Repositorio Institucional FLENI: Envíos recientes

  • Refining pituitary adenoma classification: the role of transcription factors in diagnosis and risk assessment 
    Katz, Débora Adela; Slavinsky, Patricia; Pernas, Mariana Gonzalez; Battistone, Maria Florencia; Pingel, Jesica; Arakaki, Naomi; Mezmezian, Mónica Beatriz; Sevlever, Gustavo Emilio; Rojas, Estefanía; Schultz, Marcelo; Cervio, Andrés Eduardo (bioscientifica, 2025-03-10)
    JOINT1942 Introduction: The new classification of pituitary tumors (WHO 2022) is based on transcription factors (TF) detected through immunohistochemistry (IHC) to determine tumor lineage. The aim of our study was to ...
  • Cultural adaptation and validation of the Argentine Children's Orientation and Amnesia Test 
    Dorrego, María Flavia; Colbert, Alison Margaret; Ewing-Cobbs, Linda; Andreu, Mauro Federico (Taylor & Francis, 2025-03-17)
    The Children's Orientation and Amnesia Test (COAT) is a widely used tool for assessing post-traumatic amnesia (PTA) in children, yet no validated Spanish version exists. This study aimed to translate, culturally adapt, and ...
  • Toward equity in MS care: A roadmap for accessible treatment 
    Correale, Jorge (Sage, 2025-03-17)
    Resumen no disponible
  • Generation of human induced pluripotent stem cell lines from two down syndrome patients, including a down syndrome/Alzheimer's disease case (FLENIi002-A) and a beta-amyloid-resistant case (FLENIi003-A) 
    Clas, Giulia Solange; Marazita, Mariela Claudia; Pertierra, Lucía; Vázquez, Silvia; Isaja, Luciana; Rodríguez Varela, María Soledad; Mucci, Sofía; Helou, María Belén; Tapajóz Pereira de Sampaio, Fernanda; Magrath Guimet, Nahuel; Bérgamo, Yanina; Allegri, Ricardo Francisco; Sevlever, Gustavo Emilio; Scassa, María Élida; Surace, Ezequiel Ignacio; Romorini, Leonardo (Elsevier, 2025-05-01)
    Two human induced pluripotent stem cell (hiPSC) lines, FLENIi002-A and FLENIi003-A, were generated from peripheral blood mononuclear cells (PBMCs) using the lentiviral-hSTEMCCA-loxP vector. FLENIi002-A was derived from a ...
  • Resistance and resilience to Alzheimer's disease in Down syndrome 
    Boyle, Rory; Koops, Elouise A.; Ances, Beau; Andrews, Elizabeth J.; Arenaza-Urquijo, Eider M.; Benjanin, Alexandre; Brickman, Adam M.; Buckley, Rachel F.; Clas, Giulia Solange; Costello, Emmet; Coughlan, Gillian T.; Conley, Alexander C.; Deng, Feng; de Paula Faria, Daniele; Edwards, Natalie; Flores-Aguilar, Lisi; Fortea, Juan; Saidi, Ladan Ghazi; Head, Elizabeth; Hom, Christy L. (Wiley, 2025-04-28)
    Due to the high prevalence of Alzheimer's disease (AD) in adults with Down syndrome (DS), trisomy 21 is now considered a genetic form of AD (DSAD). A better understanding of factors that can prevent or delay AD is vital ...
  • Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial 
    Bateman, Randall J.; Li, Yan; McDade, Eric; Llibre-Guerra, Jorge J.; Clifford, David B.; Atri, Alireza; Mills, Susan L.; Santacruz, Anna M.; Wang, Guoqiao; Supnet, Charlene; Benzinger, Tammie L. S.; Gordon, Brian A.; Ibanez, Laura; Klein, Gregory; Baudler, Monika; Doody, Rachelle S.; Delmar, Paul; Kerchner, Geoffrey A.; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer's Disease–Trials Unit (Elsevier, 2025-04)
    Background: Amyloid plaque removal by monoclonal antibody therapies slows clinical progression in symptomatic Alzheimer's disease; however, the potential for delaying the onset of clinical symptoms in asymptomatic people ...
  • Artificial Intelligence-Based Virtual Assistant for the Diagnostic Approach of Chronic Ataxias 
    Alessandro, Lucas; Bianciotti, Nicolas; Salama, Luciana; Volmaro, Santiago; Navarrine, Veronica; Ameghino, Lucía; Arena, Julieta E.; Bestoso, Santiago; Bruno, Veronica; Castillo Torres, Sergio; Chamorro, Mauricio; Couto, Blas; De La Riestra, Tomas; Echeverria, Florencia; Genco, Juan; Gonzalez Del Boca, Federico; Laffue, Alfredo Hernan; Tela, Marcela; Farez, Mauricio Franco; Rossi, Malco Damián (Wiley, 2025-03-22)
    Background: Chronic ataxias, a complex group of over 300 diseases, pose significant diagnostic challenges because of their clinical and genetic heterogeneity. Here, we propose that artificial intelligence (AI) can aid in ...
