Repositorio Institucional FLENI: Recent submissions

  • Estudio epidemiológico de sepsis grave pediátrica en la República Argentina 
    Jabornisky, Roberto; Sáenz, Silvia S.; Capocasa, Patricia; Jaen, Roxana; Moreno, Rodolfo P.; Landry, Luis; Rufach, Daniel; Santos, Silvia N.; Berrueta, Mabel; Carcillo, Joseph; Vassallo, Juan Carlos; Grupo de Investigación Clínica y Epidemiológica en Terapia Intensiva Pediátrica de la Sociedad Argentina de Pediatría (Sociedad Argentina de Pediatría, 2019-06)
    Introduction: Severe sepsis (SS) is one of the leading causes of pediatric mortality in Argentina. The objective was to describe the epidemiological characteristics and to analyze risk factors associated with mortality ...
  • Stroke Epidemiology in Argentina. Design of a Population-Based Study in General Villegas (EstEPA) 
    Pujol Lereis, Virginia Andrea; Melcon, Mario O.; Hawkes, Maximiliano Alberto; Gómez Schneider, Maia Macarena; Dossi, Daiana Elizabeth; Alet, Matías Javier; Povedano, Guillermo Pablo; Gonzalez, Claudio D.; Ameriso, Sebastián Francisco (Elsevier, 2018-10-04)
    Background: Epidemiological data on stroke is scarce in Latin America. Estudio Epidemiológico Poblacional sobre Accidente Cerebrovascular (EstEPA) is a population-based program planned to assess prevalence, incidence, ...
  • Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease 
    Preische, Oliver; Schultz, Stephanie A.; Apel, Anja; Kuhle, Jens; Kaeser, Stephan A.; Barro, Christian; Gräber-Sultan, Susanne; Kuder-Buletta, Elke; LaFougere, Christian; Laske, Christoph; Vöglein, Jonathan; Levin, Johannes; Masters, Colin L.; Martins, Ralph N.; Schofield, Peter R.; Rossor, Martin N.; Dominantly Inherited Alzheimer Network (Nature Publishing Group, 2019-01-21)
    Neurofilament light chain (NfL) is a promising fluid biomarker of disease progression for various cerebral proteopathies. Here we leverage the unique characteristics of the Dominantly Inherited Alzheimer Network and ...
  • Disrupted functional connectivity of the locus coeruleus in healthy adults with parental history of Alzheimer's disease 
    Del Cerro, Inés; Villarreal, Mirta Fabiana; Abulafia, Carolina; Duarte-Abritta, Bárbara; Sánchez, Stella Maris; Castro, Mariana Nair; Bocaccio, Hernán; Ferrer, Isidre; Menchón, José Manuel; Sevlever, Gustavo Emilio; Nemeroff, Charles B.; Soriano-Mas, Carles; Guinjoan, Salvador Martín (Pergamon Press, 2020-04)
    Prevention and early treatment strategies for Alzheimer's disease (AD) are hampered by the lack of research biomarkers. Neuropathological changes in the Locus Coeruleus (LC) are detected early in AD, and noradrenaline plays ...
  • Structural brain abnormalities in schizophrenia in adverse environments: examining the effect of poverty and violence in six latin american cities 
    Crossley, Nicolas; Zugman, Andre; Reyes-Madrigal, Francisco; Czepielewski, Leticia; Castro, Mariana Nair; Diaz-Zuluaga, Ana María; Pineda-Zapata, Julián; Reckziegel, Ramiro; Gadelha, Ary; Jackowski, Andrea; Noto, Cristiano; Alliende Serra, Luz Maria; Iruretagoyena, Bárbara; Ossandon, Tomas; Ramirez-Mahaluf, Juan Pablo; Castañeda, Carmen Paz; Gonzalez-Valderrama, Alfonso; Nachar, Rubén; León-Ortiz, Pablo; Undurraga, Juan; Lopez-Jaramillo, Carlos; Guinjoan, Salvador Martín; Gama, Clarissa; De la Fuente-Sandoval, Camilo; Bressan, Rodrigo (Oxford University Press, 2020-04)
    Background Social and environmental factors such as poverty or violence, modulate the risk and course of schizophrenia, but how they affect the brain in patients with psychosis remains unclear. We here studied how they ...
