Repositorio Dspace

Listar INEU por autor "Chrem Méndez, Patricio Alexis"

Listar INEU por autor "Chrem Méndez, Patricio Alexis"

Ordenar por:Orden:Resultados:

  • Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease 
    Johnson, Erik C. B.; Bian, Shijia; Haque, Rafi U.; Carter, E. Kathleen; Watson, Caroline M.; Gordon, Brian A.; Ping, Lingyan; Duong, Duc M.; Epstein, Michael P.; McDade, Eric; Barthélemy, Nicolas R.; Karch, Celeste M.; Xiong, Chengjie; Cruchaga, Carlos; Perrin, Richard J.; Wingo, Aliza P.; Dominantly Inherited Alzheimer Network (Nature Publishing Company, 2023-08-07)
    Alzheimer's disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes-aggregation of the amyloid-β (Aβ) peptide into plaques and the microtubule protein tau into ...
  • Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer's Disease 
    Horie, Kanta; Li, Yan; Barthélemy, Nicolas R.; Gordon, Brian A.; Hassenstab, Jason; Benzinger, Tammie L.S.; Fagan, Anne M.; Morris, John C.; Karch, Celeste M.; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Ikeuchi, Takeshi; Kasuga, Kensaku; Noble, James M.; Farlow, Martin R.; Chhatwal, Jasmeer P.; Day, Gregory S.; Schofield, Peter R.; Dominantly Inherited Alzheimer Network (Wiley, 2023-03-16)
    Objective: Identifying cerebrospinal fluid measures of the microtubule binding region of tau (MTBR-tau) species that reflect tau aggregation could provide fluid biomarkers that track Alzheimer's disease related neurofibrillary ...
  • Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study 
    Boerwinkle, Anna H.; Gordon, Brian A.; Wisch, Julie K.; Flores, Shaney; Henson, Rachel L.; Butt, Omar H.; McKay, Nicole S.; Chen, Charles D.; Benzinger, Tammie L.S.; Fagan, Anne M.; Handen, Benjamin L.; Christian, Bradley T.; Head, Elizabeth; Mapstone, Mark; Rafii, Michael S.; Alzheimer's Biomarker Consortium-Down Syndrome; Dominantly Inherited Alzheimer Network; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Egido, Noelia (Elsevier, 2022-12-12)
    Background: Important insights into the early pathogenesis of Alzheimer's disease can be provided by studies of autosomal dominant Alzheimer's disease and Down syndrome. However, it is unclear whether the timing and spatial ...
  • Connectivity and Patterns of Regional Cerebral Blood Flow, Cerebral Glucose Uptake, and Aβ-Amyloid Deposition in Alzheimer's Disease (Early and Late-Onset) Compared to Normal Ageing 
    Falasco, Germán; Damián, Andrés; Urrutia, Leandro; Niell, Nicolás; Lago, Graciela; Bérgamo, Yanina; Chrem Méndez, Patricio Alexis; Quagliata, Adriana; Bentancourt, Cecilia; Calandri, Ismael Luis; Cordero, Ismael; Ponce de León, Magdalena; Contreras, Valeria; Feuerstein, Viviana; Dansilio, Sergio; Allegri, Ricardo Francisco; Engler, Henry; Vázquez, Silvia (Bentham Science Publishers, 2021-11-15)
    Purpose: The aim of this study was to investigate the differences in early (EOAD) and late (LOAD) onset of Alzheimer´s disease, as well as glucose uptake, regional cerebral blood flow (R1), amyloid depositions, and functional ...
  • Dominantly inherited Alzheimer's disease in Latin America: Genetic heterogeneity and clinical phenotypes 
    Llibre Guerra, Jorge J.; Li, Yan; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio; Llibre Rodríguez, Juan J.; Sosa, Ana Luisa; Aláez-Verson, Carmen; Longoria, Erika-Mariana; Tellez, Alberto; Carrillo Sánchez, Karol; Flores Lagunes, Luis Leonardo; Sánchez, Victor; Tadao Takada, Leonel; Nitrini, Ricardo; Ferreira Frota, Norberto Anizio; Benevides Lima, Joyce; Lopera, Francisco; Ramírez, Laura; Jiménez Velázquez, Ivonne (John Wiley & Sons, 2021-04)
