• Baseline Results Investigate APOE‐Memory Connection in Latin‐American Population at Risk for Dementia ‐ LatAm‐FINGERS Initial Insights 

  Vasconcelos Friedlaender, Clarisse; Cruz de Souza, Leonardo; Tonidandel Barbosa, Maira; Braga Gomes, Karina; Gonçalves Tosatti, Jéssica Abdo; de Faria Rocha, João Victor; Melillo Cardoso, Davi; Machado Prates, Marcelo; Lopes, Andre Luis; Silva Vieira, Vitoria; Ribeiro Jeunon, Vinicius; Ferreira de Souza, Letícia Maria; Soares Figueiredo, Lais; Andrades, Andreia; Crivelli, Lucía; Calandri, Ismael Luis; Martin, Maria Eugenia; Allegri, Ricardo Francisco; Sevlever, Gustavo Emilio; Surace, Ezequiel Ignacio (Alzheimer's Association, 2025-12-21)

  Background: Latin America (LA) faces heightened vulnerability to modifiable dementia risk factors. Early identification of at‐risk individuals is crucial for implementing effective preventive strategies. The Free and Cued ...
• Ageism in a Latin American Cohort: The Role of Cognition and Gender 

  Arruabarrena, Micaela María; Corvalán, Nicolás; Morello García, Florentina; Keller, Greta; Martinez, Carlos; Crivelli, Lucía (Alzheimer's Association, 2025-12-26)

  Background: Ageism, a form of discrimination based on age‐related stereotypes, encompasses both negative (e.g., older adults as burdensome or incapable) and positive (e.g., older adults as wise or nurturing) stereotypes. ...
• Use of an exogenous DNA-free system to generate MSTN-KO calves by CRISPR/Cas9 and SCNT 

  Suvá, Mariana; Bastón, Juan Ignacio; Wiedenmann, Elisabet Astrid; Pose Ortiz de Rozas, María Belén; Roberto, Jordán; Ghetti, Alberto; Viale, Diego Luis; Moro, Lucía Natalia; Vichera, Gabriel Damián (Elsevier, 2025-09-25)

  This study aimed to obtain myostatin (MSTN)-knockout calves, while avoiding the risk of exogenous DNA integration during gene editing. To achieve this, we combined CRISPR/Cas9 ribonucleoprotein gene editing with somatic ...
• Structural connectivity correlates of response to electroconvulsive therapy in treatment-resistant depression 

  Samman, María Eugenia; Fiorentini, Leticia; Lahitou Herlyn, Delfina; Tsuchiyagaito, Aki; Castro, Mariana Nair; Costanzo, Elsa; Brusco, Luis Ignacio; Camprodon, Joan A.; Forcato, Cecilia; Guinjoan, Salvador Martín; Villarreal, Mirta Fabiana (Elsevier, 2026-04)

  Electroconvulsive therapy (ECT) remains the most effective intervention for treatment-resistant depression (TRD). We investigated whether cortico-limbic structural connectivity is associated with ECT response. Twenty-nine ...
• When and in what patient segments are low-intensity and remote interventions valuable for treating symptoms of post-concussion syndrome? 

  Russo, María Julieta; Salvat, Fernando (Taylor & Francis, 2026-06)

  Resumen no disponible.
• Human development, inequality, and their associations with brain structure across 29 countries 

  Medel, Vicente; Alliende, Luz M.; Bethlehem, Richard; Seidlitz, Jakob; Ringlein, Grace; Arango, Celso; Arnatkevičiūtė, Aurina; Asmal, Laila; Bellgrove, Mark; Benegal, Vivek; Bernardo, Miquel; Billeke, Pablo; Bosch-Bayard, Jorge; Bressan, Rodrigo; Busatto, Geraldo; Chaim-Avancini, Tiffany; Costanzi, Monise; Castro, Mariana Nair; Villarreal, Mirta Fabiana (Cambridge University Press, 2025-07-16)

  Background: The macro-social and environmental conditions in which people live, such as the level of a country's development or inequality, are associated with brain-related disorders. However, the relationship between ...
• Brucella abortus Infection Promotes Mesenchymal Stem Cell Differentiation Toward Adipogenesis, Enhancing the Proinflammatory Profile 

  Freiberger, Rosa Nicole; López, Cynthia Alicia Marcela; Palma, María Belén; Cevallos, Cintia; Sviercz, Franco Agustin; Jarmoluk, Patricio; García, Marcela Nilda; Quarleri, Jorge; Delpino, M. Victoria (MDPI AG, 2026-04-23)

