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  • Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid 
    Drieu, Antoine; Du, Siling; Storck, Steffen E.; Rustenhoven, Justin; Papadopoulos, Zachary; Dykstra, Taitea; Zhong, Fenghe; Kim, Kyungdeok; Blackburn, Susan; Mamuladze, Tornike; Harari, Oscar; Karch, Celeste M.; Bateman, Randall J.; Perrin, Richard J.; Farlow, Martin R.; Chhatwal, Jasmeer P.; Dominantly Inherited Alzheimer Network; Hu, Song; Randolph, Gwendalyn J.; Allegri, Ricardo Francisco (Nature Publishing Group, 2022-11)
    Macrophages are important players in the maintenance of tissue homeostasis1. Perivascular and leptomeningeal macrophages reside near the central nervous system (CNS) parenchyma2, and their role in CNS physiology has not ...
  • Parkin Pleiotropy: Extremely Atypical Phenotypes in Patients With Compound Heterozygous Mutations 
    Millar Vernetti, Patricio; Rossi, Malco Damián; Merello, Marcelo (Ubiquity Press, 2020-08-13)
    Background: Parkin mutations are suspected in early-onset Parkinson's disease with early motor complications, and in pedigrees showing an autosomal recessive pattern. Some compound heterozygous mutations can present with ...
  • Peritumoral adipose tissue promotes lipolysis and white adipocytes browning by paracrine action 
    Pagnotta, Priscila; Gantov, Mariana; Fletcher, Sabrina; Lombardi, Antonella; Crosbie, María Lujan; Santiso, Natalia; Ursino, Anabela; Frascarolli, Celeste; Amato, Alicia; Dreszman, Rubén; Calvo, Juan Carlos; Toneatto, Judith (Frontiers Research Foundation, 2023-04-26)
    Background: Stromal adipocytes and tumor breast epithelial cells undergo a mutual metabolic adaptation within tumor microenvironment. Therefore, browning and lipolysis occur in cancer associated adipocytes (CAA). However, ...
  • Personalized functional connectivity analysis in responders and nonresponders to ketamine and electroconvulsive therapy: A case series 
    Fazzito, María Lucía; Gonzalez, Juan José; Fiorentini, Leticia; Leiman, Marina; Pérez, Adriana; Costanzo, Elsa; Villarreal, Mirta Fabiana; Guinjoan, Salvador Martín (Elsevier, 2021-06-16)
    Objective Major depressive disorder is a common medical problem, frequently resistant to antidepressant treatments. We sought to describe functional connectivity correlates of response and non-response to rapid-acting ...
  • Perturbations in dynamical models of whole-brain activity dissociate between the level and stability of consciousness 
    Sanz Perl, Yonatan; Pallavicini, Carla; Pérez Ipiña, Ignacio; Demertzi, Athena; Bonhomme, Vincent; Martial, Charlotte; Panda, Rajanikant; Annen, Jitka; Ibañez, Agustín; Kringelbach, Morten; Deco, Gustavo; Laufs, Helmut; Sitt, Jacobo D.; Laureys, Steven; Tagliazucchi, Enzo (Public Library of Science, 2021-07-27)
    Consciousness transiently fades away during deep sleep, more stably under anesthesia, and sometimes permanently due to brain injury. The development of an index to quantify the level of consciousness across these different ...
  • PIWI-interacting RNAs are differentially expressed during cardiac differentiation of human pluripotent stem cells 
    La Greca, Alejandro; Scarafía, María Agustina; Hernández Cañás, María Clara; Pérez, Nelba; Castañeda, Sheila; Colli, Carolina; Miqueas Möbbs, Alan; Santín Velazque, Natalia Lucía; Neiman, Gabriel; Garate, Ximena; Aban, Cyntia; Waisman, Ariel; Moro, Lucía Natalia; Sevlever, Gustavo Emilio; Luzzani, Carlos Daniel; Miriuka, Santiago Gabriel (Public Library of Science, 2020-05-05)
    PIWI-interacting RNAs (piRNAs) are a class of non-coding RNAs initially thought to be restricted exclusively to germline cells. In recent years, accumulating evidence has demonstrated that piRNAs are actually expressed in ...
  • PluriBAC: A Versatile Baculovirus-Based Modular System to Express Heterologous Genes in Different Biotechnological Platforms 
    Amorós Morales, Leslie C.; Marchesini, Abril; Gómez Bergna, Santiago M.; García Fallit, Matías; Tongiani, Silvana E.; Vásquez, Larisa; Ferrelli, María Leticia; Videla Richardson, Guillermo Agustín; Candolfi, Marianela; Romanowski, Víctor; Pidre, Matías L. (MDPI, 2023-09-23)
    Baculoviruses are insect-specific pathogens widely used in biotechnology. In particular, the Autographa californica nucleopolyhedrovirus (AcMNPV) has been exploited as a platform for bio-inputs production. This is why the ...
