Repositorio Institucional FLENI: Recent submissions

  • Latin America has been under-represented in dementia clinical trials, we must turn the corner 
    Allegri, Ricardo Francisco; Román, Fabián; Barceló Martínez, Ernesto (Universidad de la Costa, 2022-06-11)
    The world’s population is aging, life expectancy is increasing in the past century as result of the improvements in healthcare and the people arrive to live longer and healthier. However, this has also resulted in increase ...
  • Consecuencias Neurológicas y Psiquiátricas a largo plazo (6 meses) en pacientes con COVID leve de la comunidad 
    Allegri, Ricardo Francisco; Calandri, Ismael Luis; Caride, Alejandro; Román, Fabián; Llera, J.; Palma, A.; Bartoloni, L.; Carozzela, A.; González Sanz, P.; Mouchet, E.; Fernández Díaz, Paula C.; Morasso, C.; Tarulla, Adriana (Universidad de la Costa, 2022-06-08)
    Las complicaciones neurológicas a largo plazo de la infección por coronavirus han sido descriptas en los pacientes hospitalizados en el episodio agudo. De ellos el 63% presentaron fatiga y debilidad muscular, el 26% ...
  • El servicio de referencia ante la pandemia de COVID-19. Estudio de caso. 
    Grimberg, Daniela; Soria, Mónica Alejandra; Colombo, Floriana (Instituto de Investigaciones Bibliotecológicas, 2022-12-02)
    La pandemia de COVID-19 impactó en el trabajo diario de todos los ciudadanos. Sobre todo en nuestras bibliotecas, dado que, a partir del Aislamiento Social, Preventivo y Obligatorio (ASPO), en poco tiempo, se vieron obligadas ...
  • Multiple sclerosis progression: time for a new mechanism-driven framework 
    Kuhlmann, Tanja; Moccia, Marcello; Coetzee, Timothy; Cohen, Jeffrey A.; Graves, Jennifer; Marrie, Ruth Ann; Montalban, Xavier; Yong, V. Wee; Thompson, Alan J.; Reich, Daniel S.; Correale, Jorge; International Advisory Committee on Clinical Trials in Multiple Sclerosis (Lancet Pub. Group, 2022-11-18)
    Traditionally, multiple sclerosis has been categorised by distinct clinical descriptors-relapsing-remitting, secondary progressive, and primary progressive-for patient care, research, and regulatory approval of medications. ...
  • Acute severe hypoxia induces apoptosis of human pluripotent stem cells by a HIF-1α and P53 independent mechanism 
    Mucci, Sofía; Isaja, Luciana; Rodríguez Varela, María Soledad; Ferriol Laffouillere, Sofía Luján; Marazita, Mariela Claudia; Videla Richardson, Guillermo Agustín; Sevlever, Gustavo Emilio; Scassa, María Élida; Romorini, Leonardo (Nature Publishing Group, 2022-10-05)
    Human embryonic and induced pluripotent stem cells are self-renewing pluripotent stem cells (hPSCs) that can differentiate into a wide range of specialized cells. Although moderate hypoxia (5% O2) improves hPSC self-renewal, ...
  • Perspectiva neurológica en la elección del anticoagulante oral directo para la prevención del accidente cerebrovascular en fibrilación auricular 
    Ameriso, Sebastián Francisco; Pujol Lereis, Virginia Andrea (Fundación Revista Medicina, 2022-10)
    La fibrilación auricular no valvular (FA) es la arritmia con potencial embolígeno más prevalente y una de las principales y crecientes causas de accidente cerebrovascular isquémico (ACVi). El principal objetivo del uso ...
  • Which biological pathways are responsible for the late appearance of brain metastases in renal cell carcinoma? Analysis of eight cases 
    Minghinelli, Federico E.; Recalde, Rodolfo José; Prost, Diego Martín; Cutuli, Hernán Javier; Giovannini, Sebastián Juan María; Zaninovich, Roberto Steven (Scientific Scholar LLC, 2022-10-14)
    Background: Renal cell carcinoma (RCC) represents 1% of all cancers and its brain metastases amount to 8.1% of all metastatic tumors. Late brain metastases are defined as tumors that appear 10 years after diagnosis of the ...
  • SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy 
    Muñiz, Javier Andrés; Facal, Carolina Lucía; Urrutia, Leandro; Clerici Delville, Ramiro; Damianich, Ana; Ferrario, Juan Esteban; Falasco, Germán; Avale, María Elena (Frontiers Media S.A., 2022-09-05)
    Tau is a microtubule-associated protein predominantly expressed in neurons, which participates in microtubule polymerization and axonal transport. Abnormal tau metabolism leads to neurodegenerative diseases named tauopathies, ...
  • Pseudo One-And-A-Half Syndrome in a Myasthenia Gravis Patient 
    Marrodán, Mariano; Castiglione, Juan Ignacio; Wainberg, Florencia N.; Rivero, Alberto Daniel (Neurological Society of India, 2022-09)
  • Predictive factors for the development of epilepsy after ischemic stroke 
    Alet, Matías Javier; Márquez, Fernando N.; Marone, Abril; Darakdjian, Maximiliano; Sosa, Federico; Bonamico, Lucas; Ameriso, Sebastián Francisco (Saunders, 2022-12)
    Objectives: Ischemic stroke is one of the most common causes of epilepsy in adults. The incidence of post-stroke epilepsy (PSE) is approximately 7%. Risk factors are higher stroke severity, cortical localization, higher ...
