Repositorio Institucional FLENI: Recent submissions

  • Microglial modulation through colony-stimulating factor-1 receptor inhibition attenuates demyelination 
    Wies Mancini, Victoria Sofía Berenice; Pasquini, Juana María; Correale, Jorge; Pasquini, Laura Andrea (Wiley, 2018-11-19)
    Multiple sclerosis (MS) is one of the most common causes of progressive disability affecting young people with very few therapeutic options available for its progressive forms. Its pathophysiology involves demyelination ...
  • Gender discrepancy in research activities during radiology residency 
    Vernuccio, Federica; Arzanauskaite, Monika; Turk, Sevcan; Terrazas Torres, Estefanía; D. Choa, Joanna Marie; Udare, Ashlesha Satish; Haroun, Dina; Serra, María Mercedes; Shelmerdine, Susan; Bold, Bayarbaatar; Bae, Jae Seok; Estades Romero, Eduardo; Vilgrain, Valérie (Springer, 2019-12-21)
    Objective: To investigate the presence of gender disparity in academic involvement during radiology residency and to identify and characterize any gender differences in perceived barriers for conducting research. Methods: ...
  • The Role of Poly(ADP-ribose) in α-Synuclein Neurodegeneration: Another Piece of the Puzzle for α-Synucleinopathies 
    Millar Vernetti, Patricio (Wiley, 2019-01-21)
    In the last few years, the involvement of poly (ADP-ribose) (PAR) polymerase-1 (PARP-1) in the cellular death process known as parthanatos, which is thought to underlie many neurodegenerative disorders1 has been gaining ...
  • Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39 
    Takenaka, Maisa C.; Gabriely, Galina; Rothhammer, Veit; Mascanfroni, Ivan D.; Wheeler, Michael A.; Chao, Chun-Cheih; Gutiérrez-Vázquez, Cristina; Kenison, Jessica; Tjon, Emily C.; Barroso, Andreia; Vandeventer, Tyler; Alves de Lima, Kalil; Rothweiler, Sonja; Mayo, Lior; Ghannam, Soufiene; Zandee, Stephanie; Healy, Luke; Sherr, David; Farez, Mauricio Franco; Prat, Alexandre; Antel, Jack; Reardon, David A.; Zhang, Hailei; Robson, Simon C.; Getz, Gad; Weiner, Howard L.; Quintana, Francisco J. (Nature Publishing Group, 2019-04-08)
    Tumor-associated macrophages (TAMs) play an important role in the immune response to cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell immunity are not completely understood. Here we ...
  • The role of fluid intelligence in ascertaining neuropsychological and functional differences between bipolar disorder and primary psychotic disorders 
    Samamé, Cecilia (Wiley, 2019-05-22)
    Resumen no disponible
  • Prognostic value of ATN Alzheimer biomarkers: 60-month follow-up results from the Argentine Alzheimer’s Disease Neuroimaging Initiative. 
    Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Calandri, Ismael Luis; Cohen, Gabriela; Martín, María Eugenia; Russo, María Julieta; Crivelli, Lucía; Pertierra, Lucía; Tapajóz Pereira de Sampaio, Fernanda; Clarens, María Florencia; Campos, Jorge; Nahas, Federico Ezequiel; Vázquez, Silvia; Surace, Ezequiel Ignacio; Sevlever, Gustavo Emilio (Elsevier, 2020)
    Purpose: To describe results of the Amyloid, Tau, Neurodegeneration (ATN) research framework classification in the Argentine-Alzheimer’s Disease Neuroimaging Initiative (arg-ADNI) cohort. Methods: Twenty-three patients ...
