Repositorio Institucional FLENI: Envíos recientes

  • Molecular mechanism underlying alcohol's residual effects: The role of acetaldehyde in mitochondrial dysfunction at synapses in mouse brain cortex 
    Karadayian, Analía G.; Carrere, Lautaro; Czerniczyniec, Analia; Lores-Arnaiz, Silvia (Elsevier, 2025-09-17)
    Alcohol residual effects impose significant physiological and cognitive burdens due to acute ethanol exposure; however, its underlying mechanisms remain poorly understood. This study investigates the role of acetaldehyde, ...
  • Young adults with ischemic stroke in Argentina: A national multicenter retrospective registry analysis (JACARANDA) 
    Gonzalez, Fabio; López, Juan I.; Tamagnini, Flavia; Bonardo, Pablo; Cotti, Norberto; Zavattieri, Agustina; Carobolante, Luciana; Arias, Carlos A .; Acosta, Maria V.; Balian, Natalia; Armaretti, Marianela L.; Mena, Ignacio A.; Gonzalez, Leonardo; Lepera, Sandra; Claverie, Santiago; Monclá, Tomas D.; Ureña, Brain C.; Apaza, Patricio I.; Farcy, Nicole; Alet, Matías Javier (Sage, 2025-09-04)
    Background: Young adults account for up to 15% of all ischemic strokes, yet data from Latin America remain scarce. Understanding their clinical profile and outcomes is essential to inform targeted interventions and public ...
  • New landscape of the diagnosis of Alzheimer's disease 
    Frisoni, Giovanni B.; Hansson, Oskar; Nichols, Emma; Garibotto, Valentina; Schindler, Suzanne E.; van der Flier, Wiesje M.; Jessen, Frank; Villain, Nicolas; Arenaza-Urquijo, Eider M.; Crivelli, Lucia; Fortea, Juan; Grinberg, Lea T.; Ismail, Zahinoor; Minoshima, Satoshi; Ossenkoppele, Rik; Zetterberg, Henrik; Petersen, Ronald C.; Dubois, Bruno (Elsevier, 2025-09-22)
    Alzheimer's disease involves a drastic departure from the cognitive, functional, and behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent cause of disability to individuals, and a leading ...
  • A journey through genetic movement disorders caused by non-coding repeat expansions 
    Pinheiro Camurugy da Hora, Raphael; Rossi, Malco Damián; Rebelo Procaci, Victor; Yoshinaga Tonholo Silva, Thiago; Alves Corazza, Luiza; Novis, Luiz Eduardo; Barsottini, Orlando G.; Pedroso, José Luiz (Elsevier, 2025-07-21)
    Nucleotide repeat expansions are a key genetic mechanism underlying various neurological disorders, especially in movement disorders. While many expansion-related conditions are caused by variants in coding regions, an ...
  • "Susceptibility of hiPSC-derived NSCs and neurons to paraquat treatment: insights into differential neurotoxicity mechanisms related to mitochondria." 
    Czerniczyniec, Analia; Mucci, Sofía; Lopez, M.A.; Apecetche, Manuela; García Chialva, Diego; Quilumbaquin, W.; Marazita, Mariela Claudia; Sevlever, Gustavo Emilio; Scassa, María Élida; Vanasco, V.; Romorini, Leonardo (Elsevier, 2025-09-13)
    Environmental exposure to paraquat (PQ), a widely used herbicide, has been associated with an increased risk of neurodegenerative diseases such as Parkinson's disease. However, species-specific limitations of traditional ...
  • The immunological role of oligodendrocytes: beyond myelin maintenance 
    Pasquini, Juana M.; Correale, Jorge (Oxford University Press on behalf of the British Society for Immunology, 2025-04-28)
    Oligodendrocytes (OGDs) are well-established cells in the central nervous system (CNS), primarily recognized for their role in myelination. However, emerging evidence suggests intrinsic differences among OGDs that may lead ...
  • Implementing Acute Stroke Services in Sub-Saharan Africa: Steps, Progress, and Perspectives from the Tanzania Stroke Project 
    Matuja, Sarah Shali; Tunkl, Christine; Roushdy, Tamer; Li, Linxin; Ouyang, Menglu; Saleh Velez, Faddi G.; Gebrewold, Meron; Minhas, Jatinder S.; Law, Zhe Kang; Katsanos, Aristeidis H.; Ullberg, Teresa; Mosconi, Maria Giulia; Khan, Maria; Alet, Matías Javier; Lotlikar, Radhika; Richardson, Alicia; Ciopleias, Bogdan; Heldner, Mirjam R.; Zuurbier, Susanna Maria; Ramage, Emily (Karger, 2025-04-23)
    Introduction: Stroke is a leading cause of morbidity and mortality globally, with Africa bearing a disproportionately high burden of poor outcomes. In sub-Saharan Africa, acute stroke care remains inconsistent, with organized ...
