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An Exploratory Study of Sleep-Wake Differences of Autonomic Activity in Patients with Mild Cognitive Impairment: The Role of Melatonin as a Modulating Factor

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dc.contributor.author Abulafia, Carolina Andrea
dc.contributor.author Vidal, María Florencia
dc.contributor.author Olivar, Natividad
dc.contributor.author Odzak, Andrea
dc.contributor.author Brusco, Luis Ignacio
dc.contributor.author Guinjoan, Salvador Martín
dc.contributor.author Cardinali, Daniel P.
dc.contributor.author Vigo, Daniel Eduardo
dc.date.accessioned 2023-12-14T17:18:37Z
dc.date.available 2023-12-14T17:18:37Z
dc.date.issued 2023-05-12
dc.identifier.citation Abulafia CA, Vidal MF, Olivar N, Odzak A, Brusco LI, Guinjoan SM, Cardinali DP, Vigo DE. An Exploratory Study of Sleep-Wake Differences of Autonomic Activity in Patients with Mild Cognitive Impairment: The Role of Melatonin as a Modulating Factor. Clin Interv Aging. 2023 May 12;18:771-781. doi: 10.2147/CIA.S394749 es_ES
dc.identifier.uri https://doi.org/10.2147/CIA.S394749
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/910
dc.description.abstract Purpose: The objective of the present study was to assess sleep-wake differences of autonomic activity in patients with mild cognitive impairment (MCI) compared to control subjects. As a post-hoc objective, we sought to evaluate the mediating effect of melatonin on this association. Patients and methods: A total of 22 MCI patients (13 under melatonin treatment) and 12 control subjects were included in this study. Sleep-wake periods were identified by actigraphy and 24hr-heart rate variability measures were obtained to study sleep-wake autonomic activity. Results: MCI patients did not show any significant differences in sleep-wake autonomic activity when compared to control subjects. Post-hoc analyses revealed that MCI patients not taking melatonin displayed lower parasympathetic sleep-wake amplitude than controls not taking melatonin (RMSSD -7 ± 1 vs 4 ± 4, p = 0.004). In addition, we observed that melatonin treatment was associated with greater parasympathetic activity during sleep (VLF 15.5 ± 0.1 vs 15.1 ± 0.1, p = 0.010) and in sleep-wake differences in MCI patients (VLF 0.5 ± 0.1 vs 0.2 ± 0.0, p = 0.004). Conclusion: These preliminary findings hint at a possible sleep-related parasympathetic vulnerability in patients at prodromal stages of dementia as well as a potential protective effect of exogenous melatonin in this population. es_ES
dc.language.iso eng es_ES
dc.publisher Dove Medical Press es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.subject Actigraphy es_ES
dc.subject Actigrafía es_ES
dc.subject Circadian Rhythm es_ES
dc.subject Ritmo Circadiano es_ES
dc.subject Cognitive Dysfunction es_ES
dc.subject Disfunción Cognitiva es_ES
dc.subject Melatonin es_ES
dc.subject Melatonina es_ES
dc.subject Sleep Wake Disorders es_ES
dc.subject Trastornos del Sueño-Vigilia es_ES
dc.title An Exploratory Study of Sleep-Wake Differences of Autonomic Activity in Patients with Mild Cognitive Impairment: The Role of Melatonin as a Modulating Factor es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Vidal, María Florencia. Fleni. Departamento de Neurología. Servicio de Psiquiatría; Argentina.
dc.relation.ispartofVOLUME 18
dc.relation.ispartofPAGINATION 771-781
dc.relation.ispartofCOUNTRY Nueva Zelanda
dc.relation.ispartofCITY Auckland
dc.relation.ispartofTITLE Clinical interventions in aging
dc.relation.ispartofISSN 1176-9092
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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