Repositorio Institucional FLENI: Envíos recientes

  • The immunological role of oligodendrocytes: beyond myelin maintenance 
    Pasquini, Juana M.; Correale, Jorge (Oxford University Press on behalf of the British Society for Immunology, 2025-04-28)
    Oligodendrocytes (OGDs) are well-established cells in the central nervous system (CNS), primarily recognized for their role in myelination. However, emerging evidence suggests intrinsic differences among OGDs that may lead ...
  • Implementing Acute Stroke Services in Sub-Saharan Africa: Steps, Progress, and Perspectives from the Tanzania Stroke Project 
    Matuja, Sarah Shali; Tunkl, Christine; Roushdy, Tamer; Li, Linxin; Ouyang, Menglu; Saleh Velez, Faddi G.; Gebrewold, Meron; Minhas, Jatinder S.; Law, Zhe Kang; Katsanos, Aristeidis H.; Ullberg, Teresa; Mosconi, Maria Giulia; Khan, Maria; Alet, Matías Javier; Lotlikar, Radhika; Richardson, Alicia; Ciopleias, Bogdan; Heldner, Mirjam R.; Zuurbier, Susanna Maria; Ramage, Emily (Karger, 2025-04-23)
    Introduction: Stroke is a leading cause of morbidity and mortality globally, with Africa bearing a disproportionately high burden of poor outcomes. In sub-Saharan Africa, acute stroke care remains inconsistent, with organized ...
  • Generation of an iPSC line from congenital hypopituitarism patient with a nonsense heterozygous variant in FOXA2 
    Camilletti, María Andrea; Chirino Felker, Gonzalo Tomás; Castañeda, Sheila; Zabalegui, Federico; Amin, Guadalupe; Belgorosky, Alicia; Ciaccio, Marta; Di Palma, Maria Isabel; Vaiani, Elisa; Waisman, Ariel; Miriuka, Santiago Gabriel; Pérez Millán, María Inés; Moro, Lucia Natalia (Elsevier, 2025-07-15)
    Forkhead box A2 (FOXA2) is a pioneer transcription factor, necessary for human development. Mutations in FOXA2 were recently associated with congenital hypopituitarism (CH); however, the pathogenic mechanism remains unknown. ...
  • Occipital structure is linked to vagal tone in borderline personality but not in major depressive disorder 
    Camacho Téllez, Vicente; Castro, Mariana Nair; De Pino, Gabriela; Duarte-Abritta, Bárbara; Wainsztein, Agustina Edith; Lahitou Herlyn, Delfina; Goldberg, Ximena; Costanzo, Elsa; Cardoner, Narcís; Menchón, José M.; Soriano-Mas, Carles; Guinjoan, Salvador Martín; Villarreal, Mirta Fabiana (Elsevier, 2025-08-09)
    Major depressive (MDD) and borderline personality disorders (BPD) are highly prevalent and frequently comorbid psychiatric conditions, both characterized by emotion dysregulation yet likely arising from distinct etiologies. ...
  • Cognitive and physical activities are associated with cognitive resilience in a memory clinic cohort 
    Bocancea, Diana I.; van Loenhoud, Anna C.; Kuijper, Bart; Calandri, Ismael Luis; Groot, Colin; Venkatraghavan, Vikram; de Boer, Casper; Ten Kate, Mara; Trieu, Calvin; Teunissen, Charlotte E.; van de Giessen, Elsmarieke; Leeuwis, Anna E.; Schlueter, Lisa-Marie; van Harten, Argonde C.; Pijnenburg, Yolande A. L.; Barkhof, Frederik; van der Flier, Wiesje M.; Ossenkoppele, Rik (Oxford University Press, 2025-09-06)
    Lifestyle factors such as participation in cognitively stimulating activities and physical activity are hypothesized to foster neural connections and enhance resilience, thereby attenuating cognitive loss in the context ...
  • Long-Term Clinical Outcomes of the Flow Ventricular Catheter for Hydrocephalus: A Follow-up Study 
    Bertani, Raphael; Gazzeri, Roberto; Etus, Volkan; Sosa, Fidel; Argañaraz, Romina; Giménez, Ángel; Amigó, José María; Semione, Gabriel; Galarza, Marcelo (Lippincott Williams & Wilkins, 2025-09-16)
    Background and objectives: Previously, we studied the flow in ventricular catheters under steady and pulsatile boundary conditions using computational fluid dynamics in catheter designs with homogeneous flow patterns. Out ...