  • What is the role of axonal ion channels in multiple sclerosis? 
    Correale, Jorge; Marrodán, Mariano; Benarroch, Eduardo E. (Lippincott Williams & Wilkins, 2020-07-21)
    Resumen no disponible
  • Use of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe): an analysis of paediatric survey data from 56 countries 
    Hsia, Yingfen; Lee, Brian L.; Versporten, Ann; Yang, Yonghong; Bielicki, Julia; Jackson, Charlotte; Newland, Jason; Goossens, Herman; Magrini, Nicola; Sharland, Mike; GARPEC network; SHARPS collaborative; Global-PPS network (Elsevier, 2019-06-11)
    Background Improving the quality of hospital antibiotic use is a major goal of WHO's global action plan to combat antimicrobial resistance. The WHO Essential Medicines List Access, Watch, and Reserve (AWaRe) classification ...
  • An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations 
    Dube, Umber; Del-Aguila, Jorge L.; Li, Zeran; Budde, John P.; Jiang, Shan; Hsu, Simon; Ibanez, Laura; Fernandez, Maria Victoria; Farias, Fabiana; Norton, Joanne; Gentsch, Jen; Wang, Fengxian; Salloway, Stephen; Masters, Colin L.; Lee, Jae-Hong; Graff-Radford, Neill R.; Dominantly Inherited Alzheimer Network (Nature Publishing Group, 2019-10-07)
    Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; ncontrol = 13; nAD = 83) from the Knight Alzheimer Disease Research Center (Knight ADRC). Using this and ...
  • Evaluation of the effects of sodium–glucose co‐transporter 2 inhibition with empagliflozin on morbidity and mortality in patients with chronic heart failure and a preserved ejection fraction: rationale for and design of the EMPEROR‐Preserved Trial 
    Anker, Stefan D.; Butler, Javed; Filippatos, Gerasimos; Waheed, Jamal; Salsali, Afshin; Schnee, Janet; Kimura, Karen; Zeller, Cordula; Jyothis, George; Brueckmann, Martina; Zannad, Faiez; Packer, Milton; EMPEROR-Preserved Trial Committees and Investigators (Wiley, 2019-09-16)
    Background: The principal biological processes that characterize heart failure with a preserved ejection fraction (HFpEF) are systemic inflammation, epicardial adipose tissue accumulation, coronary microcirculatory ...
  • Neuropsychological profile of Alzheimer’s disease based on amyloid biomarker findings results from a South American cohort. Appl Neuropsychol Adult 1–6. 
    Clarens, María Florencia; Crivelli, Lucía; Calandri, Ismael Luis; Chrem Méndez, Patricio Alexis; Martin, María Eugenia; Russo, María Julieta; Campos, Jorge; Surace, Ezequiel Ignacio; Vázquez, Silvia; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco (Taylor & Francis Group, 2020-04-30)
    Objective: Increased life expectancy and exponential growth of adults suffering from Alzheimer's disease (AD) worldwide, has led to biomarkers incorporation for diagnosis in early stages. Use of neuropsychological testing ...
  • Transverse Myelitis in Systemic Lupus Erythematosus: Clinical Features and Prognostic Factors in a Large Cohort of Latin American Patients. 
