Repositorio Institucional FLENI: Recent submissions

  • Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer's disease 
    Jiaxin Cindy, Tu; Millar, Peter R.; Strain, Jeremy F.; Eck, Andrew; Adeyemo, Babatunde; Snyder, Abraham Z.; Daniels, Alisha; Karch, Celeste; Huey, Edward D.; McDade, Eric; Day, Gregory S.; Yakushev, Igor; Hassenstab, Jason; Morris, John; Llibre-Guerra, Jorge J.; Ibanez, Laura; Jucke, Mathias; Chrem Méndez, Patricio Alexis; Dominantly Inherited Alzheimer Network (MIT Press, 2024)
    Hub regions in the brain, recognized for their roles in ensuring efficient information transfer, are vulnerable to pathological alterations in neurodegenerative conditions, including Alzheimer's disease (AD). Computational ...
  • 2- Cognitive Impairment and Dementia in Latin American Individuals with Parkinsonism and Parkinson’s Disease: A 10/66 Dementia Research Group Study (Ana Luisa Sosa) 
    Sosa, Ana Luisa; Khan, N.; Arruabarrena, Micaela María; Kim, D.J.; Jiang, M.; Llibre-Rodriguez, J.J.; Rodriguez-Salgado, A.M.; Acosta, I.; Acosta, D.; Jimenez-Velasquez, I.Z.; Guerra, M.; Salas, A.; López-Contreras, R.; Dhara, Santana; Hesse, H.; Tanner, C.; Prina, M.; Llibre-Guerra, J.J.; 10/66 Dementia ResearchGroup (International Psichogeriatrics Association, 2024-09)
  • Abstract WP131: Global Landscape of Stroke Rehabilitation: Access and Challenges 
    Velez, Faddi Saleh; Yeung, Elton Hau Lam; Pinto, Camila Bonin; Ling, Tse Mei; Carbonera, Leonardo; Alet, Matías Javier; Ciopleias, Bogdan; Khan, Abdul Hanif Khan Yusof; Law, Zhe Kang; Lotlikar, Radhika; Ramage, Emily; Xiong, Carol; Zuurbier, Susanna; Li, Linxin; Mares, Kathryn; Kiper, Pawel; Heldner, Mirjam; Matuja, Sarah; Johnson, Louise; Caso, Valeria (American Heart Association, 2025-01-30)
    Background: Stroke is a leading cause of long-term disability worldwide. Timely and adequate rehabilitation is crucial for post-stroke recovery, but access is limited due to an overburdened healthcare system, medical ...
  • Abstract 147: Telestroke Network Mapping: An Update of the World Landscape for Remote Stroke Care 
    Velez, Faddi Saleh; Tunkl, Christine; Agarwal, Ayush; Roushdy, Tamer; Ullberg, Teresa; Carbonera, Leonardo; Ciopleias, Bogdan; Khan, Abdul Hanif Khan Yusof; Heldner, Mirjam; Khan, Maria; Alet, Matías Javier; Matuja, Sarah; Ramage, Emily; Lagos, Javier; Mosconi, Maria Giulia; Katsanos, Aristeidis; Li, Linxin; Gerner, Stefan; Zuurbier, Susanna; Law, Zhe Kang (American Heart Association, 2025-01-30)
    Background: Telestroke has proven efficacy in improving clinical outcomes by providing rapid access to specialized stroke care, particularly in remote areas. However, the global implementation of telestroke networks remains ...
  • Protocolo de valoración neuroconductual estandarizada y de interpretación clínica de pacientes con trastornos crónicos de conciencia 
    Russo, María Julieta; Pavón, Hernán Marcelo; Deschle, Florencia; Marroquín, María Verónica; Aliaga, Orlando; Sampayo, María de la Paz (Elsevier, 2025-03-20)
    En este trabajo investigamos la literatura existente acerca de la posibilidad de que algunos hallazgos clínicos puedan ser de utilidad para el diagnóstico de la presencia de contenido de conciencia en los pacientes con ...
  • Evidence-based guidelines for the pharmacological treatment of migraine 
    Ornello, Raffaele; Caponnetto, Valeria; Ahmed, Fayyaz; Al-Khazali, Haidar M.; Ambrosini, Anna; Ashina, Sait; Baraldi, Carlo; Bellotti, Alessia; Brighina, Filippo; Calabresi, Paolo; Casillo, Francesco; Cevoli, Sabina; Cheng, Shuli; Chiang, Chia-Chun; Chiarugi, Alberto; Häckert Christensen, Rune; Kyung Chu, Min; Crema, Santiago; Goicochea, María Teresa (Sage, 2025-04-25)
    We here present evidence-based guidelines for the pharmacological treatment of migraine. These guidelines, created by the Italian Society for the Study of Headache and the International Headache Society, aim to offer clear, ...
