Repositorio Institucional FLENI: Envíos recientes

  • Redes neuronales y funcionamiento cognitivo en la fragilidad: una revisión sistemática de la literatura 
    Lastre Meza, Karina; Allegri, Ricardo Francisco; Barceló Martínez, Ernesto (Fundación Universitaria Católica del Norte, 2025-09-06)
    La fragilidad se presenta como un factor de riesgo clave para la disfunción cognitiva en adultos mayores. El propósito de la revisión sistemática es sintetizar la evidencia disponible en los últimos 11 años sobre la relación ...
  • The Multiple Facets of Bradykinesia: Barriers to Measurement and Diagnosis with Digital Technology 
    Merello, Marcelo (Wiley, 2025-09-02)
    Resumen no disponible
  • The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology 
    McDade, Eric; Barthélemy, Nicolas R.; Wang, Guoqiao; Li, Yan; Cao, Yuchen; Gordon, Brian; Benzinger, Tammie L. S.; Clifford, David; Goate, Alison M.; Renton, Alan E.; Hassenstab, Jason; Llibre-Guerra, Jorge J.; Perrin, Richard J.; Xiong, Chengjie; Cruchaga, Carlos; Mummery, Catherine J.; Berman, Sarah B.; Lah, James; Chrem Méndez, Patricio Alexis; DIAN‐TU Study Team and DIAN Obs Team (Wiley, 2025-09-23)
    Background: Tau-derived cerebrospinal fluid (CSF) biomarkers correlate with amyloid-beta (Aβ) plaques or tau tangles in Alzheimer's disease (AD). This study assessed the effects of long-term anti-Aβ antibodies on amyloid ...
  • Diverse paths of phenotypic evolution in functional movement disorders: A longitudinal perspective 
    Marín-Medina, Daniel S.; Lopez, Gala; Rossi, Malco Damián; Merello, Marcelo (Elsevier, 2025-09-22)
    Introduction: Functional Movement Disorders (FMD) exhibit a variable course over time. Understanding FMD phenotype trajectories may improve knowledge of its natural history and prognosis. Methods: Retrospective study ...
  • Emerging Trends in Functional Movement Disorders Consultations and the Impact of a Major Life Event 
    Marín-Medina, Daniel S.; Lopez, Gala; Rossi, Malco Damián; Merello, Marcelo (Wiley, 2025-09-03)
    Background: Awareness and major external events can contribute to the number of FMD cases. Objective: To analyze trends in new Functional Movement Disorders (FMD) consultations and the impact of the COVID-19 ...
  • Molecular mechanism underlying alcohol's residual effects: The role of acetaldehyde in mitochondrial dysfunction at synapses in mouse brain cortex 
    Karadayian, Analía G.; Carrere, Lautaro; Czerniczyniec, Analia; Lores-Arnaiz, Silvia (Elsevier, 2025-09-17)
    Alcohol residual effects impose significant physiological and cognitive burdens due to acute ethanol exposure; however, its underlying mechanisms remain poorly understood. This study investigates the role of acetaldehyde, ...
  • Young adults with ischemic stroke in Argentina: A national multicenter retrospective registry analysis (JACARANDA) 
    Gonzalez, Fabio; López, Juan I.; Tamagnini, Flavia; Bonardo, Pablo; Cotti, Norberto; Zavattieri, Agustina; Carobolante, Luciana; Arias, Carlos A .; Acosta, Maria V.; Balian, Natalia; Armaretti, Marianela L.; Mena, Ignacio A.; Gonzalez, Leonardo; Lepera, Sandra; Claverie, Santiago; Monclá, Tomas D.; Ureña, Brain C.; Apaza, Patricio I.; Farcy, Nicole; Alet, Matías Javier (Sage, 2025-09-04)
    Background: Young adults account for up to 15% of all ischemic strokes, yet data from Latin America remain scarce. Understanding their clinical profile and outcomes is essential to inform targeted interventions and public ...
  • New landscape of the diagnosis of Alzheimer's disease 
    Frisoni, Giovanni B.; Hansson, Oskar; Nichols, Emma; Garibotto, Valentina; Schindler, Suzanne E.; van der Flier, Wiesje M.; Jessen, Frank; Villain, Nicolas; Arenaza-Urquijo, Eider M.; Crivelli, Lucia; Fortea, Juan; Grinberg, Lea T.; Ismail, Zahinoor; Minoshima, Satoshi; Ossenkoppele, Rik; Zetterberg, Henrik; Petersen, Ronald C.; Dubois, Bruno (Elsevier, 2025-09-22)
    Alzheimer's disease involves a drastic departure from the cognitive, functional, and behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent cause of disability to individuals, and a leading ...