    Chiganer, Edson Hernán; Lessa, Carmen Flora; Di Pace, José Luis; Perassolo, Mónica Beatriz; Carnero Contentti, Edgar; Alessandro, Lucas; Correale, Jorge; Farfan, María Fernanda; Galiana, Graciana Lourdes; Benavides, Marvin Sánchez; Pacello, Franco; Stagno, Mauro; Cardozo, Analía; Cantero, María Belén Nacimiento; Elizaur López, Juan Gabriel; Delgadillo, Pedro Daniel; Melgarejo, Patricia; Acosta Colman, Isabel; Vázquez Báez, Marcos Aurelio; Correa Díaz, Edgar Patricio; Jácome Sánchez, Elisa Carolina; Linares, Magaly Alva; Zamora Tehozol, Erick Adrian; Fragoso-Loyo, Hilda Esther; Quintanilla-González, Lauro; Batún-Garrido, José Antonio de Jesús; Sato, Emilia Inoue; do Reis-Neto, Edgard Torres; Carreño Nigro, María Angela; Hryb, Javier Pablo (Lippincott Williams & Wilkins, 2020-02-05)
    Background: Acute transverse myelitis (ATM) is an infrequent but severe complication of systemic lupus erythematosus (SLE). The purpose of study was to describe clinical features and prognostic factors of patients with ...
  • Barriers to access and utilization of multiple sclerosis care services in a large cohort of Latin American patients 
    Carnero Contentti, Edgar; Giachello, Susana; Correale, Jorge (Sage, 2021-01)
    Background: Multiple sclerosis (MS), is an emergent disease in Latin America (LATAM), which raises substantial socioeconomic challenges to a region where most countries remain as economies in development. Objective: To ...
  • Early data on long-term efficacy and safety of inotersen in patients with hereditary transthyretin amyloidosis: a 2-year update from the open-label extension of the NEURO-TTR trial 
    Brannagan, Thomas H.; Wang, Annabel K.; Coelho, Teresa; Waddington Cruz, Marcia; Polydefkis, Michael J.; Dyck, P. James B.; Planté-Bordeneuve, Violaine; Berk, John L.; Barroso, Fabio Adrián; Merlini, Giampaolo; Conceição, Isabel; Hughes, Steven G.; Kwoh, Jesse; Jung, Shiangtung W.; Guthrie, Spencer; Pollock, Michael; Benson, Merrill D.; Gertz, Morie; NEURO-TTR open-label extension investigators (Wiley, 2020-08)
    Background and purpose: Hereditary transthyretin (hATTR) amyloidosis causes progressive polyneuropathy resulting from transthyretin (TTR) amyloid deposition throughout the body, including the peripheral nerves. The efficacy ...
  • Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives 
    Pallavicini, Carla; Vilas, Martina G.; Villarreal, Mirta Fabiana; Zamberlan, Federico; Muthukumaraswamy, Suresh; Nutt, David; Carhart-Harris, Robin; Tagliazucchi, Enzo (Elsevier, 2019-06-24)
    Classic serotonergic psychedelics are remarkable for their capacity to induce reversible alterations in consciousness of the self and the surroundings, mediated by agonism at serotonin 5-HT2A receptors. The subjective ...
  • Psychological, clinical, and therapeutic predictors of the outcome of detoxification in a large clinical population of medication-overuse headache: A six-month follow-up of the COMOESTAS Project 
    Bottiroli, Sara; Allena, Marta; Sances, Grazia; De Icco, Roberto; Avenali, Micol; Fadic, Ricardo; Katsarava, Zaza; Lainez, Miguel J. A.; Goicochea, María Teresa; Bendtsen, Lars; Højland Jensen, Rigmor; Nappi, Giuseppe; Tassorelli, Cristina; COMOESTAS Consortium (Sage, 2018-06-27)
    Aim: To identify factors that may be predictors of the outcome of a detoxification treatment in medication-overuse headache. Methods: Consecutive patients entering a detoxification program in six centres in Europe and ...
  • Economic benefits of treating medication-overuse headache - results from the multicenter COMOESTAS project 
    Jellestad, Pernille Linde; Ninett Carlsen, Louise; Westergaard, Maria Lurenda; Munksgaard, Signe Bruun; Bendtsen, Lars; Lainez, Miguel J. A.; Fadic, Ricardo; Katsarava, Zaza; Goicochea, María Teresa; Spadafora, Santiago; Højland Jensen, Rigmor; Nappi, Giuseppe; Tassorelli, Cristina; COMOESTAS Consortium (Sage, 2018-07-08)
    Background: Medication-overuse headache is a costly disease for individuals and society. Objective: To estimate the impact of medication-overuse headache treatment on direct and indirect headache-related health care ...
