Repositorio Institucional FLENI: Envíos recientes

  • Longitudinal Phenotypic Trajectories in GNAO1-Related Disorders : Defining Disease Progression and Clinical Profiles 
    Domínguez-Carral, Jana; Domínguez Cobo, Ana María; Balsells, Sol; Aguilar Ros, Anna; Chang, Chu-Ting; Ludlam, William Grant; Yang, Kathryn; Bernardi, Katerina (Wiley-Liss, 2026-07)
    Objective: Pathogenic variants in GNAO1 cause a spectrum of epilepsy, movement disorders, and developmental impairment. Clinical heterogeneity complicates prognosis and therapeutic development. We present the first ...
  • Eye tracking as a diagnostic tool in Alzheimer's disease, mild cognitive impairment, and related dementias: a systematic review 
    Verón, Gustavo Luis; Juantorena, Gustavo Ezequiel; Keller, Greta; Crivelli, Lucía; Kamienkowski, Juan Esteban (Wiley, 2025-12-30)
    Alzheimer's disease (AD) pathology begins years before symptoms emerge, making early detection essential. Eye tracking offers a rapid, non-invasive means of identifying early cognitive decline through oculomotor disturbances. ...
  • 15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN 
    Daniels, Alisha; McDade, Eric; Llibre Guerra, Jorge J.; Dominantly Inherited Alzheimer Network; Xiong, Chengjie; Perrin, Richard J.; Ibañez, Laura; Supnet Bell, Charlene; Cruchaga, Carlos; Goate, Alison M.; Renton, Alan E.; Benzinger, Tammie L.S.; Gordon, Brian A.; Hassenstab, Jason; Karch, Celeste M.; Levey, Allan I.; Morris, John C.; Buckles, Virginia; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis (Nature Publishing Group UK, 2026-02-16)
    The Dominantly Inherited Alzheimer Network Observational Study (DIAN Obs) is a longitudinal, global cohort study investigating brain aging and autosomal dominant Alzheimer's disease (ADAD), a rare monogenic form of Alzheimer's ...
  • Scientific knowledge about dementia : From the Global South to the world 
    Daly, Timothy; López Barrenechea, Ignacio; Vergara, Paulina; Arshad, Faheem; Paplikar, Avanthi; Chaudhuri, Aparajita Ray; Crivelli, Lucía; Ibañez, Agustín; Alladi, Suvarna; Slachevsky, Andrea (John Wiley & Sons, Ltd., 2026-03)
    Most people with dementia live in low- and middle-income countries (LMICs), but scientific knowledge about dementia is dominated by Global North perspectives. This interdisciplinary article combines expertise from Latin ...
  • Silk vista baby versus pipeline embolization device for unruptured distal anterior cerebral artery aneurysms : A multicenter propensity-weighted comparative study 
    Da Ros, Valerio; Frédéric Clarençon; Dmytriw, Adam A.; Jabbour, Pascal; Psychogios, Marios; Sporns, Peter; Puri, Ajit S.; Hassan, Ameer E.; Algin, Oktay; Möhlenbruch, Markus A.; Bergui, Mauro; Goren, Oded; Boulouis, Gregoire; Morimoto, Takeshi; Pop, Raoul; Ho, Joanna Wk; Pujol Lereis, Virginia Andrea; Cooper, Jared; Salsano, Giancarlo; CRETA investigators (Masson, 2026-06)
    Background: Flow diversion is effective for unruptured distal anterior cerebral artery (DACA) aneurysms, yet comparative data between the Silk Vista Baby (SVB) and Pipeline Embolization Device (PED) in this challenging ...
  • Bridging Science and Care: 14 Years of Genetic and Biomarker Research in Neurodegenerative Diseases at an Argentine Memory Clinic 
    Surace, Ezequiel Ignacio; Romorini, Leonardo; Marazita, Mariela Claudia; Clas, Giulia Solange; Massazza, Victoria; Alvarez, María Florencia; Avendaño, Daniel; Itzcovich, Tatiana; Martinetto, Horacio (Wiley, 2025-12-24)
    Understanding the biological and genetic landscape of neurodegenerative diseases in diverse populations deepens our insight into complex pathophysiological mechanisms. Our laboratory, established 14 years ago in Buenos ...
  • Dementia screening protocol for primary care in South America : a Delphi consensus study 
    Custodio, Belen; Montesinos, Rosa; Caramelli, Paulo; Calandri, Ismael Luis; Dozzi Brucki, Sonia María; Suemoto, Claudia Kimie; Allegri, Ricardo Francisco; Slachevsky, Andrea; Parodi, Jose F.; Morsch, Patricia; Willets, Clarissa; Cuba Fuentes, María Sofía; Custodio, Nilton (Frontiers Editorial Office, 2026-04-08)
    Introduction: Rapid population aging in South America (SA) highlights the need for effective dementia detection strategies. Primary care is essential for early identification, yet no shared, regionally contextualized ...