  • A journey through genetic movement disorders caused by non-coding repeat expansions 
    Pinheiro Camurugy da Hora, Raphael; Rossi, Malco Damián; Rebelo Procaci, Victor; Yoshinaga Tonholo Silva, Thiago; Alves Corazza, Luiza; Novis, Luiz Eduardo; Barsottini, Orlando G.; Pedroso, José Luiz (Elsevier, 2025-07-21)
    Nucleotide repeat expansions are a key genetic mechanism underlying various neurological disorders, especially in movement disorders. While many expansion-related conditions are caused by variants in coding regions, an ...
  • "Susceptibility of hiPSC-derived NSCs and neurons to paraquat treatment: insights into differential neurotoxicity mechanisms related to mitochondria." 
    Czerniczyniec, Analia; Mucci, Sofía; Lopez, M.A.; Apecetche, Manuela; García Chialva, Diego; Quilumbaquin, W.; Marazita, Mariela Claudia; Sevlever, Gustavo Emilio; Scassa, María Élida; Vanasco, V.; Romorini, Leonardo (Elsevier, 2025-09-13)
    Environmental exposure to paraquat (PQ), a widely used herbicide, has been associated with an increased risk of neurodegenerative diseases such as Parkinson's disease. However, species-specific limitations of traditional ...
  • The immunological role of oligodendrocytes: beyond myelin maintenance 
    Pasquini, Juana M.; Correale, Jorge (Oxford University Press on behalf of the British Society for Immunology, 2025-04-28)
    Oligodendrocytes (OGDs) are well-established cells in the central nervous system (CNS), primarily recognized for their role in myelination. However, emerging evidence suggests intrinsic differences among OGDs that may lead ...
  • Implementing Acute Stroke Services in Sub-Saharan Africa: Steps, Progress, and Perspectives from the Tanzania Stroke Project 
    Matuja, Sarah Shali; Tunkl, Christine; Roushdy, Tamer; Li, Linxin; Ouyang, Menglu; Saleh Velez, Faddi G.; Gebrewold, Meron; Minhas, Jatinder S.; Law, Zhe Kang; Katsanos, Aristeidis H.; Ullberg, Teresa; Mosconi, Maria Giulia; Khan, Maria; Alet, Matías Javier; Lotlikar, Radhika; Richardson, Alicia; Ciopleias, Bogdan; Heldner, Mirjam R.; Zuurbier, Susanna Maria; Ramage, Emily (Karger, 2025-04-23)
    Introduction: Stroke is a leading cause of morbidity and mortality globally, with Africa bearing a disproportionately high burden of poor outcomes. In sub-Saharan Africa, acute stroke care remains inconsistent, with organized ...
  • Generation of an iPSC line from congenital hypopituitarism patient with a nonsense heterozygous variant in FOXA2 
    Camilletti, María Andrea; Chirino Felker, Gonzalo Tomás; Castañeda, Sheila; Zabalegui, Federico; Amin, Guadalupe; Belgorosky, Alicia; Ciaccio, Marta; Di Palma, Maria Isabel; Vaiani, Elisa; Waisman, Ariel; Miriuka, Santiago Gabriel; Pérez Millán, María Inés; Moro, Lucia Natalia (Elsevier, 2025-07-15)
    Forkhead box A2 (FOXA2) is a pioneer transcription factor, necessary for human development. Mutations in FOXA2 were recently associated with congenital hypopituitarism (CH); however, the pathogenic mechanism remains unknown. ...
  • Occipital structure is linked to vagal tone in borderline personality but not in major depressive disorder 
    Camacho Téllez, Vicente; Castro, Mariana Nair; De Pino, Gabriela; Duarte-Abritta, Bárbara; Wainsztein, Agustina Edith; Lahitou Herlyn, Delfina; Goldberg, Ximena; Costanzo, Elsa; Cardoner, Narcís; Menchón, José M.; Soriano-Mas, Carles; Guinjoan, Salvador Martín; Villarreal, Mirta Fabiana (Elsevier, 2025-08-09)
    Major depressive (MDD) and borderline personality disorders (BPD) are highly prevalent and frequently comorbid psychiatric conditions, both characterized by emotion dysregulation yet likely arising from distinct etiologies. ...