  • Tourette syndrome: Clinical benefit with unilateral stimulation after bilateral pallidal implant 
    Rossi, Malco Damián; Cerquetti, Daniel; Cammarota, Ángel Norberto; Merello, Marcelo (Wiley, 2019-02-22)
    Resumen no disponible
  • Evaluation of Cerebrospinal Fluid Neurofilament Light Chain as a Routine Biomarker in a Memory Clinic 
    Niikado, Matías; Chrem Méndez, Patricio Alexis; Itzcovich, Tatiana; Barbieri-Kennedy, Micaela; Calandri, Ismael Luis; Martinetto, Horacio; Serra, María Mercedes; Calvar, Jorge Andrés; Campos, Jorge; Russo, María Julieta; Pertierra, Lucía; Allegri, Ricardo Francisco; Sevlever, Gustavo Emilio; Surace, Ezequiel Ignacio (Oxford, 2019-03-14)
    Systematic evaluation of biomarkers in representative populations is needed to validate their clinical utility. In this work, we assessed the diagnostic performance of cerebrospinal fluid (CSF) neurofilament light chain ...
  • Palmar pustular psoriasis associated with teriflunomide treatment 
    Negrotto, Laura; Correale, Jorge (Elsevier, 2019-01)
    Background Cutaneous adverse effects of Teriflunomide have been rarely reported. Objective and methods We report a relapsing remitting multiple sclerosis patient that developed palmar pustular psoriasis within one ...
  • Frequency of diagnoses in a specialized headache clinic in Buenos Aires 
    Nagel, Vanesa; Cavanagh, Sol; Olivier, Marina; Larripa, Natalia; Gutierrez, María T.; Grandinetti, Mariela; Calvo, Daniela; Salvat, Fernando; Bonamico, Lucas; Goicochea, María Teresa (Sociedade Brasileira de Cefaleia, 2019-09-24)
    Objective: Headache is one of the most frequent reason for consultations in neurology. The global prevalence among adults with migraine is approximately 10% with migraine, 40% for tension-type headache (TTH) and 3% for ...
  • Palbociclib Effectively Halts Proliferation but Fails to Induce Senescence in Patient-Derived Glioma Stem Cells 
    Morris-Hanon, Olivia; Marazita, Mariela Claudia; Romorini, Leonardo; Isaja, Luciana; Fernandez-Espinosa, Damián Darío; Sevlever, Gustavo Emilio; Scassa, María Élida; Videla Richardson, Guillermo Agustín (Springer, 2019-05-23)
    Glioblastoma multiforme is the most aggressive primary brain tumor. Current knowledge suggests that the growth and recurrence of these tumors are due in part to the therapy-resistant glioma stem cell subpopulation, which ...
  • R534C mutation in hERG causes a trafficking defect in iPSC-derived cardiomyocytes from patients with type 2 long QT syndrome 
    Mesquita, Fernanda C.P.; Arantes, Paulo C.; Kasai-Brunswick, Tais Hanae; Araujo, Dayana S.; Gubert, Fernanda; Monnerat, Gustavo; Silva dos Santos, Danúbia; Neiman, Gabriel; Leitão, Isabela C.; Barbosa, Raiana A. Q.; Coutinho, Jorge L.; Vaz, Isadora M.; dos Santos, Marcus N.; Borgonovo, Tamara; Cruz, Fernando E. S.; Miriuka, Santiago Gabriel; Medei, Emiliano H.; Campos de Carvalho, Antonio C.; Carvalho, Adriana B. (Nature Publishing Group, 2019-12-16)
    Patient-specific cardiomyocytes obtained from induced pluripotent stem cells (CM-iPSC) offer unprecedented mechanistic insights in the study of inherited cardiac diseases. The objective of this work was to study a type 2 ...
  • Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer’s disease 
    Vöglein, Jonathan; Paumier, Katrina; Jucker, Mathias; Preische, Oliver; McDade, Eric; Hassenstab, Jason; Benzinger, Tammie L.S.; Noble, James M.; Berman, Sarah B.; Graff-Radford, Neill R.; Ghetti, Bernardino; Farlow, Martin R.; Chhatwal, Jasmeer P.; Salloway, Stephen; Xiong, Chengjie; Karch, Celeste M.; Cairns, Nigel; Mori, Hiroshi; Schofield, Peter R.; Masters, Colin L.; Goate, Alison M.; Buckles, Virginia; Fox, Nick C.; Rossor, Martin N.; Chrem Méndez, Patricio Alexis; Allegri, Ricardo Francisco; Ringman, John M.; Höglinger, Günter U.; Steiner, Harald; Dieterich, Marianne; Haass, Christian; Laske, Christoph; Morris, John C.; Bateman, Randall J.; Danek, Adrian; Levin, Johannes; Dominantly Inherited Alzheimer Network (Oxford, 2019-03-20)
    Owing to an early and marked deposition of amyloid-β in the basal ganglia, autosomal dominant Alzheimer’s disease could distinctly involve motor symptoms. Therefore, we aimed to assess the prevalence and characteristics ...
