Repositorio Institucional FLENI: Envíos recientes

  • Microbiome-derived metabolites from vitamin B2 and B9 pathways modulate MAIT cells from multiple sclerosis patients 
    Correale, Jorge; Marrodán, Mariano; Piedrabuena, María Agustina; Soman, Karthik; Farez, Mauricio Franco; Baranzini, Sergio E. (SAGE, 2026-06-01)
    Background: Mucosal-associated invariant T (MAIT) cells recognize microbial vitamin B2 and B9 metabolites via MR1 and have been implicated in multiple sclerosis (MS). How patient-specific gut microbiota shape human MAIT-cell ...
  • Awareness, attitudes, and barriers toward Transthyretin Amyloid Cardiomyopathy in Latin America: A questionnaire-based cross-sectional study. 
    Camacho-Hubner, Cecilia; Waddington Cruz, Marcia; Rodríguez González, María Juliana; Simões, Marcus Vinicius; López-Ponce de León, Juan David; Fernandes, Fabio; Martínez Carreño, Erika María; Costabel, Juan Pablo; Berríos Bárcenas, Enrique A.; Barroso, Fabio Adrián; Cigarroa López, José Angel; Ortega Reyes, Rosa; Alvarez, Jaime; Pérez de Arenaza, Diego; Buitrago, Diana; Otero, Constanza; Bertoli de Souza, Claudenice Leite; Molina Gómez, Juan Sebastián; Silva Julian, Guilherme (Public Library of Science, 2026-06-26)
    Background: Cardiac Amyloidosis (CA), specifically Transthyretin Amyloid Cardiomyopathy (ATTR-CM), is an under-recognized, progressive, and fatal disease. Comprehensive primary data describing awareness, attitudes, and ...
  • Endovascular embolization of tentorial dural arteriovenous fistulas (EMBOTENT): a retrospective multicenter study 
    Vollherbst, Dominik F.; Krug, Nadja; Zhang, Peng; Ma, Yongjie; Su, Xin; Limbucci, Nicola; Renieri, Leonardo; Mosimann, Pascal J.; Boutet, Alexandre; Cheng, How-Chung; Marnat, Gaultier; Barreau, Xavier; Szikora, Istvan; Czencz, Máté; González, Alejandro; Albóniga-Chindurza, Asier de; Scarcia, Luca; Kalsoum, Erwah; Alexandre, Andrea M.; Pujol Lereis, Virginia Andrea (BMJ Publishing Group, 2026-05-04)
    Background: Tentorial dural arteriovenous fistulas (TDAVFs) are rare but high risk vascular lesions. Although endovascular embolization is often the preferred treatment, large scale data on efficacy and safety are limited. ...
  • Generation of a human induced pluripotent stem cell line (FLENIi004-A) from an Autosomal-Dominant Alzheimer's disease PSEN1 p.M146L patient 
    Vautier, Mercedes Florencia; Chrem Méndez, Patricio Alexis; Jerez Ferreyra, Guillermo; Massazza, Victoria; Apecetche, Manuela; Rodríguez Varela, María Soledad; Clas, Giulia Solange; Nievas, Micaela; Allegri, Ricardo Francisco; Sevlever, Gustavo Emilio; Scassa, María Élida; Surace, Ezequiel Ignacio; Marazita, Mariela Claudia; Romorini, Leonardo (Elsevier, 2026-06)
    Human induced pluripotent stem cell (hiPSC) line FLENIi004-A was generated from peripheral blood mononuclear cells (PBMCs) using the lentiviral-hSTEMCCA-loxP vector. FLENIi004-A was derived from a 41-year-old Argentinean ...
  • Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study 
    Patel, Maulikkumar; Feng, Wei; McKay, Nicole S.; Millar, Peter R.; Liu, Menghan; Yang, Chengran; Cetin, Arda; Johnson, Matthew; Budde, John P.; Western, Daniel; Marsh, Thomas W.; Saliu, Ibrahim O.; Gordon, Brian A.; Llibre Guerra, Jorge J.; Morris, John C.; Bateman, Randall J.; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio; Vázquez, Silvia (Lancet, 2026-06)
    Background: Individuals with autosomal dominant Alzheimer's disease (ADAD) arising from mutations in PSEN1, PSEN2, or APP exhibit variability in clinical presentation. Genetic studies of ADAD have shaped our understanding ...
  • Conmociones cerebrales en el fútbol: avances recientes y desafíos en la gestión clínica y preventiva 
    Russo, María Julieta; Salvat, Fernando; Ameriso, Sebastián Francisco; Villani, Donato; Vega, Jorge; Allegri, Ricardo Francisco; Sevlever, Gustavo Emilio (Fundación Revista Medicina (Buenos Aires), 2026-08)
    Concussions in soccer are a key challenge for neurological health due to their high incidence, diagnostic complexity, and risk of long-term sequelae. This article provides a narrative review of their definition, epidemiology, ...
