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Therapeutic Potential in Wound Healing of Allogeneic Use of Equine Umbilical Cord Mesenchymal Stem Cells

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dc.contributor.author Iribarne, Ailén
dc.contributor.author Palma, María Belén
dc.contributor.author Andrini, Laura B.
dc.contributor.author Riccillo, Fernando
dc.contributor.author Rodríguez, Delfina
dc.contributor.author Casella, Martín
dc.contributor.author Garay, Felipe
dc.contributor.author Spoto Zabala, Julieta
dc.contributor.author Mazza, Leandro
dc.contributor.author Muro, Adriana
dc.contributor.author Buero, Guillermo
dc.contributor.author Miriuka, Santiago Gabriel
dc.contributor.author Carosella, Edgardo D.
dc.contributor.author García, Marcela N.
dc.date.accessioned 2024-03-05T13:41:07Z
dc.date.available 2024-03-05T13:41:07Z
dc.date.issued 2024-02-16
dc.identifier.citation Iribarne A, Palma MB, Andrini L, Riccillo F, Rodriguez D, Casella M, Garay F, Zabala JS, Mazza L, Muro A, Buero G, Miriuka SG, Carosella E, García MN. Therapeutic Potential in Wound Healing of Allogeneic Use of Equine Umbilical Cord Mesenchymal Stem Cells. Int J Mol Sci. 2024 Feb 16;25(4):2350. doi: 10.3390/ijms25042350. es_ES
dc.identifier.uri https://doi.org/10.3390/ijms25042350
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/1031
dc.description.abstract Wound healing after skin injury is a complex process, particularly in equines where leg wounds are prevalent and their repair is complicated due to the anatomical characteristics. Conventional treatments are not effective enough. The umbilical cord offers an unlimited source of adult mesenchymal stem cells (ucMSCs) from Wharton's jelly tissue. The present study aims to demonstrate the safety and therapeutic potential of the allogeneic use of equine ucMSCs (e-ucMSCs) in the healing of severe equine leg wounds. The methods employed were the isolation, culture and expansion of e-ucMSCs. Flow cytometry and a PCR assay were used for cell characterization. This study included an immunomodulation assay, a murine pre-clinical trial and the first phase of an equine clinical trial. Our results showed that e-ucMSCs express a functional HLA-G homolog, EQMHCB2. In the immunomodulation assay, the e-ucMSCs inhibited the proliferation of activated equine peripheral blood mononuclear cells (e-PBMCs). In the murine pre-clinical trial, e-ucMSCs reduced healing time by 50%. In the equine clinical trial, the injection of e-ucMSCs into severe leg lesions improved the closure time and quality of the tissues involved, regenerating them without fibrous tissue scar formation. In conclusion, the results of this study suggest that e-ucMSCs can be used allogeneically for wound healing by creating a tolerogenic environment. es_ES
dc.language.iso eng es_ES
dc.publisher MDPI es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.subject Stem Cells es_ES
dc.subject Células Madre es_ES
dc.subject Horses es_ES
dc.subject Caballos es_ES
dc.title Therapeutic Potential in Wound Healing of Allogeneic Use of Equine Umbilical Cord Mesenchymal Stem Cells es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/article
dc.description.fil Fil: Miriuka, Santiago Gabriel. Fleni. Instituto de Neurociencias FLENI-CONICET. Laboratorio de Investigación Aplicada a las Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.description.fil Fil: Palma, María Belén. Fleni. Instituto de Neurociencias FLENI-CONICET. Laboratorio de Investigación Aplicada a las Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata; Argentina.
dc.relation.ispartofVOLUME 25
dc.relation.ispartofNUMBER 4
dc.relation.ispartofPAGINATION 2350
dc.relation.ispartofCOUNTRY Suiza
dc.relation.ispartofCITY Basilea
dc.relation.ispartofTITLE International journal of molecular sciences
dc.relation.ispartofISSN 1422-0067
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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