Neurología: Recent submissions

  • Real-World Effectiveness and Safety of Cladribine in Multiple Sclerosis: Longitudinal Data From the Nationwide Registry in Argentina 
    Rojas, Juan Ignacio; Alonso, Ricardo; Luetic, Geraldine G.; Patrucco, Liliana; Casas, Magdalena; Silva, Berenice Anabel; Miguez, Jimena; Deri, Norma; Vrech, Carlos; Liwacki, Susana; Piedrabuena, Raúl; Silva, Emanuel; Tkachuk, Verónica A.; Burgos, Marcos; Tavolini, Darío; Zanga, Gisela; Alvez Pinheiro, Amelia; Hryb, Javier Pablo; Leguizamon, Felisa; Knorre, Eduardo; López, Pablo Adrián; Martínez, Alejandra Diana; Carrá, Adriana; Alonso Serena, Marina; Cristiano, Edgardo; Correale, Jorge; Garcea, Orlando; Fernández Liguori, Nora; Carnero Contentti, Edgar (Lippincott Williams & Wilkins, 2024-05-23)
    Objective: The aim was to evaluate patient profiles, effectiveness and safety of cladribine (CLAD) in patients with relapsing-remitting multiple sclerosis in Argentina. Methods: This was a substudy included in RelevarEM ...
  • Molecular neuroimaging in dominantly inherited versus sporadic early-onset Alzheimer's disease. 
    Iaccarino, Leonardo; Llibre Guerra, Jorge J.; McDade, Eric; Edwards, Lauren; Gordon, Brian A.; Benzinger, Tammie L.S.; Hassenstab, Jason; Kramer, Joel H.; Li, Yan; Miller, Bruce L.; Miller, Zachary; Morris, John C.; Mundada, Nidhi; Perrin, Richard J.; Rosen, Howard J.; Soleimani Meigooni, David; Strom, Amelia; Tsoy, Elena; Wang, Guoqiao; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Vázquez, Silvia (Oxford University Press, 2024-05-03)
    Approximately 5% of Alzheimer's disease patients develop symptoms before age 65 (early-onset Alzheimer's disease), with either sporadic (sporadic early-onset Alzheimer's disease) or dominantly inherited (dominantly inherited ...
  • Efficacy and safety of erdafitinib in pediatric patients with advanced solid tumors and FGFR alterations in the phase 2 RAGNAR trial 
    Olaf Witt, Sameer Farouk Sait; Diez, Blanca; Cardoso, Agustín; Reardon, David A.; Welsh, Liam; Shih, Kent C.; Baldini, Capucine; Massard, Christophe; Loriot, Yohann; Pant, Shubham; Sweiti, Hussein; Thomas, Shibu; Hammond, Constance; Najmi, Saltanat; Triantos, Spyros; Crow, Lauren; Geoerger, Birgit (American Society of Clinical Oncology, 2024-06)
    Background: Erdafitinib is an oral selective pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor approved in the US for adult patients (pts) with locally advanced or metastatic urothelial carcinoma with ...
  • Clinical efficacy of a next-generation sequencing (NGS) and immunohistochemistry (IHC) panel in patients with advanced cancer in Argentina. 
    Cantarella, Florencia; Mendoza Bertelli, Andrea; Girotti, Romina; Marino, Ana Clara; Brest, Esteban; Dibarbora, Delfina; Mahmoud, Yamil; Veigas, Florencia; Enrico, Diego Hernan; Tsou, Florencia; Lacava, Juan A.; Piazzoni, Luciano; Riso, Aldo Alejandro; Martinengo, Gastón L.; Rodriguez, Andrés; Beguelin, Zenon; Cerrato, Sebastián; Jerez, Ignacio; Salanova, Rubén (American Society of Clinical Oncology, 2024-05-29)
    Background: The analysis of somatic genomic alterations, evaluation of DNA mismatch repair (MMR) proteins, and examination of PD-L1 expression in tumor biopsies are crucial for prognosis and informed therapeutic decisions. ...