  • Novel GNAO1 variant in α-helical domain reveals alternative mechanism of disease 
    Ludlam, William Grant; Domínguez-Carral, Jana; Schteinschnaider, Ángeles; Martemyanov, Kirill A.; Ortigoza-Escobar, Juan Darío (Elsevier, 2025-10-21)
    No abstract available.
  • Neuromodulation for Drug-Resistant Chronic Cluster Headache: Efficacy and Safety in a Series of Four Cases 
    Villamil, Facundo; StefanoParisi, Enzo; Nuñez, Maximiliano; Mandolesi, Jorge E.; Stella, Oscar (Fundación CENIT, 2025-11-18)
    Introduction: Chronic cluster headache (CCH) is a severely disabling form of trigeminal autonomic cephalalgia, often refractory to pharmacological treatment. In recent years, peripheral neuromodulation through occipital ...
  • Multiple myeloma mimicking olfactory sulcus meningioma: Case report and literature review 
    Mosquera Jiménez, Dilia Judith; Carballo, Leandro; Baldoncini, Matías; Sevlever, Gustavo Emilio; Echavarría Demichelis, Mickaela (Elsevier España, 2025-11-20)
    Central nervous system involvement by multiple myeloma is extremely rare and is diagnosed in less than 1% of cases. Differential diagnosis includes lymphomas, metastases, sarcomas, osteochondromas, hemangiopericytomas or ...
  • Validación del examen del estado mental en autismo en español : sensibilidad y especificidad en una muestra clínica argentina 
    Cukier, Sebastián H.; Maglio, Ana; Berman, Jonathan; Arduini, Marco; Barrios, Natalia; Ngue, Maranada; Montiel, Cecilia; Ferrea, Mónica; Gutson, Karina; Zieba, Emilio; Menassé, Marcela; Grodberg, David (Polemos, 2026-01-10)
    Introducción: El examen del estado mental en autismo (AMSE, por sus siglas en inglés) es un instrumento breve completado por el clínico que estructura la observación y documentación de los signos y características ...
  • A harmonized framework for studying exceptional cognitive aging in Latin America 
    Crivelli, Lucía; Fernández, Rodrigo Sebastián; Corvalán, Nicolás; Sosa, Ana Luisa; Acosta, Daisy; Agnoletti, Giulia; Surace, Ezequiel Ignacio; Acosta, Issac; Caramelli, Paulo; Aguillón, David; Leniz Martelli, Javiera; Duque Peñailillo, Lissette; Custodio, Nilton; Charamelo Baieti, Ana; Damian, Andrés; Llibre Rodríguez, Juan J.; Allegri, Ricardo Francisco; Prina, Mathew; Rogalski, Emily; Ibañez, Laura (John Wiley & Sons, 2026-04-14)
    Introduction: Biological, genetic, and sociocultural factors underlying cognitive resilience and resistance to pathology remain unexplored in Latin America. The Life-Course Epidemiology of Aging, Resilience, and Neurodegeneration ...
  • Glial Plasticity and Dysfunction : Mechanistic Insights and Therapeutic Opportunities in Neurodegeneration 
    Correale, Jorge (Wiley on behalf of the International Society for Neurochemistry, 2026-04)
    Recent advances, including single-cell transcriptomics, lineage tracing, and in vivo imaging, have unveiled the heterogeneity, plasticity, and functional versatility of astrocytes, microglia, oligodendrocytes, and Schwann ...
  • Primer Consenso Argentino en Esquizofrenia : tercera parte. Lineamientos para el abordaje integral del tratamiento 
    Corrales, Alejo; Abadi, Andrea; Bartoli, Gastón; Benavente Pinto, Carlos; Cabrera, Adrián; Camino, Sebastián; Corral, Ricardo; Delmonte, Guillermo; García Bonetto, Gerardo; Garay, Cristian Javier; Gargoloff, Damián; Gargoloff, Pedro; Goldchuk, Aníbal; Iveli, María Florencia; Jufe, Gabriela; Lamaison, Fabián; Leiderman, Eduardo; López Mato, Andrea; Marengo, Eliana; Waisman Campos, Marcela (Polemos, 2026-04-10)
    Este documento corresponde a la tercera parte del Primer Consenso Argentino sobre el manejo de la esquizofrenia y tiene como objetivo sintetizar la evidencia científica actualizada sobre los abordajes terapéuticos en ...
  • Primer Consenso Argentino para el Manejo de la Esquizofrenia : Segunda Parte. Consideraciones clínicas y diagnósticas 
    Corrales, Alejo; Abadi, Andrea; Bartoli, Gastón; Benavente Pinto, Carlos; Cabrera, Adrián; Camino, Sebastián; Corral, Ricardo; Delmonte, Guillermo; García Bonetto, Gerardo; Garay, Cristian Javier; Gargoloff, Damián; Gargoloff, Pedro; Goldchuk, Aníbal; Iveli, María Florencia; Jufe, Gabriela; Lamaison, Fabián; Leiderman, Eduardo; López Mato, Andrea; Marengo, Eliana; Waisman Campos, Marcela (Polemos, 2026-01-10)
    Este documento constituye la segunda parte del Primer Consenso Argentino sobre el Manejo de la Esquizofrenia y presenta una síntesis actualizada de la evidencia disponible sobre los aspectos clínicos y diagnósticos del ...