  • Predictors of favorable response to implanted of ventriculoperitoneal shunt in patients with idiopathic normal pressure hydrocephalus 
    Ricciardi, Mario Emiliano; Calandri, Ismael Luis; Alessandro, Lucas; Farez, Mauricio Franco; Villalonga, Juan Francisco; Fausti, Martín; Herrmann, Frida; Allegri, Ricardo Francisco (Universidad de la Costa, 2020-12-09)
    Introduction: The indication of a ventriculoperitoneal shunt (VPS) is discussed in patients with idiopathic normal pressure hydrocephalus (iNPH), due to the heterogeneity of the response to treatment and the risks involved ...
  • Prognostic value of ATN Alzheimer biomarkers: 60-month follow-up results from the Argentine Alzheimer’s Disease Neuroimaging Initiative. 
    Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Calandri, Ismael Luis; Cohen, Gabriela; Martín, María Eugenia; Russo, María Julieta; Crivelli, Lucía; Pertierra, Lucía; Tapajóz Pereira de Sampaio, Fernanda; Clarens, María Florencia; Campos, Jorge; Nahas, Federico Ezequiel; Vázquez, Silvia; Surace, Ezequiel Ignacio; Sevlever, Gustavo Emilio (Elsevier, 2020)
    Purpose: To describe results of the Amyloid, Tau, Neurodegeneration (ATN) research framework classification in the Argentine-Alzheimer’s Disease Neuroimaging Initiative (arg-ADNI) cohort. Methods: Twenty-three patients ...
  • Protocol for morphometric analysis of neurons derived from human pluripotent stem cells 
    Mucci, Sofía; Rodríguez Varela, María Soledad; Isaja, Luciana; Ferriol Laffouillere, Sofía Luján; Sevlever, Gustavo Emilio; Scassa, María Élida; Romorini, Leonardo (Cell Press, 2022-06-18)
    The analysis of morphological features of neurons derived from human pluripotent stem cells (hPSCs) is important to describe neuronal phenotypes and changes observed throughout development. Using free and easily accessible ...
  • Psychological distress associated with COVID-19 quarantine: Latent profile analysis, outcome prediction and mediation analysis 
    Fernández, Rodrigo Sebastián; Crivelli, Lucía; Magrath Guimet, Nahuel; Allegri, Ricardo Francisco; Pedreira, María Eugenia (Elsevier, 2020-12-01)
    Background: Mental health of the population during COVID-19 quarantine could be at risk. Previous studies in short quarantines, found mood-related and anxiety symptomatology. Here we aimed to characterize the subtypes of ...
  • Relationship among subjective responses, flavor, and chemical composition across more than 800 commercial cannabis varieties 
    de la Fuente, Laura A.; Zamberlan, Federico; Sánchez Ferrán, Andrés; Carrillo, Facundo; Tagliazucchi, Enzo; Pallavicini, Carla (BioMed Central Ltd, 2020-07-17)
    Background: Widespread commercialization of cannabis has led to the introduction of brand names based on users' subjective experience of psychological effects and flavors, but this process has occurred in the absence of ...
  • Religiosity/Spirituality and Mental Health in Older Adults: A Systematic Review and Meta-Analysis of Observational Studies 
    Coelho-Júnior, Hélio José; Calvani, Riccardo; Panza, Francesco; Allegri, Ricardo Francisco; Picca, Anna; Marzetti, Emanuele; Alves, Vicente Paulo (Frontiers Media S.A., 2022-05)
    Objectives: The present study investigated the association between religious and spiritual (RS) practices with the prevalence, severity, and incidence of mental health problems in older adults. Methods: We conducted a ...
  • Resistance and resilience to Alzheimer's disease in Down syndrome 
    Boyle, Rory; Koops, Elouise A.; Ances, Beau; Andrews, Elizabeth J.; Arenaza-Urquijo, Eider M.; Benjanin, Alexandre; Brickman, Adam M.; Buckley, Rachel F.; Clas, Giulia Solange; Costello, Emmet; Coughlan, Gillian T.; Conley, Alexander C.; Deng, Feng; de Paula Faria, Daniele; Edwards, Natalie; Flores-Aguilar, Lisi; Fortea, Juan; Saidi, Ladan Ghazi; Head, Elizabeth; Hom, Christy L. (Wiley, 2025-04-28)
    Due to the high prevalence of Alzheimer's disease (AD) in adults with Down syndrome (DS), trisomy 21 is now considered a genetic form of AD (DSAD). A better understanding of factors that can prevent or delay AD is vital ...