  • Genotype-Phenotype Correlations for ATX-TBP (SCA17): MDSGene Systematic Review 
    Rossi, Malco Damián; Hamed, Moath; Rodríguez Antigüedad, Jon; Cornejo Olivas, Mario; Breza, Marianthi; Lohmann, Katja; Klein, Christine; Rajalingam, Rajasumi; Marras, Connie; Van de Warrenburg, Bart (Wiley-Liss, 2022-11-14)
    Spinocerebellar ataxia type 17 or ATX-TBP is a CAG/CAA repeat expansion disorder characterized by marked clinical heterogeneity. Reports of affected carriers with subthreshold repeat expansions and of patients with Parkinson's ...
  • Connectivity and Patterns of Regional Cerebral Blood Flow, Cerebral Glucose Uptake, and Aβ-Amyloid Deposition in Alzheimer's Disease (Early and Late-Onset) Compared to Normal Ageing 
    Falasco, Germán; Damián, Andrés; Urrutia, Leandro; Niell, Nicolás; Lago, Graciela; Bérgamo, Yanina; Chrem Méndez, Patricio Alexis; Quagliata, Adriana; Bentancourt, Cecilia; Calandri, Ismael Luis; Cordero, Ismael; Ponce de León, Magdalena; Contreras, Valeria; Feuerstein, Viviana; Dansilio, Sergio; Allegri, Ricardo Francisco; Engler, Henry; Vázquez, Silvia (Bentham Science Publishers, 2021-11-15)
    Purpose: The aim of this study was to investigate the differences in early (EOAD) and late (LOAD) onset of Alzheimer´s disease, as well as glucose uptake, regional cerebral blood flow (R1), amyloid depositions, and functional ...
  • Polisomnografía nocturna y test múltiple de latencias del sueño. Nociones básicas e indicaciones. Guía práctica. Grupo de sueño – Sociedad Neurológica Argentina. 
    Berrozpe, Elda Cecilia; Folgueira, Agustín Leandro; Gonzalez Cardozo, Agustín; Ponce de León, Marcela; Valiensi, Stella Maris (Elsevier, 2022-09-10)
    Los estudios de sueño son registros no invasivos en los que se graban señales de diferentes variables fisiológicas durante el sueño y la vigilia. El objetivo de esta guía es brindar conocimientos sobre polisomnografía (PSG) ...
  • The “Dot Sign” a New Diagnostic Finding in Giant-Cell Arteritis 
    Castiglione, Juan Ignacio; Hawkes, Maximiliano Alberto; Ameriso, Sebastián Francisco (Neurological Society of India, 2022)
  • Advances in Treatment of Frontotemporal Dementia 
    Magrath Guimet, Nahuel; Zapata-Restrepo, Lina M.; Miller, Bruce L. (American Psychiatric Press, 2022)
    In this review, the authors explored the clinical features of frontotemporal dementia (FTD), focusing on treatment. The clinical features of FTD are unique, with disinhibition, apathy, loss of empathy, and compulsions ...
  • Biomarcadores radiológicos en RM para una aproximación al diagnóstico molecular en gliomas IDH-mutados (grado II y III) 
    Darakdjian, Maximiliano; Osa Sanz, Emilia; Hernández Pinzón, Jairo; Carnevale, Martín Diego; Diebel, Alfonsina; Arakaki, Naomi; Martinetto, Horacio; Sevlever, Gustavo Emilio; Yáñez, Paulina (Sociedad Argentina de Radiología, 2021-12-22)
    Objetivo: Analizar características por resonancia magnética (RM) de gliomas IDH-mutados (grado II y III) en base a parámetros cualitativos, a fin de valorar el rendimiento del signo del mismatch T2-FLAIR y otras ...
  • Cutaneous amyloid is a biomarker in early ATTRv neuropathy and progresses across disease stages 
    Freeman, Roy; González-Duarte, Alejandra; Barroso, Fabio Adrián; Campagnolo, Marta; Rajan, Sharika; Garcia, Jennifer; Young Kim, Jee; Wang, Ningshan; Orellana, Lucas Gabriel; Gibbons, Christopher (Wiley Periodicals, 2022-09)
    Objective: To determine the sensitivity and specificity of cutaneous amyloid deposition in relation to patient-reported measures in the earliest disease stage of hereditary ATTR amyloidosis (ATTRv). Methods: In a ...
  • CL28. ¿Es útil la evaluación ósea estándar en pacientes con acromegalia? 
    González Pernas, Mariana Soledad; Danilowicz, Karina; Katz, Débora Adela; Sosa, Soledad; Slavinsky, Patricia; Longobardi, Vanesa; Zanchetta, María Belén (Asociación Argentina de Osteología y Metabolismo Mineral, 2022)
  • How much time is needed in clinical practice to reach a diagnosis of clinically established Parkinson's disease? 
    Rossi, Malco Damián; Perez Lloret, Santiago; Merello, Marcelo (Elsevier, 2021-10-22)
    Introduction: The implementation of accepted clinical diagnostic criteria has improved the accuracy of a clinical diagnosis of Parkinson's disease (PD). Time frames of 3-10 years have been empirically proposed to reach a ...
  • The commercial genetic testing landscape for Parkinson's disease 
    Cook, Lola; Schulze, Jeanine; Verbrugge, Jennifer; Beck, James C.; Marder, Karen S.; Saunders-Pullman, Rachel; Klein, Christine; Naito, Anna; Alcalay, Roy N.; Clinical Genome Resource (ClinGen) Parkinson's Disease Gene Curation Expert Panel Authors; Movement Society Disorder (MDS) Task Force on Recommendations for Clinical Genetic Testing in Parkinson's Disease Authors (Elsevier, 2021-11-27)
    Introduction: There have been no specific guidelines regarding which genes should be tested in the clinical setting for Parkinson's disease (PD) or parkinsonism. We evaluated the types of clinical genetic testing offered ...

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