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Disability outcomes in NMOSD and MOGAD patients: data from a nationwide registry in Argentina

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dc.contributor.author Rojas, Juan Ignacio
dc.contributor.author Pappolla, Agustín
dc.contributor.author Patrucco, Liliana
dc.contributor.author Cristiano, Edgardo
dc.contributor.author Miguez, Jimena
dc.contributor.author Liwacki, Susana
dc.contributor.author Tkachuk, Verónica A.
dc.contributor.author Balbuena Aguirre, María Eugenia
dc.contributor.author Vrech, Carlos
dc.contributor.author Deri, Norma
dc.contributor.author Correale, Jorge
dc.contributor.author Marrodán, Mariano
dc.contributor.author Ysrraelit, María Célica
dc.contributor.author Fiol, Marcela Paula
dc.contributor.author Leguizamón, Felisa
dc.contributor.author Luetic, Geraldine G.
dc.contributor.author Menichini, María L.
dc.contributor.author López, Pablo Adrián
dc.contributor.author Pettinicchi, Juan Pablo
dc.contributor.author Criniti, Juan
dc.date.accessioned 2023-11-24T14:15:41Z
dc.date.available 2023-11-24T14:15:41Z
dc.date.issued 2022-09-27
dc.identifier.citation Rojas JI, Pappolla A, Patrucco L, Cristiano E, Miguez J, Liwacki S, Tkachuk V, Balbuena Aguirre ME, Vrech C, Deri N, Correale J, Marrodan M, Ysrraelit MC, Fiol M, Leguizamon F, Luetic G, Menichini ML, López PA, Pettinicchi JP, Criniti J, Caride A, Tavolini D, Mainella C, Zanga G, Burgos M, Hryb J, Barboza A, Lazaro L, Alonso R, Silva B, Fernández Liguori N, Nadur D, Chercoff A, Martinez A, Steinberg J, Garcea O, Carrá A, Alonso Serena M, Carnero Contentti E. Disability outcomes in NMOSD and MOGAD patients: data from a nationwide registry in Argentina. Neurol Sci. 2023 Jan;44(1):281-286. doi: 10.1007/s10072-022-06409-w. Epub 2022 Sep 27. es_ES
dc.identifier.uri https://doi.org/10.1007/s10072-022-06409-w
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/870
dc.description.abstract The objective was to evaluate time to reach an EDSS of 4, 6, and 7 in NMOSD and MOGAD patients included in the Argentinean MS and NMOSD registry (RelevarEM, NCT 03,375,177). Methods: NMOSD patients diagnosed according to 2015 criteria and with MOGAD were identified. Patients with at least 3 years of follow-up and periodic clinical evaluations with EDSS outcomes were included. AQP4-antibody and MOG-antibody status was recorded, and patients were stratified as seropositive and seronegative for AQP4-antibody. EDSS of 4, 6, and 7 were defined as dependent variables. Log rank test was used to identify differences between groups. Results: Registry data was provided for a total of 137 patients. Of these, seventy-five presented AQP4-ab-positive NMOSD, 45 AQP4-ab-negative NMOSD, and 11 MOGAD. AQP4-ab status was determined by cell-based assay (CBA) in 72% of NMOSD patients. MOG-ab status was tested by CBA in all cases. Mean time to EDSS of 4 was 53.6 ± 24.5 vs. 63.1 ± 32.2 vs. 44.7 ± 32 months in seropositive, seronegative NMOSD, and MOGAD, respectively (p = 0.76). Mean time to EDSS of 6 was 79.2 ± 44.3 vs. 75.7 ± 48.6 vs. 54.7 ± 50 months in seropositive, seronegative NMOSD, and MOGAD (p = 0.23), while mean time to EDSS of 7 was 86.8 ± 54 vs. 80.4 ± 51 vs. 58.5 ± 47 months in seropositive, seronegative NMOSD, and MOGAD (p = 0.39). Conclusion: No differences were observed between NMOSD (seropositive and seronegative) and MOGAD in survival curves. es_ES
dc.language.iso eng es_ES
dc.publisher Springer-Verlag Italia es_ES
dc.subject Epidemiology es_ES
dc.subject Epidemiología es_ES
dc.title Disability outcomes in NMOSD and MOGAD patients: data from a nationwide registry in Argentina es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Marrodán, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Ysrraelit, María Célica. Fleni. Departamento de Neurología; Argentina.
dc.description.fil Fil: Fiol, Marcela Paula. Fleni. Departamento de Neurología; Argentina.
dc.description.fil Fil: Rojas, Juan Ignacio. Centro de Esclerosis Múltiple de Buenos Aires; Argentina.
dc.description.fil Fil: Pappolla, Agustín. Hospital Italiano de Buenos Aires; Argentina.
dc.description.fil Fil: Patrucco, Liliana. Centro de Esclerosis Múltiple de Buenos Aires; Argentina.
dc.description.fil Fil: Cristiano, Edgardo. Centro de Esclerosis Múltiple de Buenos Aires; Argentina.
dc.description.fil Fil: Miguez, Jimena. Hospital Italiano de Buenos Aires; Argentina.
dc.description.fil Fil: Liwacki, Susana. Clínica Universitaria Reina Fabiola; Argentina.
dc.description.fil Fil: Tkachuk, Verónica A. Hospital de Clínicas José de San Martín; Argentina.
dc.description.fil Fil: Balbuena Aguirre, María Eugenia. Hospital de Clínicas José de San Martí; Argentina.
dc.description.fil Fil: Vrech, Carlos. Sanatorio Allende, Cordoba; Argentina.
dc.description.fil Fil: Deri, Norma. Centro de Investigaciones Diabaid; Argentina.
dc.relation.ispartofVOLUME 44
dc.relation.ispartofNUMBER 1
dc.relation.ispartofPAGINATION 281-286.
dc.relation.ispartofCOUNTRY Italia
dc.relation.ispartofCITY Milán
dc.relation.ispartofTITLE Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
dc.relation.ispartofISSN 1590-3478
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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