  The most common complication of active brucellosis in humans is osteoarticular injury. In the bone marrow microenvironment, mesenchymal stem cells (MSCs) can differentiate into either adipocytes or osteoblasts, and this ...
• 15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN 

  Daniels, Alisha; McDade, Eric; Llibre Guerra, Jorge J.; Dominantly Inherited Alzheimer Network; Xiong, Chengjie; Perrin, Richard J.; Ibañez, Laura; Supnet Bell, Charlene; Cruchaga, Carlos; Goate, Alison M.; Renton, Alan E.; Benzinger, Tammie L.S.; Gordon, Brian A.; Hassenstab, Jason; Karch, Celeste M.; Levey, Allan I.; Morris, John C.; Buckles, Virginia; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis (Nature Publishing Group UK, 2026-02-16)

  The Dominantly Inherited Alzheimer Network Observational Study (DIAN Obs) is a longitudinal, global cohort study investigating brain aging and autosomal dominant Alzheimer's disease (ADAD), a rare monogenic form of Alzheimer's ...
• Bridging Science and Care: 14 Years of Genetic and Biomarker Research in Neurodegenerative Diseases at an Argentine Memory Clinic 

  Surace, Ezequiel Ignacio; Romorini, Leonardo; Marazita, Mariela Claudia; Clas, Giulia Solange; Massazza, Victoria; Alvarez, María Florencia; Avendaño, Daniel; Itzcovich, Tatiana; Martinetto, Horacio (Wiley, 2025-12-24)

  Understanding the biological and genetic landscape of neurodegenerative diseases in diverse populations deepens our insight into complex pathophysiological mechanisms. Our laboratory, established 14 years ago in Buenos ...
• Persistent memory in network topologies following temporary stimuli 

  Sevlever, Federico; Waisman, Ariel; Miriuka, Santiago; Ventura, Alejandra C. (Elsevier, 2025-11-21)

  Molecular memory in signaling and gene regulatory networks shapes how cells respond to transient inputs. Here, we present a mathematical framework to quantify memory as changes in system state after temporary stimulation. ...
• Functional validation of the PSEN1 R358P and PSEN1 T119I variants in Alzheimer's Disease: an in vitro study 

  García Chialva, Diego; Cifarelli, Diego; Isaja, Luciana; Apecetche, Manuela; Martínes Ojeda, Laura; Itzcovich, Tatiana; Chrem Méndez, Patricio Alexis; Sevlever, Gustavo Emilio; Scassa, Maria; Surace, Ezequiel Ignacio; Romorini, Leonardo (Wiley, 2025-12-23)

  Background Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia worldwide. It is characterized by progressive neuronal degeneration and the accumulation of beta‐amyloid plaques (Aβ) ...
• Novel in-frame variant in DES (p.Glu353dup) causes myofibrillar myopathy: clinical, in silico and functional studies 

  Castañeda, Sheila; Amín, Guadalupe; Freiberger, María Inés; Zabalegui, Federico; Renes, Sol; Fernández Gamba, Ágata; Rosa, Alberto Luis; Cejas, Claudia Patricia; Pastor Rueda, José Manuel; Waisman, Ariel; Ferreiro, Diego; Sevlever, Gustavo Emilio; Miriuka, Santiago; Moro, Lucía Natalia (British Medical Association, 2025-12-31)

  Background: Desmin (DES) is a major intermediate filament protein involved in the structural integrity and function of striated muscles. Pathogenic mutations in DES are predominantly missense variants, causing isolated ...
• Capacity building in dementia research: insights from the World Young Leaders in Dementia 

  Morello-García, Florentina; Corvalán, Nicolás; Arruabarrena, Micaela; Clarens, María Florencia; Keller, Greta; De Los Santos, Loana; Martin, María Eugenia; Schaffer Aguzzoli, Cristiano; Allegri, Ricardo Francisco; Amaral, Livia; Ardohain Cristalli, Carolina; Bellaver, Bruna; Ngozi Best, Merci; Bloomquist, Madeleine; Chen, Kevin; Surace, Ezequiel Ignacio; Wilks, Hannah; Zimmer, Eduardo; Crivelli, Lucía; Hernández, Micaela Anahí; Magrath Guimet, Nahuel; Llibre Guerra, Jorge J. (Wiley, 2025-12)

  Early-career researchers from low- and middle-income countries face systemic barriers to professional development and leadership growth. This article presents results from an initiative led by the World Young Leaders in ...
• Thyrotropin Modulates Calcium Handling and Contractility in Adult Cardiac Myocytes 

