dc.contributor.author |
Barboza, Miguel A. |
|
dc.contributor.author |
Torrealba-Acosta, Gabriel |
|
dc.contributor.author |
Valdez, Hector |
|
dc.contributor.author |
Arauz-Gongora, Antonio |
|
dc.contributor.author |
Abanto-Argomedo, Carlos |
|
dc.contributor.author |
Amaya, Pablo |
|
dc.contributor.author |
Ameriso, Sebastián Francisco |
|
dc.contributor.author |
Bonardo, Pablo |
|
dc.contributor.author |
Cano, Vanessa |
|
dc.contributor.author |
Diaz-Escobar, Luis |
|
dc.contributor.author |
Ecos, Rosa Lizbeth |
|
dc.contributor.author |
Fernández Morales, Huberth |
|
dc.contributor.author |
Gómez-Schneider, Maia |
|
dc.contributor.author |
Gongora-Rivera, Fernando F. |
|
dc.contributor.author |
Huamani, Charles |
|
dc.contributor.author |
Lavados, Pablo M. |
|
dc.contributor.author |
Marquez Romero, Juan Manuel |
|
dc.contributor.author |
Martins, Sheila C. |
|
dc.contributor.author |
Navia, Víctor Hugo |
|
dc.contributor.author |
Pujol Lereis, Virginia Andrea |
|
dc.date.accessioned |
2023-09-07T14:40:46Z |
|
dc.date.available |
2023-09-07T14:40:46Z |
|
dc.date.issued |
2023-02-02 |
|
dc.identifier.citation |
Barboza, M.A., Torrealba-Acosta, G., Valdez, H., Arauz, A., Abanto, C., Amaya, P., Ameriso, S.F., Bonardo, P., Cano, V., Diaz-Escobar, L., Ecos, R.L., Fernández Morales, H., Gómez-Schneider, M., Gongora - Rivera, F.F., Huamani, C., Lavados, P.M., Marquez-Romero, J.M., Martins, S.C., Navia, V.H., Pujol Lereis, V.A., Roa Wandurraga, L.F., Ruiz-Franco, A., Serrano, F., Vences, M.A., Zurru, M., Kent, T.A., Mandava, P., 2023. Abstract WP14: A Patient-level Data Euclidean-matched Analysis Of Reperfusion Therapies In Acute Ischemic Stroke From The Latin American Stroke Registry (lase). Stroke 54, AWP14–AWP14. https://doi.org/10.1161/str.54.suppl_1.WP14 |
es_ES |
dc.identifier.uri |
https://doi.org/10.1161/str.54.suppl_1.WP14 |
|
dc.identifier.uri |
https://repositorio.fleni.org.ar/xmlui/handle/123456789/827 |
|
dc.description.abstract |
Introduction: As acute stroke therapies expand to less well-resourced regions, it is imperative to study real-world data to assess outcomes and the quality of stroke care. The present study analyzes clinical, and imaging outcomes after acute IV thrombolysis (IV-tPA) compared to mechanical thrombectomy (MT) or combined therapy in the LASE.
Methods: A retrospective analysis of consecutive acute ischemic stroke cases in 17 centers from 9 Latin American (LA) countries since 2012 was performed using weighted Euclidean matching of nearest neighbors in 3-D space of baseline NIHSS, age, and glucose.
Results: 950 patients receiving only IV-tPA were matched to 127 treated with MT+IV-tPA. Matching resulted in 97 pairs well balanced for age (69.1 vs. 69.3), baseline NIHSS (17 vs. 17), and glucose (124.3 vs. 124.5), all p>0.2. 3-month mRS 0-1 (38.3% vs 29.8%, p=0.23) and mRS 0-2 (46.8% vs 41.5%, p=0.54) were non-significantly higher in the MT+IV-tPA group, with higher hemorrhage (26.6% vs 15.5%, p=0.05) and trends for higher death (15.1% vs 9.5%, p=0.40) and symptomatic hemorrhage (7.4% vs 6.2%, p=1.0). One hundred one patients receiving only MT were matched to 127 patients with MT+IV-tPA, resulting in 61 pairs; MT+IV-tPA showed trends for higher rates of 3-month mRS 0-1 (45.0% vs 35.6%, p=0.31), mRS 0-2 (48.3% vs 42.4%, p=0.54); with trends for lower rates of death (16.9% vs 20.0%, p=1.0) and symptomatic hemorrhage (8.3% vs 11.1%, p=0.75).
Conclusions: In this real-world LA sample, trends for better functional outcomes were demonstrated with MT+IV-tPA compared to either treatment alone, as in non-LA populations. A trend for higher adverse events in the combined group requires further investigation. |
es_ES |
dc.language.iso |
eng |
es_ES |
dc.publisher |
Lippincott Williams & Wilkins |
es_ES |
dc.rights |
info:eu-repo/semantics/openAccess |
|
dc.subject |
Ischemic Stroke |
es_ES |
dc.subject |
Accidente Cerebrovascular Isquémico |
es_ES |
dc.subject |
Latin America |
es_ES |
dc.subject |
América Latina |
es_ES |
dc.title |
Abstract WP14: A Patient-level Data Euclidean-matched Analysis Of Reperfusion Therapies In Acute Ischemic Stroke From The Latin American Stroke Registry (lase) |
es_ES |
dc.type |
Presentation |
es_ES |
dc.type |
info:eu-repo/semantics/publishedVersion |
|
dc.description.fil |
Fil: Ameriso, Sebastián Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Vascular; Argentina. |
|
dc.description.fil |
Fil: Pujol Lereis, Virginia Andrea. Fleni. Centro Integral de Neurología Vascular; Argentina. |
|
dc.relation.ispartofVOLUME |
54 |
|
dc.relation.ispartofNUMBER |
Suppl_1 |
|
dc.relation.ispartofCOUNTRY |
Estados Unidos |
|
dc.relation.ispartofCITY |
Dallas |
|
dc.relation.ispartofTITLE |
Stroke |
|
dc.relation.ispartofISSN |
1347-4820 |
|
dc.type.snrd |
Presentation |
es_ES |