  • Evaluation of the correlation coefficient to determine the severity of bone marrow infiltration between bone marrow burden, fat fraction and Lyso GL1 in adult patients with Gaucher disease. A Study from the Argentine group for the diagnosis and treatment of GD 
    Soberon, Barbara C.; Drelichman, Guillermo I.; Aguilar, Gabriel H.; Fernandez Escobar, Nicolas; Basack, Nora; Larroude, Maria S.; Martin-Noguerol, Teodoro; Watman, Nora; Elena, Graciela O.; Dragosky, Marta; Cuello, Maria F.; Arizó, Adriana D.V.; Quijano, Sandra L.; Mandrile, Laura; Diez, Blanca; Lanza, Victoria C.; Rocaspana, Adriana E.; Avalos, Vanesa; Degano, Adriana N.; Borchichi, Sandra R. (Elsevier, 2025-01-30)
    Resumen no disponible
  • Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer's disease 
    Jiaxin Cindy, Tu; Millar, Peter R.; Strain, Jeremy F.; Eck, Andrew; Adeyemo, Babatunde; Snyder, Abraham Z.; Daniels, Alisha; Karch, Celeste; Huey, Edward D.; McDade, Eric; Day, Gregory S.; Yakushev, Igor; Hassenstab, Jason; Morris, John; Llibre-Guerra, Jorge J.; Ibanez, Laura; Jucke, Mathias; Chrem Méndez, Patricio Alexis; Dominantly Inherited Alzheimer Network (MIT Press, 2024)
    Hub regions in the brain, recognized for their roles in ensuring efficient information transfer, are vulnerable to pathological alterations in neurodegenerative conditions, including Alzheimer's disease (AD). Computational ...
  • 2- Cognitive Impairment and Dementia in Latin American Individuals with Parkinsonism and Parkinson’s Disease: A 10/66 Dementia Research Group Study (Ana Luisa Sosa) 
    Sosa, Ana Luisa; Khan, N.; Arruabarrena, Micaela María; Kim, D.J.; Jiang, M.; Llibre-Guerra, Jorge J.; Rodriguez-Salgado, A.M.; Acosta, I.; Acosta, D.; Jimenez-Velasquez, I.Z.; Guerra, M.; Salas, A.; López-Contreras, R.; Dhara, Santana; Hesse, H.; Tanner, C.; Prina, M.; Llibre-Guerra, J.J.; 10/66 Dementia ResearchGroup (International Psichogeriatrics Association, 2024-09)
  • Abstract WP131: Global Landscape of Stroke Rehabilitation: Access and Challenges 
    Velez, Faddi Saleh; Yeung, Elton Hau Lam; Pinto, Camila Bonin; Ling, Tse Mei; Carbonera, Leonardo; Alet, Matías Javier; Ciopleias, Bogdan; Khan, Abdul Hanif Khan Yusof; Law, Zhe Kang; Lotlikar, Radhika; Ramage, Emily; Xiong, Carol; Zuurbier, Susanna; Li, Linxin; Mares, Kathryn; Kiper, Pawel; Heldner, Mirjam; Matuja, Sarah; Johnson, Louise; Caso, Valeria (American Heart Association, 2025-01-30)
    Background: Stroke is a leading cause of long-term disability worldwide. Timely and adequate rehabilitation is crucial for post-stroke recovery, but access is limited due to an overburdened healthcare system, medical ...
  • Abstract 147: Telestroke Network Mapping: An Update of the World Landscape for Remote Stroke Care 
    Velez, Faddi Saleh; Tunkl, Christine; Agarwal, Ayush; Roushdy, Tamer; Ullberg, Teresa; Carbonera, Leonardo; Ciopleias, Bogdan; Khan, Abdul Hanif Khan Yusof; Heldner, Mirjam; Khan, Maria; Alet, Matías Javier; Matuja, Sarah; Ramage, Emily; Lagos, Javier; Mosconi, Maria Giulia; Katsanos, Aristeidis; Li, Linxin; Gerner, Stefan; Zuurbier, Susanna; Law, Zhe Kang (American Heart Association, 2025-01-30)
    Background: Telestroke has proven efficacy in improving clinical outcomes by providing rapid access to specialized stroke care, particularly in remote areas. However, the global implementation of telestroke networks remains ...
  • Protocolo de valoración neuroconductual estandarizada y de interpretación clínica de pacientes con trastornos crónicos de conciencia 
    Russo, María Julieta; Pavón, Hernán Marcelo; Deschle, Florencia; Marroquín, María Verónica; Aliaga, Orlando; Sampayo, María de la Paz (Elsevier, 2025-03-20)
    En este trabajo investigamos la literatura existente acerca de la posibilidad de que algunos hallazgos clínicos puedan ser de utilidad para el diagnóstico de la presencia de contenido de conciencia en los pacientes con ...