  • Transferrin Enhances Neuronal Differentiation 
    Pérez, María Julia; Carden, Tomás Roberto; Dos Santos Claro, Paula Ayelen; Silberstein, Susana; Páez, Pablo Martin; Cheli, Veronica Teresita; Correale, Jorge; Pasquini, Juana María (Sage, 2023-04-24)
    Although transferrin (Tf) is a glycoprotein best known for its role in iron delivery, iron-independent functions have also been reported. Here, we assessed apoTf (aTf) treatment effects on Neuro-2a (N2a) cells, a mouse ...
  • Decentralized clinical trials for medications to reduce the risk of dementia: Consensus report and guidance 
    Howard, Leanne; Abdelnour, Carla; Abner, Erin L.; Allegri, Ricardo Francisco; Dodge, Hiroko H.; Gauthier, Serge; Hoyos, Camilla M.; Jicha, Gregory A.; Kehoe, Patrick G.; Mummery, Catherine J.; Ogunniyi, Adesola; Scarmeas, Nikolaos; Chen, Xiaoying; Titiner, Jodie R.; Weber, Christopher R.; Clinical Trial Methodology Working review group members; Peters, Ruth (John Wiley & Sons, 2024-06-02)
    Introduction: Recent growth in the functionality and use of technology has prompted an increased interest in the potential for remote or decentralized clinical trials in dementia. There are many potential benefits associated ...
  • Craniopharyngiomas in adult patients: Retrospective, multicentric study in Buenos Aires, Argentina 
    Mallea-Gil, María Susana; Glerean, Mariela; Rogozinski, Amelia; Ballarino, María Carolina; Battistone, María Florencia; Danilowicz, Karina; Diez, Sabrina; Fainstein Day, Patricia; Furioso, Alejandra; Guitelman, Mirtha; Katz, Débora Adela; Loto, Mónica; Martinez, Marcela; Miragaya, Karina; Sosa, Soledad; Slavinsky, Patricia; Tkatch, Julieta; Vitale, Marcelo; González Pernas, Mariana Soledad; Pingel, Jesica (European Society of Endocrinology, 2023-05-13)
    Craniopharyngiomas are rare lesions derived from cell remnants of Rathke’s pouch, usually localized in the sellar and suprasellar areas. Objectives: To analyze clinical, endocrine and histological features in a group ...
  • Eplontersen in Hereditary ATTR-polyneuropathy: Week 66 Final Analysis of the Phase 3 NEURO-TTRansform Study 
    Khella, Sami; Marques, Wilson; Chao, Chi-Chao; Yesim Parman, Fatma; Franca, Marcondes C.; Guo, Yuh-Cherng; Ro, Long-Sun; Calandra, Cristian; Kowacs, Pedro A.; Berk, John L.; Piera Obici, Laura; Barroso, Fabio Adrián; Conceição, Isabel; Schneider, Eugene; Viney, Nicholas J.; Dyck, P. James B.; Waddington Cruz, Marcia; Coelho, Teresa (American Academy of Neurology, 2023-04-24)
    Background ATTRv-PN is a rare, progressive, and debilitating disease caused by accumulation of amyloid fibrils composed of transthyretin (TTR) protein in multiple organ systems. Eplontersen, a ligand-conjugated antisense ...
  • Axial Postural Abnormalities in Parkinsonism: Gaps in Predictors, Pathophysiology, and Management 
    Geroin, Christian; Artusi, Carlo Alberto; Nonnekes, Jorik; Aquino, Camila; Garg, Divyani; Dale, Marian L.; Schlosser, Darbe; Lai, Yijie; Al-Wardat, Mohammad; Salari, Mehri; Wolke, Robin; Tsinda Labou, Valery; Imbalzano, Gabriele; Camozzi, Serena; Merello, Marcelo; Bloem, Bastiaan R.; Capato, Tamine; Djaldetti, Ruth; Doherty, Karen; International Parkinson and Movement Disorders Society Task Force on Postural Abnormalities (Wiley, 2023-04-20)
    Axial postural abnormalities are common and disabling motor complications of Parkinson's disease (PD) and parkinsonism. They consist of abnormal trunk or neck postures in the upright position, often interfering with daily ...