  • Cognitive and physical activities are associated with cognitive resilience in a memory clinic cohort 
    Bocancea, Diana I.; van Loenhoud, Anna C.; Kuijper, Bart; Calandri, Ismael Luis; Groot, Colin; Venkatraghavan, Vikram; de Boer, Casper; Ten Kate, Mara; Trieu, Calvin; Teunissen, Charlotte E.; van de Giessen, Elsmarieke; Leeuwis, Anna E.; Schlueter, Lisa-Marie; van Harten, Argonde C.; Pijnenburg, Yolande A. L.; Barkhof, Frederik; van der Flier, Wiesje M.; Ossenkoppele, Rik (Oxford University Press, 2025-09-06)
    Lifestyle factors such as participation in cognitively stimulating activities and physical activity are hypothesized to foster neural connections and enhance resilience, thereby attenuating cognitive loss in the context ...
  • Long-Term Clinical Outcomes of the Flow Ventricular Catheter for Hydrocephalus: A Follow-up Study 
    Bertani, Raphael; Gazzeri, Roberto; Etus, Volkan; Sosa, Fidel; Argañaraz, Romina; Giménez, Ángel; Amigó, José María; Semione, Gabriel; Galarza, Marcelo (Lippincott Williams & Wilkins, 2025-09-16)
    Background and objectives: Previously, we studied the flow in ventricular catheters under steady and pulsatile boundary conditions using computational fluid dynamics in catheter designs with homogeneous flow patterns. Out ...
  • Cross-Sectional FDG in Down Syndrome and Autosomal Dominant Alzheimer's Disease 
    Abdelmoity, Omar; Wisch, Julie K.; Kennedy, James T.; Goyal, Manu; Vlassenko, Andrei; Flores, Shaney; Handen, Benjamin L.; Head, Elizabeth; Keator, David; Rafii, Michael S.; Lao, Patrick; Lai, Florence; Rosas, H. Diana; Hartley, Sigan L.; Zaman, Shahid; Brickman, Adam M.; Tudorascu, Dana; Lee, Joseph H.; Allegri, Ricardo Francisco; Alzheimer's Biomarker Consortium‐Down Syndrome and the Dominantly Inherited Alzheimer Network (Wiley, 2025-09-22)
    Objectives: Directly compare the brain glucose patterns seen with [F-18] fluorodeoxyglucose (FDG) positron emission tomography (PET) between 2 genetically determined forms of Alzheimer's disease: Down syndrome (DS) and ...
  • Factors for Rituximab Refractoriness in AQP4-IgG+ NMOSD: A Cohort Study 
    Marrodán, Mariano; Piedrabuena, María Agustina; Zárate, María Agustina; Rodríguez Murúa, Sofía; Surace, Ezequiel Ignacio; Farez, Mauricio Franco; Fiol, Marcela Paula; Ysrraelit, María Célica; Correale, Jorge (Wiley Periodicals, 2025-08)
    Objective: Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune condition of the central nervous system (CNS), often associated with aquaporin-4 antibodies (AQP4-IgG). Rituximab, a CD20+ B-cell depleting ...
  • Integrated Workflow for Drug Repurposing in Glioblastoma: Computational Prediction and Preclinical Validation of Therapeutic Candidates 
    Gonzalez, Nazareno; Pérez Küper, Melanie; Garcia Fallit, Matías; Peña Agudelo, Jorge A.; Candia, Alejandro Nicola; Suarez Velandia, Maicol; Romero, Ana Clara; Videla Richardson, Guillermo Agustín; Candolfi, Marianela (MDPI, 2025-06-13)
    Background: Glioblastoma (GBM) remains a significant challenge in oncology due to its resistance to standard treatments including temozolomide. This study aimed to develop and validate an integrated model for predicting ...
  • Targeting FOXP3 in glioblastoma: Blockade of tumor intrinsic effects boosts response to chemo-radiotherapy 
    Garcia Fallit, Matías; Peña Agudelo, Jorge A.; Nicola Candia, Alejandro J.; Gonzalez, Nazareno; Pérez Küper, Melanie; Zampini, Yamila; Romero, Ana Clara; Sobarzo, Cristian; Sánchez Rojas, Ivana; Durán, Hebe; Perona, Marina; Ripari, Luisina Belén; Videla Richardson, Guillermo Agustín; Zanetti, Flavia A.; Lozano, Teresa; Casares, Noelia; Lasarte, Juan José; Candolfi, Marianela (Elsevier, 2025-06-27)
    Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Although this disease carries a dismal prognosis due to its highly invasive nature and resistance to therapy, no significant therapeutic advances ...