    Introduction: A growing number of dominantly inherited Alzheimer's disease (DIAD) cases have become known in Latin American (LatAm) in recent years. However, questions regarding mutation distribution and frequency by country ...
  • Driving and Alzheimer’s disease: A neuropsychological screening battery for the elderly 
    Crivelli, Lucía; Russo, María Julieta; Farez, Mauricio Franco; Bonetto, Mariana; Prado, Cecilia; Calandri, Ismael Luis; Campos, Jorge; Cohen, Gabriela; Chrem Méndez, Patricio Alexis; Sabe, Liliana Raquel; Allegri, Ricardo Francisco (Associação Neurologia Cognitiva e do Comportamento, 2019-07-01)
    As life expectancy increases, there is a marked increase in the elderly population eager to continue driving. A large proportion of these elderly drive safely, however, patients with mild dementia are high-risk drivers. ...
  • Generation of a human induced pluripotent stem cell line from a familial Alzheimer's disease PSEN1 T119I patient 
    Isaja, Luciana; Rodríguez Varela, María Soledad; Marazita, Mariela Claudia; Mucci, Sofía; Itzcovich, Tatiana; Chrem Méndez, Patricio Alexis; Niikado, Matías; Ferriol Laffouillere, Sofía Luján; Allegri, Ricardo Francisco; Martinetto, Horacio; Sevlever, Gustavo Emilio; Scassa, María Élida; Surace, Ezequiel Ignacio; Romorini, Leonardo (Elsevier, 2021-04-05)
    Human induced pluripotent stem cells (hiPSC) line FLENIi001-A was reprogrammed from dermal fibroblasts using the lentiviral-hSTEMCCA-loxP vector. Fibroblasts were obtained from a skin biopsy of a 72-year-old Caucasian male ...
  • Neuropsychological profile of Alzheimer’s disease based on amyloid biomarker findings results from a South American cohort. Appl Neuropsychol Adult 1–6. 
    Clarens, María Florencia; Crivelli, Lucía; Calandri, Ismael Luis; Chrem Méndez, Patricio Alexis; Martín, María Eugenia; Russo, María Julieta; Campos, Jorge; Surace, Ezequiel Ignacio; Vázquez, Silvia; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco (Taylor & Francis Group, 2020-04-30)
    Objective: Increased life expectancy and exponential growth of adults suffering from Alzheimer's disease (AD) worldwide, has led to biomarkers incorporation for diagnosis in early stages. Use of neuropsychological testing ...
  • A novel mutation in PSEN1 (p.T119I) in an Argentine family with early- and late-onset Alzheimer's disease 
    Itzcovich, Tatiana; Chrem Méndez, Patricio Alexis; Vázquez, Silvia; Barbieri-Kennedy, Micaela; Niikado, Matías; Martinetto, Horacio; Allegri, Ricardo Francisco; Sevlever, Gustavo Emilio; Surace, Ezequiel Ignacio (Elsevier, 2020-01)
    Mutations inPSEN1are the most common cause of early-onset Alzheimer’s disease (AD). In this article,we present an Argentine family with autosomal dominant early- and late-onset AD. The proband and 6family members were ...
  • Prognostic value of ATN Alzheimer biomarkers: 60-month follow-up results from the Argentine Alzheimer’s Disease Neuroimaging Initiative. 
    Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Calandri, Ismael Luis; Cohen, Gabriela; Martín, María Eugenia; Russo, María Julieta; Crivelli, Lucía; Pertierra, Lucía; Tapajóz Pereira de Sampaio, Fernanda; Clarens, María Florencia; Campos, Jorge; Nahas, Federico Ezequiel; Vázquez, Silvia; Surace, Ezequiel Ignacio; Sevlever, Gustavo Emilio (Elsevier, 2020)
    Purpose: To describe results of the Amyloid, Tau, Neurodegeneration (ATN) research framework classification in the Argentine-Alzheimer’s Disease Neuroimaging Initiative (arg-ADNI) cohort. Methods: Twenty-three patients ...

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