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Friends with benefits: Sharing large-scale transcontinental brain MRI databases in LatAM-FINGERS and US POINTER

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dc.contributor.author DaGraça Morais Martin, Maria
dc.contributor.author Landau, Susan M.
dc.contributor.author Damián, Andrés
dc.contributor.author Vemuri, Prashanthi
dc.contributor.author Bérgamo, Yanina
dc.contributor.author Kimie Suemoto, Claudia
dc.contributor.author Calandri, Ismael Luis
dc.contributor.author Caramelli, Paulo
dc.contributor.author Lopera, Francisco
dc.contributor.author Allegri, Ricardo Francisco
dc.contributor.author Lovato, Laura
dc.contributor.author Delgado, Carolina
dc.contributor.author Nitrini, Ricardo
dc.contributor.author Dozzi Brucki, Sonia María
dc.contributor.author Duque, Lissette
dc.contributor.author Charamelo Baieti, Ana
dc.contributor.author Custodio, Nilton
dc.contributor.author Crivelli, Lucía
dc.contributor.author US POINTER
dc.contributor.author LatAm FINGERS
dc.date.accessioned 2024-04-04T15:04:06Z
dc.date.available 2024-04-04T15:04:06Z
dc.date.issued 2023-12-25
dc.identifier.citation Da Graça Morais Martin M, Landau SM, Damian A, Vemuri P, Bérgamo Y, Suemoto CK, et al. Friends with benefits: Sharing large-scale transcontinental brain MRI databases in LatAM-FINGERS and US POINTER. Alzheimer’s & Dementia. 2023;19(S17):e078835. es_ES
dc.identifier.uri https://doi.org/10.1002/alz.078835
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/1056
dc.description.abstract Background Multicentric initiatives to study brain cognition in the elderly offers us a unique collection of brain imaging data accompanied by detailed neuroclinical and neuropsychological evaluations. U.S. POINTER and LatAm-FINGERS, part of the World Wide FINGERS, are both large-scale investigations of lifestyle interventions and its impact on cognitive function. These large-scale detailed data may offer an unprecedented opportunity to compare diverse populations. Method Baseline MRI of subjects from multiple US centers (POINTER-US), distributed in 5 geographical regions, and from 9 latin-american countries (LatAm-FINGERS). The protocols vary from basic (3D T1, 3D FLAIR,T2* GRE, Cor T2 hippocampus, DWI) to advanced which also included ASL, rs-FMRI and DTI. Demographic information and clinical, cognitive and neuropsychological assessment were also included. Result MRI data was collected from 662 participants in the United States (about 65% of the total anticipated U.S. POINTER neuroimaging sample) and from 542 subjects from 9 countries in latin-america (about 80% of the total anticipated LatAm-FINGERS neuroimaging sample), with around 1200 participants scanned (table1). All participants have 3D T1, 3D FLAIR, T2* GRE images and either DWI or DTI images. Comparative demographics from the 2 datasets shows similar mean age, a predominance of females, and slight differences in education (table 2). This will allow us to compare multiethnic and multicultural volumetric and functional brain MRI information, as well as disease markers, associated with thorough neurological and clinical assessment. Reasons for not acquiring MRI were mainly due to claustrophobia or scanner unavailability. Conclusion This is an exceptional opportunity to have comparative large-scale databases, with anatomical and functional brain imaging from different populations, allowing us to study real world diverse brain data and better understand its relationships with demographics, health and risk characteristics, and cognition. es_ES
dc.language.iso eng es_ES
dc.publisher Wiley es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.subject Magnetic Resonance Imaging es_ES
dc.subject Imagen por Resonancia Magnética es_ES
dc.subject Latin America es_ES
dc.subject América Latina es_ES
dc.title Friends with benefits: Sharing large-scale transcontinental brain MRI databases in LatAM-FINGERS and US POINTER es_ES
dc.type Presentation es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Bérgamo, Yanina. Fleni. Departamento de Diagnóstico por Imágenes. Centro de Imágenes Moleculares; Argentina.
dc.description.fil Fil: Calandri, Ismael Luis. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina. Universidad de la Costa; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.description.fil Fil: Crivelli, Lucía. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.relation.ispartofVOLUME 19
dc.relation.ispartofNUMBER S17 Supplement: Biomarkers – Part 4
dc.relation.ispartofPAGINATION e078835
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Hoboken
dc.relation.ispartofTITLE Alzheimer's & dementia
dc.relation.ispartofISSN 1552-5279
dc.type.snrd Presentation es_ES


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