Repositorio Institucional FLENI: Recent submissions

  • Generation of myostatin edited horse embryos using CRISPR/Cas9 technology and somatic cell nuclear transfer 
    Moro, Lucía Natalia; Viale, Diego Luis; Bastón, Juan Ignacio; Arnold, Victoria; Suva, Mariana; Wiedenmann, Elisabet; Olguín, Martín; Miriuka, Santiago Gabriel; Vichera, Gabriel (Nature Publishing Group, 2020-08-24)
    The application of new technologies for gene editing in horses may allow the generation of improved sportive individuals. Here, we aimed to knock out the myostatin gene (MSTN), a negative regulator of muscle mass development, ...
  • Microcirugía de las fístulas durales arteriovenosas espinales, más un repaso de la anatomía vascular vertebromedular 
    Mormandi, Rubén; Ruella, Mauro; Villamil, Facundo; Cervio, Andrés Eduardo; Condomí Alcorta, Santiago G.; Salvat, Jorge M. (Asociación Argentina de Neurocirugía (AANC), 2020-11-17)
    Introducción: la fístula dural arteriovenosa espinal (FDAVE) es una enfermedad vascular rara, de etiología desconocida y frecuentemente subdiagnosticada. El tratamiento puede ser microquirúrgico o endovascular Material ...
  • Arritmias auriculares distintas a fibrilación auricular en pacientes con miocardiopatía hipertrófica 
    Moreno, Gerardo A.; Hernández Madrid, Antonio; Doxastakis Florida, Griselda B.; Moro Serrano, Concepción; Pedroso, Williams R.; Abello, Mauricio S. (Federación Argentina de Cardiología, 2020-09-21)
    La Fibrilación Auricular (FA), es la arritmia más frecuente en pacientes con Miocardiopatía Hipertrófica (MCH), sin embargo, existe poca información sobre otras arritmias auriculares en este grupo de pacientes. El objetivo ...
  • Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease 
    Montal, Victor; Vilaplana, Eduard; Pegueroles, Jordi; Bejanin, Alexandre; Alcolea, Daniel; Carmona-Iragui, María; Clarimón, Jordi; Levin, Johannes; Cruchaga, Carlos; Graff-Radford, Neill R.; Noble, James M.; Lee, Jae-Hong; Allegri, Ricardo Francisco; Karch, Celeste M.; Laske, Christoph; Schofield, Peter R.; Salloway, Stephen; Ances, Beau M.; Benzinger, Tammie L.S.; McDade, Eric; Bateman, Randall J.; Blesa, Rafael; Sánchez-Valle, Raquel; Lleó, Alberto; Fortea, Juan; Dominantly Inherited Alzheimer Network (John Wiley & Sons, 2020-11-16)
    Methods: In this study we tested this model fitting linear versus quadratic trajectories and computed the timing of the inflection points vertexwise of cortical thickness and cortical diffusivity-a novel marker of cortical ...
  • Intermediate phenotype of ATP13A2 mutation in two Chilean siblings: Towards a continuum between parkinsonism and hereditary spastic paraplegia 
    Miranda, Marcelo; Harmuth, Florian; Bustamante, M Leonor; Rossi, Malco Damián; Sturm, Marc; Magnusson, Ólafur Th.; Bauer, Peter; Klockgether, Thomas; Ramirez, Alfredo (Elsevier Science, 2020-12)
  • Parkin Pleiotropy: Extremely Atypical Phenotypes in Patients With Compound Heterozygous Mutations 
    Millar Vernetti, Patricio; Rossi, Malco Damián; Merello, Marcelo (Ubiquity Press, 2020-08-13)
    Background: Parkin mutations are suspected in early-onset Parkinson's disease with early motor complications, and in pedigrees showing an autosomal recessive pattern. Some compound heterozygous mutations can present with ...
  • Aspectos clínicos y demográficos de los pacientes con esclerosis múltiple secundaria progresiva en Argentina 
    Gaitán, María Inés; Marrodán, Mariano; Negrotto, Laura; Ysrraelit, María Célica; Miguez, Jimena; Alonso Serena, Marina; Pappolla, Agustín; Patrucco, Liliana; Cristiano, Edgardo; Vrech, Carlos; Rojas, Juan Ignacio; Grupo de Trabajo Relevar EM (Fundación Revista Medicina (Buenos Aires), 2020)
    El objetivo del estudio fue evaluar los aspectos clínicos y demográficos de los pacientes con esclerosis múltiple (EM) secundaria progresiva (EMSP) en los pacientes incluidos en el Registro Argentino de EM (RelevarEM, ...
  • SARS-CoV-2 and the risk of Parkinson's disease: facts and fantasy 
    Merello, Marcelo; Bhatia, Kailash P.; Obeso, José A. (Lancet, 2020-11-27)
  • Differential diagnosis in acute inflammatory myelitis 
    Marrodán, Mariano; Hernández, Micaela Anahí; Kohler, Alejandro Alfredo; Correale, Jorge (Elsevier, 2020-11)
    Introduction: Establishing differential diagnosis between different inflammatory causes of acute transverse myelitis (ATM) can be difficult. The objective of this study was to see which clinical, imaging or laboratory ...
  • Obesity and the risk of Multiple Sclerosis. The role of Leptin 
    Marrodán, Mariano; Farez, Mauricio Franco; Balbuena Aguirre, María Eugenia; Correale, Jorge (Wiley Periodicals, 2021-02)
    Objective: To investigate the effects of leptin on different T-cell populations, in order to gain more insight into the link between leptin and obesity. Methods: Three hundred and nine RRMS patients and 322 controls ...
