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Design of a neuropsychological battery for the detection of cognitive deficits in asymptomatic patients with low-grade glioma: a pilot study

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dc.contributor.author Keller, Greta
dc.contributor.author Carello, María Agostina
dc.contributor.author Banjsak, Vanina G.
dc.contributor.author Egido, Noelia
dc.contributor.author Calandri, Ismael Luis
dc.contributor.author Allegri, Ricardo Francisco
dc.contributor.author Cervio, Andrés Eduardo
dc.contributor.author Crivelli, Lucía
dc.date.accessioned 2024-04-25T17:16:46Z
dc.date.available 2024-04-25T17:16:46Z
dc.date.issued 2023-12-21
dc.identifier.citation Keller G, Carello MA, Banjsak V, Egido N, Clandri IL, Allegri R, et al. 14 Title: Design of a neuropsychological battery for the detection of cognitive deficits in asymptomatic patients with low-grade glioma: a pilot study. Journal of the International Neuropsychological Society. noviembre de 2023;29(s1):805-6. es_ES
dc.identifier.uri https://doi.org/10.1017/S1355617723010007
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/1091
dc.description.abstract Objective: Gliomas are a group of CNS neoplasms arising from neuroglial cells with various degrees of aggressiveness. Resection of brain tumors is complex to perform without neurological sequelae due to the diffuse nature of the tumors. This study aimed to design a neuropsychological battery to examine pre surgical cognitive deficits in a case series of patients with LGG and to determine the post-surgical effects after resection. Participants and Methods: 11 adult patients aged 19-65 years (38 ±DS:15.5) with a diagnosis of LGG without cognitive complaint were evaluated with a selection of specific neuropsychological tests to identify possible baseline cognitive deficits and their evolution after tumor resection. All participants completed a comprehensive neuropsychological evaluation assessing memory, language, attention, executive functions, visuospatial functions, social cognition, praxis, agnosias, functionality, mood, and quality of life. The neuropsychological battery design was based on a systematic review of the literature on surgical interventions in low-grade gliomas. Results: Despite not reporting subjective cognitive complaints, patients showed deficits in multiple cognitive domains in the pre-surgical evaluation when comparing their performance with normative values adjusted for age, sex, and education. Deficits in executive functions and attention were observed: 36% presented failures in graphomotor speed (TMT A), 27% of subjects presented failures in attentional span (Direct Digit Span), working memory (Inverse Digit Span), and cognitive flexibility (Wisconsin Card Sorting Test) and 9% presented difficulties in processing speed (Trail Making Test A) and inhibitory capacity (Stroop Test). Memory: 18% of the patients showed deficits in immediate logical memory and 9% in delayed memory (Craft Story 21). Likewise, 18% of the patients presented compromise in immediate auditory-verbal learning and 27% in delayed auditory-verbal learning (Rey Auditory-Verbal Test). Language: 18% showed failures in naming (Boston 60) and 9% in comprehension (Token Test). Likewise, 27% of the patients presented difficulties in social cognition (Mind in the Eyes Test). Finally 41% of the patients reported symptoms of depression and/or anxiety in the neuropsychiatric questionnaires. Conclusions: The results highlight the importance of strategically designed pre-surgical cognitive assessment for the detection and follow-up of cognitive and mood disorders associated with the location of the space-occupying lesion (LOE). The patients assessed in this study will be evaluated three months after surgery to document changes in baseline cognitive symptoms. Furthermore, in patients with lesions in the left hemisphere, an intraoperative evaluation will be performed to minimize subsequent deficits, assessing these functions during surgery and emphasizing language. es_ES
dc.language.iso eng es_ES
dc.publisher Cambridge University Press es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.subject Neuropsychological Tests es_ES
dc.subject Pruebas Neuropsicológicas es_ES
dc.subject Cognitive Dysfunction es_ES
dc.subject Disfunción Cognitiva es_ES
dc.subject Glioma es_ES
dc.title Design of a neuropsychological battery for the detection of cognitive deficits in asymptomatic patients with low-grade glioma: a pilot study es_ES
dc.type Presentation es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Keller, Greta. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina
dc.description.fil Fil: Carello, María Agostina. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina
dc.description.fil Fil: Banjsak, Vanina G. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina
dc.description.fil Fil: Egido, Noelia. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina
dc.description.fil Fil: Calandri, Ismael Luis. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Cervio, Andrés Eduardo. Fleni. Departamento de Neurocirugía; Argentina.
dc.description.fil Fil: Crivelli, Lucía. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.relation.ispartofVOLUME 29
dc.relation.ispartofNUMBER Supplement s1: Final Program Fifty First Annual Meeting International Neuropsychological Society February 1–4, 2023 San Diego, CA, USA
dc.relation.ispartofPAGINATION 805 - 806
dc.relation.ispartofCOUNTRY Reino Unido
dc.relation.ispartofCITY Cambridge
dc.relation.ispartofTITLE Journal of the International Neuropsychological Society
dc.relation.ispartofISSN 1469-7661
dc.type.snrd Presentation es_ES


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