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Abstract WP14: A Patient-level Data Euclidean-matched Analysis Of Reperfusion Therapies In Acute Ischemic Stroke From The Latin American Stroke Registry (lase)

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dc.contributor.author Barboza, Miguel A.
dc.contributor.author Torrealba-Acosta, Gabriel
dc.contributor.author Valdez, Hector
dc.contributor.author Arauz-Gongora, Antonio
dc.contributor.author Abanto-Argomedo, Carlos
dc.contributor.author Amaya, Pablo
dc.contributor.author Ameriso, Sebastián Francisco
dc.contributor.author Bonardo, Pablo
dc.contributor.author Cano, Vanessa
dc.contributor.author Diaz-Escobar, Luis
dc.contributor.author Ecos, Rosa Lizbeth
dc.contributor.author Fernández Morales, Huberth
dc.contributor.author Gómez-Schneider, Maia
dc.contributor.author Gongora-Rivera, Fernando F.
dc.contributor.author Huamani, Charles
dc.contributor.author Lavados, Pablo M.
dc.contributor.author Marquez Romero, Juan Manuel
dc.contributor.author Martins, Sheila C.
dc.contributor.author Navia, Víctor Hugo
dc.contributor.author Pujol Lereis, Virginia Andrea
dc.date.accessioned 2023-09-07T14:40:46Z
dc.date.available 2023-09-07T14:40:46Z
dc.date.issued 2023-02-02
dc.identifier.citation Barboza, M.A., Torrealba-Acosta, G., Valdez, H., Arauz, A., Abanto, C., Amaya, P., Ameriso, S.F., Bonardo, P., Cano, V., Diaz-Escobar, L., Ecos, R.L., Fernández Morales, H., Gómez-Schneider, M., Gongora - Rivera, F.F., Huamani, C., Lavados, P.M., Marquez-Romero, J.M., Martins, S.C., Navia, V.H., Pujol Lereis, V.A., Roa Wandurraga, L.F., Ruiz-Franco, A., Serrano, F., Vences, M.A., Zurru, M., Kent, T.A., Mandava, P., 2023. Abstract WP14: A Patient-level Data Euclidean-matched Analysis Of Reperfusion Therapies In Acute Ischemic Stroke From The Latin American Stroke Registry (lase). Stroke 54, AWP14–AWP14. https://doi.org/10.1161/str.54.suppl_1.WP14 es_ES
dc.identifier.uri https://doi.org/10.1161/str.54.suppl_1.WP14
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/827
dc.description.abstract Introduction: As acute stroke therapies expand to less well-resourced regions, it is imperative to study real-world data to assess outcomes and the quality of stroke care. The present study analyzes clinical, and imaging outcomes after acute IV thrombolysis (IV-tPA) compared to mechanical thrombectomy (MT) or combined therapy in the LASE. Methods: A retrospective analysis of consecutive acute ischemic stroke cases in 17 centers from 9 Latin American (LA) countries since 2012 was performed using weighted Euclidean matching of nearest neighbors in 3-D space of baseline NIHSS, age, and glucose. Results: 950 patients receiving only IV-tPA were matched to 127 treated with MT+IV-tPA. Matching resulted in 97 pairs well balanced for age (69.1 vs. 69.3), baseline NIHSS (17 vs. 17), and glucose (124.3 vs. 124.5), all p>0.2. 3-month mRS 0-1 (38.3% vs 29.8%, p=0.23) and mRS 0-2 (46.8% vs 41.5%, p=0.54) were non-significantly higher in the MT+IV-tPA group, with higher hemorrhage (26.6% vs 15.5%, p=0.05) and trends for higher death (15.1% vs 9.5%, p=0.40) and symptomatic hemorrhage (7.4% vs 6.2%, p=1.0). One hundred one patients receiving only MT were matched to 127 patients with MT+IV-tPA, resulting in 61 pairs; MT+IV-tPA showed trends for higher rates of 3-month mRS 0-1 (45.0% vs 35.6%, p=0.31), mRS 0-2 (48.3% vs 42.4%, p=0.54); with trends for lower rates of death (16.9% vs 20.0%, p=1.0) and symptomatic hemorrhage (8.3% vs 11.1%, p=0.75). Conclusions: In this real-world LA sample, trends for better functional outcomes were demonstrated with MT+IV-tPA compared to either treatment alone, as in non-LA populations. A trend for higher adverse events in the combined group requires further investigation. es_ES
dc.language.iso eng es_ES
dc.publisher Lippincott Williams & Wilkins es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.subject Ischemic Stroke es_ES
dc.subject Accidente Cerebrovascular Isquémico es_ES
dc.subject Latin America es_ES
dc.subject América Latina es_ES
dc.title Abstract WP14: A Patient-level Data Euclidean-matched Analysis Of Reperfusion Therapies In Acute Ischemic Stroke From The Latin American Stroke Registry (lase) es_ES
dc.type Presentation es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Ameriso, Sebastián Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Vascular; Argentina.
dc.description.fil Fil: Pujol Lereis, Virginia Andrea. Fleni. Centro Integral de Neurología Vascular; Argentina.
dc.relation.ispartofVOLUME 54
dc.relation.ispartofNUMBER Suppl_1
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Dallas
dc.relation.ispartofTITLE Stroke
dc.relation.ispartofISSN 1347-4820
dc.type.snrd Presentation es_ES


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