DSpace Repositorium (Manakin basiert)

Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS)

Zur Kurzanzeige

dc.contributor.author Weil, Alexander G.
dc.contributor.author Dimentberg, Evan
dc.contributor.author Lewis, Evan C.
dc.contributor.author Ibrahim, George M.
dc.contributor.author Kola, Olivia
dc.contributor.author Tseng, Chi-Hong
dc.contributor.author Chen, Jia-Shu
dc.contributor.author Lin, Kao-Min
dc.contributor.author Cai, Li-Xin
dc.contributor.author Liu, Qing-Zhu
dc.contributor.author Lin, Jiu-Luan
dc.contributor.author Zhou, Wen-Jing
dc.contributor.author Mathern, Gary W.
dc.contributor.author Smyth, Matthew D.
dc.contributor.author O'Neill, Brent R.
dc.contributor.author Dudley, Roy
dc.contributor.author Ragheb, John
dc.contributor.author Pociecha, Juan
dc.contributor.author Chamorro, Noelia
dc.contributor.author Muro, Valeria L.
dc.date.accessioned 2024-02-08T12:51:31Z
dc.date.available 2024-02-08T12:51:31Z
dc.date.issued 2023-06-22
dc.identifier.citation Weil AG, Dimentberg E, Lewis E, Ibrahim GM, Kola O, Tseng CH, Chen JS, Lin KM, Cai LX, Liu QZ, Lin JL, Zhou WJ, Mathern GW, Smyth MD, O'Neill BR, Dudley R, Ragheb J, Bhatia S, Delev D, Ramantani G, Zentner J, Wang AC, Dorfer C, Feucht M, Czech T, Bollo RJ, Issabekov G, Zhu H, Connolly M, Steinbok P, Zhang JG, Zhang K, Hidalgo ET, Weiner HL, Wong-Kisiel L, Lapalme-Remis S, Tripathi M, Sarat Chandra P, Hader W, Wang FP, Yao Y, Champagne PO, Brunette-Clément T, Guo Q, Li SC, Budke M, Pérez-Jiménez MA, Raftopoulos C, Finet P, Michel P, Schaller K, Stienen MN, Baro V, Cantillano Malone C, Pociecha J, Chamorro N, Muro VL, von Lehe M, Vieker S, Oluigbo C, Gaillard WD, Al Khateeb M, Al Otaibi F, Krayenbühl N, Bolton J, Pearl PL, Fallah A. Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS). Epilepsia. 2024 Jan;65(1):46-56. doi: 10.1111/epi.17689 es_ES
dc.identifier.uri https://doi.org/10.1111/epi.17689
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/978
dc.description.abstract Objectives: Although hemispheric surgeries are among the most effective procedures for drug-resistant epilepsy (DRE) in the pediatric population, there is a large variability in seizure outcomes at the group level. A recently developed HOPS score provides individualized estimation of likelihood of seizure freedom to complement clinical judgement. The objective of this study was to develop a freely accessible online calculator that accurately predicts the probability of seizure freedom for any patient at 1-, 2-, and 5-years post-hemispherectomy. Methods: Retrospective data of all pediatric patients with DRE and seizure outcome data from the original Hemispherectomy Outcome Prediction Scale (HOPS) study were included. The primary outcome of interest was time-to-seizure recurrence. A multivariate Cox proportional-hazards regression model was developed to predict the likelihood of post-hemispheric surgery seizure freedom at three time points (1-, 2- and 5- years) based on a combination of variables identified by clinical judgment and inferential statistics predictive of the primary outcome. The final model from this study was encoded in a publicly accessible online calculator on the International Network for Epilepsy Surgery and Treatment (iNEST) website (https://hops-calculator.com/). Results: The selected variables for inclusion in the final model included the five original HOPS variables (age at seizure onset, etiologic substrate, seizure semiology, prior non-hemispheric resective surgery, and contralateral fluorodeoxyglucose-positron emission tomography [FDG-PET] hypometabolism) and three additional variables (age at surgery, history of infantile spasms, and magnetic resonance imaging [MRI] lesion). Predictors of shorter time-to-seizure recurrence included younger age at seizure onset, prior resective surgery, generalized seizure semiology, FDG-PET hypometabolism contralateral to the side of surgery, contralateral MRI lesion, non-lesional MRI, non-stroke etiologies, and a history of infantile spasms. The area under the curve (AUC) of the final model was 73.0%. Significance: Online calculators are useful, cost-free tools that can assist physicians in risk estimation and inform joint decision-making processes with patients and families, potentially leading to greater satisfaction. Although the HOPS data was validated in the original analysis, the authors encourage external validation of this new calculator. es_ES
dc.language.iso eng es_ES
dc.publisher Wiley es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.subject Drug Resistant Epilepsy es_ES
dc.subject Epilepsia Refractaria es_ES
dc.subject Electroencephalography es_ES
dc.subject Electroencefalografía es_ES
dc.subject Epilepsy es_ES
dc.subject Epilepsia es_ES
dc.subject Fluorodeoxyglucose F18 es_ES
dc.subject Fluorodesoxiglucosa F18 es_ES
dc.subject Hemispherectomy es_ES
dc.subject Hemisferectomía es_ES
dc.subject Magnetic Resonance Imaging es_ES
dc.subject Imagen por Resonancia Magnética es_ES
dc.subject Seizures es_ES
dc.subject Convulsiones es_ES
dc.subject Spasms, Infantile es_ES
dc.subject Espasmos Infantiles es_ES
dc.title Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS) es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Pociecha, Juan. Fleni. Centro Integral de Epilepsia y Unidad de Monitoreo de Videoelectroencefalografía; Argentina.
dc.description.fil Fil: Chamorro, Noelia. Fleni. Centro Integral de Epilepsia y Unidad de Monitoreo de Videoelectroencefalografía; Argentina.
dc.description.fil Fil: Muro, Valeria L. Fleni. Centro Integral de Epilepsia y Unidad de Monitoreo de Videoelectroencefalografía; Argentina.
dc.relation.ispartofVOLUME 65
dc.relation.ispartofNUMBER 1
dc.relation.ispartofPAGINATION 46-56
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Malden
dc.relation.ispartofTITLE Epilepsia
dc.relation.ispartofISSN 1528-1167
dc.type.snrd info:ar-repo/semantics/artículo es_ES


Dateien zu dieser Ressource

Das Dokument erscheint in:

Zur Kurzanzeige

DSpace Suche


Stöbern

Mein Benutzerkonto

Statistik