  • Peak width of skeletonized mean diffusivity reveals early and multifactorial white matter injury across sporadic and Down syndrome–associated Alzheimer's disease 
    Morcillo Nieto, Alejandra O.; Franquesa Mullerat, Maria; Zsadanyi, Sara E.; Arriola‐Infante, José Enrique; Vaqué‐Alcázar, Lídia; Rozalem Aranha, Mateus; Allende Parra, José; Zhao, Zili; Arranz, Javier; Rodríguez‐Baz, Íñigo; Maure Blesa, Lucia; Videla, Laura; Barroeta, Isabel; Del Hoyo Soriano, Laura; Benejam, Bessy; Fernández, Susana; Sanjuan Hernandez, Aida; Pertierra, Lucía; Giménez, Sandra; Santos Santos, Miguel Ángel (Wiley, 2026-05-29)
    INTRODUCTION: This study investigates the evolution with disease progression and pathological correlates of peak width of skeletonized mean diffusivity (PSMD), a sensitive diffusion magnetic resonance imaging (MRI) marker ...
  • Implementation of stroke prevention: a review of challenges and opportunities in the Americas 
    Ouriques Martins, Sheila Cristina; Ordunez, Pedro; Borelli, Wyllians Vendramini; Ovbiagele, Bruce; Urrutia, Victor C.; Abanto, Carlos; Alet, Matías Javier; Almarie, Bassel; Álvarez, Tony Fabián; Amaya, Pablo; Ameriso, Sebastián Francisco; Arauz-Gongora, Antonio; Barboza, Miguel A.; Bayona, Hernán; Calleja, Juan; Cano Nigenda, Vanessa; Carbonera, Leonardo Augusto; Carrillo Larco, Rodrigo M.; Constanzo, Freddy; Pujol Lereis, Virginia Andrea (Elsevier, 2026-05-22)
    Stroke remains a leading cause of death and disability throughout the Americas, disproportionately impacting low-and middle-income countries and underserved populations. In this review, we examine the status of stroke ...
  • Incidencia de metástasis extra sistema nervioso central en pacientes con gliomas de alto grado: experiencia en una única institución 
    Martí, Maria Trinidad; Salas, Juan Cruz; Bártoli, Julia; Arakaki, Naomi; Cerrato, Sebastián; Yorio, Florencia; Delorme, Ricardo; Muggeri, Alejandro (Academia Argentina de Oncología Clínica, 2026-05-05)
    La incidencia de metástasis extra sistema nervioso central (MESNC) en pacientes con gliomas es baja, del 0.4 al 11% dependiendo del tipo de glioma. No existen reportes acerca de la incidencia en la Argentina. El objetivo ...
  • Reaction to Health Emergencies 
    Allegri, Ricardo Francisco (Springer, 2026-05-01)
    A health emergency is defined as a scenario involving health conditions that pose a risk to humans, resulting in a substantial rise in disease, disability, and death. The most recent health emergency was the last COVID-19 ...
  • Compound Heterozygous Variants in the Phospholipase Gene PNPLA6 Cause Hypopituitarism and Vision Loss 
    Vishnopolska, Sebastian; Liu, James; Camilletti, María Andrea; Martínez Mayer, Julián; Iglesias García, Lucía; Brinkmeier, Michelle; Vaiani, Elisa; Vidal, Sofia Hebe; Ciaccio, Marta; Di Palma, María Isabel; Belgorosky, Alicia; Marti, Marcelo; Hufnagel, Robert B.; Camper, Sally A.; Pérez-Millán, María Inés (Wiley, 2026-06-19)
    NPLA6 is a conserved lysophospholipase essential for maintaining nervous system integrity. Biallelic mutations in PNPLA6 have been identified in individuals with a broad spectrum of disorders that can include ataxia, vision ...
  • Assessment of sports-related concussion in children and adolescents 
    Testa, Nelly; Pochetti, Juliana; Russo, María Julieta (Sociedad Argentina de Pediatría, 2026-09-30)
    Advances in research on sports-related concussions have led to updates in diagnostic and management protocols. This article reviews the recommendations from the Sixth International Consensus Conference on Concussion in ...
  • Update on spontaneous intracranial hypotension 
    Portes Souza, Marcio Nattan; Uribe, Bernardo; Zavala, Lucía; Lopez, Reydmar; Nagel, Vanesa; Calderaro, Marcelo; Edelmuth, Diogo Guilherme (Sociedade Brasileira de Cefaleia, 2026-04-20)
    Background Spontaneous intracranial hypotension (SIH) is a secondary headache disorder caused by spontaneous cerebrospinal fluid (CSF) leakage, typically from dural tears, meningeal diverticula, or CSF venous fistulas, ...
  • Epidemiology and risk factors of stroke in the Americas: a comprehensive narrative literature review 
    Sampaio Silva, Gisele; Diestro, Jose Danilo; Tarzi, Christopher; Kishibe, Teruko; Bernabé-Ortiz, Antonio; Carrillo Larco, Rodrigo M.; Ovbiagele, Bruce; Saposnik, Gustavo; Abanto, Carlos; Alet, Matías Javier; Almarie, Bassel; Álvarez, Tony Fabián; Amaya, Pablo; Ameriso, Sebastián Francisco; Arauz, Antonio; Barboza, Miguel A.; Bayona, Hernán; Calleja, Juan; Cano Nigenda, Vanessa; Pujol Lereis, Virginia Andrea (Elsevier, 2026-05-22)
    Stroke remains a leading cause of death and disability across the Americas, disproportionately affecting low- and middle-income countries. According to the 2023 Global Burden of Disease (GBD) Study, the Americas recorded ...