  • A 15-year consolidated overview of data in over 6000 patients from the Transthyretin Amyloidosis Outcomes Survey (THAOS) 
    Gentile, Luca; Coelho, Teresa; Dispenzieri, Angela; Conceição, Isabel; Waddington Cruz, Marcia; Kristen, Arnt V.; Wixner, Jonas; Diemberger, Igor; Gonzalez-Moreno, Juan; Cariou, Eve; Maurer, Mathew S.; Planté-Bordeneuve, Violaine; Garcia-Pavia, Pablo; Tournev, Ivailo; Gonzalez-Costello, Jose; Gonzalez Duarte, Alejandra; Grogan, Martha; Mazzeo, Anna; THAOS investigators; Barroso, Fabio Adrián (BioMed Central, 2023-11-10)
    Background: Transthyretin amyloidosis (ATTR amyloidosis) is a progressive, multisystemic, life-threatening disease resulting from the deposition of variant or wild-type (ATTRwt amyloidosis) transthyretin amyloid fibrils ...
  • A Comprehensive Assessment of Progression Independent of Relapse Activity in a Cohort of Patients with Secondary Progressive Multiple Sclerosis (P8-6.010) 
    Zarate, María Agustina; Marrodán, Mariano; Piedrabuena, María Agustina; Fiol, Marcela Paula; Ysrraelit, María Célica; Correale, Jorge (American Academy of Neurology, 2024-04-09)
    Objective: To analyze characteristics of patients with secondary progressive Multiple Sclerosis (SPMS) exhibiting Progression Independent of Relapse Activity (PIRA) and to identify factors contributing to earlier ...
  • Selection of disease modifying therapies in multiple sclerosis based on patient's age and disease activity: Data from a nationwide registry 
    Piedrabuena, María Agustina; Correale, Jorge; Fiol, Marcela Paula; Marrodán, Mariano; Ysrraelit, María Célica (Elsevier, 2024-05-16)
    Background: Knowledge of the safety and efficacy of disease-modifying therapies (DMTs) in older patients with Multiple Sclerosis (pwMS) is limited due to their exclusion from clinical trials. Our purpose is to evaluate the ...
  • Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study 
    Wisch, Julie K.; McKay, Nicole S.; Boerwinkle, Anna H.; Kennedy, James; Flores, Shaney; Handen, Benjamin L.; Christian, Bradley T.; Head, Elizabeth; Mapstone, Mark; Rafii, Michael S.; O'Bryant, Sid E.; Price, Julie C.; Laymon, Charles M.; Krinsky-McHale, Sharon J.; Lai, Florence; Alzheimer's Biomarker Consortium-Down Syndrome; Dominantly Inherited Alzheimer Network; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio (Lancet Pub. Group, 2024-05)
    Background: In people with genetic forms of Alzheimer's disease, such as in Down syndrome and autosomal-dominant Alzheimer's disease, pathological changes specific to Alzheimer's disease (ie, accumulation of amyloid and ...
  • Occurrence of area postrema syndrome during follow-up: phenotype and influence over NMOSD activity in LATAM in real-world settings. 
    Pestchanker, Claudia; Bertado Cortez, Brenda; Lana Peixoto, Marco A.; Gortari, José Ignacio; Castro Suarez, Sheila; Caparo Zamalloa, César; Galiana, Graciana Lourdes; Peñalver, Francisco; Daccach Marques, Vanessa; Messias, Katharina; Galleguillos Goiry, Lorna; García, Fernando; Rojas, Juan Ignacio; Patrucco, Liliana; Cristiano, Edgardo; Tkachuk, Verónica A.; Liwacki, Susana; Correale, Jorge; Marrodán, Mariano; Ysrraelit, María Célica; Vrech, Carlos; Deri, Norma; Leguizamon, Felisa; Tavolini, Darío; Mainella, Carolina; Zanga, Gisela; Alonso Serena, Marina; Ciampi, Ethel; Herval Ribeiro Soares Neto, Herval; López, Pablo Adrián; Carnero Contentti, Edgar (Springer-Verlag, 2024-03-17)
    Introduction: We aimed to assess the frequency, duration, and severity of area postrema syndrome (APS) during follow-up in neuromyelitis optica spectrum disorder (NMOSD) patients, as well as its association with inflammatory ...