  • Cross-Sectional FDG in Down Syndrome and Autosomal Dominant Alzheimer's Disease 
    Abdelmoity, Omar; Wisch, Julie K.; Kennedy, James T.; Goyal, Manu; Vlassenko, Andrei; Flores, Shaney; Handen, Benjamin L.; Head, Elizabeth; Keator, David; Rafii, Michael S.; Lao, Patrick; Lai, Florence; Rosas, H. Diana; Hartley, Sigan L.; Zaman, Shahid; Brickman, Adam M.; Tudorascu, Dana; Lee, Joseph H.; Allegri, Ricardo Francisco; Alzheimer's Biomarker Consortium‐Down Syndrome and the Dominantly Inherited Alzheimer Network (Wiley, 2025-09-22)
    Objectives: Directly compare the brain glucose patterns seen with [F-18] fluorodeoxyglucose (FDG) positron emission tomography (PET) between 2 genetically determined forms of Alzheimer's disease: Down syndrome (DS) and ...
  • Factors for Rituximab Refractoriness in AQP4-IgG+ NMOSD: A Cohort Study 
    Marrodán, Mariano; Piedrabuena, María Agustina; Zárate, María Agustina; Rodríguez Murúa, Sofía; Surace, Ezequiel Ignacio; Farez, Mauricio Franco; Fiol, Marcela Paula; Ysrraelit, María Célica; Correale, Jorge (Wiley Periodicals, 2025-08)
    Objective: Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune condition of the central nervous system (CNS), often associated with aquaporin-4 antibodies (AQP4-IgG). Rituximab, a CD20+ B-cell depleting ...
  • Integrated Workflow for Drug Repurposing in Glioblastoma: Computational Prediction and Preclinical Validation of Therapeutic Candidates 
    Gonzalez, Nazareno; Pérez Küper, Melanie; Garcia Fallit, Matías; Peña Agudelo, Jorge A.; Candia, Alejandro Nicola; Suarez Velandia, Maicol; Romero, Ana Clara; Videla Richardson, Guillermo Agustín; Candolfi, Marianela (MDPI, 2025-06-13)
    Background: Glioblastoma (GBM) remains a significant challenge in oncology due to its resistance to standard treatments including temozolomide. This study aimed to develop and validate an integrated model for predicting ...
  • Targeting FOXP3 in glioblastoma: Blockade of tumor intrinsic effects boosts response to chemo-radiotherapy 
    Garcia Fallit, Matías; Peña Agudelo, Jorge A.; Nicola Candia, Alejandro J.; Gonzalez, Nazareno; Pérez Küper, Melanie; Zampini, Yamila; Romero, Ana Clara; Sobarzo, Cristian; Sánchez Rojas, Ivana; Durán, Hebe; Perona, Marina; Ripari, Luisina Belén; Videla Richardson, Guillermo Agustín; Zanetti, Flavia A.; Lozano, Teresa; Casares, Noelia; Lasarte, Juan José; Candolfi, Marianela (Elsevier, 2025-06-27)
    Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Although this disease carries a dismal prognosis due to its highly invasive nature and resistance to therapy, no significant therapeutic advances ...
  • Prognostic Factors for Multiple Sclerosis Symptoms in Radiologically Isolated Syndrome 
    Fissolo, Nicolás; Schaedelin, Sabine; Villar, Luisa M.; Lünemann, Jan D.; Correale, Jorge; Rejdak, Konrad; Schwab, Nicholas; Vilaseca, Andreu; Held, Friederike; García-Merino, Antonio; Bittner, Stefan; Trojano, María; Furlan, Roberto; Tumani, Hayrettin; Pérez-Miralles, Francisco; Rosenstein, Igal; Galimberti, Daniela; Álvarez-Bravo, Gary; Thouvenot, Eric; Llufriu, Sara (American Medical Associatio, 2025-07-01)
    Importance: Understanding the risk factors for symptom development will allow clinicians to stratify people with radiologically isolated syndrome (pwRIS) more effectively and tailor their management strategies accordingl ...
  • Infusiones de ketamina a dosis subanestésicas en la depresión mayor resistente al tratamiento: protocolo de aplicación en un hospital público de Argentina 
    Dines, Micaela; Bulacia, Adriana; Bamondez, Paloma; Vega, Irene Luis; Montenegro, Micaela; Díaz, Pablo Germán; Oyhamburu, Paula; Ramos, Ana Laura; Ambrosio, Florencia; Vázquez, Gustavo; Pereyra, Monica; Pereyra, Hugo; Cichello, Cynthia; Ríos Merino, Laura Natalia (Polemos, 2025-07-10)
    La depresión mayor resistente al tratamiento (DMRT) representa un desafío significativo en psiquiatría, dada la limitada respuesta a las terapias convencionales. La ketamina endovenosa (EV) a dosis subanestésicas ha emergido ...