  • A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease 
    Barthélemy, Nicolas R.; Li, Yan; Joseph-Mathurin, Nelly; Gordon, Brian A.; Hassenstab, Jason; Benzinger, Tammie L.S.; Buckles, Virginia; Fagan, Anne M.; Perrin, Richard J.; Goate, Alison M.; Morris, John C.; Karch, Celeste M.; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Berman, Sarah B.; Ikeuchi, Takeshi; Mori, Hiroshi; Shimada, Hiroyuki; Shoji, Mikio; Suzuki, Kazushi; Noble, James M.; Farlow, Martin R.; Chhatwal, Jasmeer P.; Graff-Radford, Neill R.; Salloway, Stephen; Schofield, Peter R.; Masters, Colin L.; Martins, Ralph N.; O’Connor, Antoinette; Fox, Nick C.; Levin, Johannes; Jucker, Mathias; Gabelle, Audrey; Lehmann, Sylvain; Sato, Chihiro; Bateman, Randall J.; McDade, Eric; Dominantly Inherited Alzheimer Network (Nature, 2020-03)
    Development of tau-based therapies for Alzheimer's disease requires an understanding of the timing of disease-related changes in tau. We quantified the phosphorylation state at multiple sites of the tau protein in cerebrospinal ...
  • Menarche, pregnancies, and breastfeeding do not modify long-term prognosis in multiple sclerosis 
    Zuluaga, María I.; Otero-Romero, Susana; Rovira, Álex; Perez Hoyos, Santiago; Arrambide, Georgina; Negrotto, Laura; Galán, Ingrid; Río, Jordi; Comabella, Manuel; Nos, Carlos; Arévalo, María Jesus; Vidal Jordana, Angela; Castilló, Joaquín; Rodríguez, Breogán; Midaglia, Luciana; Mulero, Patricia; Mitjana, Raquel; Auger, Cristina; Sastre Garriga, Jaume; Montalban, Xavier; Tintoré, Mar (Lippincott Williams & Wilkins, 2019-03-01)
    Objective: To investigate the effect of menarche, pregnancies, and breastfeeding on the risk of developing multiple sclerosis (MS) and disability accrual using a multivariate approach based on a large prospective cohort ...
  • Sensitivity and specificity of different hand positions to assess upper limb rest tremor 
    Wilken, Miguel; Bruno, Verónica; Rossi, Malco Damián; Ameghino, Lucía; Deuschl, Günther; Merello, Marcelo (Wiley, 2019-02-20)
    Background: Hand position for rest tremor evaluation in PD is not standardized. We evaluated the sensitivity and specificity of different hand positions commonly used to evaluate rest tremor. Methods: Twenty patients ...
  • Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN) 
    Aschenbrenner, Andrew J.; James, Bryan D.; McDade, Eric; Wang, Guoqiao; Lim, Yen Ying; Benzinger, Tammie L.S.; Cruchaga, Carlos; Goate, Alison M.; Xiong, Chengjie; Perrin, Richard J.; Buckles, Virginia; Allegri, Ricardo Francisco; Berman, Sarah B.; Chhatwal, Jasmeer P.; Fagan, Anne M.; Farlow, Martin R.; O’Connor, Antoinette; Ghetti, Bernardino; Graff-Radford, Neill R.; Goldman, Jill; Gräber-Sultan, Susanne; Karch, Celeste M.; Lee, Jae-Hong; Levin, Johannes; Martins, Ralph N.; Masters, Colin L.; Mori, Hiroshi; Noble, James M.; Salloway, Stephen; Schofield, Peter R.; Morris, John C.; Bateman, Randall J.; Hassenstab, Jason; Dominantly Inherited Alzheimer Network; Dominantly Inherited Alzheimer Network (Wiley, 2020-06)
    Introduction: Although some members of families with autosomal dominant Alzheimer's disease mutations learn their mutation status, most do not. How knowledge of mutation status affects clinical disease progression is ...

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