  • Mechanical thrombectomy for reperfusion of acute ischemic stroke in a Stroke Unit in Argentina 
    Alet, Matías Javier; Rodríguez Lucci, Federico; Ameriso, Sebastián Francisco (Associacao Arquivos De Neuro-Psiquitria Dr Oswaldo Lange, 2020-01)
    Objective: Stroke is an important cause of morbidity and mortality worldwide. Reperfusion therapy with intravenous tissue plasminogen activator (IV-tPA) was first implemented in 1996. More recently, endovascular reperfusion ...
  • Acute amnestic syndromes 
    Alessandro, Lucas; Ricciardi, Mario Emiliano; Chaves, Hernán; Allegri, Ricardo Francisco (Elsevier, 2020-03-18)
    Acute amnestic syndromes are usually rare clinical events occurring in emergency situations. Etiological diagnosis can be challenging and underlying causes diverse. They can be transient and totally reversible, or accompanied ...
  • Differential Diagnosis in Late Onset Multiple Sclerosis 
    Yorio, Florencia; Marrodán, Mariano; Farez, Mauricio Franco; Correale, Jorge (AAN, 2019-04-09)
    Objective: To identify clinical-radiological characteristics of patients consulting with suspected Late Onset Multiple Sclerosis (LOMS). Background: LOMS is defined by clinical presentation after 50 years of age, being ...
  • Deep Learning Neural Networks Highly Predict Very Early Onset of Pluripotent Stem Cell Differentiation 
    Waisman, Ariel; La Greca, Alejandro; Möbbs, Alan Miqueas; Scarafía, María Agustina; Santín Velazque, Natalia Lucía; Neiman, Gabriel; Moro, Lucía Natalia; Luzzani, Carlos Daniel; Sevlever, Gustavo Emilio; Guberman, Alejandra S.; Miriuka, Santiago Gabriel (Elsevier, 2019-04-09)
    Deep learning is a significant step forward for developing autonomous tasks. One of its branches, computer vision, allows image recognition with high accuracy thanks to the use of convolutional neural networks (CNNs). Our ...
  • Cell cycle dynamics of mouse embryonic stem cells in the ground state and during transition to formative pluripotency 
    Waisman, Ariel; Sevlever, Federico; Costa, Martín Elías; Cosentino, María Soledad; Miriuka, Santiago Gabriel; Ventura, Alejandra C.; Guberman, Alejandra S. (Nature Publishing Group, 2019-05-29)
    Mouse embryonic stem cells (mESCs) can be maintained as homogeneous populations in the ground state of pluripotency. Release from this state in minimal conditions allows to obtain cells that resemble those of the early ...
  • Video Head Impulse Test Contributes to Susac Syndrome Diagnosis 
    Marrodán, Mariano; Laffue, Alfredo Hernan; Fiol, Marcela Paula; Correale, Jorge; Gualtieri, Francisco José (Springer, 2019-05-07)
    Resumen no disponible
  • Disease activity impacts disability progression in primary progressive multiple sclerosis 
    Marrodán, Mariano; Bensi, Catalina; Pappolla, Agustín; Rojas, Juan Ignacio; Gaitán, María Inés; Ysrraelit, María Célica; Negrotto, Laura; Fiol, Marcela Paula; Patrucco, Liliana; Cristiano, Edgardo; Farez, Mauricio Franco; Correale, Jorge (Elsevier, 2019-12-14)
    Background Although solid information on the natural history of primary progressive multiple sclerosis (PPMS) is available, evidence regarding impact of disease activity on PPMS progression remains controversial. Objective To ...

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