  • Generation of an iPSC line from congenital hypopituitarism patient with a nonsense heterozygous variant in FOXA2 
    Camilletti, María Andrea; Chirino Felker, Gonzalo Tomás; Castañeda, Sheila; Zabalegui, Federico; Amin, Guadalupe; Belgorosky, Alicia; Ciaccio, Marta; Di Palma, Maria Isabel; Vaiani, Elisa; Waisman, Ariel; Miriuka, Santiago Gabriel; Pérez Millán, María Inés; Moro, Lucia Natalia (Elsevier, 2025-07-15)
    Forkhead box A2 (FOXA2) is a pioneer transcription factor, necessary for human development. Mutations in FOXA2 were recently associated with congenital hypopituitarism (CH); however, the pathogenic mechanism remains unknown. ...
  • Occipital structure is linked to vagal tone in borderline personality but not in major depressive disorder 
    Camacho Téllez, Vicente; Castro, Mariana Nair; De Pino, Gabriela; Duarte-Abritta, Bárbara; Wainsztein, Agustina Edith; Lahitou Herlyn, Delfina; Goldberg, Ximena; Costanzo, Elsa; Cardoner, Narcís; Menchón, José M.; Soriano-Mas, Carles; Guinjoan, Salvador Martín; Villarreal, Mirta Fabiana (Elsevier, 2025-08-09)
    Major depressive (MDD) and borderline personality disorders (BPD) are highly prevalent and frequently comorbid psychiatric conditions, both characterized by emotion dysregulation yet likely arising from distinct etiologies. ...
  • Cognitive and physical activities are associated with cognitive resilience in a memory clinic cohort 
    Bocancea, Diana I.; van Loenhoud, Anna C.; Kuijper, Bart; Calandri, Ismael Luis; Groot, Colin; Venkatraghavan, Vikram; de Boer, Casper; Ten Kate, Mara; Trieu, Calvin; Teunissen, Charlotte E.; van de Giessen, Elsmarieke; Leeuwis, Anna E.; Schlueter, Lisa-Marie; van Harten, Argonde C.; Pijnenburg, Yolande A. L.; Barkhof, Frederik; van der Flier, Wiesje M.; Ossenkoppele, Rik (Oxford University Press, 2025-09-06)
    Lifestyle factors such as participation in cognitively stimulating activities and physical activity are hypothesized to foster neural connections and enhance resilience, thereby attenuating cognitive loss in the context ...
  • Long-Term Clinical Outcomes of the Flow Ventricular Catheter for Hydrocephalus: A Follow-up Study 
    Bertani, Raphael; Gazzeri, Roberto; Etus, Volkan; Sosa, Fidel; Argañaraz, Romina; Giménez, Ángel; Amigó, José María; Semione, Gabriel; Galarza, Marcelo (Lippincott Williams & Wilkins, 2025-09-16)
    Background and objectives: Previously, we studied the flow in ventricular catheters under steady and pulsatile boundary conditions using computational fluid dynamics in catheter designs with homogeneous flow patterns. Out ...
  • Cross-Sectional FDG in Down Syndrome and Autosomal Dominant Alzheimer's Disease 
    Abdelmoity, Omar; Wisch, Julie K.; Kennedy, James T.; Goyal, Manu; Vlassenko, Andrei; Flores, Shaney; Handen, Benjamin L.; Head, Elizabeth; Keator, David; Rafii, Michael S.; Lao, Patrick; Lai, Florence; Rosas, H. Diana; Hartley, Sigan L.; Zaman, Shahid; Brickman, Adam M.; Tudorascu, Dana; Lee, Joseph H.; Allegri, Ricardo Francisco; Alzheimer's Biomarker Consortium‐Down Syndrome and the Dominantly Inherited Alzheimer Network (Wiley, 2025-09-22)
    Objectives: Directly compare the brain glucose patterns seen with [F-18] fluorodeoxyglucose (FDG) positron emission tomography (PET) between 2 genetically determined forms of Alzheimer's disease: Down syndrome (DS) and ...
  • Factors for Rituximab Refractoriness in AQP4-IgG+ NMOSD: A Cohort Study 
    Marrodán, Mariano; Piedrabuena, María Agustina; Zárate, María Agustina; Rodríguez Murúa, Sofía; Surace, Ezequiel Ignacio; Farez, Mauricio Franco; Fiol, Marcela Paula; Ysrraelit, María Célica; Correale, Jorge (Wiley Periodicals, 2025-08)
    Objective: Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune condition of the central nervous system (CNS), often associated with aquaporin-4 antibodies (AQP4-IgG). Rituximab, a CD20+ B-cell depleting ...
  • Integrated Workflow for Drug Repurposing in Glioblastoma: Computational Prediction and Preclinical Validation of Therapeutic Candidates 
    Gonzalez, Nazareno; Pérez Küper, Melanie; Garcia Fallit, Matías; Peña Agudelo, Jorge A.; Candia, Alejandro Nicola; Suarez Velandia, Maicol; Romero, Ana Clara; Videla Richardson, Guillermo Agustín; Candolfi, Marianela (MDPI, 2025-06-13)
    Background: Glioblastoma (GBM) remains a significant challenge in oncology due to its resistance to standard treatments including temozolomide. This study aimed to develop and validate an integrated model for predicting ...