  • International Headache Society Global Practice Recommendations for Preventive Pharmacological Treatment of Migraine 
    Puledda, Francesca; Sacco, Simona; Diener, Hans-Christoph; Ashina, Messoud; Al-Khazali, Haidar M.; Ashina, Sait; Burstein, Rami; Liebler, Eric; Cipriani, Andrea; Chu, Min Kyung; Cocores, Alexandra; Dodd-Glover, Freda; Ekizoğlu, Esme; Garcìa Azorìn, David; Göbel, Carl; Goicochea, María Teres; Hassan, Amr; Hirata, Koichi; Hoffmann, Jan; Jenkins, Bronwyn (Sage, 2024-09)
  • Improvement in cerebral hypoperfusion by stellate ganglion block in refractory vasospasm 
    Maskin, Luis Patricio; Rodríguez Lucci, Federico (Elsevier, 2025-02-24)
    Resumen no disponible
  • Abstract TP148: The Need for Standardized Stroke Care: Assessing Global Provider Training and Institutional Disparities 
    Owens, Cameron; Bonin Pinto, Camila; Heldner, Mirjam; Carbonera, Leonardo; De Souza, Ana; Tunkl, Christine; Matuja, Sarah; Orjuela, Karen; Guerrero, Rodrigo; Alet, Matías Javier; Vasquez, Sebastian; Cano-Nigenda, Vanessa; Roa Wandurraga, Luis; Lagos-Servellon, Javier Alfredo; Saposnik, Gustavo; Rosales, Julieta Soledad; Velez, Faddi Saleh (American Heart Association, 2025-01-30)
    The development of vascular neurology as the primary specialty for stroke evaluation and treatment is a relatively recent advancement. Vascular neurology is well-established in the United States, ensuring most stroke ...
  • In Memoriam C. Warren Olanow (1941–2024) 
    Fung, Victor S.C.; Bhatia, Kailash P.; Burn, David J.; Goetz, Christopher G.; Hallett, Mark; Jankovic, Joseph; Kieburtz, Karl; Klein, Christine; Kordower, Jeffrey H.; Lang, Anthony E.; Merello, Marcelo; Stern, Matthew B.; Stoessl, A. Jon; Thompson, Philip D. (Wiley, 2025-02-13)
    Resumen no disponible
  • Risk and impact of stroke across 38 countries and territories of the Americas from 1990 to 2021: a population-based trends analysis from the Global Burden of Disease Study 2021 
    Martinez, Ramón; Muñoz-Venturelli, Paula; Ordunez, Pedro; Fregni, Felipe; Abanto, Carlos; Alet, Matías Javier; Alvarez, Tony Fabián; Amaya, Pablo; Ameriso, Sebastián Francisco; Arauz, Antonio; Barboza, Miguel A.; Bayona, Hernán; Bernabé-Ortiz, Antonio; Calleja, Juan; Cano-Nigenda, Vanessa; Carbonera, Leonardo Augusto; Carrillo-Larco, Rodrigo M.; Corredor, Angel; de Souza, Ana Cláudia; Rosales, Julieta Soledad (Elsevier, 2025-02-15)
    Background: Despite substantial declines in burden over time, stroke remains a public health threat in the Americas. This study aimed to assess the current magnitude, trends, and disparities in the estimates of stroke ...
  • Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia 
    Llibre Guerra, Jorge J.; Fernandez, M. Victoria; Joseph-Mathurin, Nelly; Bian, Shijia; Carter, Kathleen; Li, Yan; Aschenbrenner, Andrew J.; Pottier, Cyril; Sigurdson, Wendy; McDade, Eric; Gordon, Brian A.; Renton, Alan E.; Benzinger, Tammie L. S.; Ibañez, Laura; Barthelemy, Nico; Dominantly Inherited Alzheimer Network (Nature Publishing Company, 2025-02-10)
    We conducted an in-depth longitudinal study on an individual carrying the presenilin 2 p.Asn141Ile mutation, traditionally associated with dominantly inherited Alzheimer's disease (AD), who has remarkably remained asymptomatic ...