  Sepúlveda, Marisa; Racioppi, Florencia; Burgos, Juan Ignacio; Murillo, Alexandra; Fernandez-Ruocco, Julieta; Gonano, Luis; Neiman, Gabriel; Miriuka, Santiago Gabriel; Fellet, Andrea; Casis, Oscar; Medei, Emiliano; Colareda, German; Vila Petroff, Martín (Elsevier, 2025-10-15)

  Hypothyroidism is an independent risk factor for cardiovascular disease and, if chronically sustained, leads to myocardial contractile dysfunction resulting in heart failure. However, the subcellular mechanisms underlying ...
• A RoadMap for Neuropsychological Assessment of the Right Temporal Variant of Frontotemporal Dementia (rtvFTD): Case Studies and Practical Applications 

  De Los Santos, Loana; Morello García, Florentina; Ardohain Cristalli, Carolina Agata; Tabernero, María Eugenia; Clarens, María Florencia; Crivelli, Lucía; Magrath Guimet, Nahuel (Wiley, 2025)

  Background: The right temporal variant of frontotemporal dementia (rtvFTD) is a neurodegenerative condition characterized by progressive atrophy of the right anterior temporal lobe (rATL), significantly impairing ...
• Comparative diagnostic performance of artificial intelligence models in structural MRI for schizophrenia: A systematic review and meta-analysis 

  Kotochinsky, Martin; Oliveira Fonseca, Pandora Eloa; Ramirez Lopera, Veronica; Mora, Laura; Wellgner Fernandes Oliveira, Amador; Cesar Teixeira Sirena, Eduardo; Bandeira de Melo Guimarães, Felipe; Lahitou Herlyn, Delfina; Norbu Sherpa, Nima; Gonzalez Lezana, Andrea; Pardini Fagundes, Thales (Elsevier, 2025-11-04)

  Introduction: Timely diagnosis of schizophrenia is essential to ensure prompt treatment initiation and adherence. Structural magnetic resonance imaging (sMRI), when combined with artificial intelligence (AI), offers a ...
• Clinical and functional evidence supporting the pathogenicity of the novel PSEN1 p.R358P variant in early-onset Alzheimer's disease 

  García Chialva, Diego; Itzcovich, Tatiana; Cifarelli, Diego; Apecetche, Manuela; Chrem Méndez, Patricio; Magrath Guimet, Nahuel; Vázquez, Silvia; Bérgamo, Yanina; Allegri, Ricardo Francisco; Marazita, Mariela; Sevlever, Gustavo Emilio; Isaja, Luciana; Surace, Ezequiel Ignacio; Romorini, Leonardo (Sage, 2025-11-06)

  BackgroundPathogenic variants in PSEN1, PSEN2, or AβPP cause early-onset Alzheimer's disease (EOAD). Several novel variants remain of uncertain significance (VUS) due to limited evidence. The PSEN1 p.R358P variant has not ...
• HIV infection drives proinflammatory adipocyte differentiation in an in vitro model and reveals a new inflammatory pathway 

  Freiberger, Rosa Nicole; López, Cynthia Alicia Marcela; Sviercz, Franco Agustin; Jarmoluk, Patricio; Palma, María Belén; García, Marcela Nilda; Quarleri, Jorge; Delpino, M. Victoria (Frontiers Media, 2025-07-17)

  Introduction: Adipose tissue regulates metabolic homeostasis and serves as a reservoir for mesenchymal stem cells (MSCs), which differentiate into osteoblasts and adipocytes, balancing bone and lipid metabolism. Bone loss ...
• Formación en Neuropsicología Clínica en Argentina: Creación de la Primera Residencia en Neuropsicología de Adultos en Fleni 

  Clarens, María Florencia; Morello García, Florentina; De Los Santos, Loana; Martin, María Eugenia; Sevlever, Gustavo Emilio; Crivelli, Lucía (Universidad de la Costa, 2025-07-21)

  La neuropsicología en Argentina cuenta con una trayectoria sólida, iniciada con estudios tempranos sobre trastornos del lenguaje a comienzos del siglo XX. A pesar de que el contexto sociopolítico ...
• Multi-Channel Nuclear Analysis: An ImageJ/FIJI Plugin for Automated Nuclear Segmentation and Multi-Channel Fluorescence Analysis 

  Waisman, Ariel (Caltech Library, 2025)

  Quantitative analysis of fluorescence microscopy images is essential for studying expression levels, subcellular localization and co-occurrence of proteins and other biomolecules. While several automated tools exist for ...

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