  • Longitudinal subcortical volume changes and their correlations with multiple PET and fluid biomarkers in dominantly inherited Alzheimer's disease 
    Choo, Il Han; Park, Hoyoung; Gordon, Brian A.; Bateman, Randall J.; Dominantly Inherited Alzheimer Network; Daniels, Alisha; Courtney, Laura; Ziegemeier, Angela; Skrbec, Karina; Hellm, Cortaiga; Martin, Mariana; Ziegemeier, Ellen; Bartzel, Jamie; McDade, Eric; Libre-Guerra, Jorge J.; Supnet Bell, Charlene; Xiong, Chengie; Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio; Vázquez, Silvia; Allegri, Ricardo Francisco (Elsevier, 2026-04)
    Background: Alzheimer's disease postmortem studies demonstrate that amyloid plaques and neurofibrillary tangles are present in subcortical regions. Objective: To investigate longitudinal subcortical structural changes in ...
  • Levodopa-Induced dyskinesia in Latin America : Prevalence and associated clinical factors in the LARGE-PD cohort 
    Chaparro-Solano, Henry Mauricio; Teixeira-Dos-Santos, Daniel; Waldo, Emily; Leal, Thiago P.; Inca-Martinez, Miguel; Alcauter, Sarael; Medina-Rivera, Alejandra; Ruiz-Contreras, Alejandra E.; Cornejo Olivas, Mario; Mejia-Rojas, Koni; Armas, Cintia; Chaná Cuevas, Pedro; Rojas, Natalia; Orozco, Jorge L.; Muñoz Ospina, Beatriz; Aguillón, David; Buritica, Omar; Moreno Masmela, Sonia; Merello, Marcelo (IOS Press, 2026-04-17)
    BackgroundAlthough levodopa is the gold standard treatment for Parkinson's disease (PD), its chronic use is associated with levodopa-induced dyskinesia (LID), a motor complication that impacts prognosis, quality of life, ...
  • Brief Cognitive Screening Tools for Dementia in Low-Educated Population from South America : A Systematic Review 
    Chambergo Michilot, Diego; Custodio, Nilton; Montesinos, Rosa; Custodio, Belen; Cahuapaza Gutierrez, Nelson Luis; Caramelli, Paulo; Calandri, Ismael Luis; Dozzi Brucki, Sonia María; Suemoto, Claudia Kimie; Allegri, Ricardo Francisco; Slachevsky, Andrea; Parodi, Jose F. (Karger, 2025-09-29)
    Introduction: Despite less education being common in Latin America, there is no systematic review on the use of brief cognitive screening (BCS) tools in illiterate and low-educated adults in the region. We systematically ...
  • Collaborative Latin American Imaging Network In Neuroimmunology Research (BRAIMS) : Rationale, Structure, Challenges, and Future Directions 
    Carnero Contentti, Edgar; Alonso, Ricardo; Boldrini, Vinícius; Cárcamo, Claudia A.; Casas, Magdalena; Ciampi, Ethel; Damasceno, Alfredo; dos Santos Silva, Jonadab; de Medeiros Rimkus, Carolina; Marrodán, Mariano; Navas, Carlos; Patrucco, Liliana; Pitombeira, Milena; Ramari, Cintia; Sato, Henry Koiti; Soler, Bernardita; Treviño Frenk, Irene; Wagner, Mario; Ontaneda, Daniel; Becker, Jefferson (Elsevier B. V., 2026-06)
    Magnetic resonance imaging (MRI) plays a central role in the diagnosis, differential diagnosis, and monitoring of neuroimmunological disorders, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder ...
  • Nucleoli-localized KANSL2 as an epigenetic regulator of ribosome biogenesis in glioblastoma cells 
    Budnik, Nicolás; Canedo, Lucía; Morellato, Agustín E.; Cuenca, Marina B.; Garmendia, Martina; Senin, Sergio; Romano, Sebastián A.; Andrysik, Zdenek; Videla Richardson, Guillermo Agustín; Graner, Michael W.; Kobayashi, Ken; Zhou, Yilong; Wiese, Meike; Akhtar, Asifa; Espinosa, Joaquín M.; Perez-Castro, Carolina (Nature Publishing Group UK, 2026-03-05)
    KANSL2 is a subunit of the non-specific lethal (NSL) chromatin-modifying complex associated with glioblastoma (GBM) progression, but the intrinsic role of KANSL2 in GBM cells is poorly understood. By analyzing TCGA-GBM and ...