  • Cervicodorsal extramedullary anaplastic ependymoma with intracranial metastasis 
    Marcó Del Pont, Francisco; Villamil, Facundo; Lorefice, Emiliano; Caffaratti, Guido; Ries Centeno, Tomás; Ruella, Mauro; Mormandi, Rubén (Masson, 2020-10-12)
  • Laminoplastia cervical con foraminotomía unilateral C4-C5: nota técnica y serie de casos 
    Marcó Del Pont, Francisco; Giovannini, Sebastián Juan María; Ries Centeno, Tomás; Caffaratti, Guido; Lorefice, Emiliano; Cervio, Andrés Eduardo (Elsevier España, 2020-11-17)
    Objetivo: La laminoplastía «open door» es una técnica ampliamente utilizada para el tratamiento de la mielopatía cervical multinivel. A pesar de presentar resultados funcionales y radiológicos satisfactorios a largo plazo, ...
  • Dominantly inherited Alzheimer's disease in Latin America: Genetic heterogeneity and clinical phenotypes 
    Llibre Guerra, Jorge J.; Li, Yan; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio; Llibre Rodríguez, Juan J.; Sosa, Ana Luisa; Aláez-Verson, Carmen; Longoria, Erika-Mariana; Tellez, Alberto; Carrillo Sánchez, Karol; Flores Lagunes, Luis Leonardo; Sánchez, Victor; Tadao Takada, Leonel; Nitrini, Ricardo; Ferreira Frota, Norberto Anizio; Benevides Lima, Joyce; Lopera, Francisco; Ramírez, Laura; Jiménez Velázquez, Ivonne (John Wiley & Sons, 2021-04)
    Introduction: A growing number of dominantly inherited Alzheimer's disease (DIAD) cases have become known in Latin American (LatAm) in recent years. However, questions regarding mutation distribution and frequency by country ...
  • Asistencia Endoscópica en la Descompresión Microquirúrgica del Hemiespasmo Facial 
    Lorefice, Emiliano; Ries Centeno, Tomás; Giovannini, Sebastián Juan María; Marcó Del Pont, Francisco; Mormandi, Rubén; Cervio, Andrés Eduardo (Asociación Argentina de Neurocirugía (AANC), 2020-03-12)
    Introducción: El hemiespasmo facial primario (HFP) se produce por la hiperexcitabilidad del nervio facial y sus núcleos de origen como consecuencia de la compresión vascular. La cirugía de descompresión neurovascular se ...
  • World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia 
    Kivipelto, Miia; Mangialasche, Francesca; Snyder, Heather M.; Allegri, Ricardo Francisco; Andrieu, Sandrine; Arai, Hidenori; Baker, Laura; Belleville, Sylvie; Brodaty, Henry; Brucki, Sonia M.; Calandri, Ismael Luis; Caramelli, Paulo; Chen, Christopher; Chertkow, Howard; Chew, Effie; Choi, Seong H.; Chowdhary, Neerja; Crivelli, Lucía; De La Torre, Rafael; Du, Yifeng; Sevlever, Gustavo Emilio (John Wiley & Sons, 2020-07)
    Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of ...
  • Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA 
    Johnston, S Claiborne; Amarenco, Pierre; Denison, Hans; Evans, Scott R; Himmelmann, Anders; James, Stefan; Knutsson, Mikael; Ladenvall, Per; Molina, Carlos A.; Wang, Yongjun; THALES Investigators; Ameriso, Sebastián Francisco (Massachusetts Medical Society, 2020-07-16)
    Background: Trials have evaluated the use of clopidogrel and aspirin to prevent stroke after an ischemic stroke or transient ischemic attack (TIA). In a previous trial, ticagrelor was not better than aspirin in preventing ...
  • Emerging drugs for the treatment of adult MOG-IgG-associated diseases 
    Carnero Contentti, Edgar; Marrodán, Mariano; Correale, Jorge (Taylor & Francis, 2021-04-16)
    Resumen no disponible
  • Optic tract and internal capsule lesion in a patient with Wernicke-Korsakoff syndrome 
    Hernández, Micaela Anahí; Varela, Francisco José; Bensi, Catalina (Universidad de la Costa, 2020-12-07)
    A 72-year-old man, presented with a one-week history of confusion and an anterograde amnesic disorder accompanied by confabulation, with lack of insight to his symptoms. Medical history included alcohol abuse and admitted ...
  • Acute Ischemic Stroke 
    Hawkes, Maximiliano Alberto; Rabinstein, Alejandro A. (Springer, 2020)
    Ischemic stroke is a medical emergency associated with significant morbidity and mortality. Over the past 25 years, the treatment of acute ischemic stroke has dramatically evolved. Currently, ischemic brain reperfusion is ...
  • Chemical hypoxia induces apoptosis of human pluripotent stem cells by a NOXA-mediated HIF-1α and HIF-2α independent mechanism 
    Isaja, Luciana; Mucci, Sofía; Vera, Jonathan; Rodríguez Varela, María Soledad; Marazita, Mariela Claudia; Morris-Hanon, Olivia; Videla Richardson, Guillermo Agustín; Sevlever, Gustavo Emilio; Scassa, María Élida; Romorini, Leonardo (Nature Publishing Group, 2020-10-26)
    Human embryonic and induced pluripotent stem cells (hESCs and hiPSCs) are self-renewing human pluripotent stem cells (hPSCs) that can differentiate to a wide range of specialized cells. Notably, hPSCs enhance their ...

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