  • Peer Reviewing a Case-Based Manuscript in Movement Disorders Neurology 
    Di Luca, Daniel G.; Prasad, Shweta; Kirby, Alana; Merello, Marcelo; Bhatia, Kailash P.; Goetz, Christopher (Wiley, 2025-05-05)
  • Lifetime Risk of First Symptomatic ICH or Seizure in Familial Cerebral Cavernous Malformations: A Multicenter Patient Data Analysis 
    Dammann, Philipp; Santos, Alejandro N.; Mavarani, Laven; Guey, Stéphanie; Chabriat, Hugues; Herve, Dominique; Croft, Jacob; Renteria, Mellisa; Jang, David; Zhang, Jun; Li, Da; Wu, Zhen; Weng, Jian-Cong; Petracca, Antonio; Fusco, Carmela; D'Agruma, Leonardo; Cervio, Andrés Eduardo; Villamil, Facundo; Rosales, Julieta Soledad; Brain Vascular Malformation Consortium Cerebral Cavernous Malformation Investigator Group (Lippincott Williams & Wilkins, 2025-06-10)
    Background and objectives: Familial cavernous malformations (FCMs) are vascular lesions that pose a lifelong risk of symptomatic hemorrhage (SH) and seizures, yet their natural history remains unclear. This study aims to ...
  • Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease 
    Chen, Charles D.; Franklin, Erin E.; Li, Yan; Joseph-Mathurin, Nelly; Burns, Aime L.; Hobbs, Diana A.; McCullough, Austin A.; Schultz, Stephanie A.; Xion, Chengjie; Wang, Guoqiao; Masellis, Mario; Robin Hsiung, Ging-Yuek; Gauthier, Serge; Berman, Sarah B.; Roberson, Erik D.; Honig, Lawrence S.; Clarnette, Roger; Allegri, Ricardo Francisco; DIAN-TU Study Team; DIAN-Obs Study Team (Springer Verlag, 2025-06-03)
    Clinical trials of anti-amyloid-β (Aβ) monoclonal antibodies in Alzheimer disease (AD) infer target engagement from Aβ positron emission tomography (PET) and/or fluid biomarkers such as cerebrospinal fluid (CSF) Aβ42/40. ...
  • Embolización Selectiva como tratamiento de la capsulitis adhesiva. Reporte de un caso 
    Bertoni, Hernán Gabriel; Rosado, Martín; Cavallo, Jorge (Sociedad Argentina de Reumatología, 2025-03-29)
    La capsulitis adhesiva constituye una patología del hombro que genera rigidez y restricción dolorosa al movimiento activo y pasivo de esta articulación. Es habitual su evolución crónica, generando limitaciones funcionales ...
  • Reevaluating triptan contraindications: A follow-up survey among Latin American neurologists 
    Bancalari, Ernesto; Robblee, Jennifer; Goicochea, María Teresa; Muñoz, Joe; Peres, Mario F.P.; Velez, Karina (Sage, 2025-06-04)
    ObjectiveSurvey Latin American (LATAM) neurologists on their comfort with prescribing triptans in the setting of common contraindications. BackgroundTriptans are associated with multiple contraindications due to 5-HT1B-mediated ...
  • Prospective longitudinal cohort of Argentinean patients with progressive supranuclear palsy and corticobasal syndrome: A platform for epidemiological and translational research 
    Ángel, María José; Mizraji, Gabril F.; Gómez-Arévalo, Gonzalo; Garcia, Silvia; González-Toledo, María Eugenia; Avale, Elena; Paez-Paz, Indiana; Falzone, Tomás; Holubiec, Mariana; Peralta, María C.; Castano, Federico; Sevlever, Gustavo Emilio; Mezmezian, Mónica Beatriz; Marras, Connie; Gershanik, Oscar; Chade, Anabel; Pardo, Carolina; Rellan, Florencia; Campastri, Ana; Couto, Blas (Elsevier, 2025-05-15)
    Background: Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are neurodegenerative disorders with disabling postural instability, falls and cognitive impairment associated with 4-repeat tau protein ...
  • Cambios en nivel de la lesión de pacientes pediátricos con trauma medular 
    Ares, Julieta Jael; Gatti, Marcelo Andrés; Benett, Nalia Milagros; Monzón, Estela Maris; Andreu, Mauro Federico (Sociedad Chilena de Pediatría, 2025-06-25)
    La lesión medular traumática (LMT) es poco frecuente en población pediátrica, con un significativo impacto en la calidad de vida. Existe escasa literatura en esta población que documente la recuperación neurológica en los ...
  • Patent foramen ovale: is a change in the diagnostic paradigm necessary? 
    Magariños, Eduardo; Scuteri, Antonio; Romano, Ariel; Herrera Paz, Juan José; Razzini, Sofía; Lagos, Roberto; Colombero, Darío; Pujol Lereis, Virginia Andrea; Ameriso, Sebastián Francisco (Fundación Revista Medicina (Buenos Aires), 2025)
    The patent foramen ovale has been a well-known medical entity for a long time. With the advent of new diagnostic tools, the methodology for evaluating patients with stroke and suspected patent foramen ovale is evolving. ...