  • Targeting FOXP3 in glioblastoma: Blockade of tumor intrinsic effects boosts response to chemo-radiotherapy 
    Garcia Fallit, Matías; Peña Agudelo, Jorge A.; Nicola Candia, Alejandro J.; Gonzalez, Nazareno; Pérez Küper, Melanie; Zampini, Yamila; Romero, Ana Clara; Sobarzo, Cristian; Sánchez Rojas, Ivana; Durán, Hebe; Perona, Marina; Ripari, Luisina Belén; Videla Richardson, Guillermo Agustín; Zanetti, Flavia A.; Lozano, Teresa; Casares, Noelia; Lasarte, Juan José; Candolfi, Marianela (Elsevier, 2025-06-27)
    Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Although this disease carries a dismal prognosis due to its highly invasive nature and resistance to therapy, no significant therapeutic advances ...
  • Prognostic Factors for Multiple Sclerosis Symptoms in Radiologically Isolated Syndrome 
    Fissolo, Nicolás; Schaedelin, Sabine; Villar, Luisa M.; Lünemann, Jan D.; Correale, Jorge; Rejdak, Konrad; Schwab, Nicholas; Vilaseca, Andreu; Held, Friederike; García-Merino, Antonio; Bittner, Stefan; Trojano, María; Furlan, Roberto; Tumani, Hayrettin; Pérez-Miralles, Francisco; Rosenstein, Igal; Galimberti, Daniela; Álvarez-Bravo, Gary; Thouvenot, Eric; Llufriu, Sara (American Medical Associatio, 2025-07-01)
    Importance: Understanding the risk factors for symptom development will allow clinicians to stratify people with radiologically isolated syndrome (pwRIS) more effectively and tailor their management strategies accordingl ...
  • Infusiones de ketamina a dosis subanestésicas en la depresión mayor resistente al tratamiento: protocolo de aplicación en un hospital público de Argentina 
    Dines, Micaela; Bulacia, Adriana; Bamondez, Paloma; Vega, Irene Luis; Montenegro, Micaela; Díaz, Pablo Germán; Oyhamburu, Paula; Ramos, Ana Laura; Ambrosio, Florencia; Vázquez, Gustavo; Pereyra, Monica; Pereyra, Hugo; Cichello, Cynthia; Ríos Merino, Laura Natalia (Polemos, 2025-07-10)
    La depresión mayor resistente al tratamiento (DMRT) representa un desafío significativo en psiquiatría, dada la limitada respuesta a las terapias convencionales. La ketamina endovenosa (EV) a dosis subanestésicas ha emergido ...
  • Peer Reviewing a Case-Based Manuscript in Movement Disorders Neurology 
    Di Luca, Daniel G.; Prasad, Shweta; Kirby, Alana; Merello, Marcelo; Bhatia, Kailash P.; Goetz, Christopher (Wiley, 2025-05-05)
  • Lifetime Risk of First Symptomatic ICH or Seizure in Familial Cerebral Cavernous Malformations: A Multicenter Patient Data Analysis 
    Dammann, Philipp; Santos, Alejandro N.; Mavarani, Laven; Guey, Stéphanie; Chabriat, Hugues; Herve, Dominique; Croft, Jacob; Renteria, Mellisa; Jang, David; Zhang, Jun; Li, Da; Wu, Zhen; Weng, Jian-Cong; Petracca, Antonio; Fusco, Carmela; D'Agruma, Leonardo; Cervio, Andrés Eduardo; Villamil, Facundo; Rosales, Julieta Soledad; Brain Vascular Malformation Consortium Cerebral Cavernous Malformation Investigator Group (Lippincott Williams & Wilkins, 2025-06-10)
    Background and objectives: Familial cavernous malformations (FCMs) are vascular lesions that pose a lifelong risk of symptomatic hemorrhage (SH) and seizures, yet their natural history remains unclear. This study aims to ...
  • Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease 
    Chen, Charles D.; Franklin, Erin E.; Li, Yan; Joseph-Mathurin, Nelly; Burns, Aime L.; Hobbs, Diana A.; McCullough, Austin A.; Schultz, Stephanie A.; Xion, Chengjie; Wang, Guoqiao; Masellis, Mario; Robin Hsiung, Ging-Yuek; Gauthier, Serge; Berman, Sarah B.; Roberson, Erik D.; Honig, Lawrence S.; Clarnette, Roger; Allegri, Ricardo Francisco; DIAN-TU Study Team; DIAN-Obs Study Team (Springer Verlag, 2025-06-03)
    Clinical trials of anti-amyloid-β (Aβ) monoclonal antibodies in Alzheimer disease (AD) infer target engagement from Aβ positron emission tomography (PET) and/or fluid biomarkers such as cerebrospinal fluid (CSF) Aβ42/40. ...