  • Cierre de foramen oval permeable guiado por ecocardiografía intracardíaca: resultados iniciales y descripción de la técnica 
    Magariños, Eduardo; Henestrosa, Germán; Scuteri, Antonio; Romano, Ariel; Sandoval, Carla Elizabeth; Pujol Lereis, Virginia Andrea; Ameriso, Sebastián Francisco (Colegio Argentino de Cardioangiólogos Intervencionistas, 2025)
    Introducción: El cierre percutáneo del foramen oval permeable (FOP) está establecido como tratamiento para prevención secundaria de un nuevo accidente cerebrovascular (ACV) en un grupo seleccionado de pacientes. En este ...
  • Recommendations for genetic counseling for individuals at risk of autosomal dominant Alzheimer's disease in Latin America 
    Jiménez, Daniel A.; Bagnati, Pablo M.; Flores Montes, Rosa Elena; Fernández, María Laura; Zuno Reyes, Angélica; Aguillón, David; Aláez Versón, Carmen; Becerra Solano, Luis Eduardo; Behrens, María Isabel; Branda, Kelly; Chrem Méndez, Patricio Alexis; Custodio, Nilton; Ducaine, Whitney; Dumois Petersen, Sofía; Figuera, Luis; Londoño Castaño, Marisol; Longoria, Erika Mariana; Matute, Esmeralda; Surace, Ezequiel Ignacio; Programa de asesoramiento genético en América Latina (PRAGA) (Wiley, 2026-05-27)
    Autosomal dominant Alzheimer's disease (ADAD) represents a small but impactful subset of Alzheimer's cases. Asymptomatic individuals at genetic risk face substantial personal and family implications when considering ...
  • Early use of high-efficacy disease-modifying therapies reduces the risk of progression independent of relapse and MRI activity in patients with relapsing-remitting multiple sclerosis 
    Guarnaschelli, María Flor; Marrodán, Mariano; Sosa, Brian Ezequiel; Perez Arana, Carolina I.; Farez, Mauricio Franco; Fiol, Marcela Paula; Ysrraelit, María Célica; Correale, Jorge (SAGE, 2026-04-29)
    Background: Progression independent of relapse and MRI activity (PIRMA) is a major contributor to long-term disability in relapsing-remitting multiple sclerosis (RRMS). In Latin America, limited access to high-efficacy ...
  • Characterizing circadian rest-activity rhythm patterns across Alzheimer's disease continuum in Down syndrome 
    Giménez, Sandra; Vaqué-Alcázar, Lídia; Clos, Susana; Benejam, Bessy; Carmona-Iragui, María; Maure Blesa, Lucia; Videla, Laura; Zhu, Nuole; Altuna, Miren; Arranz, Javier; Barroeta, Isabel; Rodríguez-Baz, Íñigo; Bejanin, Alexandre; Bueno, Ana; Fernández, Susana; Del Hoyo Soriano, Laura; Pertierra, Lucía; Alcolea, Daniel; Miller, Bruce; Grinberg, Lea T. (Wiley, 2026-05)
    Introduction: Sleep and circadian rest-activity rhythm (RAR) disruption may bidirectionally relate to Alzheimer's disease (AD). Down syndrome (DS), the most common genetic cause of AD, presents sleep disorders, yet RAR ...
  • ABSTRACT NUMBER: ESOC2026A1514 ADAPTIVE CONTROL ANKLE ROBOTICS INTEGRATED WITH PHYSIOTHERAPY FOR SEVERE HEMIPARESIS IN SUBACUTE STROKE: A CASE REPORT 
    Dossi, Daiana Elizabeth; Gianella, Matías Gabriel; Rivas, María Elisa; Mattei, Martín; Best, María Gabriela; Moya, Diego; Crespo, Marcos José; Hernández, Micaela Anahí; MacKo, Richard; MacKo, Charlene; Ameriso, Sebastián Francisco (Oxford University Press, 2026-03-06)
    Background and aims: Adaptive control ankle robotics is a promising but underexplored strategy for stroke rehabilitation. AMBLE is a wireless impedance-controlled ankle exoskeleton with foot switches that adapt dorsiflexion ...
  • Regression-based normative data for neuropsychological assessment in Buenos Aires, Argentina: RAVLT, trail making test, digit span, and verbal fluency 
    Corvalán, Nicolás; Morello García, Florentina; Leiva, Samanta; Allegri, Ricardo Francisco; Crivelli, Lucía (Cambridge University Press, 2026-05-11)
    Objective: To develop regression-based normative data for a set of widely used neuropsychological tests and to provide a freely accessible normative data calculator for use in Buenos Aires, Argentina. Methods: Participants ...