  • IAPRD new consensus classification of myoclonus 
    Latorre, Anna; van der Veen, S.; Pena, Ashley; Truong, Daniel; Erro, Roberto; Frucht, Steven; Ganos, Christos; Hallett, Mark; Perez-Duenas, Belen; Rossi, Malco Damián; Roze, Emmanuel; Vidailhet, Marie; Aj de Koning-Tijssen, Marina; Caviness, John N. (Elsevier, 2025-02-20)
    Introduction: Recent new advances in myoclonus characterization and etiology justify an update of the 40-year-old respected classification of myoclonus proposed by Marsden, Hallett, and Fahn. New advances include genetic ...
  • Experts envision a valuable role for tau-PET in clinical practiceand drug trials 
    Vermeiren, Marie R.; Calandri, Ismael Luis; van der Flier, Wiesje M.; van de Giessen, Elsmarieke; Ossenkoppele, Rik (Wiley, 2024)
    Background: Recent advancements in Alzheimer’s disease (AD) biomarker researchand AD drug trials prompt reflection on the value and appropriate use of tau-PET infuture clinical practice and trials. We therefore conducted ...
  • Development of a Multidomain Composite InterventionEngagement Score in the U.S. POINTER Trial 
    Ghadimi Nouran, Mina; Katula, Jeffrey A.; Ventrelle, Jennifer; Graef, Sarah; Garcia, Katelyn R.; Lovato, Laura; Wilmoth, Sharon; Woolard, Nancy; Leng, Xiaoyan; Calandri, Ismael Luis; Snyder, Heather M.; Bake, Laura D. (Wiley, 2024)
    Background Multidomain lifestyle interventions have shown promise to slow cognitive decline and possibly prevent dementia. However, challenges arise in analyzing and interpreting treatment response when participants vary ...
  • Multi-Component and Cognitive Skills Training in MildCognitive Impairment: Outcomes from a South American Study 
    Martín, María Eugenia; Martínez, Carlos; Worff, Iris; Belucci, María Agustina; Keller, Greta; Arruabarrena, Micaela María; Corvalàn, Nicolás; Clarens, María Florencia; Allegri, Ricardo Francisco; Crivelli, Lucía (Wiley, 2024)
    Background: Dementia represents a significant health challenge, with evidencesuggesting that it can be potentially delayed or prevented through non-pharmacological interventions. There are different types of non-pharmaco ...
  • Is FDG-PET metabolism associated with cognitive performancein long-Covid patients? 
    Hernández, Micaela Anahí; Santos Machado, Luiza; De Bastiani, Marco; Hugentobler Schlickmann, Thomas; Ferrari-Souza, João Pedro; Carello, Agostina; Helou, Belén; Crivelli, Lucía; Osa Sanz, Emilia; Bérgamo, Yanina; Vázquez, Silvia; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco; Zimmer, Eduardo R.; Calandri, Ismael Luis (Wiley, 2024)
    Background: Current evidence indicates that COVID-19 infection can lead toneurological complications that persist beyond 12 weeks of infection (long-COVID),often associated with cognitive decline. However, the underlying ...
  • Multi-modal AI screening for MCI and Alzheimer's Disease: results from an Argentine Cohort 
    Belloli, Laouen; Keller, Greta; Carello, Agostina; Gauder, Lara; Juantorena, Gustavo; Corvalan, Nicolás; Allegri, Ricardo Francisco; Crivelli, Lucía; Fernández Slezak, Diego (Wiley, 2024)
    Early detection of Mild Cognitive Impairment (MCI) is crucial for effective prevention. Traditional methods like expert judgment, clinical evaluations, and manual linguistic analyses are now complemented by Artificial ...
  • SARS-CoV-2 Impairs Osteoblast Differentiation Through Spike Glycoprotein and Cytokine Dysregulation 
    Freiberger, Rosa Nicole; López, Cynthia Alicia Marcela; Jarmoluk, Patricio; Palma, María Belén; Cevallos, Cintia; Sviercz, Franco Agustin; Grosso, Tomás Martín; García, Marcela Nilda; Quarleri, Jorge; Delpino, María Victoria (MDPI, 2025-01-22)
    Pulmonary and extrapulmonary manifestations have been reported following infection with SARS-CoV-2, the causative agent of COVID-19. The virus persists in multiple organs due to its tropism for various tissues, including ...
  • Tic Disorders Care Gaps in Spanish-Speaking Latin America 
    Medina Escobar, Alex; Munoz, Daniela; Gautreau, Sylvia; Rossi, Malco Damián; Pringsheim, Tamara (Wiley, 2025-02-22)
    Background: Primary tic disorders (TD) are common movement disorders in childhood. However, it is unclear if international guidelines are applied in Latin America. Objectives: To investigate the applicability of TD ...

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