eLife Sciences Publications, 2023-01-06)

  Background: Estimates of 'brain-predicted age' quantify apparent brain age compared to normative trajectories of neuroimaging features. The brain age gap (BAG) between predicted and chronological age is elevated in symptomatic ...
• LatAm Fingers Initiative: Challenges and opportunities of launching amulticultural trial in pandemic times 

  Calandri, Ismael Luis; Crivelli, Lucía; Caramelli, Paulo; Lopera, Francisco; Nitrini, Ricardo; Sosa Ortiz, Ana Luisa; Salinas-Contreras, Rosa María; Suemoto, Claudia Kimie; Velilla, Lina M.; Sanches Yassuda, Mónica; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco; LatAm FINGERS initiative (The Alzheimer's Association, 2022-12-20)
• LatAm FINGERS:Overcoming Barriers for a Dementia Prevention Trial Startup 

  Calandri, Ismael Luis; Crivelli, Lucía; Caramelli, Paulo; Lopera, Francisco; Nitrini, Ricardo; Sosa Ortiz, Ana Luisa; Salinas-Contreras, Rosa María; Suemoto, Claudia Kimie; Velilla, Lina M.; Sanches Yassuda, Mónica; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco; LatAm FINGERS initiative (The Alzheimer's Association, 2022)
• Teleneuropsychological assessment in South America: A perspective from patients and neuropsychologists 

  Arruabarrena, Micaela María; Martin, María Eugenia; Calandri, Ismael Luis; Corvalán, Nicolás; Helou, María Belén; Martínez, Carlos; Crivelli, Lucía (Universidad de la Costa, 2022-12-23)

  Teleneuropsychology (teleNP) in Argentina was promoted by the COVID-19 pandemic. This investigation aimed to evaluate patients’ and neuropsychologists’ satisfaction with teleNP and to identify the advantages and disadvantages ...
• La Organización Mundial de la Salud acaba de lanzar un Blueprint for Dementia Research. Algunas notas para impulsar la investigación sobre la demencia en América Latina... 

  Allegri, Ricardo Francisco; Román, Fabián; Barceló, Ernesto (Universidad de la Costa, 2022-12-28)

  La demencia es la causa más importante de discapacidad y dependencia en los adultos mayores y actualmente afecta a más de 55 millones de personas, el 60% de las cuales vive en países de ingresos bajos y medios (PRMB). El ...
• Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer's Disease 

  Horie, Kanta; Li, Yan; Barthélemy, Nicolas R.; Gordon, Brian; Hassenstab, Jason; Benzinger, Tammie L. S.; Fagan, Anne M.; Morris, John C.; Karch, Celeste M.; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Ikeuchi, Takeshi; Kasuga, Kensaku; Noble, James; Farlow, Martin; Chhatwal, Jasmeer; Day, Gregory; Schofield, Peter R.; Dominantly Inherited Alzheimer Network (Wiley, 2023-03-16)

  Objective: Identifying cerebrospinal fluid measures of the microtubule binding region of tau (MTBR-tau) species that reflect tau aggregation could provide fluid biomarkers that track Alzheimer's disease related neurofibrillary ...
• Evaluation of Baculoviruses as Gene Therapy Vectors for Brain Cancer 

  Garcia Fallit, Matías; Pidre, Matías L.; Asad, Antonela S.; Peña Agudelo, Jorge A.; Vera, Mariana B.; Nicola Candia, Alejandro J.; Sagripanti, Sofia B.; Pérez Kuper, Melanie; Amorós Morales, Leslie C.; Marchesini, Abril; Gonzalez, Nazareno; Caruso, Carla M.; Romanowski, Víctor; Seilicovich, Adriana; Videla-Richardson, Guillermo Agustín; Zanetti, Flavia A.; Candolfi, Marianela (MDPI, 2023-02-22)

  We aimed to assess the potential of baculoviral vectors (BV) for brain cancer gene therapy. We compared them with adenoviral vectors (AdV), which are used in neuro-oncology, but for which there is pre-existing immunity. ...
• Abnormal brain network community structure related to psychological stress in schizophrenia 

  Castro, Mariana Nair; Bocaccio, Hernán; De Pino, Gabriela; Sánchez, Stella M.; Agustina Edith, Wainsztein; Drucaroff, Lucas; Costanzo, Elsa; Crossley, Nicolas; Mirta Fabiana, Villarreal; Guinjoan, Salvador Martín (Elsevier, 2023-02-15)

  Recent functional imaging studies in schizophrenia consistently report a disruption of brain connectivity. However, most of these studies analyze the brain connectivity during resting state. Since psychological stress is ...
• Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study 

  Boerwinkle, Anna H.; Gordon, Brian A.; Wisch, Julie; Flores, Shaney; Henson, Rachel L.; Butt, Omar H.; McKay, Nicole; Chen, Charles D.; Benzinger, Tammie L. S.; Fagan, Anne M.; Handen, Benjamin L.; Christian, Bradley T.; Head, Elizabeth; Mapstone, Mark; Rafii, Michael S.; Alzheimer's Biomarker Consortium-Down Syndrome; Dominantly Inherited Alzheimer Network; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Egido, Noelia (Elsevier, 2022-12-12)