  • α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden 
    Levin, Johannes; Baiardi, Simone; Quadalti, Corinne; Rossi, Marcello; Mammana, Angela; Vöglein, Jonathan; Bernhardt, Alexander; Perrin, Richard J.; Jucker, Mathias; Preische, Oliver; Hofmann, Anna; Höglinger, Günter U.; Cairns, Nigel; Franklin, Erin E.; Chrem Méndez, Patricio Alexis; Dominantly Inherited Alzheimer Network (John Wiley & Sons, 2024-04-26)
    Introduction: Amyloid beta and tau pathology are the hallmarks of sporadic Alzheimer's disease (AD) and autosomal dominant AD (ADAD). However, Lewy body pathology (LBP) is found in ≈ 50% of AD and ADAD brains. Methods: ...
  • Impacto del Programa de Rehabilitación Interdisciplinario de Dolor Crónico en pacientes sin y con trastornos del sueño 
    Salvat, Fernando; Berrozpe, Elda Cecilia; Pueyrredón, Honorio; Amuchastegui, Carolina; López, Victoria; Castrillo, Rocío; Alza, Florencia; Rivas, Romina; Madrazo, Jimena; Mazzola, María Elena; Lujan, Sofía; Farez, Mauricio Franco; Parada Marcilla, Marcela (Revista De Neurologia, 2023-04-17)
    Introducción. Los trastornos del sueño y el dolor crónico están relacionados bidireccionalmente. Ambos están relacionados con trastornos afectivos, fatiga, depresión, ansiedad y abuso de fármacos, y afectan significativamente ...
  • ¿Cómo evitamos un nuevo evento isquémico? 
    Pujol Lereis, Virginia Andrea (Sociedad Argentina de Diabetes, 2023-09)
    El accidente cerebrovascular (ACV) representa la cuarta causa de muerte en Argentina y una de las principales causas de discapacidad. La recurrencia del ACV continúa siendo elevada, llegando al 15-20% a los 10 años del ...
  • Long-term Effect of Ofatumumab on Serum Immunoglobulin Levels in Patients with Relapsing Multiple Sclerosis (P9-6.007) 
    Bar-Or, Amit; Wiendl, Heinz; de Seze, Jerome; Correale, Jorge; Cross, Anne H.; Derfuss, Tobías; Selmaj, Krzysztof; Winthrop, Kevin; Giacomini, Paul Steven; Sacca, Francesco; Hu, Xixi; Sullivan, Roseanne; Jehl, Valentine; Boer, Ibolya; Bhatt, Alit; Hauser, Stephen L. (American Academy of Neurology, 2024-03-09)
  • 6P Extraosseous central nervous system Ewing sarcoma: A single-center retrospective case series 
    Yorio, Florencia; Arakaki, Naomi; Alessandro, Lucas; Palomar, Nicolás; Diez, Blanca; Muggeri, Alejandro (ESMO, 2024-03)
    Background Ewing Sarcoma (ES) tumors are malignant tumors mainly affecting pediatric patients. Extra-osseous primary sites are infrequent, being central nervous system (CNS)-ES extremely rare. Diverse differential ...
  • Cognitive Rehabilitation Using Teleneuropsychology. A Cohort Study in South America 
    Martínez Canyazo, Carlos; Fernández, Rodrigo Sebastián; Helou, María Belén; Arruabarrena, Micaela María; Corvalán, Nicolás; Carello, María Agostina; Harris, Paula; Feldman, Mónica; Calandri, Ismael Luis; Martin, María Eugenia; Allegri, Ricardo Francisco; Crivelli, Lucía (Cambridge University Press, 2023-12-21)
    Objective: The COVID-19 pandemic has affected the continuity of cognitive rehabilitation (CR) worldwide. However, the use of teleneuropsychology (TNP) to provide CR has contributed significantly to the continuity of ...

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