  • Role of hydroxymethylglutharyl-coenzyme A reductase in the induction of stem-like states in breast cancer 
    Marks, María Paula; Giménez, Carla Alejandra; Isaja, Luciana; Vera, Mariana Belén; Borzone, Francisco Raúl; Pereyra-Bonnet, Federico; Romorini, Leonardo; Videla Richardson, Guillermo Agustín; Chasseing, Norma Alejandra; Calvo, Juan Carlos; Vellón, Luciano (Springer-Verlag, 2024-02-28)
    Purpose: De novo synthesis of cholesterol and its rate-limiting enzyme, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMGCR), is deregulated in tumors and critical for tumor cell survival and proliferation. However, ...
  • SARS-CoV-2 Impairs Osteoblast Differentiation Through Spike Glycoprotein and Cytokine Dysregulation 
    Freiberger, Rosa Nicole; López, Cynthia Alicia Marcela; Jarmoluk, Patricio; Palma, María Belén; Cevallos, Cintia; Sviercz, Franco Agustin; Grosso, Tomás Martín; García, Marcela Nilda; Quarleri, Jorge; Delpino, María Victoria (MDPI, 2025-01-22)
    Pulmonary and extrapulmonary manifestations have been reported following infection with SARS-CoV-2, the causative agent of COVID-19. The virus persists in multiple organs due to its tropism for various tissues, including ...
  • Simple Microcontact Printing Technique to Obtain Cell Patterns by Lithography Using Grayscale, Photopolymer Flexographic Mold, and PDMS 
    Gimenez, Rocio; Pérez-Sosa, Camilo; Bourguignon, Natalia; Miriuka, Santiago Gabriel; Bhansali, Shekhar; Arroyo, Carlos R.; Debut, Alexis; Lerner, Betiana; Pérez, Maximiliano S. (MDPI AG, 2022-10-08)
    Microcontact printing using PDMS embossing tools and its variations have aroused the interest of a wide spectrum of research fields, hence the feasibility of defining micro and nanoscale patterns. In this work, we have ...
  • Single cell transfection of human-induced pluripotent stem cells using a droplet-based microfluidic system 
    Pérez-Sosa, Camilo; Sanluis-Verdes, Anahí; Waisman, Ariel; Lombardi, Antonella; Rosero, Gustavo; La Greca, Alejandro; Bhansali, Shekhar; Bourguignon, Natalia; Luzzani, Carlos Daniel; Pérez, Maximiliano S.; Miriuka, Santiago Gabriel; Lerner, Betiana (Royal Society Publishing, 2022-01-12)
    Microfluidic tools have recently made possible many advances in biological and biomedical research. Research in fields such as physics, engineering, chemistry and biology have combined to produce innovation in microfluidics ...
  • Social Cognition In Early Multiple Sclerosis: Neuropsychological And Anatomical Approach 
    Crivelli, Lucía; Calandri, Ismael Luis; Helou, María Belén; Keller, Greta; Fiol, Marcela Paula; Ysrraelit, María Célica; Gaitán, María Inés; Correale, Jorge (Universidad de la Costa, 2021-03-27)
    Cognitive impairment and deficits in social cognition (SC) are frequent in patients with multiple sclerosis (MS). The aim of the present work is to study SC in patients with early MS and to analyze its neuroanatomical ...
  • Structural brain abnormalities in schizophrenia in adverse environments: examining the effect of poverty and violence in six Latin American cities 
    Crossley, Nicolas; Zugman, Andre; Reyes-Madrigal, Francisco; Czepielewski, Leticia; Castro, Mariana Nair; Diaz-Zuluaga, Ana María; Pineda-Zapata, Julián; Reckziegel, Ramiro; Gadelha, Ary; Jackowski, Andrea; Noto, Cristiano; Alliende Serra, Luz Maria; Iruretagoyena, Bárbara; Ossandon, Tomas; Ramirez-Mahaluf, Juan Pablo; Castañeda, Carmen Paz; Gonzalez-Valderrama, Alfonso; Nachar, Rubén; Guinjoan, Salvador Martín; ANDES Network (Cambridge University Press, 2020-08-18)
    Background Social and environmental factors such as poverty or violence modulate the risk and course of schizophrenia. However, how they affect the brain in patients with psychosis remains unclear. Aims We studied how ...

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