  Background: Important insights into the early pathogenesis of Alzheimer's disease can be provided by studies of autosomal dominant Alzheimer's disease and Down syndrome. However, it is unclear whether the timing and spatial ...
• Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology 

  Morris, John C.; Weiner, Michael; Xiong, Chengjie; Beckett, Laurel; Coble, Dean; Saito, Naomi; Aisen, Paul S.; Allegri, Ricardo Francisco; Benzinger, Tammie L.S.; Berman, Sarah B.; Cairns, Nigel J.; Carrillo, Maria C.; Chui, Helena C.; Chhatwal, Jasmeer P.; Cruchaga, Carlos; Fagan, Anne M.; Farlow, Martin; Fox, Nick C.; Ghetti, Bernardino; Goate, Alison M. (Oxford University Press, 2022-10-21)

  The extent to which the pathophysiology of autosomal dominant Alzheimer's disease corresponds to the pathophysiology of 'sporadic' late onset Alzheimer's disease is unknown, thus limiting the extrapolation of study findings ...
• A critical pathway in human development: C19MC micrornas regulates FGF2 response in a model of human pluripotent stem cells cardiac differentiation 

  Möbbs, Alan Miqueas; Garate, Ximena; Scarafia, Maria Agustina; Colli, Carolina; Moro, Natalia Lucía; Luzzani, Carlos; Waisman, Ariel; La Greca, Alejandro; Miriuka, Santiago Gabriel (Fundación Revista Medicina, 2021-11)

  Human pluripotent stem cells (hPSC) have the capacity to self-renew and differentiate in vitro into all cell types of the organism, and it is an established model for early human embryo development. Recently, we found ...
• Addressing the disparities in dementia risk, early detection and care in Latino populations: Highlights from the second Latinos & Alzheimer's Symposium 

  Quiroz, Yakeel T.; Solis, Michele; Aranda, María P.; Arbaje, Alicia I.; Arroyo-Miranda, Mirna; Cabrera, Laura Y.; Carrasquillo, Minerva Maria; Corrada, Maria M.; Crivelli, Lucía; Diminich, Erica D.; Dorsman, Karen A.; Gonzales, Mitzi; González, Héctor M.; Gonzalez-Seda, Ana L.; Grinberg, Lea T.; Guerrero, Lourdes R.; Hill, Carl V.; Jimenez-Velazquez, Ivonne Z.; Llibre Guerra, Jorge J.; Lopera, Francisco (John Wiley & Sons, 2022-09)

  The Alzheimer's Association hosted the second Latinos & Alzheimer's Symposium in May 2021. Due to the COVID-19 pandemic, the meeting was held online over 2 days, with virtual presentations, discussions, mentoring sessions, ...
• First presentation with neuropsychiatric symptoms in autosomal dominant Alzheimer's disease: the Dominantly Inherited Alzheimer's Network Study 

  O'Connor, Antoinette; Rice, Helen; Barnes, Josephine; Ryan, Natalie S.; Liu, Kathy Y.; Allegri, Ricardo Francisco; Berman, Sarah; Ringman, John M.; Cruchaga, Carlos; Farlow, Martin R.; Hassenstab, Jason; Lee, Jae-Hong; Perrin, Richard J.; Xiong, Chengjie; Gordon, Brian; Levey, Allan I.; Goate, Alison; Graff-Radford, Neil; Levin, Johannes; Dominantly Inherited Alzheimer Network (BMJ Publishing Group, 2022-12-15)
• Simple Microcontact Printing Technique to Obtain Cell Patterns by Lithography Using Grayscale, Photopolymer Flexographic Mold, and PDMS 

  Gimenez, Rocio; Pérez-Sosa, Camilo; Bourguignon, Natalia; Miriuka, Santiago Gabriel; Bhansali, Shekhar; Arroyo, Carlos R.; Debut, Alexis; Lerner, Betiana; Pérez, Maximiliano S. (MDPI AG, 2022-10-08)

  Microcontact printing using PDMS embossing tools and its variations have aroused the interest of a wide spectrum of research fields, hence the feasibility of defining micro and nanoscale patterns. In this work, we have ...
• Improvement of episodic memory retention by a memory reactivation intervention across the lifespan: from younger adults to amnesic patients 

  Fernández, Rodrigo S.; Picco, Soledad; Beron, Juan Cruz; Bavassi, Luz; Campos, Jorge; Allegri, Ricardo Francisco; Pedreira, María E. (Nature Pub. Group, 2022-04-05)

  Spontaneous reactivation of recently acquired memories is a fundamental mechanism of memory stabilization. Re-exposure to specific learned cues during sleep or awake states, namely targeted memory reactivation, has been ...
• Oculomotor Abnormalities during Reading in the Offspring of Late-Onset Alzheimer's Disease 

  Fernández, Gerardo; González, Ana Paula; Abulafia, Carolina; Fiorentini, Leticia; Agamennoni, Osvaldo; Guinjoan, Salvador Martín (Bentham Science Publishers, 2022)

  Introduction: Eye movement patterns during reading are well defined and documented. Each eye movement ends up in a fixation point, which allows the brain to process the incoming information and program the following saccade. ...

View more