  • Evidence-based guidelines for the pharmacological treatment of migraine 
    Ornello, Raffaele; Caponnetto, Valeria; Ahmed, Fayyaz; Al-Khazali, Haidar M.; Ambrosini, Anna; Ashina, Sait; Baraldi, Carlo; Bellotti, Alessia; Brighina, Filippo; Calabresi, Paolo; Casillo, Francesco; Cevoli, Sabina; Cheng, Shuli; Chiang, Chia-Chun; Chiarugi, Alberto; Häckert Christensen, Rune; Kyung Chu, Min; Crema, Santiago; Goicochea, María Teresa (Sage, 2025-04-25)
    We here present evidence-based guidelines for the pharmacological treatment of migraine. These guidelines, created by the Italian Society for the Study of Headache and the International Headache Society, aim to offer clear, ...
  • International Headache Society Global Practice Recommendations for Preventive Pharmacological Treatment of Migraine 
    Puledda, Francesca; Sacco, Simona; Diener, Hans-Christoph; Ashina, Messoud; Al-Khazali, Haidar M.; Ashina, Sait; Burstein, Rami; Liebler, Eric; Cipriani, Andrea; Chu, Min Kyung; Cocores, Alexandra; Dodd-Glover, Freda; Ekizoğlu, Esme; Garcìa Azorìn, David; Göbel, Carl; Goicochea, María Teres; Hassan, Amr; Hirata, Koichi; Hoffmann, Jan; Jenkins, Bronwyn (Sage, 2024-09)
  • Improvement in cerebral hypoperfusion by stellate ganglion block in refractory vasospasm 
    Maskin, Luis Patricio; Rodríguez Lucci, Federico (Elsevier, 2025-02-24)
    Resumen no disponible
  • Abstract TP148: The Need for Standardized Stroke Care: Assessing Global Provider Training and Institutional Disparities 
    Owens, Cameron; Bonin Pinto, Camila; Heldner, Mirjam; Carbonera, Leonardo; De Souza, Ana; Tunkl, Christine; Matuja, Sarah; Orjuela, Karen; Guerrero, Rodrigo; Alet, Matías Javier; Vasquez, Sebastian; Cano-Nigenda, Vanessa; Roa Wandurraga, Luis; Lagos-Servellon, Javier Alfredo; Saposnik, Gustavo; Rosales, Julieta Soledad; Velez, Faddi Saleh (American Heart Association, 2025-01-30)
    The development of vascular neurology as the primary specialty for stroke evaluation and treatment is a relatively recent advancement. Vascular neurology is well-established in the United States, ensuring most stroke ...
  • In Memoriam C. Warren Olanow (1941–2024) 
    Fung, Victor S.C.; Bhatia, Kailash P.; Burn, David J.; Goetz, Christopher G.; Hallett, Mark; Jankovic, Joseph; Kieburtz, Karl; Klein, Christine; Kordower, Jeffrey H.; Lang, Anthony E.; Merello, Marcelo; Stern, Matthew B.; Stoessl, A. Jon; Thompson, Philip D. (Wiley, 2025-02-13)
    Resumen no disponible
  • Risk and impact of stroke across 38 countries and territories of the Americas from 1990 to 2021: a population-based trends analysis from the Global Burden of Disease Study 2021 
    Martinez, Ramón; Muñoz-Venturelli, Paula; Ordunez, Pedro; Fregni, Felipe; Abanto, Carlos; Alet, Matías Javier; Alvarez, Tony Fabián; Amaya, Pablo; Ameriso, Sebastián Francisco; Arauz, Antonio; Barboza, Miguel A.; Bayona, Hernán; Bernabé-Ortiz, Antonio; Calleja, Juan; Cano-Nigenda, Vanessa; Carbonera, Leonardo Augusto; Carrillo-Larco, Rodrigo M.; Corredor, Angel; de Souza, Ana Cláudia; Rosales, Julieta Soledad (Elsevier, 2025-02-15)
    Background: Despite substantial declines in burden over time, stroke remains a public health threat in the Americas. This study aimed to assess the current magnitude, trends, and disparities in the estimates of stroke ...
  • Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia 
    Llibre Guerra, Jorge J.; Fernandez, M. Victoria; Joseph-Mathurin, Nelly; Bian, Shijia; Carter, Kathleen; Li, Yan; Aschenbrenner, Andrew J.; Pottier, Cyril; Sigurdson, Wendy; McDade, Eric; Gordon, Brian A.; Renton, Alan E.; Benzinger, Tammie L. S.; Ibañez, Laura; Barthelemy, Nico; Dominantly Inherited Alzheimer Network (Nature Publishing Company, 2025-02-10)
    We conducted an in-depth longitudinal study on an individual carrying the presenilin 2 p.Asn141Ile mutation, traditionally associated with dominantly inherited Alzheimer's disease (AD), who has remarkably remained asymptomatic ...